EPS-HOS-00027

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00027

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	192.3	6.7E-56	718	964	247

Status

Reviewed

Ensembl Protein

ENSP00000377159

UniProt Accession

Q6ZVD8; A1L374; Q9NV17; Q9Y2E3;

Protein Name

PH domain leucine-rich repeat-containing protein phosphatase 2

Protein Synonyms/Alias

PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like;

Gene Name

PHLPP2

Gene Synonyms/Alias

PHLPP2; KIAA0931, PHLPPL;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000040199	ENSP00000445781	ENST00000540628
ENSG00000040199	ENSP00000353610	ENST00000360429
ENSG00000040199	ENSP00000454519	ENST00000567016
ENSG00000040199	ENSP00000377159	ENST00000393524
ENSG00000040199	ENSP00000457991	ENST00000568954
ENSG00000040199	ENSP00000458660	ENST00000568004
ENSG00000040199	ENSP00000348611	ENST00000356272
ENSG00000040199	ENSP00000456572	ENST00000564884

Organism

Homo sapiens

Functional Description

Protein phosphatase that mediates dephosphorylation of'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.

Protein Length

1256

Protein Sequence
(FASTA)

MKRNGSRNCL NRRSRFGSRE RDWLREDVKR GCVYLYGADT TTATTTTTTS SSSSSSSSSS 60

DLHLVLCTVE TPASEICAGE GRESLYLQLH GDLVRRLEPT ERPLQIVYDY LSRLGFDDPV 120

RIQEEATNPD LGCMIRFYGE KPCHMDRLDR ILLSGIYNVR KGKTQLHKWA ERLVVLCGTC 180

LIVSSVKDCQ TGKMHILPLV GGKIEEVKRR QYSLAFSSAG AQAQTYHVSF ETLAEYQRWQ 240

RQASKVVSQR ISTVDLSCYS LEEVPEHLFY SQDITYLNLR HNFMQLERPG GLDTLYKFSQ 300

LKGLNLSHNK LGLFPILLCE ISTLTELNLS CNGFHDLPSQ IGNLLNLQTL CLDGNFLTTL 360

PEELGNLQQL SSLGISFNNF SQIPEVYEKL TMLDRVVMAG NCLEVLNLGV LNRMNHIKHV 420

DLRMNHLKTM VIENLEGNKH ITHVDLRDNR LTDLDLSSLC SLEQLHCGRN QLRELTLSGF 480

SLRTLYASSN RLTAVNVYPV PSLLTFLDLS RNLLECVPDW ACEAKKIEVL DVSYNLLTEV 540

PVRILSSLSL RKLMLGHNHV QNLPTLVEHI PLEVLDLQHN ALTRLPDTLF SKALNKLNKL 600

EQLEELNLSG NKLKTIPTTI ANCKRLHTLV AHSNNISIFP EILQLPQIQF VDLSCNDLTE 660

ILIPEALPAT LQDLDLTGNT NLVLEHKTLD IFSHITTLKI DQKPLPTTDS TVTSTFWSHG 720

LAEMAGQRNK LCVSALAMDS FAEGVGAVYG MFDGDRNEEL PRLLQCTMAD VLLEEVQQST 780

NDTVFMANTF LVSHRKLGMA GQKLGSSALL CYIRPDTADP ASSFSLTVAN VGTCQAVLCR 840

GGKPVPLSKV FSLEQDPEEA QRVKDQKAII TEDNKVNGVT CCTRMLGCTY LYPWILPKPH 900

ISSTPLTIQD ELLILGNKAL WEHLSYTEAV NAVRHVQDPL AAAKKLCTLA QSYGCQDNVG 960

AMVVYLNIGE EGCTCEMNGL TLPGPVGFAS TTTIKDAPKP ATPSSSSGIA SEFSSEMSTS 1020

EVSSEVGSTA SDEHNAGGLD TALLPRPERR CSLHPTPTSG LFQRQPSSAT FSSNQSDNGL 1080

DSDDDQPVEG VITNGSKVEV EVDIHCCRGR DLENSPPLIE SSPTLCSEEH ARGSCFGIRR 1140

QNSVNSGMLL PMSKDRMELQ KSPSTSCLYG KKLSNGSIVP LEDSLNLIEV ATEVPKRKTG 1200

YFAAPTQMEP EDQFVVPHDL EEEVKEQMKQ HQDSRLEPEP HEEDRTEPPE EFDTAL 1256

Nucleotide Sequence
(FASTA)

