| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00424 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/DAPK | 474.1 | 5.1E-142 | 24 | 285 | 262 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000261891 |
| UniProt Accession | Q9UIK4; O75892; Q24JS1; |
| Protein Name | Death-associated protein kinase 2 |
| Protein Synonyms/Alias | DAP kinase 2; DAP-kinase-related protein 1; DRP-1; |
| Gene Name | DAPK2 |
| Gene Synonyms/Alias | DAPK2; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Calcium/calmodulin-dependent serine/threonine kinaseinvolved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Isoform 2 can phosphorylate MYL9. It can induce membraneblebbing and autophagic cell death. |
| Protein Length | 370 |
Protein Sequence
(FASTA) | | MFQASMRSPN MEPFKQQKVE DFYDIGEELG SGQFAIVKKC REKSTGLEYA AKFIKKRQSR 60 | | ASRRGVSREE IEREVSILRQ VLHHNVITLH DVYENRTDVV LILELVSGGE LFDFLAQKES 120 | | LSEEEATSFI KQILDGVNYL HTKKIAHFDL KPENIMLLDK NIPIPHIKLI DFGLAHEIED 180 | | GVEFKNIFGT PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGD TKQETLANIT 240 | | AVSYDFDEEF FSQTSELAKD FIRKLLVKET RKRLTIQEAL RHPWITPVDN QQAMVRRESV 300 | | VNLENFRKQY VRRRWKLSFS IVSLCNHLTR SLMKKVHLRP DEDLRNCESD TEEDIARRKA 360 | | LHPRRRSSTS 370 |
|
Nucleotide Sequence
(FASTA) | | ATGTTCCAGG CCTCAATGAG GAGTCCAAAC ATGGAGCCAT TCAAGCAGCA GAAGGTGGAG 60 | | GACTTTTATG ACATCGGAGA GGAGCTGGGG AGTGGCCAGT TTGCCATCGT GAAGAAGTGC 120 | | CGGGAGAAGA GCACGGGGCT TGAGTATGCA GCCAAGTTCA TCAAGAAGCG GCAGAGCCGG 180 | | GCGAGCCGGC GCGGTGTGAG CCGGGAGGAG ATCGAGCGGG AGGTGAGCAT CCTGCGGCAG 240 | | GTGCTGCACC ACAATGTCAT CACGCTGCAC GACGTCTATG AGAACCGCAC CGACGTGGTG 300 | | CTCATCCTTG AGCTAGTGTC TGGAGGAGAG CTCTTCGATT TCCTGGCCCA GAAGGAGTCA 360 | | CTGAGTGAGG AGGAGGCCAC CAGCTTCATT AAGCAGATCC TGGATGGGGT GAACTACCTT 420 | | CACACAAAGA AAATTGCTCA CTTTGATCTC AAGCCAGAAA ACATTATGTT GTTAGACAAG 480 | | AATATTCCCA TTCCACACAT CAAGCTGATT GACTTTGGTC TGGCTCACGA AATAGAAGAT 540 | | GGAGTTGAAT TTAAGAATAT TTTTGGGACG CCGGAATTTG TTGCTCCAGA AATTGTGAAC 600 | | TACGAGCCCC TGGGTCTGGA GGCTGACATG TGGAGCATAG GCGTCATCAC CTACATCCTC 660 | | TTAAGTGGAG CATCCCCTTT CCTGGGAGAC ACGAAGCAGG AAACACTGGC AAATATCACA 720 | | GCAGTGAGTT ACGACTTTGA TGAGGAATTC TTCAGCCAGA CGAGCGAGCT GGCCAAGGAC 780 | | TTTATTCGGA AGCTTCTGGT TAAAGAGACC CGGAAACGGC TCACAATCCA AGAGGCTCTC 840 | | AGACACCCCT GGATCACGCC GGTGGACAAC CAGCAAGCCA TGGTGCGCAG GGAGTCTGTG 900 | | GTCAATCTGG AGAACTTCAG GAAGCAGTAT GTCCGCAGGC GGTGGAAGCT TTCCTTCAGC 960 | | ATCGTGTCCC TGTGCAACCA CCTCACCCGC TCGCTGATGA AGAAGGTGCA CCTGAGGCCG 1020 | | GATGAGGACC TGAGGAACTG TGAGAGTGAC ACTGAGGAGG ACATCGCCAG GAGGAAAGCC 1080 | | CTCCACCCAC GGAGGAGGAG CAGCACCTCC TAA 1113 |
|
| Domain Profile | S: 2 etgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirs 61 | ++g+elgsG+fa+v+kcrekstG eyaakf+kkr++++srrgvsreeierev++l+++ | Q: 24 DIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL- 82 | 689********************************************************. |
| S: 62 epnvinlhevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylhs 121 | ++nvi+lh+vyen++dv+lilelv+GGelfd+la+keslseeeat+++kqil+gv+ylh+ | Q: 83 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 142 | 9*********************************************************** |
| S: 122 kkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivnye 181 | kki+h+dlkPeni+lldk++p ++iklidfGl+++ie+g+e+k+i+GtPefvaPeivnye | Q: 143 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE 202 | ************************************************************ |
| S: 182 plsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdfi 241 | pl+le+dmwsiGvityillsgasPflGdtkqetl+ni+av++df+ee+fs++selakdfi | Q: 203 PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFI 262 | ************************************************************ |
| S: 242 rrllvkdpekrltieeclehswl 264 | r+llvk+++krlti+e+l+h+w+ | Q: 263 RKLLVKETRKRLTIQEALRHPWI 285 | **********************8 |
|
Domain Sequence
(FASTA) | | DIGEELGSGQ FAIVKKCREK STGLEYAAKF IKKRQSRASR RGVSREEIER EVSILRQVLH 60 | | HNVITLHDVY ENRTDVVLIL ELVSGGELFD FLAQKESLSE EEATSFIKQI LDGVNYLHTK 120 | | KIAHFDLKPE NIMLLDKNIP IPHIKLIDFG LAHEIEDGVE FKNIFGTPEF VAPEIVNYEP 180 | | LGLEADMWSI GVITYILLSG ASPFLGDTKQ ETLANITAVS YDFDEEFFSQ TSELAKDFIR 240 | | KLLVKETRKR LTIQEALRHP WI 262 |
|
| Keyword | 3D-structure; Alternative splicing; Apoptosis; ATP-binding; Calmodulin-binding; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
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| Prints | |
| Created Date | 20-Feb-2013 |