EKS-FEC-00063

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-FEC-00063

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	371.5	2.5E-111	729	1022	294

Status

Unreviewed

Ensembl Protein

ENSFCAP00000009183

Gene Name

CDK12

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSFCAG00000009897	ENSFCAP00000009183	ENSFCAT00000009900

Organism

Felis catus

Protein Length

1492

Protein Sequence
(FASTA)

MPNPERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA 60

APLGTIIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GTDRSDRLHK HRHHQHRRSR 120

DLLKTKQTEK EKNQEVSSKS GSMKDRISGS SKRSNEENED YGKAQISKSS SNKESRSSKL 180

HKEKTRKERE LKSGHKDRSK SHRKRETPKS YKTVDSPKRR SRSPHRKWSD SPKQDDSPSG 240

ASYGQDYDLS PPRSHTSSNY DSYKKSPGST SRRQSISPPY KEPSAYQSST RSPSPYSRRQ 300

RSVSPYGRRR SSSYERSGSY SGRSPSPYGR RRSSSPFMSK RSLSRSPLPS RKSMKSRSRS 360

PAYSRHSSSH SKKKRSGSRS RHSSISPVRL PLNSSLGAEL SRKKKERAAA AAAAKMDGKE 420

SKGSPVFLPR KENSLVEAKD SGLESKKLPR GVKLEKSAPD TELVNVPHLN TEVKNSLDTG 480

KVKLDENSEK HPILKDLKAQ GSRDSKPVAL KEEIVTPKET EVSEKETHPP LPTVTSPPPP 540

LPTTTPPPQT PPLPPLPPLP AIPQQPPLPP PQPAFSQVLA SSTSTLPPST HPRTSTLSSQ 600

ANSQPPVQVS VKTQVSVTAA IPHLKTSTLP PLPLPPLLPG DDDMDSPKET PPSKPVKKEK 660

EQRPRHLLTD LPLPPELPGG DPSPPDSPEP KAVTPPQQPY KKRPKICCPR YGERRQTESD 720

WGKRCVDKFD IIGIIGEGTY GQVYKAKDKD TGELVALKKV RLDNEKEGFP ITAIREIKIL 780

RQLIHRSVVN MKEIVTDKQD ALDFKKDKGA FYLVFEYMDH DLMGLLESGL VHFSEDHIKS 840

FMKQLMEGLD YCHKKNFLHR DIKCSNILLN NSGQIKLADF GLARLYNSEE SRPYTNKVIT 900

LWYRPPELLL GEERYTPAID VWSCGCILGE LFTKKPIFQA NLELAQLELI SRLCGSPCPA 960

VWPDVIKLPY FNTMKPKKQY RRRLREEFSF IPSAALDLLD HMLTLDPSKR CTAEQTLQSD 1020

FLKDVELSKM DPPDLPHWQD CHELWSKKRR RQRQSGVVIE EPPPSKASRK ETTSGTSAEP 1080

VKNSSPAPPQ PAPGKVEPGT GDAVGLGDIT QQLNQSELAV LLNLLQSQTD LSIPQMAQLL 1140

NIHSNPEMQQ QLEALNQSIS ALTEATSQQQ DSEPMAPEES LKEAPPALVV QPSAEQTTSE 1200

ASSTPADMQN MLAVLLSQLM KTQEPAGSLE ENNSDKNSGP QGPRRTPTMP QEEAAACPPH 1260

ILPPEKRPPE PPGPPPPPPP PPLVEGDLSS APQELNPAVT AALLQLLSQP EAEPPGHLPH 1320

EHQALRPMEY STRPHPNRTY GNTDGPETGF SAADTDERNS GPALTESLTQ TLVKNRTFSG 1380

SVSHLGESSS YQGTGSVQFP GDQDLRFARV PLALHSVVGQ PFLKAEGSSN SVVHAETKLQ 1440

NYGELGPGTT GASSSGTGLN WGGPAQSSAY GKLYRGPTRV PPRGGRGRGV PY 1492

Nucleotide Sequence
(FASTA)

