EKS-HOS-00490

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00490

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMK1	428.7	4.0E-128	23	277	255

Status

Reviewed

Ensembl Protein

ENSP00000009105

UniProt Accession

Q96NX5; Q86UH5; Q9Y3J7;

Protein Name

Calcium/calmodulin-dependent protein kinase type 1G

Protein Synonyms/Alias

CaM kinase I gamma; CaM kinase IG; CaM-KI gamma; CaMKI gamma; CaMKIG; CaMK-like CREB kinase III; CLICK III;

Gene Name

CAMK1G

Gene Synonyms/Alias

CAMK1G; VWS1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000008118	ENSP00000392173	ENST00000423146
ENSG00000008118	ENSP00000354861	ENST00000361322
ENSG00000008118	ENSP00000009105	ENST00000009105

Organism

Homo sapiens

Functional Description

Calcium/calmodulin-dependent protein kinase belonging toa proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity).

Protein Length

476

Protein Sequence
(FASTA)

MGRKEEDDCS SWKKQTTNIR KTFIFMEVLG SGAFSEVFLV KQRLTGKLFA LKCIKKSPAF 60

RDSSLENEIA VLKKIKHENI VTLEDIYEST THYYLVMQLV SGGELFDRIL ERGVYTEKDA 120

SLVIQQVLSA VKYLHENGIV HRDLKPENLL YLTPEENSKI MITDFGLSKM EQNGIMSTAC 180

GTPGYVAPEV LAQKPYSKAV DCWSIGVITY ILLCGYPPFY EETESKLFEK IKEGYYEFES 240

PFWDDISESA KDFICHLLEK DPNERYTCEK ALSHPWIDGN TALHRDIYPS VSLQIQKNFA 300

KSKWRQAFNA AAVVHHMRKL HMNLHSPGVR PEVENRPPET QASETSRPSS PEITITEAPV 360

LDHSVALPAL TQLPCQHGRR PTAPGGRSLN CLVNGSLHIS SSLVPMHQGS LAAGPCGCCS 420

SCLNIGSKGK SSYCSEPTLL KKANKKQNFK SEVMVPVKAS GSSHCRAGQT GVCLIM 476

Nucleotide Sequence
(FASTA)

