EKS-HOS-00323

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00323

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	348.8	9.8E-104	16	273	258

Status

Reviewed

Ensembl Protein

ENSP00000345434

UniProt Accession

Q8IVH8; Q6IQ39; Q8IVH7; Q9UDM5; Q9Y6R5;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase 3

Protein Synonyms/Alias

Germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3;

Gene Name

MAP4K3

Gene Synonyms/Alias

MAP4K3; RAB8IPL1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000011566	ENSP00000405137	ENST00000429397
ENSG00000011566	ENSP00000399228	ENST00000414968
ENSG00000011566	ENSP00000410183	ENST00000437968
ENSG00000011566	ENSP00000345434	ENST00000341681
ENSG00000011566	ENSP00000440580	ENST00000536018
ENSG00000011566	ENSP00000263881	ENST00000263881
ENSG00000011566	ENSP00000416958	ENST00000437545

Organism

Homo sapiens

Functional Description

May play a role in the response to environmental stress.Appears to act upstream of the JUN N-terminal pathway.

Protein Length

873

Protein Sequence
(FASTA)

MNPGFDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE PGEDFAVVQQ 60

EIIMMKDCKH PNIVAYFGSY LRRDKLWICM EFCGGGSLQD IYHVTGPLSE LQIAYVSRET 120

LQGLYYLHSK GKMHRDIKGA NILLTDNGHV KLADFGVSAQ ITATIAKRKS FIGTPYWMAP 180

EVAAVERKGG YNQLCDLWAV GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKM 240

KWSNSFHHFV KMALTKNPKK RPTAEKLLQH PFVTQHLTRS LAIELLDKVN NPDHSTYHDF 300

DDDDPEPLVA VPHRIHSTSR NVREEKTRSE ITFGQVKFDP PLRKETEPHH ELDLQLEYGQ 360

GHQGGYFLGA NKSLLKSVEE ELHQRGHVAH LEDDEGDDDE SKHSTLKAKI PPPLPPKPKS 420

IFIPQEMHST EDENQGTIKR CPMSGSPAKP SQVPPRPPPP RLPPHKPVAL GNGMSSFQLN 480

GERDGSLCQQ QNEHRGTNLS RKEKKDVPKP ISNGLPPTPK VHMGACFSKV FNGCPLKIHC 540

ASSWINPDTR DQYLIFGAEE GIYTLNLNEL HETSMEQLFP RRCTWLYVMN NCLLSISGKA 600

SQLYSHNLPG LFDYARQMQK LPVAIPAHKL PDRILPRKFS VSAKIPETKW CQKCCVVRNP 660

YTGHKYLCGA LQTSIVLLEW VEPMQKFMLI KHIDFPIPCP LRMFEMLVVP EQEYPLVCVG 720

VSRGRDFNQV VRFETVNPNS TSSWFTESDT PQTNVTHVTQ LERDTILVCL DCCIKIVNLQ 780

GRLKSSRKLS SELTFDFQIE SIVCLQDSVL AFWKHGMQGR SFRSNEVTQE ISDSTRIFRL 840

LGSDRVVVLE SRPTDNPTAN SNLYILAGHE NSY 873

Nucleotide Sequence
(FASTA)

