EKS-FEC-00448

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-FEC-00448

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	346.4	1.1E-103	20	316	297

Status

Unreviewed

Ensembl Protein

ENSFCAP00000011663

UniProt Accession

Q6B9Z6;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase 6;

Gene Name

MAPK6

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSFCAG00000012570	ENSFCAP00000011663	ENSFCAT00000012573

Organism

Felis catus

Functional Description

Protein Length

722

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAIKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE LNSVYIVQEY METDLANVLE 120

QGPLLEEHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV VHEEDRQELL SVIPVYIRND MTEPHKPLTQ LLPGISREAL DFLEQILTFS 300

PMDRLTAEEA LSHPYMSIYS FPMDEPISSH PFHIEDEVDD ILLMDETHSH IYNWERYHDC 360

QFSEHDWPIH NNFDIDEVQL DPRALSDVTD EEEVQVDPRK YLDGDREKYL EDPAFDTNYS 420

TEPCWQYPDH HENKYCDLEC SHTCNYKTRS SSYLDNLVWR ESEVNHYYEP KLIIDLSNWK 480

EQSKEKSDKK GKSKCERNGL VKAQIALEEA SQQLAEKERE KNQGFDFDSF IAGTIQLSSQ 540

HEPTDVVDKL NDLNSSVSQL ELKSLISKSV SREKQEKGMA NLAQLEALYQ SSWDSQFVGG 600

GEDCFLINQF CCEVRKDEQI EKENTYTSYL DKFFSRKEDT EMLETEPVED GKLGERGNEE 660

GFLNNSGEFL FNKQLESIGI PQFHSPVGSP LKSIQATLTP SAMKSSPQIP HKTYSSILKH 720

LN 722

Nucleotide Sequence
(FASTA)

