EKS-FEC-00283

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-FEC-00283

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	497.5	7.4E-150	712	969	258

Status

Unreviewed

Ensembl Protein

ENSFCAP00000014342

UniProt Accession

E2JE31;

Protein Name

Protein Synonyms/Alias

Epidermal growth factor receptor;

Gene Name

EGFR

Gene Synonyms/Alias

EGFR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSFCAG00000015468	ENSFCAP00000014342	ENSFCAT00000015472

Organism

Felis catus

Functional Description

Protein Length

1209

Protein Sequence
(FASTA)

MRPSGTAGAA LLLLLAAHFQ ASPALEEKKV CQGTSNRLTQ LGTFEDHFLS LQRMFNNCEV 60

VLGNLEITYM QRNYDLSFLK TIQEVAGYVL IALNTVEKIP LENLQIIRGN VLYENTHALS 120

VLSNYGTNKT GLRELPMRNL HEILQGAVRF SNNPVLCNVE TIQWRDIVDN DFISNMSMDF 180

QNHVGNCQKC DPGCPNGSCW GPGKENCQKL TKIICAQQCS GRCRGRSPSD CCHNQCAAGC 240

TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300

VTDHGSCVRA CSSDSYEVEE DGVRKCKKCE GPCRKVCNGI GIGEFKDTLS INATNIKHFK 360

NCTSISGDLH ILPVAFRGDS FTHTPPLDPK ELDILKTVKE ITGFLLIQAW PENRTDLHAF 420

ENLEIIRGRT KQHGQFSLAV VGLDITSLGL RSLKEISDGD VIVSGNQKLC YANTINWKKL 480

FGTSSQKTKI INNKDEKGCK AIGHVCHPLC SSEGCWGPEP KDCVSCQNVT RGKECVEKCN 540

VLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDSCV QCAHYIDGPH CVKTCPAGIM 600

GENNTLVWKF ADANRMCHLC HSNCTYGCSG PGLEGCATDG PKIPSIATGI VGGLLLVVVV 660

ALGVGLFLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS 720

GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI 780

CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA 840

RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY 900

GVTVWELMTF GSKPYDGIPA SEISTILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK 960

FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMEDV VDADEYLIPQ 1020

QGFFHSPSTS RTPLLSSLSA TSNNSTVTCI DRNGVCSCPL KEDSFLQRYS SDPTGTLTED 1080

NMDDTFLPAP EYINQAVPKR PAGSVQNPVY HNQPLNPAPG RDPHYQNPHS NAVDNPEYLN 1140

THPTCVNSVL DGPTLWAQKG NHQISLDNPD YQQDFFPKEA KSNGIFKGPA AENADYLRVA 1200

PPSSEFIGA 1209

Nucleotide Sequence
(FASTA)

