EKS-HOS-00064
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00064
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK377.51.9E-112389674286
StatusReviewed
Ensembl ProteinENSP00000348529
UniProt AccessionQ9UQ88; O95227; O95228; O96012; Q12821; Q12853; Q12854; Q2TAJ0; Q5QPR0; Q5QPR1; Q5QPR2; Q9UBC4; Q9UBI3; Q9UEI1; Q9UEI2; Q9UP53; Q9UP54; Q9UP55; Q9UP56; Q9UQ86; Q9UQ87; Q9UQ89;
Protein NameCyclin-dependent kinase 11A
Protein Synonyms/Alias Cell division cycle 2-like protein kinase 2; Cell division protein kinase 11A; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L2;
Gene NameCDK11A
Gene Synonyms/Alias CDK11A; CDC2L2, CDC2L3, PITSLREB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000008128ENSP00000384442ENST00000404249
ENSG00000008128ENSP00000348529ENST00000356200
ENSG00000008128ENSP00000367902ENST00000378635
ENSG00000008128ENSP00000383874ENST00000401096
ENSG00000008128ENSP00000351629ENST00000358779
ENSG00000008128ENSP00000462289ENST00000460465
ENSG00000008128ENSP00000367905ENST00000378638
ENSG00000008128ENSP00000423900ENST00000479362
ENSG00000008128ENSP00000422149ENST00000509982
ENSG00000008128ENSP00000367900ENST00000378633
ENSG00000008128ENSP00000350403ENST00000357760
OrganismHomo sapiens
Functional DescriptionAppears to play multiple roles in cell cycleprogression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
Protein Length746
Protein Sequence
(FASTA)
MSQSDDRDSK RDSLEEGELR DHCMEITIRN SPYRREDSME DRGEEDDSLA IKPPQQMSRK 60
EKVHHRKDEK RKEKCRHHSH SAEGGKHARV KEREHERRKR HREEQDKARR EWERQKRREM 120
AREHSRRERD RLEQLERKRE RERKMREQQK EQREQKERER RAEERRKERE ARREVSAHHR 180
TMREDYSDKV KASHWSRSPP RPPRERFELG DGRKPVKEEK MEERDLLSDL QDISDSERKT 240
SSAESSSAES GSGSEEEEEE EEEEEEEGST SEESEEEEEE EEEEEEETGS NSEEASEQSA 300
EEVSEEEMSE DEERENENHL LVVPESRFDR DSGESEEAEE EVGEGTPQSS ALTEGDYVPD 360
SPALLPIELK QELPKYLPAL QGCRSVEEFQ CLNRIEEGTY GVVYRAKDKK TDEIVALKRL 420
KMEKEKEGFP ITSLREINTI LKAQHPNIVT VREIVVGSNM DKIYIVMNYV EHDLKSLMET 480
MKQPFLPGEV KTLMIQLLRG VKHLHDNWIL HRDLKTSNLL LSHAGILKVG DFGLAREYGS 540
PLKAYTPVVV TQWYRAPELL LGAKEYSTAV DMWSVGCIFG ELLTQKPLFP GNSEIDQINK 600
VFKELGTPSE KIWPGYSELP VVKKMTFSEH PYNNLRKRFG ALLSDQGFDL MNKFLTYFPG 660
RRISAEDGLK HEYFRETPLP IDPSMFPTWP AKSEQQRVKR GTSPRPPEGG LGYSQLGDDD 720
LKETGFHLTT TNQGASAAGP GFSLKF 746
Nucleotide Sequence
(FASTA)
ATGTCGCAGT CTGATGACCG GGATTCCAAG CGGGATTCCC TTGAGGAGGG GGAGCTGAGA 60
GATCACTGCA TGGAGATCAC AATAAGGAAC TCCCCGTATA GAAGAGAAGA CTCAATGGAA 120