ATGGGTCGAA AGGAAGAAGA TGACTGCAGT TCCTGGAAGA AACAGACCAC CAACATCCGG 60

AAAACCTTCA TTTTTATGGA AGTGCTGGGA TCAGGAGCTT TCTCAGAAGT TTTCCTGGTG 120

AAGCAAAGAC TGACTGGGAA GCTCTTTGCT CTGAAGTGCA TCAAGAAGTC ACCTGCCTTC 180

CGGGACAGCA GCCTGGAGAA TGAGATTGCT GTGTTGAAAA AGATCAAGCA TGAAAACATT 240

GTGACCCTGG AGGACATCTA TGAGAGCACC ACCCACTACT ACCTGGTCAT GCAGCTTGTT 300

TCTGGTGGGG AGCTCTTTGA CCGGATCCTG GAGCGGGGTG TCTACACAGA GAAGGATGCC 360

AGTCTGGTGA TCCAGCAGGT CTTGTCGGCA GTGAAATACC TACATGAGAA TGGCATCGTC 420

CACAGAGACT TAAAGCCCGA AAACCTGCTT TACCTTACCC CTGAAGAGAA CTCTAAGATC 480

ATGATCACTG ACTTTGGTCT GTCCAAGATG GAACAGAATG GCATCATGTC CACTGCCTGT 540

GGGACCCCAG GCTACGTGGC TCCAGAAGTG CTGGCCCAGA AACCCTACAG CAAGGCTGTG 600

GATTGCTGGT CCATCGGCGT CATCACCTAC ATATTGCTCT GTGGATACCC CCCATTCTAT 660

GAAGAAACGG AGTCTAAGCT TTTCGAGAAG ATCAAGGAGG GCTACTATGA GTTTGAGTCT 720

CCATTCTGGG ATGACATTTC TGAGTCAGCC AAGGACTTTA TTTGCCACTT GCTTGAGAAG 780

GATCCGAACG AGCGGTACAC CTGTGAGAAG GCCTTGAGTC ATCCCTGGAT TGACGGAAAC 840

ACAGCCCTCC ACCGGGACAT CTACCCATCA GTCAGCCTCC AGATCCAGAA GAACTTTGCT 900

AAGAGCAAGT GGAGGCAAGC CTTCAACGCA GCAGCTGTGG TGCACCACAT GAGGAAGCTA 960

CACATGAACC TGCACAGCCC GGGCGTCCGC CCAGAGGTGG AGAACAGGCC GCCTGAAACT 1020

CAAGCCTCAG AAACCTCTAG ACCCAGCTCC CCTGAGATCA CCATCACCGA GGCACCTGTC 1080

CTGGACCACA GTGTAGCACT CCCTGCCCTG ACCCAATTAC CCTGCCAGCA TGGCCGCCGG 1140

CCCACTGCCC CTGGTGGCAG GTCCCTCAAC TGCCTGGTCA ATGGCTCCCT CCACATCAGC 1200

AGCAGCCTGG TGCCCATGCA TCAGGGGTCC CTGGCCGCCG GGCCCTGTGG CTGCTGCTCC 1260

AGCTGCCTGA ACATTGGGAG CAAAGGAAAG TCCTCCTACT GCTCTGAGCC CACACTCCTC 1320

AAAAAGGCCA ACAAAAAACA GAACTTCAAG TCGGAGGTCA TGGTACCAGT TAAAGCCAGT 1380

GGCAGCTCCC ACTGCCGGGC AGGGCAGACT GGAGTCTGTC TCATTATGTG A 1431

Domain Profile

S: 1     yklkeklGeGafsevlkakekktqkavaikvikkkalkgkeesveneiavlkklkhpniv  60

         + ++e lG+Gafsev+++k++ t+k +a+k+ikk+    +++s+eneiavlkk+kh+niv

Q: 23    FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAF-RDSSLENEIAVLKKIKHENIV  81

         6799******************************9966.899******************

S: 61    alkdiyesksklylvlelvtGGelfdrivekgvytekdasevikqvleavkylhelgivh  120

         +l+diyes++++ylv++lv+GGelfdri+e+gvytekdas vi+qvl+avkylhe+givh

Q: 82    TLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVH  141

         ************************************************************

S: 121   rdlkPenllylskeedskikiadfGlskleekellktacGtvgyvapevlkqkkyskkvd  180

         rdlkPenllyl++ee+ski+i+dfGlsk+e++++++tacGt+gyvapevl+qk+ysk+vd

Q: 142   RDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVD  201

         ************************************************************

S: 181   vWsiGvityillcGyppfydekeekllekilkgeyefesPyWdeisesakdfikklleld  240

         +WsiGvityillcGyppfy+e+e+kl+eki++g yefesP+Wd+isesakdfi++lle+d

Q: 202   CWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKD  261

         ************************************************************

S: 241   pekrytieqaledpWi  256

         p++ryt+e+al++pWi

Q: 262   PNERYTCEKALSHPWI  277

         ***************8

Domain Sequence
(FASTA)

FIFMEVLGSG AFSEVFLVKQ RLTGKLFALK CIKKSPAFRD SSLENEIAVL KKIKHENIVT 60

LEDIYESTTH YYLVMQLVSG GELFDRILER GVYTEKDASL VIQQVLSAVK YLHENGIVHR 120

DLKPENLLYL TPEENSKIMI TDFGLSKMEQ NGIMSTACGT PGYVAPEVLA QKPYSKAVDC 180

WSIGVITYIL LCGYPPFYEE TESKLFEKIK EGYYEFESPF WDDISESAKD FICHLLEKDP 240

NERYTCEKAL SHPWI 255

Keyword

3D-structure; Allosteric enzyme; Alternative splicing; ATP-binding; Calmodulin-binding; Cell membrane; Complete proteome; Cytoplasm; Golgi apparatus; Kinase; Lipoprotein; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Prenylation; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005954	; C:calcium- and calmodulin-dependent protein kinase complex
GO:0000139	; C:Golgi membrane
GO:0043005	; C:neuron projection
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004683	; F:calmodulin-dependent protein kinase activity

KEGG

hsa:57172

;

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013