ATGCCCAATC CAGAGAGACA TGGGGGCAAG AAGGACGGGA GTGGAGGAGC TTCTGGAACT 60

TTGCAGCCGT CATCGGGAGG TGGCAGCTCC AACAGCAGAG AGCGTCACCG CTTGGTGTCG 120

AAGCACAAGC GGCATAAATC CAAGCACTCC AAAGACATGG GGTTGGTGAC CCCCGAAGCA 180

GCACCTTTAG GTACAATTAT CAAACCTTTG GTGGAGTATG ATGACATCAG TTCTGATTCA 240

GATACCTTCT CTGACGATAT GGCCTTCAAA CTAGACAGGA GGGAGAATGA TGAGCGTCGT 300

GGAACTGATC GGAGTGACCG CCTGCACAAA CATCGTCACC ACCAGCACAG ACGTTCCCGG 360

GACTTACTAA AAACTAAACA GACAGAAAAA GAAAAAAACC AGGAAGTCTC CAGCAAATCG 420

GGATCTATGA AGGACCGGAT ATCAGGAAGT TCAAAGCGTT CAAATGAGGA GAATGAGGAC 480

TATGGGAAGG CACAGATATC CAAAAGCAGC AGCAACAAGG AATCCAGGTC ATCCAAACTA 540

CATAAGGAGA AGACCCGGAA AGAACGTGAG TTGAAGTCTG GGCACAAAGA CCGGAGTAAA 600

AGTCATCGGA AAAGGGAAAC ACCCAAAAGC TACAAGACGG TGGACAGCCC CAAACGGAGA 660

TCCAGGAGTC CCCATAGGAA ATGGTCTGAC AGCCCCAAGC AAGATGATAG CCCCTCAGGA 720

GCTTCTTATG GCCAAGATTA TGACCTTAGT CCTCCAAGAT CTCACACCTC TAGCAATTAT 780

GACTCCTACA AGAAGAGTCC TGGAAGTACC TCAAGAAGGC AGTCAATTAG TCCTCCCTAC 840

AAGGAGCCCT CGGCCTACCA GTCCAGCACC CGATCACCCA GTCCTTACAG TAGACGACAA 900

AGGTCTGTGA GTCCCTATGG CCGGAGACGT TCTTCCAGCT ATGAAAGGAG TGGCTCTTAC 960

AGTGGGAGAT CACCCAGTCC CTATGGTCGA AGACGGTCCA GCAGCCCTTT CATGAGCAAA 1020

CGGTCTCTGA GTCGGAGTCC ACTCCCCAGT AGGAAATCCA TGAAGTCTAG AAGTAGAAGT 1080

CCCGCATATT CAAGACACTC ATCTTCTCAT AGTAAAAAGA AGAGATCGGG GTCACGCAGT 1140

CGACATTCCA GCATCTCACC TGTCAGGCTT CCATTGAACT CCAGCTTGGG AGCTGAACTC 1200

AGTAGGAAAA AGAAGGAAAG AGCAGCAGCT GCTGCTGCAG CAAAAATGGA TGGAAAGGAG 1260

TCCAAGGGTT CACCTGTGTT TTTGCCTAGA AAAGAGAACA GTTTAGTAGA GGCTAAGGAT 1320

TCAGGCTTGG AGTCTAAAAA GTTACCCAGA GGTGTAAAAT TGGAAAAATC TGCCCCAGAT 1380

ACTGAACTGG TGAATGTACC ACATCTCAAT ACAGAAGTCA AAAATTCTTT AGATACAGGG 1440

AAAGTAAAGT TGGATGAGAA CTCTGAGAAG CATCCTATTC TTAAAGATTT GAAAGCACAG 1500

GGATCAAGAG ACTCTAAACC CGTAGCATTG AAAGAGGAGA TTGTTACTCC AAAAGAGACA 1560

GAGGTATCAG AAAAGGAGAC CCATCCGCCT CTCCCCACAG TTACTTCTCC TCCACCTCCT 1620

TTACCAACTA CTACCCCTCC ACCTCAAACA CCCCCTTTGC CACCTTTGCC TCCACTACCA 1680

GCTATTCCAC AGCAACCACC TCTGCCTCCT CCCCAACCAG CATTTAGTCA GGTTCTTGCT 1740

TCTAGTACTT CAACTCTGCC CCCTTCTACT CACCCAAGGA CATCTACTCT GTCCTCTCAG 1800

GCAAATTCTC AGCCCCCTGT ACAGGTGTCT GTGAAGACTC AAGTATCTGT AACAGCTGCT 1860

