EKS-FEC-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-FEC-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	342.2	2.3E-102	849	1121	273

Status

Unreviewed

Ensembl Protein

ENSFCAP00000025536

Gene Name

JAK2

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSFCAG00000028588	ENSFCAP00000025536	ENSFCAT00000022254

Organism

Felis catus

Protein Length

1133

Protein Sequence
(FASTA)

MGMACLTMTE MEGVSVSPVH QNGDIPGNAN SVKQIDPLLQ VYLYHSLEKA DGEYLKFPTG 60

EYVAEEICVA ASKACGITPV YHSMFALMSE TERTWYPPNH VFHVDESTRH NVLYRIRFYF 120

PYWYCNGSNR TYRHGVSRGA EAPLLDDFVM SYLFAQWRHD FLHGWIKIPV THETQEECLG 180

MAVLDMMRLA KEKDQTPLDI YSSISYKTFL PKCVRAKIQD YHILTRKRIR YRFRRFIEQF 240

SHCKATARNL KLKYLINLET LQSAFYTEQF EVKEPGRGPS GEEIFATIVI TGNGGIQWSR 300

GKHKESETLT EQDLQLYCDF PDIIDVTIKQ GNQEGSNESR IVTIHKQDGK NLEIELSSLR 360

EALSFVSLID GYYRLTADAH HYLCKEVAPP MVLENIQSNC HGPILMDFAI SKLKKAGNQT 420

GLYVLRCSPK DFNKYFLTFA VERDNVIEYK HCLITKNENG EYNLSGTKKN FSNLKDLLNC 480

YQMETVRSDS IIFQFTKCCP PKLKTDKSNL LVFRTNGVSD VPTSPTLQRH NNVNQMVFHK 540

IRNEDLIFNE SLGQGTFTKI FKGVRREVGD YGQLHETEVL LKVLDKAHRN YSESFFEAAS 600

MMSQLSHKHL VLNYGVCVCG EENILVQEFV KFGSLDTYLK KNKNSISILW KLEVAKQLAW 660

AMHFLEEKAL IHGNVCAKNI LLIREEDRKT GNPPFIKLSD PGISITVLPK DILQERIPWV 720

PPECIENPKN LNLATDKWSF GTTLWEICSG GDKPLSALDS QRKLQFYEDR HQLPAPKWTE 780

LANLINNCMD YEPDFRPSFR AIIRDLNSLF TPDYELLTEN DMLPNRIGTL GFSGAFEDRD 840

PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE 900

ILKSLQHDNI VKYKGVCYSA EGRRNLRLIM EYLPYGSLRD YLQKHKERID HKKLLQYTSQ 960

ICKGMEYLGT KRYIHRDLAT RNILVENENR VKIGDFGLTK VLPQDKEYYK VKEPGESPIF 1020

WYAPESLTES KFSVASDVWS FGVVLYELFT YIEKSKSPPA EFMRMIGNDK QGQMIVFHLI 1080

ELLKNNGRLP RPDGCPDEIY LIMTECWNNN VNQRPSFRDL ALRVDQIRDN MAG 1133

Nucleotide Sequence
(FASTA)