ATGGCAGAGA AATTTGAAAG TCTCATGAAC ATTCATGGTT TTGATCTGGG CTCTAGGTAT 60

ATGGACTTAA AACCATTGGG TTGTGGAGGC AATGGCTTGG TTTTTTCTGC TGTAGACAAT 120

GACTGTGACA AAAGAGTAGC CATCAAGAAA ATTGTCCTTA CTGATCCCCA AAGTGTCAAA 180

CATGCTCTAC GTGAAATCAA AATTATTAGA AGACTTGACC ATGATAACAT TGTGAAAGTG 240

TTTGAAATTC TTGGTCCTAG TGGAAGCCAG TTAACAGACG ATGTGGGCTC TCTTACCGAA 300

CTGAACAGTG TTTACATTGT TCAGGAGTAC ATGGAGACAG ACTTGGCTAA TGTGCTGGAG 360

CAGGGCCCTT TACTGGAAGA GCATGCCAGA CTTTTCATGT ATCAGCTGCT ACGTGGGCTC 420

AAATATATTC ACTCTGCAAA CGTACTGCAC AGAGATCTCA AACCAGCTAA TCTTTTCATT 480

AATACTGAAG ACTTGGTGCT GAAGATAGGT GACTTTGGTC TTGCACGGAT CATGGATCCC 540

CATTATTCCC ATAAGGGTCA TCTTTCTGAA GGATTGGTTA CTAAATGGTA CAGGTCTCCA 600

CGTCTTTTAC TTTCTCCTAA TAATTATACT AAAGCCATTG ATATGTGGGC TGCAGGCTGC 660

ATCTTTGCTG AAATGCTGAC TGGTAAAACC CTCTTTGCAG GTGCACATGA ACTTGAACAG 720

ATGCAGCTGA TTTTAGAATC TATTCCTGTA GTACATGAGG AAGATCGTCA GGAGCTTCTC 780

AGCGTAATTC CAGTTTACAT TAGAAATGAC ATGACTGAGC CACACAAACC TTTAACTCAG 840

CTGCTTCCAG GAATTAGTCG AGAAGCACTG GATTTCCTGG AACAAATTCT GACATTTAGC 900

CCAATGGATC GGTTGACTGC AGAGGAAGCG CTTTCTCATC CTTACATGAG CATATATTCT 960

TTTCCAATGG ATGAGCCAAT TTCCAGTCAT CCTTTTCATA TTGAAGATGA AGTTGATGAT 1020

ATTTTGCTTA TGGATGAAAC TCATAGTCAC ATTTATAACT GGGAAAGGTA CCACGATTGC 1080

CAATTTTCAG AGCATGATTG GCCTATACAT AACAACTTTG ATATTGATGA AGTTCAGCTT 1140

GACCCAAGAG CTCTGTCTGA TGTCACTGAT GAAGAAGAAG TACAAGTCGA TCCTCGAAAA 1200

TATTTGGATG GAGATCGTGA GAAGTATTTG GAGGATCCTG CTTTCGATAC GAATTACTCT 1260

ACCGAGCCTT GTTGGCAGTA CCCAGATCAT CATGAAAACA AATATTGTGA TCTGGAGTGT 1320

AGCCATACTT GTAACTACAA AACAAGGTCA TCATCTTATT TAGATAACTT AGTTTGGAGA 1380

GAGAGTGAAG TTAACCATTA TTATGAACCC AAGCTTATCA TAGATCTTTC CAATTGGAAA 1440

GAACAAAGCA AAGAAAAGTC TGATAAGAAA GGCAAGTCAA AATGTGAAAG GAATGGATTG 1500

GTTAAAGCCC AGATAGCTCT AGAGGAAGCA TCACAGCAAC TGGCTGAAAA AGAAAGGGAA 1560

AAGAATCAGG GATTTGACTT TGATTCCTTT ATTGCAGGAA CTATTCAACT TAGTTCACAA 1620

CATGAACCTA CTGATGTTGT TGATAAATTG AATGACTTGA ATAGCTCAGT GTCCCAACTA 1680

GAATTGAAAA GTTTGATATC AAAGTCAGTA AGCCGAGAAA AACAGGAAAA AGGCATGGCA 1740

AATTTGGCTC AGTTAGAAGC CTTGTACCAG TCTTCTTGGG ATAGCCAGTT TGTGGGTGGT 1800

GGGGAGGACT GTTTTCTTAT AAATCAATTT TGTTGTGAGG TAAGGAAGGA TGAACAAATT 1860

GAGAAGGAAA ACACTTATAC CAGTTACCTG GACAAGTTCT TTAGCAGGAA AGAAGATACC 1920

GAAATGCTAG AAACTGAGCC AGTAGAGGAT GGGAAGCTTG GGGAGAGAGG AAATGAGGAA 1980

GGATTTCTGA ACAACAGTGG GGAGTTCCTC TTTAACAAGC AGCTCGAATC CATAGGCATC 2040

CCGCAGTTTC ACAGTCCAGT TGGGTCCCCA CTGAAGTCAA TCCAGGCCAC CTTAACACCT 2100

TCTGCTATGA AATCTTCCCC TCAGATTCCT CATAAGACAT ACAGCAGCAT TCTGAAACAT 2160

CTGAACTAA 2169

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rvaikk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++++ p+         +l+el++vY+v+e+metdL++v+++  l +eh++l++yq+l

Q: 78    VKVFEILGPSGsqltddvgSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLL  137

         *********999999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl++n++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFINTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++ ++ee+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++ s  +  yi++ +++++k++++l+p  s+eald+le++L+++p++R+++eeaL+hpY+

Q: 258   ELLSV-IPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGCG GNGLVFSAVD NDCDKRVAIK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFEILGPSGS QLTDDVGSLT ELNSVYIVQE YMETDLANVL EQGPLLEEHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF INTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VVHEEDRQEL 240

LSVIPVYIRN DMTEPHKPLT QLLPGISREA LDFLEQILTF SPMDRLTAEE ALSHPYM 297

Keyword

Kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>