EKS-FEC-00284
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-FEC-00284
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR496.02.1E-149720977258
StatusUnreviewed
Ensembl ProteinENSFCAP00000022496
UniProt AccessionE0Z5T2;
Protein Name
Protein Synonyms/Alias Receptor tyrosine kinase HER2;
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSFCAG00000009903ENSFCAP00000009189ENSFCAT00000009906
ENSFCAG00000009903ENSFCAP00000022496ENSFCAT00000031039
OrganismFelis catus
Functional Description
Protein Length1260
Protein Sequence
(FASTA)
MELAAWCRWG LLLALLPSGA TGTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL 60
ELTYLHANAS LSFLQDIQEV QGYVLIAHNQ VKQVPLQRLR IVRGTQLFED NYALAVLDNG 120
DPLDSGTPAT GTALGGLREL QLRSLTEILK GGVLIQRNPQ LCHQDTILWK DIFHKNNQLA 180
LMLIDTNRSR ACKPCFSLPV ASSLSHPHPA LCLTVTRTVC AGGCARCKGP QPTDCCHEQC 240
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP 300
YNYLSTDVGS CTLVCPLNNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REARAVTSAN 360
IQEFVGCKKI FGSLAFLPES FEGDPASNTA PLQPEQLRVF EALEEITGYL YISAWPDSLP 420
NLSVFQNLRV IRGRVLHDGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHR NSRLCFVHTV 480
PWDQLFRNPH QALLHSANRP EDECAGEGLA CYPLCAHGHC WGPGPTQCVN CSQFLRGQEC 540
VEECRVLQGL PREYVKDRFC LPCHPECQPQ NGSVTCLGSE ADQCVACAHY KDPPFCVARC 600
PSGVKPDLSF MPIWKFADEE GTCQPCPINC THSCADLDEK GCPAEQRASP VTSIIAAVVG 660
ILLVVVVGLV LGILIKRRRQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL 720
RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP 780
YVSRLLGICL TSTVQLVTQL MPYGCLLDHV REHRGRLGSQ DLLNWCVQIA KGMSYLEDVR 840
LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT 900
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM 960
IDSECRPRFR ELVAEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DEDMGDLVDA 1020
EEYLVPQQGF FCPDPAPGAG GTAHRRHRSS STRSGGGELT LGLEPSEEEP PKSPLAPSEG 1080
AGSDVFDGDL GMGAAKGLQS LSPQDPSPLQ RYSEDPTVPL PPETDGYVAP LTCSPQPEYV 1140
NQPEVWPKPP SPLEGPLPPS RPAGATLERP KTLSPKTLSP GKNGVVKDVF AFGGAVENPE 1200
YLAPRGRAAP QPHPPPAFSP AFDNLYYWDQ DTSERGSPPS TFEGTPTAEN PEYLGLDVPV 1260
Nucleotide Sequence
(FASTA)
ATGGAGCTGG CGGCCTGGTG CCGCTGGGGG CTCCTCCTCG CCCTCCTGCC CTCCGGAGCC 60
ACGGGCACCC AAGTGTGCAC CGGCACAGAC ATGAAGCTGC GGCTCCCAGC CAGTCCCGAG 120
ACCCACCTGG ACATGCTCCG CCACCTCTAC CAGGGCTGTC AAGTGGTACA GGGCAACCTG 180
GAGCTCACCT ACCTGCATGC CAATGCCAGC CTCTCCTTCC TGCAGGATAT CCAGGAGGTG 240
CAAGGCTATG TGCTCATTGC CCACAACCAA GTGAAACAGG TCCCACTGCA GAGGCTACGA 300
ATCGTGCGAG GCACCCAGCT CTTTGAGGAC AACTACGCCC TGGCCGTGCT GGACAACGGA 360
GACCCACTGG ACAGTGGCAC CCCTGCTACA GGGACTGCCC TAGGAGGGCT GCGGGAGCTG 420
CAGCTCCGAA GCCTCACAGA GATCCTGAAG GGAGGGGTCC TCATTCAGCG GAACCCGCAG 480
CTCTGCCACC AGGACACGAT TCTGTGGAAG GACATCTTCC ACAAGAACAA CCAGCTGGCC 540
CTCATGCTGA TAGACACCAA CCGCTCTCGG GCCTGTAAGC CATGCTTCTC CCTGCCTGTA 600
GCTTCCTCTC TTTCTCACCC TCATCCTGCC CTTTGTCTCA CAGTGACTCG AACTGTCTGT 660
GCTGGTGGCT GTGCCCGCTG CAAGGGCCCG CAGCCCACCG ACTGCTGCCA CGAGCAGTGT 720
GCTGCTGGCT GCACGGGCCC CAAGCATTCT GACTGCCTGG CCTGCCTCCA CTTCAACCAC 780
