EKS-HOS-00454
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00454
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/PDHK220.04.3E-65243367125
StatusReviewed
Ensembl ProteinENSP00000005178
UniProt AccessionQ16654;
Protein Name[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
Protein Synonyms/Alias Pyruvate dehydrogenase kinase isoform 4;
Gene NamePDK4
Gene Synonyms/Alias PDK4; PDHK4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000004799ENSP00000005178ENST00000005178
OrganismHomo sapiens
Functional DescriptionInhibits the mitochondrial pyruvate dehydrogenasecomplex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
Protein Length411
Protein Sequence
(FASTA)
MKAARFVLRS AGSLNGAGLV PREVEHFSRY SPSPLSMKQL LDFGSENACE RTSFAFLRQE 60
LPVRLANILK EIDILPTQLV NTSSVQLVKS WYIQSLMDLV EFHEKSPDDQ KALSDFVDTL 120
IKVRNRHHNV VPTMAQGIIE YKDACTVDPV TNQNLQYFLD RFYMNRISTR MLMNQHILIF 180
SDSQTGNPSH IGSIDPNCDV VAVVQDAFEC SRMLCDQYYL SSPELKLTQV NGKFPDQPIH 240
IVYVPSHLHH MLFELFKNAM RATVEHQENQ PSLTPIEVIV VLGKEDLTIK ISDRGGGVPL 300
RIIDRLFSYT YSTAPTPVMD NSRNAPLAGF GYGLPISRLY AKYFQGDLNL YSLSGYGTDA 360
IIYLKALSSE SIEKLPVFNK SAFKHYQMSS EADDWCIPSR EPKNLAKEVA M 411
Nucleotide Sequence
(FASTA)
ATGAAGGCGG CCCGCTTCGT GCTGCGCAGC GCTGGCTCGC TCAACGGCGC CGGCCTGGTG 60
CCCCGAGAGG TGGAGCATTT CTCGCGCTAC AGCCCGTCCC CGCTGTCCAT GAAGCAGCTA 120
CTGGACTTTG GTTCAGAAAA TGCATGTGAA AGAACTTCTT TTGCATTTTT GCGACAAGAA 180
TTGCCTGTGA GACTCGCCAA CATTCTGAAG GAAATTGATA TCCTCCCGAC CCAATTAGTA 240
AATACCTCTT CAGTGCAATT GGTTAAAAGC TGGTATATAC AGAGCCTGAT GGATTTGGTG 300
GAATTCCATG AGAAAAGCCC AGATGACCAG AAAGCATTAT CAGACTTTGT AGATACACTC 360
ATCAAAGTTC GAAATAGACA CCATAATGTA GTCCCTACAA TGGCACAAGG AATCATAGAG 420
TATAAAGATG CCTGTACAGT TGACCCAGTC ACCAATCAAA ATCTTCAATA TTTCTTGGAT 480
CGATTTTACA TGAACCGTAT TTCTACTCGG ATGCTGATGA ACCAGCACAT TCTTATATTT 540
AGTGACTCAC AGACAGGAAA CCCAAGCCAC ATTGGAAGCA TTGATCCTAA CTGTGATGTG 600
GTAGCAGTGG TCCAAGATGC CTTTGAGTGT TCAAGGATGC TCTGTGATCA GTATTATTTA 660
TCATCTCCAG AATTAAAGCT TACACAAGTG AATGGAAAAT TTCCAGACCA ACCAATTCAC 720
ATCGTGTATG TTCCTTCTCA CCTCCATCAT ATGCTCTTTG AACTATTTAA GAATGCAATG 780
CGGGCAACAG TTGAACACCA GGAAAATCAG CCTTCCCTTA CACCAATAGA GGTTATTGTT 840
GTCTTGGGAA AAGAAGACCT TACCATTAAG ATTTCAGACA GAGGAGGTGG TGTTCCCCTG 900
AGAATTATTG ACCGCCTCTT TAGTTATACA TACTCCACTG CACCAACGCC TGTGATGGAT 960
AATTCCCGGA ATGCTCCTTT GGCTGGTTTT GGTTACGGCT TGCCAATTTC TCGTCTGTAT 1020
