EPS-HOS-00123

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00123

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	622.7	5.0E-187	185	496	312

Status

Reviewed

Ensembl Protein

ENSP00000012443

UniProt Accession

P53041; Q16722; Q53XV2;

Protein Name

Serine/threonine-protein phosphatase 5

Protein Synonyms/Alias

PP5; Protein phosphatase T; PP-T; PPT;

Gene Name

PPP5C

Gene Synonyms/Alias

PPP5C; PPP5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000011485	ENSP00000434329	ENST00000478046
ENSG00000011485	ENSP00000012443	ENST00000012443
ENSG00000011485	ENSP00000375786	ENST00000391919

Organism

Homo sapiens

Functional Description

May play a role in the regulation of RNA biogenesisand/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1.

Protein Length

499

Protein Sequence
(FASTA)

MAMAEGERTE CAEPPRDEPP ADGALKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPS 60

NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY RRAASNMALG KFRAALRDYE 120

TVVKVKPHDK DAKMKYQECN KIVKQKAFER AIAGDEHKRS VVDSLDIESM TIEDEYSGPK 180

LEDGKVTISF MKELMQWYKD QKKLHRKCAY QILVQVKEVL SKLSTLVETT LKETEKITVC 240

GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 300

RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG 360

VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSISKR GVSCQFGPDV TKAFLEENNL 420

DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP 480

HPNVKPMAYA NTLLQLGMM 499

Nucleotide Sequence
(FASTA)

ATGGCGATGG CGGAGGGCGA GAGGACTGAG TGTGCTGAGC CCCCCCGGGA CGAACCCCCG 60

GCTGATGGAG CTCTGAAGCG GGCAGAGGAG CTCAAGACTC AGGCCAATGA CTACTTCAAA 120

GCCAAGGACT ACGAGAACGC CATCAAGTTC TACAGCCAGG CCATCGAGCT GAACCCCAGC 180

AATGCCATCT ACTATGGCAA CCGCAGCCTG GCCTACCTGC GCACTGAGTG CTATGGCTAC 240

GCGCTGGGAG ACGCCACGCG GGCCATTGAG CTGGACAAGA AGTACATCAA GGGTTATTAC 300

CGCCGGGCTG CCAGCAACAT GGCACTGGGC AAGTTCCGGG CCGCGCTGCG AGACTACGAG 360

ACGGTGGTCA AGGTGAAGCC CCATGACAAG GATGCCAAAA TGAAATACCA GGAGTGCAAC 420

AAGATCGTGA AGCAGAAGGC CTTTGAGCGG GCCATCGCGG GCGACGAGCA CAAGCGCTCC 480

GTGGTGGACT CGCTGGACAT CGAGAGCATG ACCATTGAGG ATGAGTACAG CGGACCCAAG 540

CTTGAAGACG GCAAAGTGAC AATCAGTTTC ATGAAGGAGC TCATGCAGTG GTACAAGGAC 600

CAGAAGAAAC TGCACCGGAA ATGTGCCTAC CAGATTCTGG TACAGGTCAA AGAGGTCCTC 660

TCCAAGCTGA GCACGCTCGT GGAAACCACA CTCAAAGAGA CAGAGAAGAT TACAGTATGT 720

GGGGACACCC ATGGCCAGTT CTATGACCTC CTCAACATAT TCGAGCTCAA CGGTTTACCC 780

TCGGAGACCA ACCCCTATAT ATTTAATGGT GACTTTGTGG ACCGAGGCTC CTTCTCTGTA 840

GAAGTGATCC TCACCCTTTT CGGCTTCAAG CTCCTGTACC CAGATCACTT TCACCTCCTT 900

CGAGGCAACC ACGAGACAGA CAACATGAAC CAGATCTACG GTTTCGAGGG TGAGGTGAAG 960

GCCAAGTACA CAGCCCAGAT GTACGAGCTC TTTAGCGAGG TGTTCGAGTG GCTCCCGTTG 1020

GCCCAGTGCA TCAACGGCAA AGTGCTGATC ATGCACGGAG GCCTGTTCAG TGAAGACGGT 1080

GTCACCCTGG ATGACATCCG GAAAATTGAG CGGAATCGAC AACCCCCAGA TTCAGGGCCC 1140

ATGTGTGACC TGCTCTGGTC AGATCCACAG CCACAGAACG GGCGCTCGAT CAGCAAGCGG 1200

GGCGTGAGCT GTCAGTTTGG GCCTGACGTC ACCAAGGCCT TCTTGGAAGA GAACAACCTG 1260

GACTATATCA TCCGCAGCCA CGAAGTCAAG GCCGAGGGCT ACGAGGTGGC TCACGGAGGC 1320

CGCTGTGTCA CCGTCTTCTC TGCCCCCAAC TACTGCGACC AGATGGGGAA CAAAGCCTCC 1380

TACATCCACC TCCAGGGCTC TGACCTACGG CCTCAGTTCC ACCAGTTCAC AGCAGTGCCT 1440

CATCCCAACG TCAAGCCCAT GGCCTATGCC AACACGCTGC TGCAGCTAGG AATGATGTGA 1500

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         kv+i+f+k+l++++k++kkl+rk+a++ilv+v++vl+kl++++e+++ke++kitvcGdth

Q: 185   KVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTH  244

         799*********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         GqfydllnifelnGlpse+npy+fnGdfvdrGsfsveviltlfg+kllyPdhf+llrGnh

Q: 245   GQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH  304

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn+iyGfegevkakyta++yelf+evfewlPlaq+ingkvl+mhGGlfsedgvtld

Q: 305   ETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLD  364

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirkiern+qPP++G++c+llWsdPq++nGr++skrGv++qfGpdvtk+fleen+ldyii

Q: 365   DIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYII  424

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++g++vtvfsapnycd++gn+as+ih++++dlr+++++f+av+hp+v

Q: 425   RSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNV  484

         ************************************************************

S: 302   kpmaysngllgl  313

         kpmay+n+ll+l

Q: 485   KPMAYANTLLQL  496

         *********997

Domain Sequence
(FASTA)

KVTISFMKEL MQWYKDQKKL HRKCAYQILV QVKEVLSKLS TLVETTLKET EKITVCGDTH 60

GQFYDLLNIF ELNGLPSETN PYIFNGDFVD RGSFSVEVIL TLFGFKLLYP DHFHLLRGNH 120

ETDNMNQIYG FEGEVKAKYT AQMYELFSEV FEWLPLAQCI NGKVLIMHGG LFSEDGVTLD 180

DIRKIERNRQ PPDSGPMCDL LWSDPQPQNG RSISKRGVSC QFGPDVTKAF LEENNLDYII 240

RSHEVKAEGY EVAHGGRCVT VFSAPNYCDQ MGNKASYIHL QGSDLRPQFH QFTAVPHPNV 300

KPMAYANTLL QL 312

Keyword

3D-structure; Acetylation; Complete proteome; Cytoplasm; Hydrolase; Iron; Manganese; Metal-binding; Nucleus; Protein phosphatase; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005794	; C:Golgi apparatus
GO:0043005	; C:neuron projection
GO:0043025	; C:neuronal cell body
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0004871	; F:signal transducer activity
GO:0007067	; P:mitosis
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0006470	; P:protein dephosphorylation
GO:0043278	; P:response to morphine
GO:0006351	; P:transcription, DNA-dependent

KEGG

hsa:5536

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 2.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013