ATGAAACGCA ATGGGAGCAG AAATTGTTTG AATAGGAGAA GTAGGTTTGG TTCTCGAGAA 60

AGAGACTGGC TAAGAGAAGA TGTAAAGAGA GGCTGTGTTT ACCTTTATGG AGCAGACACT 120

ACCACTGCCA CTACAACCAC CACCACCTCC TCTTCCTCTT CCTCCTCCTC CTCTTCCTCT 180

GACTTACATC TCGTCCTTTG CACTGTAGAG ACACCAGCAT CAGAAATATG TGCTGGAGAG 240

GGAAGAGAAA GTCTTTATTT ACAGCTTCAT GGAGACCTGG TCAGGAGACT GGAACCTACT 300

GAACGACCTC TTCAGATCGT TTATGATTAC TTATCCAGGC TGGGATTTGA TGATCCTGTG 360

CGCATACAGG AGGAGGCTAC AAATCCTGAC CTCGGCTGTA TGATTCGATT TTATGGTGAA 420

AAACCATGCC ACATGGATCG TTTGGATCGA ATCCTATTGT CTGGCATCTA TAATGTACGC 480

AAGGGAAAGA CCCAGCTGCA TAAGTGGGCT GAGCGCCTAG TTGTCCTCTG TGGTACCTGC 540

CTTATCGTTT CCTCAGTGAA GGATTGTCAA ACTGGAAAGA TGCACATTTT GCCTCTGGTT 600

GGTGGAAAGA TAGAAGAAGT GAAGCGACGG CAATACTCCC TTGCTTTCAG CTCAGCAGGA 660

GCCCAAGCTC AGACCTATCA TGTCAGCTTC GAGACTTTGG CCGAGTACCA GCGATGGCAA 720

CGGCAAGCAT CCAAGGTGGT GTCCCAGCGA ATCAGTACCG TGGATCTCTC GTGTTACAGC 780

CTCGAGGAGG TTCCTGAGCA TCTCTTCTAT AGTCAAGATA TTACCTACCT CAACTTGCGA 840

CACAACTTCA TGCAGTTAGA AAGACCCGGA GGCCTCGATA CACTCTACAA ATTTTCTCAA 900

CTGAAGGGCC TGAACTTGTC CCATAATAAA CTTGGGTTGT TTCCTATATT GTTATGCGAG 960

ATCTCTACCC TGACTGAGCT CAACCTTTCC TGTAATGGAT TTCATGACCT ACCAAGTCAA 1020

ATTGGCAATC TGCTAAATCT TCAAACCCTC TGTCTTGATG GCAACTTTCT GACTACTTTA 1080

CCTGAAGAAT TGGGAAATCT ACAACAGCTT TCCTCCTTGG GAATTTCCTT CAACAACTTT 1140

AGTCAAATTC CTGAGGTTTA TGAGAAACTC ACTATGTTAG ATAGAGTGGT TATGGCAGGA 1200

AATTGCCTGG AAGTCCTGAA CTTAGGGGTG CTGAATAGGA TGAACCATAT CAAGCATGTG 1260

GATTTAAGGA TGAACCATTT GAAAACCATG GTTATTGAAA ATCTGGAGGG AAATAAACAC 1320

ATCACCCACG TGGATCTGCG GGACAACCGA CTGACTGACT TGGATCTTAG CTCCTTATGC 1380

AGCTTGGAAC AGCTGCACTG TGGGCGGAAT CAGCTGAGGG AGCTAACACT CAGTGGCTTT 1440

TCCCTTCGGA CCCTCTATGC CAGTTCCAAC AGGCTGACAG CAGTGAACGT CTATCCAGTA 1500

CCCAGCCTGC TCACTTTCTT GGATCTCTCC CGAAACCTGC TAGAGTGTGT CCCTGACTGG 1560

GCCTGTGAAG CAAAGAAGAT AGAAGTATTA GATGTGAGCT ATAATCTTCT CACAGAGGTT 1620

CCCGTGAGAA TTCTGAGTAG CTTGAGTCTT AGAAAACTGA TGCTGGGACA CAATCATGTG 1680

CAAAACCTTC CAACACTGGT AGAGCACATC CCCCTCGAGG TGCTGGATCT TCAGCATAAT 1740

GCACTCACGA GGCTGCCAGA CACCCTCTTC TCCAAGGCCT TAAACAAACT AAATAAATTG 1800

GAGCAATTGG AGGAACTGAA CCTAAGTGGC AACAAGCTTA AAACCATTCC CACAACCATA 1860