ATGAACCCCG GCTTCGATTT GTCCCGCCGG AACCCGCAGG AGGACTTCGA GCTGATTCAG 60

CGCATCGGCA GCGGCACCTA CGGCGACGTC TACAAGGCAC GGAATGTTAA CACTGGTGAA 120

TTAGCAGCAA TTAAAGTAAT AAAATTGGAA CCAGGAGAAG ACTTTGCAGT TGTGCAGCAA 180

GAAATTATTA TGATGAAAGA CTGTAAACAC CCAAATATTG TTGCTTATTT TGGAAGCTAT 240

CTCAGGCGAG ATAAGCTTTG GATTTGCATG GAGTTTTGTG GAGGTGGTTC TTTACAGGAT 300

ATTTATCACG TAACTGGACC TCTGTCAGAA CTGCAAATTG CATATGTTAG CAGAGAAACA 360

CTGCAGGGAT TATATTATCT TCACAGTAAA GGAAAAATGC ACAGAGATAT AAAGGGAGCT 420

AACATTCTAT TAACGGATAA TGGTCATGTG AAATTGGCTG ATTTTGGAGT ATCTGCACAG 480

ATAACAGCTA CAATTGCCAA ACGGAAGTCT TTCATTGGCA CACCATATTG GATGGCTCCA 540

GAAGTTGCAG CTGTTGAGAG GAAGGGGGGT TACAATCAAC TCTGTGATCT CTGGGCAGTG 600

GGAATCACTG CCATAGAACT TGCAGAGCTT CAGCCTCCTA TGTTTGACTT ACACCCAATG 660

AGAGCATTAT TTCTAATGAC AAAAAGCAAT TTTCAGCCTC CTAAACTAAA GGATAAAATG 720

AAATGGTCAA ATAGTTTTCA TCACTTTGTG AAAATGGCAC TTACCAAAAA TCCGAAAAAA 780

AGACCTACTG CTGAAAAATT ATTACAGCAT CCTTTTGTAA CACAACATTT GACACGGTCT 840

TTGGCAATCG AGCTGTTGGA TAAAGTAAAT AATCCAGATC ATTCCACTTA CCATGATTTC 900

GATGATGATG ATCCTGAGCC TCTTGTTGCT GTACCACATA GAATTCACTC AACAAGTAGA 960

AACGTGAGAG AAGAAAAAAC ACGCTCAGAG ATAACCTTTG GCCAAGTGAA ATTTGATCCA 1020

CCCTTAAGAA AGGAGACAGA ACCACATCAT GAACTTGATC TGCAACTGGA ATATGGACAA 1080

GGACACCAAG GTGGTTACTT TTTAGGTGCA AACAAGAGTC TTCTCAAGTC TGTTGAAGAA 1140

GAATTGCATC AGCGAGGACA CGTCGCACAT TTAGAAGATG ATGAAGGAGA TGATGATGAA 1200

TCTAAACACT CAACTCTGAA AGCAAAAATT CCACCTCCTT TGCCACCAAA GCCTAAGTCT 1260

ATCTTCATAC CACAGGAAAT GCATTCTACT GAGGATGAAA ATCAAGGAAC AATCAAGAGA 1320

TGTCCCATGT CAGGGAGCCC AGCAAAGCCA TCCCAAGTTC CACCTAGACC ACCACCTCCC 1380

AGATTACCCC CACACAAACC TGTTGCCTTA GGAAATGGAA TGAGCTCCTT CCAGTTAAAT 1440

GGTGAACGAG ATGGCTCATT ATGTCAACAA CAGAATGAAC ATAGAGGCAC AAACCTTTCA 1500

AGAAAAGAAA AGAAAGATGT ACCAAAGCCT ATTAGTAATG GTCTTCCTCC AACACCTAAA 1560

GTGCATATGG GTGCATGTTT TTCAAAAGTT TTTAATGGGT GTCCCTTGAA AATTCACTGT 1620

GCATCATCAT GGATAAACCC AGATACAAGA GATCAGTACT TGATATTTGG TGCCGAAGAA 1680

GGGATTTATA CCCTCAATCT TAATGAACTT CATGAAACAT CAATGGAACA GCTATTCCCT 1740

CGAAGGTGTA CATGGTTGTA TGTAATGAAC AATTGCTTGC TATCAATATC TGGTAAAGCT 1800

TCTCAGCTTT ATTCCCATAA TTTACCAGGG CTTTTTGATT ATGCAAGACA AATGCAAAAG 1860

TTACCTGTTG CTATTCCAGC ACACAAACTC CCTGACAGAA TACTGCCAAG GAAATTTTCT 1920

GTATCAGCAA AAATCCCTGA AACCAAATGG TGCCAGAAGT GTTGTGTTGT AAGAAATCCT 1980

TACACGGGCC ATAAATACCT ATGTGGAGCA CTTCAGACTA GCATTGTTCT ATTAGAATGG 2040

GTTGAACCAA TGCAGAAATT TATGTTAATT AAGCACATAG ATTTTCCTAT ACCATGTCCA 2100

CTTAGAATGT TTGAAATGCT GGTAGTTCCT GAACAGGAGT ACCCTTTAGT TTGTGTTGGT 2160

GTCAGTAGAG GTAGAGACTT CAACCAAGTG GTTCGATTTG AGACGGTCAA TCCAAATTCT 2220

ACCTCTTCAT GGTTTACAGA ATCAGATACC CCACAGACAA ATGTTACTCA TGTAACCCAA 2280

CTGGAGAGAG ATACCATCCT TGTATGCTTG GACTGTTGTA TAAAAATAGT AAATCTCCAA 2340

GGAAGATTAA AATCTAGCAG GAAATTGTCA TCAGAACTCA CCTTTGATTT CCAGATTGAA 2400

TCAATAGTGT GCCTACAAGA CAGTGTGCTA GCTTTCTGGA AACATGGAAT GCAAGGTAGA 2460

AGTTTTAGAT CTAATGAGGT AACACAAGAA ATTTCAGATA GCACAAGAAT TTTCAGGCTG 2520

CTTGGATCTG ACAGGGTCGT GGTTTTGGAA AGTAGGCCAA CTGATAACCC CACAGCAAAT 2580

AGCAATTTGT ACATCCTGGC GGGTCATGAA AACAGTTACT GA 2622

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +el+++ig+G++g+vy+ar+++tgel+aik+i+le  e+ + +q+ei ++k++khpniv+

Q: 16    FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVA  75

         899*********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+l++++lw++me++ gGsl+d+++  ++ +l+E qiay+ re+l++L ylHsk+++

Q: 76    YFGSYLRRDKLWICMEFCGGGSLQDIYH--VTGPLSELQIAYVSRETLQGLYYLHSKGKM  133

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlt++g+VkL+dfgv+aq+++t +krk+++gtpywmAPEv a+e + gY++

Q: 134   HRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVErKGGYNQ  193

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +D+w++GItaielae +pP++dl+p++al++++k++  ppklk+k k+s++f++fv+ +

Q: 194   LCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNfqPPKLKDKMKWSNSFHHFVKMA  253

         ******************************999999888*********************

S: 238   lqknpekRpsasellkhkFl  257

         l+knp+kRp+a++ll+h+F+

Q: 254   LTKNPKKRPTAEKLLQHPFV  273

         *******************7

Domain Sequence
(FASTA)

FELIQRIGSG TYGDVYKARN VNTGELAAIK VIKLEPGEDF AVVQQEIIMM KDCKHPNIVA 60

YFGSYLRRDK LWICMEFCGG GSLQDIYHVT GPLSELQIAY VSRETLQGLY YLHSKGKMHR 120

DIKGANILLT DNGHVKLADF GVSAQITATI AKRKSFIGTP YWMAPEVAAV ERKGGYNQLC 180

DLWAVGITAI ELAELQPPMF DLHPMRALFL MTKSNFQPPK LKDKMKWSNS FHHFVKMALT 240

KNPKKRPTAE KLLQHPFV 258

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007254	; P:JNK cascade

KEGG

hsa:8491

;

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

Created Date

20-Feb-2013