GCAAAGTACT TTCAAGGAGA TCTGAATCTC TACTCTTTAT CAGGATATGG AACAGATGCT 1080
ATCATCTACT TAAAGGCTTT GTCTTCTGAG TCTATAGAAA AACTTCCAGT TTTTAACAAG 1140
TCAGCCTTCA AACATTATCA GATGAGCTCT GAGGCTGATG ACTGGTGTAT CCCAAGCAGG 1200
GAACCAAAGA ACCTGGCAAA AGAAGTGGCC ATGTGA 1236
Domain Profile
S: 1     yvpshlyyllfellknamratveshedkkvlpdvkvlvalgkedliikisdrGGGvplrk  60
         yvpshl+++lfel+knamratve++e++++l++++v+v+lgkedl+ikisdrGGGvplr 
Q: 243   YVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPLRI  302
         9***********************************************************
S: 61    idrlldymystapapskddaraaplaGfGyGlpisrlyakylqGdlkllsleGiGtdavi  120
         idrl++y+ystap+p +d++r+aplaGfGyGlpisrlyaky+qGdl+l+sl+G+Gtda+i
Q: 303   IDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAII  362
         ************************************************************
S: 121   ylkal  125
         ylkal
Q: 363   YLKAL  367
         ***85
Domain Sequence
(FASTA)
YVPSHLHHML FELFKNAMRA TVEHQENQPS LTPIEVIVVL GKEDLTIKIS DRGGGVPLRI 60
IDRLFSYTYS TAPTPVMDNS RNAPLAGFGY GLPISRLYAK YFQGDLNLYS LSGYGTDAII 120
YLKAL 125
Keyword3D-structure; ATP-binding; Carbohydrate metabolism; Complete proteome; Glucose metabolism; Kinase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00417
EKS-ANC-00436
EKS-BOT-00449
EKS-CAJ-00452
EKS-CAF-00446
EKS-CAP-00480
EKS-CHH-00030
EKS-DAR-00850
EKS-EQC-00437
EKS-FEC-00428
EKS-GAM-00258
EKS-GAG-00378
EKS-GAA-00541
EKS-GOG-00439
EKS-ICT-00429
EKS-LOA-00456
EKS-MAM-00445
EKS-MAE-00061
EKS-MEG-00369
EKS-MOD-00436
EKS-MUM-00480
EKS-MUP-00440
EKS-MYL-00440
EKS-NOL-00406
EKS-ORN-00566
EKS-ORC-00420
EKS-ORL-00516
EKS-OTG-00450
EKS-PAT-00422
EKS-PES-00395
EKS-POA-00436
EKS-PRC-00053
EKS-PTV-00155
EKS-RAN-00461
EKS-SAH-00413
EKS-SUS-00396
EKS-TAG-00514
EKS-TAR-00556
EKS-TUB-00042
EKS-TUT-00160
EKS-VIP-00081
EKS-XET-00599
EKS-XIM-00560
Gene Ontology
GO:0005743; C:mitochondrial inner membrane
GO:0005759; C:mitochondrial matrix
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0006006; P:glucose metabolic process
GO:0006090; P:pyruvate metabolic process
GO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate
KEGG
hsa:5166;
InterPros
IPR003594; ATPase-like_ATP-bd.
IPR018955; BCDHK/PDK_N.
IPR005467; Sig_transdc_His_kinase_core.
Pfam
PF10436; BCDHK_Adom3; 1.
PF02518; HATPase_c; 1.
SMARTs
SM00387; HATPase_c; 1.
Prosites
PS50109; HIS_KIN; 1.
Prints
Created Date20-Feb-2013