EKS-FEC-00114

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-FEC-00114

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	479.2	3.0E-144	1079	1339	261

Status

Reviewed

Ensembl Protein

ENSFCAP00000008842

UniProt Accession

A0M8S8;

Protein Name

Hepatocyte growth factor receptor

Protein Synonyms/Alias

HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met;

Gene Name

MET

Gene Synonyms/Alias

MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSFCAG00000009534	ENSFCAP00000008842	ENSFCAT00000009536

Organism

Felis catus

Functional Description

Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).

Protein Length

1382

Protein Sequence
(FASTA)

MKAPAVLAPG ILVLLFTLVQ KSYGECREAL VKSEMNVNMK YQLPNFTAET PIQNVVLHKH 60

HIYLGAVNYI YVLNDKDLQK VAEYKTGPVL EHPDCFPCQD CSHKANLSGG VWKDNINMAL 120

LIDTYYDDQL ISCGSVHRGT CQRHVLPPSN TADILSKVHC MYSPQADEES SHCPDCVVSA 180

LGTKVLISEK GRFINFFVGN TINSSYLTDH SLHSISVRRL KETQDGFKFL TDQSYIDVLP 240

EFRDSYPIKY IHAFESNRFI YFLTVQRETL DAQTFHTRII RFCSVDSGLH SYMEMPLECI 300

LTEKRRKRST REEVFNILQA AYVSKPGAHL AKQIGANLND DILYGVFAQS KPDSAEPMNR 360

SAVCAFPIKY VNEFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRSDEYRTE 420

FTTALQRVDL FMGQFNQVLL TSISTFIKGD LTIANLGTSE GRFMQVVVSR SGSSTPHVNF 480

RLDSHPVSSE AIVEHPLNQN GYTLVVTGKK ITKIPLNGLG CEHFQSCSQC LSAPPFVQCG 540

WCHDKCVQLE ECPSGTWTQE ICLPTIYEVF PTSAPLEGGT MLTVCGWDFG FRRNNKFDLK 600

KTRVFLGNES CTLTLSESTT NMLKCTVGPA VNEHFNISII ISNGRGTAQY STFSYVDPVI 660

TSIFPSYGPK TGGTLLTLTG KYLNSGNSRH ISIGGKTCTL KSVSDSILEC YTPAQTIPTE 720

FPIKLKIDLA NREMNSFSYQ EDPIVYAIHP TKSFISGGST ITAVGKNLNS VSVLRMVISV 780

HETRRNFTVA CHHRSNSEII CCTTPSLQQL NLQLPLKTKA FFMLDGIHSK YFDLIYVHNP 840

VFKPFEKPVM ISIGNENVLE IKGNDIDPEA VKGEVLKVGN KSCETIYSDS EAVLCKVPND 900

LLKLNNELNI EWKQAVSSTI LGKVIVQPDQ NFTGLIVGVI SISIILLLLL GVFLWLKKRK 960

QIKDLGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNSSQNG 1020

SCRQVQYPLT DLSPMLNSGD SDISSPLLQN TVHIDLSALN PELVQAVQHV VIGPSSLIVH 1080

FNEVIGRGHF GCVYHGTLLD SDDKKIHCAV KSLNRITDIG EVSQFLTEGI IMKDFSHPNV 1140

LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK 1200

FVHRDLAARN CMLDEKFTVK VADFGLARDM YDKEYYSVHN KTGAKLPVKW MALESLQTQK 1260

FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITVYLLQG RRLLQPEYCP DPLYEVMLKC 1320

WHPKAELRPS FSELVSRISA IFSTFIGEHY VHVNATYVNV KCVAPYPSLL SSQDNIDGEG 1380

DT 1382

Nucleotide Sequence
(FASTA)