AGTGGCATCT GTGAGCTGCA CTGCCCAGCC CTGGTCACCT ACAACACGGA CACCTTCGAA 840
TCCATGCCCA ACCCTGAGGG CCGTTATACC TTCGGTGCCA GCTGTGTGAC TGCCTGTCCC 900
TACAACTACC TGTCTACGGA CGTGGGATCC TGCACCCTGG TCTGTCCCCT GAACAACCAA 960
GAGGTGACAG CTGAGGATGG AACACAGCGG TGTGAGAAAT GCAGCAAGCC CTGTGCCCGA 1020
GTGTGCTACG GCCTAGGCAT GGAGCACCTG CGGGAGGCGA GGGCAGTCAC CAGTGCCAAC 1080
ATCCAAGAAT TTGTCGGCTG CAAGAAGATC TTTGGGAGCC TGGCGTTTCT GCCAGAGAGC 1140
TTTGAGGGGG ACCCAGCCTC CAACACTGCC CCCCTGCAGC CTGAGCAGCT CAGAGTGTTT 1200
GAGGCTCTGG AGGAGATTAC AGGTTACCTG TACATCTCAG CGTGGCCAGA CAGCTTGCCT 1260
AACCTCAGTG TCTTCCAGAA CCTCAGAGTG ATCCGGGGCC GAGTTCTGCA TGACGGTGCT 1320
TACTCGCTGA CCCTTCAAGG GCTGGGCATC AGCTGGCTGG GGCTGCGCTC GCTGCGGGAG 1380
CTGGGCAGTG GGCTGGCCCT CATCCACCGC AACTCCCGCC TCTGCTTCGT ACACACGGTG 1440
CCCTGGGACC AGCTCTTCCG GAACCCCCAC CAGGCCCTGC TCCACAGCGC CAACCGGCCA 1500
GAGGACGAGT GCGCGGGTGA GGGCCTGGCC TGCTATCCGC TGTGTGCCCA CGGGCACTGC 1560
TGGGGTCCGG GACCCACCCA GTGTGTCAAC TGCAGCCAGT TCCTTCGGGG CCAGGAGTGC 1620
GTGGAGGAAT GCCGAGTATT GCAGGGGCTT CCCCGGGAGT ATGTGAAGGA TAGGTTCTGT 1680
CTGCCATGCC ACCCGGAGTG TCAGCCCCAG AATGGCTCAG TGACCTGCTT GGGCTCGGAA 1740
GCTGACCAGT GTGTGGCCTG TGCCCACTAC AAGGACCCTC CTTTCTGTGT GGCTCGCTGC 1800
CCCAGTGGGG TGAAACCTGA CCTCTCCTTC ATGCCCATCT GGAAGTTCGC AGATGAGGAG 1860
GGCACGTGCC AGCCATGCCC CATCAACTGC ACCCACTCCT GTGCGGACCT GGACGAGAAG 1920
GGCTGCCCCG CTGAGCAGAG AGCCAGCCCT GTGACGTCCA TCATTGCTGC TGTGGTGGGC 1980
ATTCTGCTGG TCGTGGTTGT GGGGCTGGTC CTTGGCATCC TAATCAAGCG AAGGCGGCAG 2040
AAGATCCGGA AGTACACGAT GCGGAGGCTG CTGCAGGAGA CGGAGCTGGT GGAGCCCCTG 2100
ACGCCTAGTG GAGCCATGCC CAACCAGGCT CAGATGCGAA TCCTGAAAGA AACAGAGCTG 2160
AGGAAGGTGA AGGTGCTTGG ATCCGGAGCT TTTGGCACTG TCTACAAGGG CATCTGGATC 2220
CCTGATGGGG AAAATGTGAA AATCCCAGTG GCCATCAAAG TGTTGAGGGA AAATACATCT 2280
CCCAAAGCCA ACAAAGAAAT CTTGGACGAA GCATATGTGA TGGCTGGCGT GGGCTCCCCA 2340
TATGTGTCTC GCCTTCTGGG CATCTGTCTG ACATCCACCG TGCAGTTGGT GACACAGCTT 2400
ATGCCTTATG GCTGCCTCTT AGACCATGTC CGAGAACACC GTGGGCGCCT AGGCTCCCAG 2460
GACCTGCTGA ACTGGTGTGT GCAGATTGCC AAGGGGATGA GCTACTTGGA GGATGTTCGG 2520
CTCGTGCACA GGGACCTGGC TGCCCGGAAC GTGCTGGTCA AGAGTCCCAA CCACGTCAAG 2580
ATTACAGATT TTGGGCTGGC TCGGCTGCTG GACATTGACG AGACAGAGTA CCATGCCGAT 2640
GGGGGCAAGG TGCCCATCAA GTGGATGGCG CTGGAGTCCA TTCTCCGCCG GCGGTTCACC 2700
CATCAGAGTG ACGTGTGGAG CTACGGTGTG ACTGTATGGG AACTGATGAC TTTTGGGGCC 2760
AAACCTTATG ATGGGATCCC AGCCCGGGAG ATTCCTGACC TGCTGGAGAA GGGGGAACGG 2820
CTGCCCCAGC CCCCCATCTG CACCATTGAT GTCTACATGA TCATGGTCAA ATGTTGGATG 2880
ATAGACTCTG AATGTCGGCC ACGTTTCCGG GAGCTGGTGG CCGAATTCTC CCGGATGGCC 2940
AGGGACCCCC AGCGCTTTGT GGTCATCCAG AATGAGGACT TGGGCCCAGC GAGTCCCCTG 3000
GACAGCACTT TCTACCGTTC ACTGCTGGAG GATGAGGACA TGGGAGACCT GGTGGATGCT 3060
GAGGAGTACC TGGTACCCCA GCAGGGTTTC TTCTGCCCAG ACCCTGCCCC AGGCGCCGGG 3120
GGCACAGCCC ACCGCAGACA CCGCAGCTCA TCCACCAGGA GTGGCGGTGG TGAGCTGACA 3180
CTGGGGCTGG AGCCCTCCGA GGAAGAGCCT CCCAAGTCTC CACTGGCACC CTCAGAAGGG 3240
GCTGGCTCTG ATGTGTTTGA TGGCGACTTG GGAATGGGGG CAGCCAAGGG GCTGCAGAGC 3300