GACAGAGGAG AAGAAGATGA TTCTTTGGCC ATCAAACCAC CCCAGCAAAT GTCTCGGAAA 180
GAAAAAGTTC ATCACAGAAA AGATGAAAAG AGAAAAGAAA AATGTAGGCA TCATAGCCAT 240
TCAGCAGAAG GGGGGAAGCA TGCTAGAGTG AAAGAAAGAG AGCACGAACG TCGGAAACGA 300
CATCGAGAAG AACAGGATAA AGCTCGCCGG GAATGGGAAA GACAGAAGAG AAGGGAAATG 360
GCAAGGGAGC ATTCCAGGAG AGAAAGGGAC CGCTTGGAGC AGTTAGAAAG GAAGCGGGAG 420
CGGGAGCGCA AGATGCGGGA GCAGCAGAAG GAGCAGCGGG AGCAGAAGGA GCGCGAGCGG 480
CGGGCGGAGG AGCGGCGCAA GGAGCGGGAG GCCCGCAGGG AAGTGTCTGC ACATCACCGA 540
ACGATGAGAG AGGACTACAG CGACAAAGTG AAAGCCAGCC ACTGGAGTCG CAGCCCGCCT 600
CGGCCGCCGC GGGAGCGGTT CGAGTTGGGA GACGGCCGGA AGCCAGTAAA AGAAGAGAAA 660
ATGGAAGAAA GGGACCTGCT GTCCGACTTA CAGGACATCA GCGACAGCGA GAGGAAGACC 720
AGCTCGGCCG AGTCCTCGTC AGCGGAATCA GGCTCAGGTT CTGAGGAAGA AGAGGAGGAG 780
GAGGAAGAGG AGGAGGAGGA AGGGAGCACC AGTGAAGAAT CAGAGGAGGA GGAGGAGGAA 840
GAGGAAGAGG AGGAGGAGGA GACCGGCAGC AACTCTGAGG AGGCATCAGA GCAGTCTGCC 900
GAAGAAGTAA GTGAGGAAGA AATGAGTGAA GATGAAGAAC GAGAAAATGA AAACCACCTC 960
TTGGTTGTTC CAGAGTCACG GTTCGACCGA GATTCCGGGG AGAGTGAAGA AGCAGAGGAA 1020
GAAGTGGGTG AGGGAACGCC GCAGAGCAGC GCCCTGACAG AGGGCGACTA TGTGCCCGAC 1080
TCCCCTGCCC TGTTGCCCAT CGAGCTCAAG CAGGAGCTGC CCAAGTACCT GCCGGCCCTG 1140
CAGGGCTGCC GGAGCGTCGA GGAGTTCCAG TGCCTGAACA GGATCGAGGA GGGCACCTAT 1200
GGAGTGGTCT ACAGAGCAAA AGACAAGAAA ACAGATGAAA TTGTGGCTCT AAAGCGGCTG 1260
AAGATGGAGA AGGAGAAGGA GGGCTTCCCG ATCACGTCCC TGAGGGAGAT CAACACCATC 1320
CTCAAGGCCC AGCATCCCAA CATTGTCACC GTTAGAGAGA TTGTGGTGGG CAGCAACATG 1380
GACAAGATCT ACATCGTGAT GAACTACGTG GAGCACGACC TCAAGAGCCT GATGGAGACC 1440
ATGAAACAGC CCTTCCTGCC AGGGGAGGTG AAGACCCTGA TGATCCAGCT GCTGCGGGGG 1500
GTGAAACACC TGCACGACAA CTGGATCCTG CACCGTGACC TCAAGACGTC CAACCTGCTG 1560
CTGAGCCACG CCGGCATCCT CAAGGTGGGT GATTTTGGGC TGGCGCGGGA GTACGGATCC 1620
CCTCTGAAGG CCTACACCCC GGTCGTGGTG ACCCAGTGGT ACCGCGCCCC AGAGCTGCTG 1680
CTTGGTGCCA AGGAATACTC CACGGCCGTG GACATGTGGT CAGTGGGCTG CATCTTCGGG 1740
GAGCTGCTGA CTCAGAAGCC TCTGTTCCCC GGGAATTCGG AAATCGATCA GATCAACAAA 1800
GTGTTCAAGG AGCTGGGGAC CCCCAGTGAG AAAATCTGGC CCGGCTACAG TGAGCTCCCA 1860
GTAGTCAAAA AGATGACCTT CAGCGAGCAC CCCTACAACA ACCTCCGCAA GCGCTTCGGG 1920
GCTCTGCTCT CAGACCAGGG CTTCGACCTC ATGAACAAGT TCCTGACCTA CTTCCCCGGG 1980
AGGAGGATCA GCGCTGAGGA CGGCCTCAAG CATGAGTATT TCCGCGAGAC CCCCCTCCCC 2040
ATCGACCCCT CCATGTTCCC CACGTGGCCC GCCAAGAGCG AGCAGCAGCG TGTGAAGCGG 2100
GGCACCAGCC CGAGGCCCCC TGAGGGAGGC CTGGGCTACA GCCAGCTGGG TGACGACGAC 2160