ATGAAGGCCC CTGCTGTGCT TGCACCTGGC ATCCTTGTGC TTCTGTTTAC CTTGGTGCAG 60

AAGAGCTACG GGGAGTGCAG AGAGGCACTA GTAAAGTCTG AGATGAATGT GAACATGAAG 120

TATCAGCTTC CCAACTTCAC TGCAGAAACA CCCATCCAGA ATGTTGTTTT ACACAAGCAT 180

CATATTTACC TTGGTGCAGT TAACTATATT TACGTTTTAA ATGACAAAGA CCTTCAGAAG 240

GTTGCTGAGT ACAAGACTGG GCCCGTGCTG GAACACCCAG ATTGTTTCCC ATGTCAGGAC 300

TGCAGCCACA AAGCCAATTT ATCAGGTGGT GTTTGGAAAG ATAACATCAA CATGGCTCTA 360

CTTATTGACA CGTACTATGA CGACCAACTC ATTAGCTGTG GCAGTGTCCA CAGAGGGACC 420

TGCCAGCGAC ATGTCCTTCC ACCCAGCAAT ACTGCTGACA TACTGTCAAA AGTTCATTGC 480

ATGTACTCCC CACAGGCAGA CGAAGAGTCC AGCCACTGTC CTGACTGTGT GGTGAGTGCC 540

CTGGGAACCA AAGTCCTGAT ATCTGAAAAG GGCCGGTTCA TCAACTTCTT CGTGGGCAAT 600

ACCATAAATT CCTCTTACCT AACAGATCAT TCATTGCATT CAATATCAGT GAGAAGGCTA 660

AAGGAAACTC AAGATGGCTT TAAGTTTTTA ACAGACCAGT CTTATATTGA TGTTCTCCCT 720

GAATTCAGAG ATTCCTACCC TATTAAATAC ATCCATGCCT TTGAAAGCAA CCGTTTTATT 780

TACTTTTTGA CAGTCCAGCG AGAAACTCTA GATGCTCAGA CTTTTCACAC AAGAATAATC 840

AGGTTCTGTT CTGTAGACTC TGGATTGCAT TCCTACATGG AAATGCCTCT GGAATGTATC 900

CTCACAGAAA AGAGAAGAAA GAGATCCACA AGGGAGGAAG TGTTTAATAT TCTCCAAGCT 960

GCATATGTCA GTAAGCCTGG GGCCCACCTT GCTAAGCAAA TAGGTGCCAA CCTGAATGAT 1020

GACATTCTCT ATGGAGTATT CGCACAAAGC AAGCCGGATT CTGCTGAACC AATGAATCGC 1080

TCTGCCGTCT GTGCATTCCC TATCAAATAT GTCAATGAAT TCTTCAACAA GATTGTAAAC 1140

AAAAACAACG TGAGATGTCT TCAACATTTT TATGGACCCA ACCACGAACA CTGCTTTAAT 1200

AGGACACTTT TGAGAAATTC ATCAGGCTGT GAAGTGCGCA GTGATGAATA TCGAACGGAG 1260

TTTACCACAG CTTTGCAGCG AGTTGACTTA TTCATGGGCC AATTCAACCA AGTCCTCTTA 1320

ACATCTATAT CCACCTTCAT TAAAGGAGAC CTCACCATTG CTAATCTTGG GACATCAGAG 1380

GGTCGCTTTA TGCAGGTTGT GGTTTCTCGA TCAGGATCAT CAACACCTCA TGTGAATTTT 1440

CGCCTGGATT CCCACCCTGT GTCTTCAGAA GCAATTGTGG AGCACCCATT AAACCAAAAT 1500

GGCTACACAC TGGTTGTTAC TGGAAAGAAG ATCACCAAGA TCCCACTGAA TGGCTTAGGC 1560

TGTGAACATT TCCAGTCCTG CAGTCAGTGT CTTTCTGCCC CTCCCTTTGT GCAGTGTGGC 1620

TGGTGCCACG ATAAATGTGT GCAACTGGAG GAATGCCCCA GTGGAACATG GACTCAAGAG 1680

ATCTGTCTGC CTACAATCTA TGAGGTTTTC CCAACCAGTG CACCCCTGGA AGGAGGAACG 1740

ATGCTCACTG TGTGTGGCTG GGACTTTGGA TTCAGGAGGA ATAATAAATT TGATTTAAAG 1800

AAAACTAGAG TTTTCCTTGG AAATGAGAGC TGCACTTTGA CCTTAAGTGA GAGCACAACA 1860

AATATGTTGA AATGCACAGT TGGTCCTGCA GTGAATGAGC ATTTCAATAT ATCCATAATT 1920

ATTTCAAATG GGCGAGGGAC AGCACAATAC AGTACATTTT CCTATGTGGA TCCTGTAATA 1980

ACAAGTATTT TTCCAAGTTA TGGTCCTAAG ACCGGTGGCA CCTTGCTTAC TTTAACTGGA 2040

AAGTACCTTA ACAGTGGGAA TTCTAGACAC ATTTCAATTG GTGGAAAAAC GTGTACTTTA 2100

AAAAGTGTGT CAGATAGTAT TCTCGAATGT TATACCCCAG CTCAAACCAT TCCAACTGAG 2160

TTTCCTATTA AATTGAAAAT TGACTTAGCC AACCGAGAGA TGAACAGTTT CAGTTACCAG 2220

GAAGACCCCA TTGTCTATGC AATTCATCCA ACCAAATCTT TTATTAGTGG TGGGAGCACC 2280

ATAACAGCTG TTGGGAAAAA CCTGAATTCA GTTAGTGTCC TAAGGATGGT AATAAGTGTA 2340

CATGAAACAA GAAGGAACTT TACAGTGGCA TGTCACCATC GCTCTAATTC AGAGATAATC 2400

TGCTGTACAA CTCCTTCACT GCAACAGCTG AATCTGCAAC TCCCTCTGAA AACCAAAGCC 2460

TTTTTCATGT TAGATGGGAT CCATTCCAAA TACTTTGATC TCATTTATGT ACATAATCCT 2520

GTGTTTAAGC CTTTTGAAAA GCCAGTGATG ATCTCAATAG GCAATGAAAA TGTACTGGAA 2580