ATGGGAATGG CTTGCCTTAC CATGACGGAA ATGGAAGGAG TATCTGTATC TCCTGTGCAT 60

CAGAATGGTG ATATTCCTGG AAATGCTAAT TCTGTGAAGC AAATAGATCC ACTCCTTCAG 120

GTGTATCTTT ATCATTCTCT TGAGAAGGCT GATGGAGAAT ATCTGAAGTT TCCAACTGGG 180

GAGTATGTTG CAGAAGAAAT TTGTGTTGCT GCTTCTAAAG CTTGTGGAAT CACGCCCGTG 240

TATCATAGTA TGTTTGCTTT AATGAGTGAA ACCGAAAGGA CCTGGTATCC GCCCAACCAT 300

GTCTTCCATG TAGATGAATC AACCAGGCAC AACGTACTCT ACAGAATAAG ATTTTACTTT 360

CCTTACTGGT ATTGTAATGG CAGCAACAGA ACCTATCGGC ATGGAGTGTC TCGAGGTGCT 420

GAAGCTCCTC TTCTTGATGA CTTTGTCATG TCTTACCTTT TTGCTCAGTG GCGGCATGAT 480

TTTTTACATG GATGGATAAA AATACCGGTG ACTCATGAAA CGCAGGAAGA ATGTCTTGGA 540

ATGGCAGTGT TAGATATGAT GAGACTAGCC AAAGAGAAGG ATCAAACCCC ATTGGACATC 600

TATAGCTCTA TCAGCTACAA GACATTCTTA CCAAAATGTG TTCGAGCAAA GATCCAAGAC 660

TATCATATTT TGACAAGGAA GAGAATAAGG TATAGATTTC GCAGATTTAT TGAGCAGTTC 720

AGCCACTGCA AAGCCACTGC CAGAAACTTG AAACTTAAGT ATCTTATAAA TCTGGAAACA 780

CTTCAGTCTG CCTTCTACAC AGAGCAATTT GAAGTAAAAG AACCTGGAAG AGGTCCTTCA 840

GGTGAGGAGA TTTTTGCAAC CATTGTAATA ACTGGAAACG GTGGAATTCA GTGGTCAAGA 900

GGGAAACATA AAGAAAGTGA GACACTGACA GAACAGGATT TACAGTTATA TTGTGACTTT 960

CCTGATATCA TTGATGTGAC TATTAAACAA GGAAACCAAG AAGGCTCAAA TGAAAGTAGA 1020

ATTGTAACTA TCCATAAGCA AGATGGTAAA AATCTGGAAA TTGAACTAAG CTCATTAAGA 1080

GAAGCTTTAT CCTTTGTGTC ATTAATTGAT GGCTATTACA GATTAACCGC GGATGCACAT 1140

CATTACCTCT GTAAAGAAGT AGCTCCTCCG ATGGTGCTTG AAAATATACA AAGCAACTGT 1200

CATGGCCCGA TTTTAATGGA TTTTGCCATC AGTAAACTGA AGAAAGCAGG TAATCAGACT 1260

GGACTCTATG TACTTCGATG CAGTCCTAAG GACTTTAATA AATATTTTCT GACTTTTGCT 1320

GTCGAGCGAG ATAATGTCAT CGAATATAAG CATTGTTTGA TTACAAAAAA TGAGAACGGA 1380

GAATACAACC TCAGTGGGAC CAAGAAGAAC TTCAGTAATC TTAAAGATCT TTTGAATTGC 1440

TACCAGATGG AAACTGTTCG CTCAGACAGT ATAATTTTCC AGTTTACTAA ATGCTGCCCC 1500

CCAAAGTTGA AGACAGATAA ATCAAATCTT CTAGTCTTTA GAACCAATGG CGTTTCTGAT 1560

GTACCAACAT CACCAACATT ACAGAGGCAT AATAATGTGA ACCAAATGGT GTTTCACAAA 1620

ATCAGAAATG AAGATTTAAT ATTTAATGAA AGCCTTGGGC AAGGCACTTT TACAAAAATT 1680

TTTAAAGGTG TAAGAAGAGA AGTAGGAGAC TATGGTCAAC TGCATGAAAC AGAAGTTCTT 1740

TTAAAAGTTC TGGATAAAGC ACACAGAAAC TATTCAGAGT CTTTCTTTGA AGCAGCAAGC 1800

ATGATGAGCC AGCTTTCTCA CAAGCACCTG GTTTTAAATT ATGGAGTATG TGTCTGTGGA 1860

GAGGAAAATA TTCTGGTTCA GGAGTTTGTA AAATTTGGAT CATTAGATAC ATACCTGAAA 1920

AAGAATAAAA ATTCTATAAG TATATTATGG AAACTTGAAG TGGCTAAACA GTTGGCATGG 1980

GCCATGCATT TTCTAGAAGA AAAAGCCCTT ATTCATGGGA ATGTGTGTGC CAAAAATATT 2040

CTGCTTATCA GAGAAGAAGA CAGAAAGACA GGAAATCCTC CTTTCATCAA ACTTAGTGAT 2100

CCTGGCATTA GTATTACAGT TTTGCCAAAG GACATTCTTC AGGAGAGAAT ACCATGGGTA 2160

CCACCTGAAT GCATTGAAAA TCCTAAAAAT CTAAACTTGG CAACAGACAA ATGGAGTTTT 2220

GGTACCACTT TGTGGGAAAT CTGCAGTGGA GGAGACAAGC CTCTGAGTGC TTTGGATTCT 2280

CAAAGAAAGC TCCAGTTTTA TGAAGATAGG CACCAGCTTC CTGCACCAAA GTGGACAGAA 2340