ATGCGACCCT CCGGGACCGC GGGAGCCGCG CTCCTGCTGC TGCTGGCTGC GCACTTCCAG 60

GCGAGTCCGG CGCTGGAGGA GAAGAAAGTT TGCCAAGGCA CAAGTAACCG GCTCACCCAG 120

TTGGGCACTT TTGAGGACCA CTTTCTCAGC CTGCAGAGGA TGTTTAATAA CTGTGAGGTG 180

GTCCTTGGGA ATTTGGAAAT CACCTACATG CAAAGGAATT ATGACCTTTC CTTCTTAAAA 240

ACCATCCAAG AGGTTGCCGG CTATGTACTC ATTGCCCTCA ACACAGTGGA GAAGATTCCC 300

TTGGAAAACC TGCAGATCAT CCGAGGAAAT GTGCTCTATG AAAACACCCA TGCCTTATCT 360

GTCTTATCCA ACTATGGCAC AAATAAAACC GGACTGCGGG AGCTGCCCAT GAGAAACTTA 420

CATGAAATCC TGCAAGGCGC TGTGCGGTTC AGCAACAACC CTGTCCTCTG CAACGTGGAA 480

ACCATCCAGT GGCGGGATAT CGTTGACAAT GATTTCATAA GCAACATGTC GATGGACTTC 540

CAGAACCACG TGGGCAACTG CCAAAAGTGT GATCCAGGAT GTCCCAATGG AAGCTGCTGG 600

GGTCCGGGAA AGGAGAATTG CCAGAAATTG ACCAAAATCA TCTGCGCCCA GCAGTGTTCC 660

GGGCGCTGCC GCGGCAGGTC CCCCAGCGAC TGCTGCCATA ACCAGTGTGC TGCCGGCTGC 720

ACGGGGCCCC GAGAGAGCGA CTGCCTGGTC TGCCGCAAGT TCCGGGATGA AGCCACGTGC 780

AAGGACACCT GCCCGCCACT CATGCTCTAC AACCCCACCA CCTACCAGAT GGACGTCAAC 840

CCAGAGGGAA AATACAGCTT TGGTGCCACC TGTGTGAAGA AATGCCCCCG TAACTACGTG 900

GTGACAGACC ACGGTTCGTG TGTCCGTGCC TGCAGTTCTG ACAGCTACGA AGTGGAGGAA 960

GATGGCGTCC GCAAGTGTAA AAAGTGTGAG GGGCCTTGCC GTAAAGTTTG TAATGGAATA 1020

GGAATTGGTG AATTTAAAGA CACACTTTCC ATCAATGCTA CAAATATTAA ACACTTCAAA 1080

AATTGCACCT CGATCAGTGG AGATCTTCAT ATCCTGCCAG TAGCATTTAG AGGTGACTCC 1140

TTCACGCATA CTCCACCTCT AGATCCAAAG GAACTGGATA TTCTAAAAAC TGTAAAGGAA 1200

ATTACAGGGT TTTTGCTGAT TCAGGCCTGG CCTGAAAACA GGACTGACCT CCATGCTTTC 1260

GAGAACCTAG AAATCATACG TGGAAGAACA AAGCAACATG GTCAGTTTTC TCTTGCGGTT 1320

GTGGGCCTGG ACATAACGTC CTTGGGATTA CGCTCCCTCA AGGAGATAAG TGATGGAGAT 1380

GTGATCGTTT CAGGAAACCA AAAATTGTGC TATGCAAATA CAATAAACTG GAAAAAACTG 1440

TTTGGGACTT CAAGTCAGAA AACCAAAATT ATAAACAACA AAGATGAAAA AGGCTGCAAG 1500

GCCATAGGCC ATGTCTGTCA TCCGTTATGC TCATCAGAGG GATGCTGGGG CCCGGAGCCG 1560

AAAGACTGCG TGTCCTGCCA AAACGTCACC CGTGGCAAGG AATGTGTGGA GAAGTGCAAT 1620

GTTCTGGAGG GGGAGCCAAG GGAGTTTGTG GAGAATTCTG AGTGCATACA GTGCCATCCA 1680

GAATGCCTGC CCCAGGCCAT GAATATCACC TGCACAGGAC GAGGACCAGA CAGCTGCGTG 1740

CAGTGTGCAC ACTACATCGA CGGCCCTCAC TGCGTCAAGA CCTGCCCGGC TGGCATCATG 1800

GGAGAAAACA ACACCCTGGT CTGGAAGTTT GCGGACGCCA ATCGCATGTG TCACCTGTGC 1860

CATTCAAACT GTACCTACGG CTGTTCTGGG CCAGGTCTTG AAGGCTGTGC TACAGATGGG 1920

CCCAAGATCC CATCCATCGC CACTGGGATT GTTGGGGGCC TCCTCTTGGT GGTGGTGGTG 1980

GCCCTTGGGG TGGGCCTCTT TCTGCGCCGA CGCCACATCG TCCGCAAGCG CACACTTCGC 2040

AGACTGCTGC AGGAAAGAGA GCTTGTTGAG CCTCTTACGC CCAGCGGAGA AGCTCCCAAC 2100

CAAGCTCTCT TGAGGATCTT AAAGGAAACA GAATTCAAAA AGATCAAGGT GCTGGGCTCT 2160

GGAGCATTTG GCACAGTGTA CAAGGGACTC TGGATCCCAG AAGGTGAGAA GGTTAAAATT 2220

CCTGTGGCCA TCAAGGAGTT ACGAGAAGCC ACATCTCCAA AAGCCAACAA GGAAATCCTT 2280

GATGAAGCTT ACGTGATGGC CAGTGTGGAC AATCCCCACG TGTGCCGCCT CCTGGGCATC 2340