ATTCCACACT TAAAAACTTC AACGTTGCCT CCTCTGCCCC TCCCACCCTT ATTACCTGGA 1920

GACGATGACA TGGATAGTCC AAAAGAGACT CCACCTTCAA AACCTGTAAA GAAAGAGAAG 1980

GAACAAAGGC CACGTCACTT ACTCACGGAC CTCCCTCTCC CTCCAGAGCT TCCTGGTGGG 2040

GATCCATCTC CTCCAGACTC GCCAGAACCA AAGGCAGTTA CACCACCTCA GCAACCATAT 2100

AAAAAGAGAC CAAAAATTTG TTGTCCTCGT TATGGAGAAA GAAGACAAAC AGAAAGTGAC 2160

TGGGGAAAAC GCTGTGTGGA CAAGTTTGAC ATTATTGGGA TTATTGGAGA GGGAACCTAT 2220

GGCCAAGTAT ATAAAGCCAA GGACAAAGAC ACAGGAGAGC TGGTAGCCCT AAAGAAGGTG 2280

AGACTGGATA ATGAAAAGGA GGGCTTCCCG ATCACAGCCA TTCGTGAGAT CAAAATCCTT 2340

CGTCAGCTAA TCCACCGAAG TGTTGTTAAC ATGAAGGAAA TTGTTACAGA TAAACAAGAT 2400

GCACTGGATT TCAAGAAGGA CAAAGGTGCC TTTTACCTTG TATTTGAGTA TATGGACCAT 2460

GACTTAATGG GACTGCTAGA ATCTGGTTTG GTGCACTTTT CTGAGGACCA TATCAAGTCA 2520

TTCATGAAAC AGCTAATGGA AGGATTGGAT TACTGTCACA AAAAGAATTT CCTGCATCGG 2580

GATATTAAGT GTTCTAACAT TTTGCTGAAC AACAGTGGAC AAATCAAACT AGCAGATTTT 2640

GGACTTGCTC GACTCTATAA CTCTGAAGAG AGTCGCCCTT ATACAAACAA AGTCATCACC 2700

CTGTGGTATC GACCTCCAGA ACTTCTGCTG GGAGAGGAGC GTTACACACC AGCTATTGAT 2760

GTTTGGAGCT GTGGATGCAT CCTTGGGGAA CTGTTCACAA AGAAGCCTAT TTTTCAAGCC 2820

AATCTGGAAC TGGCTCAGCT AGAACTGATC AGTCGACTCT GTGGTAGCCC TTGTCCAGCT 2880

GTGTGGCCTG ATGTTATCAA GCTGCCCTAC TTCAATACCA TGAAACCGAA GAAGCAATAT 2940

AGAAGGCGTC TGCGAGAAGA ATTCTCTTTC ATTCCTTCGG CAGCACTTGA TTTACTGGAC 3000

CACATGCTGA CACTAGATCC TAGCAAACGT TGCACAGCTG AACAGACTCT ACAGAGTGAC 3060

TTCCTTAAAG ATGTTGAGCT CAGCAAAATG GATCCTCCAG ACCTCCCCCA CTGGCAGGAT 3120

TGCCATGAAT TGTGGAGTAA GAAACGGCGA CGACAGAGAC AAAGTGGTGT TGTGATAGAA 3180

GAGCCACCTC CATCCAAAGC CTCACGGAAA GAAACTACCT CAGGGACAAG TGCTGAGCCC 3240

GTGAAGAACA GCAGTCCAGC ACCACCTCAG CCTGCTCCTG GCAAGGTGGA ACCTGGGACT 3300

GGGGATGCAG TAGGCCTCGG TGACATCACA CAGCAGTTGA ATCAAAGTGA ATTGGCAGTG 3360

TTACTGAATC TGCTGCAGAG CCAAACCGAC CTAAGCATCC CTCAAATGGC ACAGCTGCTT 3420

AACATCCACT CCAACCCAGA GATGCAGCAG CAGCTGGAGG CCCTGAACCA GTCCATCAGT 3480

GCCCTAACGG AAGCCACTTC CCAGCAGCAG GACTCAGAGC CCATGGCCCC AGAGGAGTCT 3540

TTGAAGGAGG CACCTCCTGC CCTAGTGGTC CAGCCTTCAG CAGAACAGAC AACCTCTGAG 3600

GCTTCAAGCA CACCAGCTGA CATGCAGAAT ATGTTGGCAG TTCTTTTGAG TCAGCTGATG 3660

AAAACCCAGG AGCCAGCAGG CAGCCTGGAG GAAAACAACA GTGACAAGAA CAGTGGGCCA 3720

CAGGGGCCCC GAAGAACTCC CACAATGCCA CAGGAGGAGG CAGCAGCATG TCCTCCTCAC 3780