TTAGCAAATC TTATTAATAA CTGTATGGAT TATGAACCAG ATTTTAGACC TTCTTTCAGA 2400

GCCATCATAC GAGATCTTAA TAGTTTGTTT ACTCCAGATT ACGAGCTATT AACAGAAAAT 2460

GACATGTTGC CAAATAGGAT AGGCACCCTT GGGTTTTCTG GAGCTTTTGA AGACCGAGAC 2520

CCGACACAGT TTGAAGAGAG ACACTTGAAA TTTCTACAGC AGCTTGGCAA GGGCAATTTT 2580

GGCAGTGTGG AGATGTGCCG GTATGACCCT CTACAAGACA ACACTGGGGA GGTGGTGGCC 2640

GTGAAGAAGC TCCAGCACAG TACTGAGGAG CACCTGAGAG ACTTTGAAAG AGAAATTGAA 2700

ATCCTTAAAT CCCTGCAGCA TGACAACATT GTCAAGTACA AGGGAGTGTG CTACAGTGCT 2760

GAAGGCCGGC GTAATTTAAG ATTAATTATG GAATATTTAC CATATGGAAG TTTACGAGAT 2820

TATCTCCAAA AACATAAAGA ACGGATAGAT CATAAAAAAC TTCTGCAGTA TACATCTCAG 2880

ATATGCAAGG GCATGGAGTA TCTTGGTACA AAAAGGTATA TCCACAGGGA TCTGGCAACA 2940

AGGAATATAT TGGTGGAGAA TGAAAACAGG GTTAAAATTG GAGATTTTGG TTTAACCAAA 3000

GTCTTGCCAC AAGACAAAGA ATACTACAAA GTGAAAGAAC CTGGTGAAAG TCCCATATTC 3060

TGGTATGCTC CAGAATCACT GACAGAGAGC AAGTTTTCTG TGGCTTCAGA TGTTTGGAGC 3120

TTTGGAGTGG TTCTGTATGA ACTTTTCACA TACATCGAGA AGAGTAAAAG TCCACCAGCG 3180

GAATTTATGC GTATGATTGG CAATGACAAA CAAGGACAGA TGATTGTGTT TCATTTGATA 3240

GAACTCCTAA AGAATAATGG AAGATTACCA AGACCAGATG GATGCCCAGA TGAGATTTAT 3300

TTGATTATGA CTGAATGCTG GAACAATAAT GTAAATCAGC GCCCCTCTTT TAGAGACCTA 3360

GCTCTTCGAG TTGATCAAAT AAGGGACAAC ATGGCTGGAT GA 3402

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+

Q: 849   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  908

         6899********************************************************

S: 61    hivklkgvcvaegen...rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         +ivk+kgvc++ + +   rl+mey+++GsL++yL+k+ke++++++ll++++q++k+meYL

Q: 909   NIVKYKGVCYSAEGRrnlRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYL  968

         *********98765557*******************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         ++k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+

Q: 969   GTKRYIHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWY  1022

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rkle  223

         ape+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++e

Q: 1023  APESLTESK-FSVASDVWSFGVVLYELFTyIEKSKSPpaefMRMIGNDkqgqmivfHLIE  1081

         *********.*******************************999999999**********

S: 224   lleekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         ll+++ rlp+p+ cp+e++ +mt+c++++ +qrpsFr+++

Q: 1082  LLKNNGRLPRPDgCPDEIYLIMTECWNNNVNQRPSFRDLA  1121

         *************************************995

Domain Sequence
(FASTA)

LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60

NIVKYKGVCY SAEGRRNLRL IMEYLPYGSL RDYLQKHKER IDHKKLLQYT SQICKGMEYL 120

GTKRYIHRDL ATRNILVENE NRVKIGDFGL TKVLPQDKEY YKVKEPGESP IFWYAPESLT 180

ESKFSVASDV WSFGVVLYEL FTYIEKSKSP PAEFMRMIGN DKQGQMIVFH LIELLKNNGR 240

LPRPDGCPDE IYLIMTECWN NNVNQRPSFR DLA 273

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>