TGCCTGACGT CCACGGTCCA GCTCATCACA CAGCTCATGC CCTTCGGCTG CCTCCTGGAC 2400

TATGTCCGCG AGCACAAGGA CAACATTGGC TCCCAGTACC TGCTCAACTG GTGTGTGCAG 2460

ATTGCGAAGG GCATGAACTA CCTGGAAGAC CGGCGCTTGG TGCACCGTGA CCTGGCAGCC 2520

AGGAATGTCC TGGTGAAGAC GCCACAGCAT GTCAAGATCA CAGATTTTGG GCTGGCCAAA 2580

CTGCTTGGTG CCGAGGAGAA AGAATACCAC GCGGAAGGAG GCAAAGTGCC TATCAAGTGG 2640

ATGGCTTTGG AATCAATTTT ACACCGAATT TACACCCACC AAAGTGACGT CTGGAGCTAT 2700

GGAGTCACCG TTTGGGAGTT GATGACCTTT GGGTCTAAAC CTTACGACGG AATCCCCGCA 2760

AGTGAGATCT CGACCATCCT GGAGAAAGGA GAGCGCCTCC CGCAGCCACC CATATGCACC 2820

ATCGATGTCT ACATGATCAT GGTCAAGTGC TGGATGATAG ATGCAGACAG TCGCCCGAAA 2880

TTCCGTGAGT TGATCATTGA ATTCTCCAAA ATGGCCCGAG ACCCCCAGCG CTACCTTGTC 2940

ATCCAGGGAG ATGAGAGAAT GCATCTGCCA AGCCCTACAG ACTCCAATTT TTACCGCGCC 3000

CTGATGGACG AAGAAGACAT GGAAGACGTC GTAGATGCCG ATGAGTACCT CATCCCCCAG 3060

CAAGGCTTCT TCCACAGCCC CTCCACATCC CGGACCCCCC TCCTGAGTTC TCTGAGTGCC 3120

ACCAGCAACA ATTCCACCGT GACTTGCATC GATAGAAATG GGGTATGTAG CTGCCCCCTC 3180

AAGGAAGACA GCTTCTTGCA GCGGTACAGC TCAGACCCCA CTGGCACCTT GACTGAGGAC 3240

AACATGGATG ACACTTTCCT CCCGGCACCT GAATACATAA ACCAGGCTGT TCCCAAAAGG 3300

CCTGCGGGTT CCGTCCAGAA CCCCGTCTAT CACAATCAGC CTCTAAATCC AGCTCCTGGC 3360

AGAGACCCTC ACTACCAAAA TCCCCACAGC AATGCAGTGG ACAACCCTGA GTATCTCAAC 3420

ACCCACCCCA CTTGCGTCAA CAGTGTGCTC GACGGCCCCA CCCTCTGGGC CCAGAAAGGC 3480

AACCACCAGA TTAGCCTGGA CAACCCTGAC TACCAGCAGG ACTTCTTTCC CAAGGAAGCC 3540

AAGTCAAATG GCATCTTTAA GGGTCCTGCA GCTGAAAATG CAGACTACCT AAGGGTAGCA 3600

CCGCCCAGCA GTGAATTTAT TGGAGCA 3627

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+

Q: 712   FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  771

         59**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+ql+tql+p+Gclldyvrehkd++Gsq+llnwcvqiakGm+yle++

Q: 772   PHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDR  831

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y

Q: 832   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  891

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+ +lekGerl+qppictidvym++vkcw

Q: 892   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISTILEKGERLPQPPICTIDVYMIMVKCW  951

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkf+el+ efs

Q: 952   MIDADSRPKFRELIIEFS  969

         ****************96

Domain Sequence
(FASTA)

FKKIKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60

PHVCRLLGIC LTSTVQLITQ LMPFGCLLDY VREHKDNIGS QYLLNWCVQI AKGMNYLEDR 120

RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180

THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISTILEKGE RLPQPPICTI DVYMIMVKCW 240

MIDADSRPKF RELIIEFS 258

Keyword

ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein; Receptor; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013