ATTCTTCCAC CAGAGAAGAG GCCCCCTGAG CCCCCCGGAC CTCCACCGCC GCCACCTCCA 3840

CCCCCTCTGG TTGAAGGCGA TCTTTCCAGC GCCCCCCAGG AGTTGAACCC AGCCGTGACA 3900

GCCGCCTTGC TGCAACTTTT ATCCCAGCCT GAAGCAGAGC CTCCTGGCCA CCTGCCACAT 3960

GAGCACCAGG CCTTGAGACC AATGGAGTAC TCCACCCGAC CCCATCCCAA CAGGACTTAC 4020

GGAAACACTG ATGGGCCTGA AACAGGGTTC AGTGCCGCTG ACACTGATGA ACGCAACTCT 4080

GGTCCAGCTT TGACAGAATC CTTGACCCAG ACCCTGGTGA AGAACAGGAC CTTCTCAGGC 4140

TCTGTGAGCC ACCTTGGGGA GTCCAGCAGT TACCAGGGCA CAGGGTCAGT GCAGTTCCCA 4200

GGGGACCAGG ACCTCCGTTT TGCCAGGGTC CCCTTAGCAT TACACTCAGT GGTCGGGCAA 4260

CCATTCCTGA AGGCTGAGGG AAGCAGCAAC TCTGTGGTAC ATGCAGAGAC CAAATTGCAG 4320

AACTATGGGG AGCTGGGGCC AGGAACCACT GGGGCCAGCA GTTCAGGAAC AGGCCTAAAC 4380

TGGGGGGGCC CAGCTCAGTC TTCTGCTTAT GGAAAACTCT ATCGGGGACC TACAAGAGTC 4440

CCGCCAAGAG GGGGAAGAGG GAGAGGAGTT CCTTACTAA 4479

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++l h+ +

Q: 729   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSV  788

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s++++ks+++ql+e

Q: 789   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFSEDHIKSFMKQLME  847

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar ++s+++  yt++v+TlwYr+Pe

Q: 848   GLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESrPYTNKVITLWYRPPE  907

         ***************************************7766527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq++ e  qle i++l+g+p  +vwp+v k

Q: 908   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK  967

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         lp +++  pkk+++ +l+e+++ + ++aldll+++l+ldp+kR++a+++lq++++

Q: 968   LPYFNTMKPKKQYRrRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL  1022

         *****7777777777******9999**************************9985

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLIHRSV 60

VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFSEDHI KSFMKQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNSGQIKLA DFGLARLYNS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANLELAQLE LISRLCGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRRLREEF SFIPSAALDL LDHMLTLDPS KRCTAEQTLQ SDFL 294

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>