EKS-HOS-00377
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00377
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src433.11.6E-129197446250
StatusReviewed
Ensembl ProteinENSP00000445302
UniProt AccessionP09769; D3DPL7; Q9UIQ3;
Protein NameTyrosine-protein kinase Fgr
Protein Synonyms/Alias Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; Proto-oncogene c-Fgr; p55-Fgr; p58-Fgr; p58c-Fgr;
Gene NameFGR
Gene Synonyms/Alias FGR; SRC2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000000938ENSP00000407670ENST00000457296
ENSG00000000938ENSP00000363117ENST00000374005
ENSG00000000938ENSP00000363116ENST00000374004
ENSG00000000938ENSP00000382126ENST00000399173
ENSG00000000938ENSP00000363115ENST00000374003
ENSG00000000938ENSP00000445302ENST00000545953
OrganismHomo sapiens
Functional DescriptionNon-receptor tyrosine-protein kinase that transmitssignals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK- dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
Protein Length463
Protein Sequence
(FASTA)
MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI PNYSNFSSQA 60
INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK GEKFHILNNT EGAYSLSIRD 120
WDQTRGDHVK HYKIRKLDMG GYYITTRVQF NSVQELVQHY MEVNDGLCNL LIAPCTIMKP 180
QTLGLAKDAW EISRSSITLE RRLGTGCFGD VWLGTWNGST KVAVKTLKPG TMSPKAFLEE 240
AQVMKLLRHD KLVQLYAVVS EEPIYIVTEF MCHGSLLDFL KNPEGQDLRL PQLVDMAAQV 300
AEGMAYMERM NYIHRDLRAA NILVGERLAC KIADFGLARL IKDDEYNPCQ GSKFPIKWTA 360
PEAALFGRFT IKSDVWSFGI LLTELITKGR IPYPGMNKRE VLEQVEQGYH MPCPPGCPAS 420
LYEAMEQTWR LDPEERPTFE YLQSFLEDYF TSAEPQYQPG DQT 463
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGTTCTGCAA GAAATTGGAG CCGGTGGCCA CGGCCAAGGA GGATGCTGGC 60
CTGGAAGGGG ACTTCAGAAG CTACGGGGCA GCAGACCACT ATGGGCCTGA CCCCACTAAG 120
GCCCGGCCTG CATCCTCATT TGCCCACATC CCCAACTACA GCAACTTCTC CTCTCAGGCC 180
ATCAACCCTG GCTTCCTTGA TAGTGGCACC ATCAGGGGTG TGTCAGGGAT TGGGGTGACC 240
CTGTTCATTG CCCTGTATGA CTATGAGGCT CGAACTGAGG ATGACCTCAC CTTCACCAAG 300
GGCGAGAAGT TCCACATCCT GAACAATACT GAAGGTGCCT ACTCCCTGTC CATCCGGGAC 360
TGGGATCAGA CCAGAGGCGA TCATGTGAAG CATTACAAGA TCCGCAAACT GGACATGGGC 420
GGCTACTACA TCACCACACG GGTTCAGTTC AACTCGGTGC AGGAGCTGGT GCAGCACTAC 480
ATGGAGGTGA ATGACGGGCT GTGCAACCTG CTCATCGCGC CCTGCACCAT CATGAAGCCG 540
CAGACGCTGG GCCTGGCCAA GGACGCCTGG GAGATCAGCC GCAGCTCCAT CACGCTGGAG 600
CGCCGGCTGG GCACCGGCTG CTTCGGGGAT GTGTGGCTGG GCACGTGGAA CGGCAGCACT 660
AAGGTGGCGG TGAAGACGCT GAAGCCGGGC ACCATGTCCC CGAAGGCCTT CCTGGAGGAG 720
GCGCAGGTCA TGAAGCTGCT GCGGCACGAC AAGCTGGTGC AGCTGTACGC CGTGGTGTCG 780
GAGGAGCCCA TCTACATCGT GACCGAGTTC ATGTGTCACG GCAGCTTGCT GGATTTTCTC 840
AAGAACCCAG AGGGCCAGGA TTTGAGGCTG CCCCAATTGG TGGACATGGC AGCCCAGGTA 900
GCTGAGGGCA TGGCCTACAT GGAACGCATG AACTACATTC ACCGCGACCT GAGGGCAGCC 960
AACATCCTGG TTGGGGAGCG GCTGGCGTGC AAGATCGCAG ACTTTGGCTT GGCGCGTCTC 1020
ATCAAGGACG ATGAGTACAA CCCCTGCCAA GGTTCCAAGT TCCCCATCAA GTGGACAGCC 1080
CCAGAAGCTG CCCTCTTTGG CAGATTCACC ATCAAGTCAG ACGTGTGGTC CTTTGGGATC 1140
CTGCTCACTG AGCTCATCAC CAAGGGCCGA ATCCCCTACC CAGGCATGAA TAAACGGGAA 1200
