EKS-FEC-00255

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-FEC-00255

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	445.7	9.7E-134	150	470	321

Status

Unreviewed

Ensembl Protein

ENSFCAP00000019059

Gene Name

DYRK1A

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSFCAG00000024560	ENSFCAP00000019059	ENSFCAT00000027414

Organism

Felis catus

Protein Length

754

Protein Sequence
(FASTA)

MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD QQVSALSYSD 60

QIQQPLTNQR RMPQTFRDPA TAPLRKLSVD LIKTYKHINE VYYAKKKRRH QQGQGDDSSH 120

KKERKVYNDG YDDDNYDYIV KNGEKWMDRY EIDSLIGKGS FGQVVKAYDR VEQEWVAIKI 180

IKNKKAFLNQ AQIEVRLLEL MNKHDTEMKY YIVHLKRHFM FRNHLCLVFE MLSYNLYDLL 240

RNTNFRGVSL NLTRKFAQQM CTALLFLATP ELSIIHCDLK PENILLCNPK RSAIKIVDFG 300

SSCQLGQRIY QYIQSRFYRS PEVLLGMPYD LAIDMWSLGC ILVEMHTGEP LFSGANEVDQ 360

MNKIVEVLSI PPAHILDQAP KARKFFEKLP DGTWNLKKTK DGKREYKPPG TRKLHNILGV 420

ETGGPGGRRA GESGHTVADY LKFKDLILRM LDYDPKTRIQ PYYALQHSFF KKTADEGTNT 480

SNSVSTSPAM EQSQSSGTTS STSSSSGGSS GTSNSGRARS DPTHQHRHSG GHFTAAVQAM 540

DCETHSPQVR QQFPAPLGWS GTEAPTQVTV ETHPVQETTF HVAPQQNALH HHHGNSSHHH 600

HHHHHHHHHH GQQALGNRTR PRVYNSPTNS SSTQDSMEVG HSHHSMTSLS SSTTSSSTSS 660

SSTGNQGNQA YQNRPVAANT LDFGQNGAMD VNLTVYSNPR QETGLAGHSA YQFSANTGST 720

HYMTEGHLTM RQGADREESP MTGVCVQQSS VASS 754

Nucleotide Sequence
(FASTA)