CTGAAGGAGA CGGGCTTCCA CCTTACCACC ACGAACCAGG GGGCCTCTGC CGCGGGCCCC 2220
GGCTTCAGCC TCAAGTTCTG A 2241
Domain Profile
S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60
         +++l++i+eGtyg+vy+akdk+t+e+vAlK++++ekekeg+pit+lrEi+++ + +h+ni
Q: 389   FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNI  448
         7899********************************************************
S: 61    vkLlevva.kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119
         v++ e+v+ ++ +k+y+v++++e+dLk+l++++k+  + + evk+l++qll+g+++lH+n
Q: 449   VTVREIVVgSNMDKIYIVMNYVEHDLKSLMETMKQ-PFLPGEVKTLMIQLLRGVKHLHDN  507
         *******95666***********************.9999********************
S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179
         +ilHRDlK++NlL+s+ g+lk++DfGlar+++splk+yt++vvT wYraPelLlgakeYs
Q: 508   WILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYS  567
         ************************************************************
S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238
         tavD+Wsvgci+ ellt+kplf+g+seidq++++fk lgtpsek+wp++s+lp +k ++f
Q: 568   TAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKkMTF  627
         ********************************************************999*
S: 239   pkkkkkklkekvkklkek.aldllekllaldpkkRisakealqhkyf  284
         +++++++l++++ +l ++ ++dl++k+l++ p +Risa++ l+h+yf
Q: 628   SEHPYNNLRKRFGALLSDqGFDLMNKFLTYFPGRRISAEDGLKHEYF  674
         ************8877554***************************9
Domain Sequence
(FASTA)
FQCLNRIEEG TYGVVYRAKD KKTDEIVALK RLKMEKEKEG FPITSLREIN TILKAQHPNI 60
VTVREIVVGS NMDKIYIVMN YVEHDLKSLM ETMKQPFLPG EVKTLMIQLL RGVKHLHDNW 120
ILHRDLKTSN LLLSHAGILK VGDFGLAREY GSPLKAYTPV VVTQWYRAPE LLLGAKEYST 180
AVDMWSVGCI FGELLTQKPL FPGNSEIDQI NKVFKELGTP SEKIWPGYSE LPVVKKMTFS 240
EHPYNNLRKR FGALLSDQGF DLMNKFLTYF PGRRISAEDG LKHEYF 286
KeywordAlternative initiation; Alternative splicing; Apoptosis; ATP-binding; Cell cycle; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ciona intestinalis"; ?>
EKS-CII-00023
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004693; F:cyclin-dependent protein kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0006915; P:apoptotic process
GO:0007067; P:mitosis
GO:0001558; P:regulation of cell growth
GO:0050684; P:regulation of mRNA processing
GO:0006355; P:regulation of transcription, DNA-dependent
KEGG
hsa:728642;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013