EKS-HOS-00151

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00151

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	451.1	4.0E-135	194	437	244

Status

Reviewed

Ensembl Protein

ENSP00000378481

UniProt Accession

P42679; B3KNZ9; Q9NST8;

Protein Name

Megakaryocyte-associated tyrosine-protein kinase

Protein Synonyms/Alias

CSK homologous kinase; CHK; Hematopoietic consensus tyrosine-lacking kinase; Protein kinase HYL; Tyrosine-protein kinase CTK;

Gene Name

MATK

Gene Synonyms/Alias

MATK; CTK, HYL;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000007264	ENSP00000468576	ENST00000590493
ENSG00000007264	ENSP00000378481	ENST00000395040
ENSG00000007264	ENSP00000468465	ENST00000587180
ENSG00000007264	ENSP00000378485	ENST00000395045
ENSG00000007264	ENSP00000467472	ENST00000590980
ENSG00000007264	ENSP00000468030	ENST00000585778
ENSG00000007264	ENSP00000465761	ENST00000588983
ENSG00000007264	ENSP00000308734	ENST00000310132
ENSG00000007264	ENSP00000467006	ENST00000590028
ENSG00000007264	ENSP00000465556	ENST00000591059
ENSG00000007264	ENSP00000467992	ENST00000590849

Organism

Homo sapiens

Functional Description

Could play a significant role in the signal transductionof hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.

Protein Length

466

Protein Sequence
(FASTA)

MPTRRWAPGT QCITKCEHTR PKPGELAFRK GDVVTILEAC ENKSWYRVKH HTSGQEGLLA 60

AGALREREAL SADPKLSLMP WFHGKISGQE AVQQLQPPED GLFLVRESAR HPGDYVLCVS 120

FGRDVIHYRV LHRDGHLTID EAVFFCNLMD MVEHYSKDKG AICTKLVRPK RKHGTKSAEE 180

ELARAGWLLN LQHLTLGAQI GEGEFGAVLQ GEYLGQKVAV KNIKCDVTAQ AFLDETAVMT 240

KMQHENLVRL LGVILHQGLY IVMEHVSKGN LVNFLRTRGR ALVNTAQLLQ FSLHVAEGME 300

YLESKKLVHR DLAARNILVS EDLVAKVSDF GLAKAERKGL DSSRLPVKWT APEALKHGKF 360

TSKSDVWSFG VLLWEVFSYG RAPYPKMSLK EVSEAVEKGY RMEPPEGCPG PVHVLMSSCW 420

EAEPARRPPF RKLAEKLARE LRSAGAPASV SGQDADGSTS PRSQEP 466

Nucleotide Sequence
(FASTA)

ATGCCAACGA GGCGCTGGGC CCCGGGCACC CAGTGTATCA CCAAATGCGA GCACACCCGC 60

CCCAAGCCAG GGGAGCTGGC CTTCCGCAAG GGCGACGTGG TCACCATCCT GGAGGCCTGC 120

GAGAACAAGA GCTGGTACCG CGTCAAGCAC CACACCAGTG GACAGGAGGG GCTGCTGGCA 180

GCTGGGGCGC TGCGGGAGCG GGAGGCCCTC TCCGCAGACC CCAAGCTCAG CCTCATGCCG 240

TGGTTCCACG GGAAGATCTC GGGCCAGGAG GCTGTCCAGC AGCTGCAGCC TCCCGAGGAT 300

GGGCTGTTCC TGGTGCGGGA GTCCGCGCGC CACCCCGGCG ACTACGTCCT GTGCGTGAGC 360

TTTGGCCGCG ACGTCATCCA CTACCGCGTG CTGCACCGCG ACGGCCACCT CACAATCGAT 420

GAGGCCGTGT TCTTCTGCAA CCTCATGGAC ATGGTGGAGC ATTACAGCAA GGACAAGGGC 480

GCTATCTGCA CCAAGCTGGT GAGACCAAAG CGGAAACACG GGACCAAGTC GGCCGAGGAG 540

GAGCTGGCCA GGGCGGGCTG GTTACTGAAC CTGCAGCATT TGACATTGGG AGCACAGATC 600

GGAGAGGGAG AGTTTGGAGC TGTCCTGCAG GGTGAGTACC TGGGGCAAAA GGTGGCCGTG 660

AAGAATATCA AGTGTGATGT GACAGCCCAG GCCTTCCTGG ACGAGACGGC CGTCATGACG 720

AAGATGCAAC ACGAGAACCT GGTGCGTCTC CTGGGCGTGA TCCTGCACCA GGGGCTGTAC 780

ATTGTCATGG AGCACGTGAG CAAGGGCAAC CTGGTGAACT TTCTGCGGAC CCGGGGTCGA 840

GCCCTCGTGA ACACCGCTCA GCTCCTGCAG TTTTCTCTGC ACGTGGCCGA GGGCATGGAG 900

TACCTGGAGA GCAAGAAGCT TGTGCACCGC GACCTGGCCG CCCGCAACAT CCTGGTCTCA 960

GAGGACCTGG TGGCCAAGGT CAGCGACTTT GGCCTGGCCA AAGCCGAGCG GAAGGGGCTA 1020

GACTCAAGCC GGCTGCCCGT CAAGTGGACG GCGCCCGAGG CTCTCAAACA CGGGAAGTTC 1080

ACCAGCAAGT CGGATGTCTG GAGTTTTGGG GTGCTGCTCT GGGAGGTCTT CTCATATGGA 1140

CGGGCTCCGT ACCCTAAAAT GTCACTGAAA GAGGTGTCGG AGGCCGTGGA GAAGGGGTAC 1200

CGCATGGAAC CCCCCGAGGG CTGTCCAGGC CCCGTGCACG TCCTCATGAG CAGCTGCTGG 1260

GAGGCAGAGC CCGCCCGCCG GCCACCCTTC CGCAAACTGG CCGAGAAGCT GGCCCGGGAG 1320

CTACGCAGTG CAGGTGCCCC AGCCTCCGTC TCAGGGCAGG ACGCCGACGG CTCCACCTCG 1380

CCCCGAAGCC AGGAGCCCTG A 1401

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         l+lg++ig+gefg+vl+gey g+kvavk+ik+d+taqaflde++vmtk++henlv+llgv

Q: 194   LTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGV  253

         6899********************************************************

S: 61    ileekglylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrdl  120

         il++ gly+v+e+v+kg+lv++lr+rgral++++qll+f+l+vaegmeyleskklvhrdl

Q: 254   ILHQ-GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDL  312

         ***9.*******************************************************

S: 121   aarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgil  180

         aarn+lvsedlvakvsdfglak+e+k+lds++lpvkwtapealk++kf++ksdvwsfg+l

Q: 313   AARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVL  372

         ************************************************************

S: 181   lweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfak  240

         lwe+fs+gr+pyp+++lk+v++avekgy+me+pegcp+ v+ lm+++we+e+a+rp+f+k

Q: 373   LWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRK  432

         ************************************************************

S: 241   lkekl  245

         l+ekl

Q: 433   LAEKL  437

         **997

Domain Sequence
(FASTA)

LTLGAQIGEG EFGAVLQGEY LGQKVAVKNI KCDVTAQAFL DETAVMTKMQ HENLVRLLGV 60

ILHQGLYIVM EHVSKGNLVN FLRTRGRALV NTAQLLQFSL HVAEGMEYLE SKKLVHRDLA 120

ARNILVSEDL VAKVSDFGLA KAERKGLDSS RLPVKWTAPE ALKHGKFTSK SDVWSFGVLL 180

WEVFSYGRAP YPKMSLKEVS EAVEKGYRME PPEGCPGPVH VLMSSCWEAE PARRPPFRKL 240

AEKL 244

Keyword

3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0008283	; P:cell proliferation
GO:0007498	; P:mesoderm development
GO:0008284	; P:positive regulation of cell proliferation

KEGG

hsa:4145

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013