ATTAAGGGAA ATGATATTGA CCCTGAAGCA GTTAAAGGTG AAGTGTTAAA AGTTGGAAAT 2640

AAGAGCTGTG AGACTATATA CTCAGATTCT GAAGCTGTTT TATGCAAGGT CCCCAATGAC 2700

CTGCTGAAAT TGAACAACGA GCTAAATATA GAGTGGAAGC AAGCAGTTTC TTCAACCATC 2760

CTTGGAAAAG TAATAGTTCA ACCAGATCAG AATTTCACAG GATTGATTGT TGGTGTTATC 2820

TCAATATCAA TAATACTCTT ACTATTACTT GGGGTTTTCC TGTGGCTGAA AAAGAGAAAG 2880

CAAATTAAAG ATCTGGGCAG TGAATTAGTT CGCTATGATG CAAGAGTACA CACTCCTCAT 2940

TTGGATAGGC TTGTAAGTGC CCGAAGTGTA AGCCCAACTA CAGAAATGGT TTCAAATGAA 3000

TCTGTAGACT ACCGAGCTAC TTTTCCAGAA GACCAGTTTC CTAACTCATC TCAGAATGGA 3060

TCGTGCAGAC AAGTACAGTA TCCTCTGACG GACCTGTCCC CCATGCTTAA TAGTGGGGAC 3120

TCTGATATAT CCAGTCCATT ACTGCAAAAT ACTGTCCACA TTGACCTCAG TGCTCTAAAT 3180

CCAGAGCTGG TCCAGGCAGT CCAGCACGTA GTGATTGGGC CAAGTAGCCT GATTGTGCAT 3240

TTCAATGAAG TCATAGGAAG AGGACATTTT GGGTGTGTGT ACCATGGGAC TTTATTGGAC 3300

AGCGATGACA AGAAGATTCA CTGTGCTGTG AAATCCTTGA ATAGAATCAC TGACATAGGT 3360

GAAGTTTCCC AGTTTCTGAC TGAGGGAATC ATCATGAAAG ATTTTAGTCA TCCAAATGTT 3420

CTCTCACTCT TGGGAATCTG CCTTCGAAGT GAGGGGTCTC CACTGGTGGT CCTACCATAT 3480

ATGAAACATG GAGATCTTCG AAATTTCATC AGAAATGAGA CTCATAACCC AACTGTAAAA 3540

GATCTTATTG GCTTTGGTCT TCAAGTAGCC AAAGGCATGA AATATCTTGC AAGCAAAAAG 3600

TTTGTACACA GAGACTTGGC TGCTAGAAAC TGTATGTTGG ATGAAAAATT CACTGTCAAG 3660

GTTGCTGATT TTGGTCTGGC CAGAGACATG TATGATAAAG AATACTACAG TGTACACAAC 3720

AAAACGGGCG CCAAGCTGCC AGTGAAGTGG ATGGCTCTAG AAAGTCTACA AACTCAGAAG 3780

TTTACCACCA AGTCAGATGT GTGGTCCTTT GGTGTGCTCC TCTGGGAACT GATGACAAGA 3840

GGGGCTCCAC CTTATCCTGA TGTCAACACC TTTGATATAA CAGTTTACTT ATTGCAAGGC 3900

AGAAGACTCT TACAGCCTGA ATACTGCCCA GATCCCTTAT ATGAAGTGAT GCTAAAATGC 3960

TGGCACCCTA AAGCTGAACT GCGCCCATCT TTTTCTGAAC TGGTCTCCAG GATATCAGCG 4020

ATATTCTCTA CTTTCATTGG GGAGCACTAT GTCCATGTGA ACGCTACTTA TGTGAATGTC 4080

AAATGTGTTG CTCCATACCC TTCTCTGTTG TCATCACAAG ATAACATTGA TGGCGAGGGG 4140

GACACATGA 4149

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+ds++kki++avksl+ritdi++v++fl+eg++mk+++hp

Q: 1079  VHFNEVIGRGHFGCVYHGTLLDSDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP  1138

         799*********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 1139  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1198

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt

Q: 1199  KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  1258

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd ly+vm

Q: 1259  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM  1317

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++k++ rp+fs+lvs+is

Q: 1318  LKCWHPKAELRPSFSELVSRIS  1339

         ********************98

Domain Sequence
(FASTA)

VHFNEVIGRG HFGCVYHGTL LDSDDKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHP 60

NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLYEVML 240

KCWHPKAELR PSFSELVSRI S 261

Keyword

ATP-binding; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Proto-oncogene; Receptor; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007275	; P:multicellular organismal development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013