| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00456 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Atypical/PDHK | 215.5 | 1.1E-63 | 176 | 299 | 124 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000007708 |
| UniProt Accession | Q15119; A8K3A7; B3KNW0; Q6P515; Q9BS05; |
| Protein Name | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial |
| Protein Synonyms/Alias | Pyruvate dehydrogenase kinase isoform 2; |
| Gene Name | PDK2 |
| Gene Synonyms/Alias | PDK2; PDHK2; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Inhibits the mitochondrial pyruvate dehydrogenasecomplex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. |
| Protein Length | 343 |
Protein Sequence
(FASTA) | | MKEINLLPDR VLSTPSVQLV QSWYVQSLLD IMEFLDKDPE DHRTLSQFTD ALVTIRNRHN 60 | | DVVPTMAQGV LEYKDTYGDD PVSNQNIQYF LDRFYLSRIS IRMLINQHTL IFDGSTNPAH 120 | | PKHIGSIDPN CNVSEVVKDA YDMAKLLCDK YYMASPDLEI QEINAANSKQ PIHMVYVPSH 180 | | LYHMLFELFK NAMRATVESH ESSLILPPIK VMVALGEEDL SIKMSDRGGG VPLRKIERLF 240 | | SYMYSTAPTP QPGTGGTPLA GFGYGLPISR LYAKYFQGDL QLFSMEGFGT DAVIYLKALS 300 | | TDSVERLPVY NKSAWRHYQT IQEAGDWCVP STEPKNTSTY RVS 343 |
|
Nucleotide Sequence
(FASTA) | | ATGAAAGAGA TCAACCTGCT TCCCGACCGA GTGCTGAGCA CACCCTCCGT GCAGCTGGTG 60 | | CAGAGCTGGT ATGTCCAGAG CCTCCTGGAC ATCATGGAGT TCCTGGACAA GGATCCCGAG 120 | | GACCATCGCA CCCTGAGCCA GTTCACTGAC GCCCTGGTCA CCATCCGGAA CCGGCACAAC 180 | | GACGTGGTGC CCACCATGGC ACAAGGCGTG CTTGAGTACA AGGACACCTA CGGCGATGAC 240 | | CCCGTCTCCA ACCAGAACAT CCAGTACTTC CTGGACCGCT TCTACCTCAG CCGCATCTCC 300 | | ATCCGCATGC TCATCAACCA GCACACCCTC ATCTTTGATG GCAGCACCAA CCCAGCCCAT 360 | | CCCAAACACA TCGGCAGCAT CGACCCCAAC TGCAACGTCT CTGAGGTGGT CAAAGATGCC 420 | | TACGACATGG CTAAGCTCCT GTGTGACAAG TATTACATGG CCTCACCTGA CCTGGAGATC 480 | | CAGGAGATCA ATGCAGCCAA CTCCAAACAG CCGATTCACA TGGTCTACGT CCCCTCCCAC 540 | | CTCTACCACA TGCTCTTTGA GCTCTTCAAG AATGCCATGA GGGCGACTGT GGAAAGCCAT 600 | | GAGTCCAGCC TCATTCTCCC ACCCATCAAG GTCATGGTGG CCTTGGGTGA GGAAGATCTG 660 | | TCCATCAAGA TGAGTGACCG AGGTGGGGGT GTTCCCTTGA GGAAGATTGA GCGACTCTTC 720 | | AGCTACATGT ACTCCACAGC ACCCACCCCC CAGCCTGGCA CCGGGGGAAC GCCGCTGGCT 780 | | GGCTTTGGTT ATGGGCTCCC CATTTCCCGC CTCTACGCCA AGTACTTCCA GGGAGACCTG 840 | | CAGCTCTTCT CCATGGAAGG CTTTGGGACC GATGCTGTCA TCTATCTCAA GGCCCTGTCC 900 | | ACGGACTCGG TGGAGCGCCT GCCTGTCTAC AACAAGTCAG CCTGGCGCCA CTACCAGACC 960 | | ATCCAGGAGG CCGGCGACTG GTGTGTGCCC AGCACGGAGC CCAAGAACAC GTCCACGTAC 1020 | | CGCGTCAGCT AA 1032 |
|
| Domain Profile | S: 1 yvpshlyyllfellknamratveshedkkvlpdvkvlvalgkedliikisdrGGGvplrk 60 | yvpshly++lfel+knamratveshe++ +lp++kv+valg+edl+ik+sdrGGGvplrk | Q: 176 YVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRK 235 | 9*********************************************************** |
| S: 61 idrlldymystapapskddaraaplaGfGyGlpisrlyakylqGdlkllsleGiGtdavi 120 | i+rl++ymystap+p+ + ++plaGfGyGlpisrlyaky+qGdl+l+s+eG+Gtdavi | Q: 236 IERLFSYMYSTAPTPQPG-TGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVI 294 | ***************998.899************************************** |
| S: 121 ylkal 125 | ylkal | Q: 295 YLKAL 299 | ***85 |
|
Domain Sequence
(FASTA) | | YVPSHLYHML FELFKNAMRA TVESHESSLI LPPIKVMVAL GEEDLSIKMS DRGGGVPLRK 60 | | IERLFSYMYS TAPTPQPGTG GTPLAGFGYG LPISRLYAKY FQGDLQLFSM EGFGTDAVIY 120 | | LKAL 124 |
|
| Keyword | 3D-structure; Alternative splicing; ATP-binding; Carbohydrate metabolism; Complete proteome; Glucose metabolism; Kinase; Mitochondrion; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |