EKS-HOS-00216

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00216

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	463.8	7.8E-139	13	297	285

Status

Reviewed

Ensembl Protein

ENSP00000369325

UniProt Accession

O76039; G9B9X4; Q14198; Q5H985; Q8IYC7; Q9UJL6;

Protein Name

Cyclin-dependent kinase-like 5

Protein Synonyms/Alias

Serine/threonine-protein kinase 9;

Gene Name

CDKL5

Gene Synonyms/Alias

CDKL5; STK9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000008086	ENSP00000369332	ENST00000379996
ENSG00000008086	ENSP00000369325	ENST00000379989

Organism

Homo sapiens

Functional Description

Mediates phosphorylation of MECP2.

Protein Length

1030

Protein Sequence
(FASTA)

MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI 120

KAIHWCHKND IVHRDIKPEN LLISHNDVLK LCDFGFARNL SEGNNANYTE YVATRWYRSP 180

ELLLGAPYGK SVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS 240

NPRFHGLRFP AVNHPQSLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ 300

RLLDRSPSRS AKRKPYHVES STLSNRNQAG KSTALQSHHR SNSKDIQNLS VGLPRADEGL 360

PANESFLNGN LAGASLSPLH TKTYQASSQP GSTSKDLTNN NIPHLLSPKE AKSKTEFDFN 420

IDPKPSEGPG TKYLKSNSRS QQNRHSFMES SQSKAGTLQP NEKQSRHSYI DTIPQSSRSP 480

SYRTKAKSHG ALSDSKSVSN LSEARAQIAE PSTSRYFPSS CLDLNSPTSP TPTRHSDTRT 540

LLSPSGRNNR NEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS 600

PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS IGQGMAARAN SLQLLSPQPG EQLPPEMTVA 660

RSSVKETSRE GTSSFHTRQK SEGGVYHDPH SDDGTAPKEN RHLYNDPVPR RVGSFYRVPS 720

PRPDNSFHEN NVSTRVSSLP SESSSGTNHS KRQPAFDPWK SPENISHSEQ LKEKEKQGFF 780

RSMKKKKKKS QTVPNSDSPD LLTLQKSIHS ASTPSSRPKE WRPEKISDLQ TQSQPLKSLR 840

KLLHLSSASN HPASSDPRFQ PLTAQQTKNS FSEIRIHPLS QASGGSSNIR QEPAPKGRPA 900

LQLPDGGCDG RRQRHHSGPQ DRRFMLRTTE QQGEYFCCGD PKKPHTPCVP NRALHRPISS 960

PAPYPVLQVR GTSMCPTLQV RGTDAFSCPT QQSGFSFFVR HVMREALIHR AQVNQAALLT 1020

YHENAALTGK 1030

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTAGGT 60

GAAGGAGCCT ATGGAGTTGT ACTTAAATGC AGACACAAGG AAACACATGA AATTGTGGCG 120

ATCAAGAAAT TCAAGGACAG TGAAGAAAAT GAAGAAGTCA AAGAAACGAC TTTACGAGAG 180

CTTAAAATGC TTCGGACTCT CAAGCAGGAA AACATTGTGG AGTTGAAGGA AGCATTTCGT 240

CGGAGGGGAA AGTTGTACTT GGTGTTTGAG TATGTTGAAA AAAATATGCT CGAATTGCTG 300

GAAGAAATGC CAAATGGAGT TCCACCTGAG AAAGTAAAAA GCTACATCTA TCAGCTAATC 360

AAGGCTATTC ACTGGTGCCA TAAGAATGAT ATTGTCCATC GAGATATAAA ACCAGAAAAT 420

CTCTTAATCA GCCACAATGA TGTCCTAAAA CTGTGTGACT TTGGTTTTGC TCGTAATCTG 480

TCAGAAGGCA ATAATGCTAA TTACACAGAG TACGTTGCCA CCAGATGGTA TCGGTCCCCA 540

GAACTCTTAC TTGGCGCTCC CTATGGAAAG TCCGTGGACA TGTGGTCGGT GGGCTGTATT 600

CTTGGGGAGC TTAGCGATGG ACAGCCTTTA TTTCCTGGAG AAAGTGAAAT TGACCAACTT 660

TTTACTATTC AGAAGGTGCT AGGACCACTT CCATCTGAGC AGATGAAGCT TTTCTACAGT 720

AATCCTCGCT TCCATGGGCT CCGGTTTCCA GCTGTTAACC ATCCTCAGTC CTTGGAAAGA 780

AGATACCTTG GAATTTTGAA TAGTGTTCTA CTTGACCTAA TGAAGAATTT ACTGAAGTTG 840

GACCCAGCTG ACAGATACTT GACAGAACAG TGTTTGAATC ACCCTACATT TCAAACCCAG 900

AGACTTCTGG ATCGTTCTCC TTCAAGGTCA GCAAAAAGAA AACCTTACCA TGTGGAAAGC 960

AGCACATTGT CTAATAGAAA CCAAGCCGGC AAAAGTACTG CTTTGCAGTC TCACCACAGA 1020

TCTAACAGCA AGGACATCCA GAACCTGAGT GTAGGCCTGC CCCGGGCTGA CGAAGGTCTC 1080

CCTGCCAATG AAAGCTTCCT AAATGGAAAC CTTGCTGGAG CTAGTCTTAG TCCACTGCAC 1140

ACCAAAACCT ACCAAGCAAG CAGCCAGCCT GGGTCTACCA GCAAAGATCT CACCAACAAC 1200

AACATACCAC ACCTTCTTAG CCCAAAAGAA GCCAAGTCAA AAACAGAGTT TGATTTTAAT 1260

ATTGACCCAA AGCCTTCAGA AGGCCCAGGG ACAAAGTACC TCAAGTCAAA CAGCAGATCT 1320

CAGCAGAACC GCCACTCATT CATGGAAAGC TCTCAAAGCA AAGCTGGGAC ACTGCAGCCC 1380

AATGAAAAGC AGAGTCGGCA TAGCTATATT GACACAATTC CCCAGTCCTC TAGGAGTCCC 1440

TCCTACAGGA CCAAGGCCAA AAGCCATGGG GCACTGAGTG ACTCCAAGTC TGTGAGCAAC 1500

CTTTCTGAAG CCAGGGCCCA AATTGCGGAG CCCAGTACCA GTAGGTACTT CCCATCTAGC 1560

TGCTTAGACT TGAATTCTCC CACCAGCCCA ACCCCCACCA GACACAGTGA CACGAGAACT 1620

TTGCTCAGCC CTTCTGGAAG AAATAACCGA AATGAGGGAA CGCTGGACTC ACGTCGAACC 1680

ACAACCAGAC ATTCTAAGAC GATGGAGGAA TTGAAGCTGC CGGAGCACAT GGACAGTAGC 1740

CATTCCCATT CACTGTCTGC ACCTCACGAA TCTTTTTCTT ATGGACTGGG CTACACCAGC 1800

CCCTTTTCTT CCCAGCAACG TCCTCATAGG CATTCTATGT ATGTGACCCG TGACAAAGTG 1860

AGAGCCAAGG GCTTGGATGG AAGCTTGAGC ATAGGGCAAG GGATGGCAGC TAGAGCCAAC 1920

AGCCTGCAAC TCTTGTCACC CCAGCCTGGA GAACAGCTCC CTCCAGAGAT GACTGTGGCA 1980

AGATCTTCGG TCAAAGAGAC CTCCAGAGAA GGCACCTCTT CCTTCCATAC ACGCCAGAAG 2040

TCTGAGGGTG GAGTGTATCA TGACCCACAC TCTGATGATG GCACAGCCCC CAAAGAAAAT 2100

AGACACCTAT ACAATGATCC TGTGCCAAGG AGAGTTGGTA GCTTTTACAG AGTGCCATCT 2160

CCACGTCCAG ACAATTCTTT CCATGAAAAT AATGTGTCAA CTAGAGTTTC TTCTCTACCA 2220

TCAGAGAGCA GTTCTGGAAC CAACCACTCA AAAAGACAAC CAGCATTCGA TCCATGGAAA 2280

AGTCCTGAAA ATATTAGTCA TTCAGAGCAA CTCAAGGAAA AAGAGAAGCA AGGATTTTTC 2340

AGGTCAATGA AAAAGAAAAA GAAGAAATCT CAAACAGTAC CCAATTCCGA CAGCCCTGAT 2400

CTTCTGACGT TGCAGAAATC CATTCATTCT GCTAGCACTC CAAGCAGCAG ACCAAAGGAG 2460

TGGCGCCCCG AGAAGATCTC AGATCTGCAG ACCCAAAGCC AGCCATTAAA ATCACTGCGC 2520

AAGTTGTTAC ATCTCTCTTC GGCCTCAAAT CACCCGGCTT CCTCAGATCC CCGCTTCCAG 2580

CCCTTAACAG CTCAACAAAC CAAAAATTCC TTCTCAGAAA TTCGGATTCA CCCCCTGAGC 2640

CAGGCCTCTG GCGGGAGCAG CAACATCCGG CAGGAACCCG CACCGAAGGG CAGGCCAGCC 2700

CTCCAGCTGC CAGACGGTGG ATGTGATGGC AGAAGACAGA GACACCATTC TGGACCCCAA 2760

GATAGACGCT TCATGTTAAG GACGACAGAA CAACAAGGAG AATACTTCTG CTGTGGTGAC 2820

CCAAAGAAGC CTCACACTCC GTGCGTCCCA AACCGAGCCC TTCATCGTCC AATCTCCAGT 2880

CCTGCTCCCT ATCCAGTACT CCAGGTCCGA GGCACTTCCA TGTGCCCGAC ACTCCAGGTC 2940

CGAGGCACTG ATGCTTTCAG CTGCCCAACC CAGCAATCCG GGTTCTCTTT CTTCGTGAGA 3000

CACGTTATGA GGGAAGCCCT GATTCACAGG GCCCAGGTAA ACCAAGCTGC GCTCCTGACA 3060

TACCATGAGA ATGCGGCACT GACGGGCAAG TGA 3093

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg+vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+++v+klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGks

Q: 133   HRDIKPENLLISHNDVLKLCDFGFARNLSeGNNANYTEYVATRWYRSPELLLG-APYGKS  191

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v++++sle++y   ln+vlldl+k++lkldpa+r+++e++l+h++f

Q: 252   VNHPQSLERRYLgILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF  297

         ***********9899****************************998

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHNDVLKLC DFGFARNLSE GNNANYTEYV ATRWYRSPEL LLGAPYGKSV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPS EQMKLFYSNP RFHGLRFPAV 240

NHPQSLERRY LGILNSVLLD LMKNLLKLDP ADRYLTEQCL NHPTF 285

Keyword

Alternative splicing; ATP-binding; Chromosomal rearrangement; Complete proteome; Disease mutation; Epilepsy; Kinase; Mental retardation; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0032839	; C:dendrite cytoplasm
GO:0044294	; C:dendritic growth cone
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0048365	; F:Rac GTPase binding
GO:0007049	; P:cell cycle
GO:0001764	; P:neuron migration
GO:0045773	; P:positive regulation of axon extension
GO:0050775	; P:positive regulation of dendrite morphogenesis
GO:0032855	; P:positive regulation of Rac GTPase activity
GO:0046777	; P:protein autophosphorylation

KEGG

hsa:6792

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013