CTTTCCCCAC AGGACCCCAG CCCTCTACAG CGGTACAGTG AGGATCCTAC CGTACCCCTA 3360
CCCCCTGAGA CTGATGGCTA CGTTGCCCCC CTGACCTGCA GTCCCCAGCC TGAATACGTG 3420
AACCAGCCAG AGGTTTGGCC AAAGCCCCCA TCGCCCTTAG AAGGCCCTCT GCCTCCTTCT 3480
CGACCTGCCG GTGCCACTCT GGAAAGGCCC AAGACTCTGT CCCCCAAGAC TCTTTCCCCC 3540
GGCAAGAATG GGGTTGTCAA AGACGTTTTT GCCTTTGGGG GTGCTGTGGA GAACCCCGAG 3600
TACTTGGCAC CCCGGGGCAG GGCTGCCCCT CAGCCTCACC CTCCTCCAGC CTTCAGCCCA 3660
GCCTTTGACA ACCTCTATTA CTGGGACCAG GACACATCTG AGCGGGGCTC TCCACCCAGC 3720
ACCTTTGAAG GGACCCCTAC AGCAGAGAAC CCCGAATACC TGGGCCTGGA TGTGCCAGTG 3780
TGA 3783
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 720   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  779
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclld+vreh+++lGsq+llnwcvqiakGmsyle+ 
Q: 780   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDV  839
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++
Q: 840   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  899
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw
Q: 900   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  959
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid+e+rp+f+el++efs
Q: 960   MIDSECRPRFRELVAEFS  977
         ****************96
Domain Sequence
(FASTA)
LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60
PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEDV 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 240
MIDSECRPRF RELVAEFS 258
KeywordKinase; Receptor; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-BOT-00298
EKS-CAJ-00305
EKS-CAF-00305
EKS-CAP-00334
EKS-DAR-00646
EKS-EQC-00290
EKS-GAA-00370
EKS-GOG-00296
EKS-HOS-00305
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MAM-00302
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORN-00389
EKS-ORC-00281
EKS-ORL-00360
EKS-OTG-00303
EKS-PAT-00284
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TAR-00391
EKS-TEN-00386
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0010008; C:endosome membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0004888; F:transmembrane signaling receptor activity
GO:0007166; P:cell surface receptor signaling pathway
GO:0007507; P:heart development
GO:0008045; P:motor neuron axon guidance
GO:0042552; P:myelination
GO:0033088; P:negative regulation of immature T cell proliferation in thymus
GO:0007528; P:neuromuscular junction development
GO:0007422; P:peripheral nervous system development
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0045785; P:positive regulation of cell adhesion
GO:0030307; P:positive regulation of cell growth
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0032321; P:positive regulation of Rho GTPase activity
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter
GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter
GO:0045727; P:positive regulation of translation
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0032886; P:regulation of microtubule-based process
GO:0042060; P:wound healing
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013