GCAAACTGTA AAAGGCTGCA CACCCTTGTT GCACACTCCA ACAACATCAG CATTTTCCCA 1920

GAAATACTGC AGTTGCCTCA GATCCAGTTT GTAGACCTAA GTTGCAACGA CTTGACAGAA 1980

ATCCTGATTC CAGAGGCTTT GCCTGCTACA TTACAAGACC TTGACCTGAC TGGAAATACA 2040

AATCTGGTTC TGGAACACAA GACACTGGAC ATATTTAGCC ATATCACAAC CCTGAAAATT 2100

GATCAGAAAC CTTTGCCAAC CACAGATTCT ACAGTTACGT CAACCTTCTG GAGCCATGGA 2160

CTGGCTGAGA TGGCAGGGCA GAGAAATAAG CTGTGTGTCT CAGCACTTGC TATGGATAGC 2220

TTTGCAGAGG GGGTGGGAGC TGTGTATGGC ATGTTTGATG GAGACCGAAA TGAGGAGCTC 2280

CCGCGCCTGC TGCAGTGTAC GATGGCAGAT GTGCTTTTAG AAGAGGTACA GCAGTCAACT 2340

AATGACACAG TTTTCATGGC TAACACCTTC TTGGTATCTC ACAGGAAATT AGGAATGGCT 2400

GGCCAGAAGT TGGGCTCCTC CGCTCTCCTG TGCTACATCC GCCCTGACAC TGCCGATCCA 2460

GCAAGTAGCT TTAGCTTGAC TGTAGCCAAT GTTGGCACGT GCCAAGCAGT CCTGTGCCGA 2520

GGTGGGAAGC CAGTGCCCCT CTCTAAAGTC TTCAGCCTGG AGCAGGACCC AGAGGAGGCT 2580

CAAAGGGTGA AGGACCAAAA AGCCATCATC ACAGAGGACA ACAAAGTGAA TGGGGTAACC 2640

TGCTGTACCC GGATGCTGGG CTGTACATAC CTCTACCCTT GGATCCTCCC CAAGCCCCAC 2700

ATATCTTCCA CTCCGCTGAC CATTCAAGAT GAGTTGCTGA TTCTGGGAAA CAAAGCATTG 2760

TGGGAACACT TGTCCTACAC AGAAGCTGTC AATGCTGTAC GTCACGTACA AGACCCATTA 2820

GCAGCTGCTA AGAAGCTGTG CACATTAGCG CAGAGCTATG GCTGTCAGGA CAATGTAGGG 2880

GCGATGGTAG TTTATTTGAA TATTGGTGAG GAAGGCTGCA CTTGTGAAAT GAATGGGCTC 2940

ACCCTCCCAG GTCCTGTGGG ATTTGCTTCA ACCACCACTA TCAAGGATGC CCCTAAGCCA 3000

GCCACTCCAT CCTCTAGCAG TGGGATTGCC TCTGAGTTCA GCAGTGAGAT GTCCACCTCA 3060

GAGGTGAGCA GTGAAGTGGG GTCCACTGCT TCTGATGAGC ATAATGCTGG GGGCCTGGAC 3120

ACTGCCTTGC TTCCGAGGCC AGAGCGGCGC TGCAGCCTCC ACCCAACACC CACCTCTGGG 3180

CTGTTTCAGC GCCAGCCTTC TTCTGCTACC TTCTCCAGTA ACCAGTCTGA CAACGGCCTG 3240

GACAGTGATG ATGACCAGCC CGTTGAGGGG GTCATAACCA ATGGCAGCAA GGTAGAGGTG 3300

GAAGTAGACA TCCACTGCTG CAGGGGGAGG GATCTGGAGA ACTCACCCCC TCTCATAGAG 3360

AGTTCTCCTA CCCTGTGTTC TGAGGAACAT GCTAGAGGGT CGTGTTTTGG GATCCGAAGA 3420

CAGAACAGTG TGAATAGTGG CATGCTCCTG CCAATGAGCA AGGACAGGAT GGAGTTACAG 3480

AAGTCTCCCT CCACCTCCTG CCTCTATGGG AAGAAACTCT CCAATGGCTC TATTGTGCCC 3540

CTAGAGGACA GCCTGAACCT CATTGAAGTG GCCACAGAAG TGCCCAAGAG GAAAACTGGC 3600

TATTTTGCTG CCCCCACTCA GATGGAACCA GAGGACCAGT TTGTTGTGCC TCATGACCTG 3660

GAAGAAGAAG TGAAGGAACA AATGAAACAG CACCAGGACA GCCGGCTCGA GCCTGAGCCC 3720

CATGAAGAGG ATCGGACCGA GCCCCCGGAG GAGTTCGACA CAGCACTATG A 3771

