Tag | Content |
---|
EKPD ID | EKS-HOS-00377 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
---|
TK/Src | 433.1 | 1.6E-129 | 197 | 446 | 250 |
|
Status | Reviewed |
Ensembl Protein | ENSP00000445302 |
UniProt Accession | P09769; D3DPL7; Q9UIQ3; |
Protein Name | Tyrosine-protein kinase Fgr |
Protein Synonyms/Alias | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; Proto-oncogene c-Fgr; p55-Fgr; p58-Fgr; p58c-Fgr; |
Gene Name | FGR |
Gene Synonyms/Alias | FGR; SRC2; |
Ensembl Information | |
Organism | Homo sapiens |
Functional Description | Non-receptor tyrosine-protein kinase that transmitssignals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK- dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. |
Protein Length | 463 |
Protein Sequence (FASTA) | MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI PNYSNFSSQA 60 | INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK GEKFHILNNT EGAYSLSIRD 120 | WDQTRGDHVK HYKIRKLDMG GYYITTRVQF NSVQELVQHY MEVNDGLCNL LIAPCTIMKP 180 | QTLGLAKDAW EISRSSITLE RRLGTGCFGD VWLGTWNGST KVAVKTLKPG TMSPKAFLEE 240 | AQVMKLLRHD KLVQLYAVVS EEPIYIVTEF MCHGSLLDFL KNPEGQDLRL PQLVDMAAQV 300 | AEGMAYMERM NYIHRDLRAA NILVGERLAC KIADFGLARL IKDDEYNPCQ GSKFPIKWTA 360 | PEAALFGRFT IKSDVWSFGI LLTELITKGR IPYPGMNKRE VLEQVEQGYH MPCPPGCPAS 420 | LYEAMEQTWR LDPEERPTFE YLQSFLEDYF TSAEPQYQPG DQT 463 |
|
Nucleotide Sequence (FASTA) | ATGGGCTGTG TGTTCTGCAA GAAATTGGAG CCGGTGGCCA CGGCCAAGGA GGATGCTGGC 60 | CTGGAAGGGG ACTTCAGAAG CTACGGGGCA GCAGACCACT ATGGGCCTGA CCCCACTAAG 120 | GCCCGGCCTG CATCCTCATT TGCCCACATC CCCAACTACA GCAACTTCTC CTCTCAGGCC 180 | ATCAACCCTG GCTTCCTTGA TAGTGGCACC ATCAGGGGTG TGTCAGGGAT TGGGGTGACC 240 | CTGTTCATTG CCCTGTATGA CTATGAGGCT CGAACTGAGG ATGACCTCAC CTTCACCAAG 300 | GGCGAGAAGT TCCACATCCT GAACAATACT GAAGGTGCCT ACTCCCTGTC CATCCGGGAC 360 | TGGGATCAGA CCAGAGGCGA TCATGTGAAG CATTACAAGA TCCGCAAACT GGACATGGGC 420 | GGCTACTACA TCACCACACG GGTTCAGTTC AACTCGGTGC AGGAGCTGGT GCAGCACTAC 480 | ATGGAGGTGA ATGACGGGCT GTGCAACCTG CTCATCGCGC CCTGCACCAT CATGAAGCCG 540 | CAGACGCTGG GCCTGGCCAA GGACGCCTGG GAGATCAGCC GCAGCTCCAT CACGCTGGAG 600 | CGCCGGCTGG GCACCGGCTG CTTCGGGGAT GTGTGGCTGG GCACGTGGAA CGGCAGCACT 660 | AAGGTGGCGG TGAAGACGCT GAAGCCGGGC ACCATGTCCC CGAAGGCCTT CCTGGAGGAG 720 | GCGCAGGTCA TGAAGCTGCT GCGGCACGAC AAGCTGGTGC AGCTGTACGC CGTGGTGTCG 780 | GAGGAGCCCA TCTACATCGT GACCGAGTTC ATGTGTCACG GCAGCTTGCT GGATTTTCTC 840 | AAGAACCCAG AGGGCCAGGA TTTGAGGCTG CCCCAATTGG TGGACATGGC AGCCCAGGTA 900 | GCTGAGGGCA TGGCCTACAT GGAACGCATG AACTACATTC ACCGCGACCT GAGGGCAGCC 960 | AACATCCTGG TTGGGGAGCG GCTGGCGTGC AAGATCGCAG ACTTTGGCTT GGCGCGTCTC 1020 | ATCAAGGACG ATGAGTACAA CCCCTGCCAA GGTTCCAAGT TCCCCATCAA GTGGACAGCC 1080 | CCAGAAGCTG CCCTCTTTGG CAGATTCACC ATCAAGTCAG ACGTGTGGTC CTTTGGGATC 1140 | CTGCTCACTG AGCTCATCAC CAAGGGCCGA ATCCCCTACC CAGGCATGAA TAAACGGGAA 1200 | GTGTTGGAAC AGGTGGAGCA GGGCTACCAC ATGCCGTGCC CTCCAGGCTG CCCAGCATCC 1260 | CTGTACGAGG CCATGGAACA GACCTGGCGT CTGGACCCGG AGGAGAGGCC TACCTTCGAG 1320 | TACCTGCAGT CCTTCCTGGA GGACTACTTC ACCTCCGCTG AACCACAGTA CCAGCCCGGG 1380 | GATCAGACAT AG 1392 |
|
Domain Profile | S: 1 lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly 60 | ++l+++lG+G+fG+vwlg+w+gs+kvavktlk+gt+sp+afleeaq++k lrh+klv+ly | Q: 197 ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLY 256 | 5799******************************************************** |
| S: 61 avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr 120 | avvse ePiyivte+m +Gslldflk+ eg+ l+lp+lvd+aaqvaeGmay+e++n+ihr | Q: 257 AVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHR 315 | ****9.****************************************************** |
| S: 121 dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv 180 | dl+a+n+lvge+l++k+adfGlarli+ddey++ +g+k+PikWtaPea+ +g+ftiksdv | Q: 316 DLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDV 375 | ************************************************************ |
| S: 181 WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee 240 | WsfGillte++tkG++PypGm+++evleqve+gy++p+p cp++lye+++++w+ dpee | Q: 376 WSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEE 435 | ************************************************************ |
| S: 241 rPtfetlqevl 251 | rPtfe+lq++l | Q: 436 RPTFEYLQSFL 446 | ********986 |
|
Domain Sequence (FASTA) | ITLERRLGTG CFGDVWLGTW NGSTKVAVKT LKPGTMSPKA FLEEAQVMKL LRHDKLVQLY 60 | AVVSEEPIYI VTEFMCHGSL LDFLKNPEGQ DLRLPQLVDM AAQVAEGMAY MERMNYIHRD 120 | LRAANILVGE RLACKIADFG LARLIKDDEY NPCQGSKFPI KWTAPEAALF GRFTIKSDVW 180 | SFGILLTELI TKGRIPYPGM NKREVLEQVE QGYHMPCPPG CPASLYEAME QTWRLDPEER 240 | PTFEYLQSFL 250 |
|
Keyword | ATP-binding; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Immunity; Innate immunity; Kinase; Lipoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase; Ubl conjugation. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |