EKS-HOS-00215

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00215

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	486.2	1.2E-145	4	286	283

Status

Reviewed

Ensembl Protein

ENSP00000395559

UniProt Accession

Q8IVW4; D3DQA0; D3DQA1; Q9P114;

Protein Name

Cyclin-dependent kinase-like 3

Protein Synonyms/Alias

Serine/threonine-protein kinase NKIAMRE;

Gene Name

CDKL3

Gene Synonyms/Alias

CDKL3; NKIAMRE;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000006837	ENSP00000441545	ENST00000536186
ENSG00000006837	ENSP00000265334	ENST00000265334
ENSG00000006837	ENSP00000427836	ENST00000518990
ENSG00000006837	ENSP00000428689	ENST00000521118
ENSG00000006837	ENSP00000430777	ENST00000520693
ENSG00000006837	ENSP00000430496	ENST00000523832
ENSG00000006837	ENSP00000399807	ENST00000435240
ENSG00000006837	ENSP00000427964	ENST00000521755
ENSG00000006837	ENSP00000428498	ENST00000520592
ENSG00000006837	ENSP00000395559	ENST00000435211
ENSG00000006837	ENSP00000428500	ENST00000523054
ENSG00000006837	ENSP00000427738	ENST00000519312

Organism

Homo sapiens

Functional Description

Protein Length

455

Protein Sequence
(FASTA)

MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE IKFLKQFHHE 60

NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK RLRKYLFQIL RAIDYLHSNN 120

IIHRDIKPEN ILVSQSGITK LCDFGFARTL AAPGDIYTDY VATRWYRAPE LVLKDTSYGK 180

PVDIWALGCM IIEMATGNPY LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP 240

QVQHPKNARK KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK 300

AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE KKPKEIKVRV 360

IKVKGGRGDI SEPKKKEYEG GLGQQDANEN VHPMSPDTKL VTIEPPNPIN PSTNCNGLKE 420

NPHCGGSVTM PPINLTNSNL MAANLSSNLF HPSVR 455

Nucleotide Sequence
(FASTA)

ATGGAGATGT ATGAAACCCT TGGAAAAGTG GGAGAGGGAA GTTACGGAAC AGTCATGAAA 60

TGTAAACATA AGAATACTGG GCAGATAGTG GCCATTAAGA TATTTTATGA GAGACCAGAA 120

CAATCTGTCA ACAAAATTGC GATGAGAGAA ATAAAGTTTC TAAAGCAATT TCATCACGAA 180

AACCTGGTCA ATCTGATTGA AGTTTTTAGA CAGAAAAAGA AAATTCATTT GGTATTTGAA 240

TTTATTGACC ACACAGTATT AGATGAGTTA CAACATTATT GTCATGGACT AGAGAGTAAG 300

CGACTTAGAA AATACCTCTT CCAGATCCTT CGAGCAATTG ACTATCTTCA CAGTAATAAT 360

ATCATTCATC GAGATATAAA ACCTGAGAAT ATTTTAGTAT CCCAGTCAGG AATTACTAAG 420

CTCTGTGATT TTGGTTTTGC ACGAACACTA GCAGCTCCTG GGGACATTTA TACGGACTAT 480

GTGGCCACAC GCTGGTATAG AGCTCCCGAA TTAGTATTAA AAGATACTTC TTATGGAAAA 540

CCTGTGGATA TCTGGGCTTT GGGCTGTATG ATCATTGAGA TGGCCACTGG AAATCCCTAT 600

CTTCCTAGTA GTTCTGATTT GGATTTACTC CATAAAATTG TTTTGAAAGT GGGCAATTTG 660

TCACCTCACT TGCAGAATAT CTTTTCCAAG AGCCCCATTT TTGCTGGGGT AGTTCTTCCT 720

CAAGTTCAAC ACCCCAAAAA TGCAAGAAAA AAATATCCAA AGCTTAATGG ATTGTTGGCA 780

GATATAGTTC ATGCTTGTTT ACAAATTGAT CCTGCTGACA GGATATCATC TAGTGATCTT 840

TTGCATCATG AGTATTTTAC TAGAGATGGA TTTATTGAAA AATTCATGCC AGAACTGAAA 900

GCTAAATTAC TGCAGGAAGC AAAAGTCAAT TCATTAATAA AGCCAAAAGA GAGTTCTAAA 960

GAAAATGAAC TCAGGAAAGA TGAAAGAAAA ACAGTTTATA CCAATACACT GCTAAGTAGT 1020

TCAGTTTTGG GAAAGGAAAT AGAAAAAGAG AAAAAGCCCA AGGAGATCAA AGTCAGAGTT 1080

ATTAAAGTCA AAGGAGGAAG AGGAGATATC TCAGAACCAA AAAAGAAAGA GTATGAAGGT 1140

GGACTTGGTC AACAGGATGC AAATGAAAAT GTTCATCCTA TGTCTCCAGA TACAAAACTT 1200

GTAACCATTG AACCACCAAA CCCTATCAAT CCCAGCACTA ACTGTAATGG CTTGAAAGAA 1260

AATCCACATT GCGGAGGTTC TGTGACAATG CCACCCATCA ATCTAACTAA CAGTAATTTG 1320

ATGGCTGCAA ATCTCAGTTC AAATCTCTTT CACCCCAGTG TGAGGTGA 1368

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lgkvGeGsyG+v+kc++k+tgqivaik f+e+++ ++v+kia+reik+lkq++henl

Q: 4     YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPE-QSVNKIAMREIKFLKQFHHENL  62

         9***********************************9.99********************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnl+evfr+kkk++lvfe++d+tvldel++y++G+e+++++k+l+qil+ai+++h+nnii

Q: 63    VNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNII  122

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenil+s+sg++klcdfGfar+laapgd+ytdyvatrwyrapel+++dt+yGk+v

Q: 123   HRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPV  182

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         d+wa+Gc+++e++tG+p++p++sd+d l+ki+ ++G+l+p+ q+ifsk+++faGv+lp+v

Q: 183   DIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQV  242

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +++++++kkypkln +l+d++++cl++dpa+r+s+++ll+heyf

Q: 243   QHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF  286

         *******************************************9

Domain Sequence
(FASTA)

YETLGKVGEG SYGTVMKCKH KNTGQIVAIK IFYERPEQSV NKIAMREIKF LKQFHHENLV 60

NLIEVFRQKK KIHLVFEFID HTVLDELQHY CHGLESKRLR KYLFQILRAI DYLHSNNIIH 120

RDIKPENILV SQSGITKLCD FGFARTLAAP GDIYTDYVAT RWYRAPELVL KDTSYGKPVD 180

IWALGCMIIE MATGNPYLPS SSDLDLLHKI VLKVGNLSPH LQNIFSKSPI FAGVVLPQVQ 240

HPKNARKKYP KLNGLLADIV HACLQIDPAD RISSSDLLHH EYF 283

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0004672	; F:protein kinase activity
GO:0007049	; P:cell cycle

KEGG

hsa:51265

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013