GTGTTGGAAC AGGTGGAGCA GGGCTACCAC ATGCCGTGCC CTCCAGGCTG CCCAGCATCC 1260
CTGTACGAGG CCATGGAACA GACCTGGCGT CTGGACCCGG AGGAGAGGCC TACCTTCGAG 1320
TACCTGCAGT CCTTCCTGGA GGACTACTTC ACCTCCGCTG AACCACAGTA CCAGCCCGGG 1380
GATCAGACAT AG 1392
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         ++l+++lG+G+fG+vwlg+w+gs+kvavktlk+gt+sp+afleeaq++k lrh+klv+ly
Q: 197   ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLY  256
         5799********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m +Gslldflk+ eg+ l+lp+lvd+aaqvaeGmay+e++n+ihr
Q: 257   AVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHR  315
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvge+l++k+adfGlarli+ddey++ +g+k+PikWtaPea+ +g+ftiksdv
Q: 316   DLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDV  375
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte++tkG++PypGm+++evleqve+gy++p+p  cp++lye+++++w+ dpee
Q: 376   WSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEE  435
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 436   RPTFEYLQSFL  446
         ********986
Domain Sequence
(FASTA)
ITLERRLGTG CFGDVWLGTW NGSTKVAVKT LKPGTMSPKA FLEEAQVMKL LRHDKLVQLY 60
AVVSEEPIYI VTEFMCHGSL LDFLKNPEGQ DLRLPQLVDM AAQVAEGMAY MERMNYIHRD 120
LRAANILVGE RLACKIADFG LARLIKDDEY NPCQGSKFPI KWTAPEAALF GRFTIKSDVW 180
SFGILLTELI TKGRIPYPGM NKREVLEQVE QGYHMPCPPG CPASLYEAME QTWRLDPEER 240
PTFEYLQSFL 250
KeywordATP-binding; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Immunity; Innate immunity; Kinase; Lipoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase; Ubl conjugation.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>
EKS-AIM-00344
EKS-BOT-00371
EKS-CAJ-00374
EKS-CAF-00373
EKS-CAP-00403
EKS-EQC-00362
EKS-GOG-00361
EKS-ICT-00349
EKS-MAM-00370
EKS-MUP-00364
EKS-NOL-00341
EKS-ORC-00348
EKS-OTG-00373
EKS-PAT-00350
EKS-POA-00360
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0005829; C:cytosol
GO:0005743; C:mitochondrial inner membrane
GO:0005758; C:mitochondrial intermembrane space
GO:0005886; C:plasma membrane
GO:0032587; C:ruffle membrane
GO:0005524; F:ATP binding
GO:0034988; F:Fc-gamma receptor I complex binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0001784; F:phosphotyrosine binding
GO:0019901; F:protein kinase binding
GO:0007596; P:blood coagulation
GO:0050830; P:defense response to Gram-positive bacterium
GO:0002768; P:immune response-regulating cell surface receptor signaling pathway
GO:0045087; P:innate immune response
GO:0007229; P:integrin-mediated signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0030335; P:positive regulation of cell migration
GO:0050715; P:positive regulation of cytokine secretion
GO:0043306; P:positive regulation of mast cell degranulation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0045088; P:regulation of innate immune response
GO:0050764; P:regulation of phagocytosis
GO:0045859; P:regulation of protein kinase activity
GO:0009615; P:response to virus
KEGG
hsa:2268;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013