ATGCATACAG GAGGAGAGAC TTCAGCATGC AAACCTTCAT CTGTTCGGCT CGCACCGTCA 60

TTTTCATTCC ATGCTGCTGG CCTTCAGATG GCTGGACAGA TGCCCCATTC ACATCAGTAC 120

AGTGACCGTC GCCAGCCAAA CATAAGTGAC CAACAGGTTT CTGCCTTATC TTATTCTGAC 180

CAGATTCAGC AACCTCTCAC TAACCAGAGG CGGATGCCCC AAACCTTCCG TGATCCAGCA 240

ACTGCTCCCC TGAGAAAACT TTCTGTTGAC TTGATCAAAA CATATAAGCA TATTAATGAG 300

GTTTACTATG CAAAAAAGAA GCGAAGACAC CAACAGGGCC AGGGAGACGA TTCTAGTCAT 360

AAGAAGGAGC GGAAGGTTTA CAATGATGGT TATGATGATG ATAACTATGA TTATATTGTA 420

AAAAACGGAG AGAAGTGGAT GGATCGTTAC GAAATTGACT CCTTGATAGG CAAAGGTTCC 480

TTTGGACAGG TTGTAAAAGC ATATGATCGT GTGGAGCAAG AATGGGTTGC CATTAAAATA 540

ATAAAGAACA AGAAGGCTTT TCTGAATCAA GCCCAGATAG AAGTGCGACT TCTTGAGCTC 600

ATGAACAAAC ATGACACTGA AATGAAATAC TACATAGTGC ATTTGAAGCG CCACTTTATG 660

TTTCGAAACC ATCTCTGTTT AGTTTTTGAA ATGCTGTCCT ACAACCTCTA TGACTTGTTG 720

AGGAACACCA ATTTTCGAGG TGTCTCTTTG AACCTAACAC GAAAGTTTGC ACAACAGATG 780

TGCACTGCAC TGCTTTTCCT CGCGACTCCA GAACTTAGTA TCATTCACTG TGACCTAAAA 840

CCTGAGAATA TCCTTCTTTG TAACCCCAAA CGCAGTGCAA TCAAGATCGT TGACTTTGGC 900

AGTTCCTGTC AGTTGGGGCA GAGGATATAC CAGTATATTC AGAGTCGCTT TTATCGGTCT 960

CCAGAGGTGC TACTGGGAAT GCCTTATGAC CTTGCTATCG ACATGTGGTC CCTTGGGTGT 1020

ATTTTGGTTG AAATGCACAC TGGAGAACCT CTGTTCAGTG GAGCCAATGA GGTAGATCAG 1080

ATGAATAAAA TAGTGGAAGT TCTGAGTATT CCACCTGCTC ACATTCTTGA CCAAGCACCA 1140

AAAGCAAGAA AGTTCTTTGA GAAGTTGCCA GATGGCACTT GGAACTTAAA GAAGACCAAA 1200

GATGGAAAAC GGGAGTATAA ACCACCAGGA ACCCGTAAAC TTCATAATAT TCTCGGAGTA 1260

GAAACAGGAG GACCTGGTGG GCGTCGTGCT GGGGAATCGG GTCATACCGT GGCTGACTAC 1320

TTGAAGTTCA AAGACCTCAT TTTAAGGATG CTTGATTATG ACCCCAAAAC TCGAATTCAA 1380

CCATACTATG CCCTGCAGCA CAGTTTTTTC AAGAAGACAG CTGACGAAGG TACAAACACA 1440

AGTAACAGCG TGTCCACGAG TCCCGCGATG GAGCAGTCAC AGTCCTCCGG AACCACCTCC 1500

AGCACGTCCT CCAGCTCAGG TGGATCGTCG GGGACGAGCA ACAGTGGGAG AGCCAGGTCA 1560

GACCCGACGC ACCAGCACCG GCACAGCGGC GGGCACTTCA CAGCTGCCGT CCAGGCCATG 1620

GACTGTGAGA CTCACAGTCC CCAGGTGCGT CAACAATTTC CTGCTCCCCT TGGTTGGTCA 1680

GGCACTGAAG CTCCTACACA GGTTACTGTT GAAACTCATC CCGTTCAAGA AACAACCTTT 1740

CATGTAGCCC CTCAACAGAA TGCATTGCAT CATCACCATG GAAATAGTTC CCATCACCAT 1800

CACCACCACC ACCACCACCA CCACCACCAC GGACAACAAG CCTTGGGTAA CCGGACCAGG 1860

CCAAGGGTCT ACAATTCTCC AACGAATAGC TCCTCTACCC AGGATTCTAT GGAGGTTGGC 1920

CATAGTCACC ACTCCATGAC ATCCCTGTCT TCCTCAACTA CTTCTTCCTC TACGTCCTCC 1980

TCCTCTACCG GTAATCAAGG CAACCAGGCC TACCAGAATC GCCCGGTGGC TGCTAACACC 2040

TTGGACTTTG GACAGAATGG AGCTATGGAC GTTAATTTGA CCGTCTACTC CAATCCCCGC 2100

CAAGAGACTG GCCTAGCTGG ACATTCAGCG TACCAATTTT CTGCTAATAC AGGTTCTACA 2160

CATTACATGA CTGAGGGACA TCTGACGATG AGGCAAGGAG CTGACAGAGA AGAGTCCCCC 2220

ATGACAGGAG TTTGTGTGCA ACAGAGTTCT GTAGCTAGCT CGTGA 2265

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+k

Q: 150   YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK  209

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 210   YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAt  269

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 270   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  328

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevl +pp+++l++a ka+kff+k

Q: 329   YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLSIPPAHILDQAPKARKFFEK  388

         ************************************************************

S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

           + ++ lk++          ++rk +++l+v++ +     p+ +++ge+ ++++d+l f

Q: 389   LPDGTWNLKKTkdgkreykpPGTRKLHNILGVETGG-----PGGRRAGESGHTVADYLkF  443

         ********9997777777777777777777777776.....99*****************

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         kdl+ rml++dp++Ri+p++al+h+f+

Q: 444   KDLILRMLDYDPKTRIQPYYALQHSFF  470

         **************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLS IPPAHILDQA PKARKFFEKL 240

PDGTWNLKKT KDGKREYKPP GTRKLHNILG VETGGPGGRR AGESGHTVAD YLKFKDLILR 300

MLDYDPKTRI QPYYALQHSF F 321

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>