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++++ g+rn+++ ++ ++++f++  +     a++g++DG++++e  + +++++ ++l

Q: 718   SHGLAEMAGQRNKLCVSALAMDSFAEGVG-----AVYGMFDGDRNEELPRLLQCTMADVL  772

         6899********************99877.....59************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

          ee++    ++++ + ++a++Fl  +++l       ++ +k Gs+a++++i+++

Q: 773   LEEVQ----QSTNDTVFMANTFLVSHRKL------GMAGQKLGSSALLCYIRPDtadpas  822

         ***99....77888889************......89***************99999***

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsre.dEleRieeaggsvilkdgaRvlGvL  172

           +l+vanvG ++avLcr+gk+v+ls+ ++ +++ +E +R++++++ +++++  +v+Gv+

Q: 823   sfSLTVANVGTCQAVLCRGGKPVPLSKVFSLEQDpEEAQRVKDQKAIITEDN--KVNGVT  880

         ******************************99866**********9999998..******

S: 173   avsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekk  232

         +++R+lG++yl+p++ p+P+++s++lt +de liL+ + lw+++s  eav++vr+v +

Q: 881   CCTRMLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQD--  938

         **********************************************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           + +aakkL++la+++g++dnv a+vv

Q: 939   --PLAAAKKLCTLAQSYGCQDNVGAMVV  964

         ..************************97

Domain Sequence
(FASTA)

SHGLAEMAGQ RNKLCVSALA MDSFAEGVGA VYGMFDGDRN EELPRLLQCT MADVLLEEVQ 60

QSTNDTVFMA NTFLVSHRKL GMAGQKLGSS ALLCYIRPDT ADPASSFSLT VANVGTCQAV 120

LCRGGKPVPL SKVFSLEQDP EEAQRVKDQK AIITEDNKVN GVTCCTRMLG CTYLYPWILP 180

KPHISSTPLT IQDELLILGN KALWEHLSYT EAVNAVRHVQ DPLAAAKKLC TLAQSYGCQD 240

NVGAMVV 247

Keyword

Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Leucine-rich repeat; Manganese; Membrane; Metal-binding; Nucleus; Protein phosphatase; Reference proteome; Repeat; Tumor suppressor.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0008152	; P:metabolic process

KEGG

hsa:23035

;

InterPros

IPR001611	; Leu-rich_rpt.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR011993	; PH_like_dom.
IPR001932	; PP2C-like.

Pfam

PF00560	; LRR_1; 2.
PF00481	; PP2C; 1.

SMARTs

SM00369	; LRR_TYP; 1.
SM00332	; PP2Cc; 1.

Prosites

PS51450	; LRR; 18.
PS50003	; PH_DOMAIN; FALSE_NEG.

Prints

Created Date

20-Feb-2013