Tag | Content |
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EKPD ID | EKS-HOS-00068 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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CMGC/CDK | 369.9 | 3.8E-110 | 89 | 373 | 285 |
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Status | Reviewed |
Ensembl Protein | ENSP00000385034 |
UniProt Accession | O94921; A4D1E6; A6NK51; A8WFP6; B4DHG5; B4DNM2; Q75N06; Q75N22; Q8N764; Q9H3D7; Q9UDR0; |
Protein Name | Cyclin-dependent kinase 14 |
Protein Synonyms/Alias | Cell division protein kinase 14; Serine/threonine-protein kinase PFTAIRE-1; hPFTAIRE1; |
Gene Name | CDK14 |
Gene Synonyms/Alias | CDK14; KIAA0834, PFTK1; |
Ensembl Information | |
Organism | Homo sapiens |
Functional Description | Serine/threonine-protein kinase involved in the controlof the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. |
Protein Length | 423 |
Protein Sequence (FASTA) | MSTRNCQGMD SVIKPLDTIP EDKKVRVQRT QSTFDPFEKP ANQVKRVHSE NNACINFKTS 60 | STGKESPKVR RHSSPSSPTS PKFGKADSYE KLEKLGEGSY ATVYKGKSKV NGKLVALKVI 120 | RLQEEEGTPF TAIREASLLK GLKHANIVLL HDIIHTKETL TLVFEYVHTD LCQYMDKHPG 180 | GLHPDNVKLF LFQLLRGLSY IHQRYILHRD LKPQNLLISD TGELKLADFG LARAKSVPSH 240 | TYSNEVVTLW YRPPDVLLGS TEYSTCLDMW GVGCIFVEMI QGVAAFPGMK DIQDQLERIF 300 | LVLGTPNEDT WPGVHSLPHF KPERFTLYSS KNLRQAWNKL SYVNHAEDLA SKLLQCSPKN 360 | RLSAQAALSH EYFSDLPPRL WELTDMSSIF TVPNVRLQPE AGESMRAFGK NNSYGKSLSN 420 | SKH 423 |
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Nucleotide Sequence (FASTA) | ATGTCTACAC GGAACTGCCA GGGAATGGAC TCAGTGATCA AACCCCTGGA CACAATTCCT 60 | GAGGATAAAA AAGTCAGAGT TCAGAGGACA CAGAGCACTT TTGACCCATT TGAGAAACCA 120 | GCTAATCAAG TAAAGAGGGT GCATTCTGAG AACAATGCTT GCATTAACTT TAAGACCTCC 180 | TCCACTGGCA AAGAGTCACC TAAAGTTAGG CGGCACTCCA GCCCCAGCTC GCCAACAAGT 240 | CCCAAATTTG GAAAAGCTGA CTCATATGAA AAGCTGGAAA AACTAGGGGA AGGATCTTAT 300 | GCTACAGTAT ACAAAGGGAA AAGCAAGGTA AATGGGAAGT TGGTAGCTCT GAAGGTGATC 360 | AGGCTGCAGG AAGAAGAAGG GACACCTTTC ACAGCTATCA GGGAAGCTTC TCTTTTAAAA 420 | GGACTAAAAC ATGCTAACAT AGTGCTACTT CATGACATCA TCCATACCAA GGAGACGCTG 480 | ACACTTGTGT TTGAATATGT GCACACTGAT TTATGTCAGT ACATGGACAA GCACCCTGGG 540 | GGGCTGCATC CAGATAATGT GAAGTTGTTT TTATTTCAGT TGCTGCGAGG TCTGTCTTAC 600 | ATCCACCAGC GTTATATTTT GCACAGAGAC CTGAAACCAC AGAACCTTCT GATCAGTGAC 660 | ACGGGGGAGT TAAAGCTGGC AGATTTCGGT CTTGCAAGAG CAAAATCCGT CCCTAGCCAC 720 | ACATACTCCA ACGAAGTGGT TACCTTGTGG TACAGACCTC CAGATGTCCT TCTAGGCTCA 780 | ACAGAATATT CCACCTGCCT TGACATGTGG GGAGTAGGTT GCATCTTTGT TGAAATGATC 840 | CAAGGAGTTG CTGCTTTTCC AGGAATGAAA GACATTCAGG ATCAACTTGA ACGAATATTT 900 | CTGGTTCTTG GAACACCAAA TGAGGACACA TGGCCTGGAG TTCATTCTTT ACCACATTTT 960 | AAGCCAGAAC GCTTTACCCT GTACAGCTCT AAAAACCTTA GACAAGCATG GAATAAGCTC 1020 | AGCTATGTGA ACCATGCAGA GGACCTGGCC TCCAAGCTCC TACAATGTTC CCCAAAGAAC 1080 | AGACTGTCGG CACAGGCTGC CTTGAGCCAC GAGTATTTTA GTGACCTGCC GCCACGGCTA 1140 | TGGGAACTCA CCGACATGTC TTCTATTTTT ACTGTCCCAA ATGTGAGATT GCAACCAGAA 1200 | GCTGGAGAAA GCATGCGGGC CTTTGGGAAA AACAATAGTT ATGGCAAAAG TCTATCAAAC 1260 | AGCAAGCACT GA 1272 |
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Domain Profile | S: 1 yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni 60 | yeklek+geG+y++vyk+k+k +g++vAlK irl++e eg p+ta+rE sllk lkh+ni | Q: 89 YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHANI 147 | 99********************************998.9********************* |
| S: 61 vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk 120 | v L+++++ +k++l+Lvfe++++dL ++++k++ +l++++vk +l+qll+gl+y+H++ | Q: 148 VLLHDIIH-TKETLTLVFEYVHTDLCQYMDKHPG-GLHPDNVKLFLFQLLRGLSYIHQRY 205 | ********.99***********************.************************* |
| S: 121 ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst 180 | ilHRDlKpqNlLis++g+lklaDfGlara s+p++ty++evvTlwYr+P++Llg++eYst | Q: 206 ILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYST 265 | ************************************************************ |
| S: 181 avDiWsvgcilaelltrkplfqgkse.idqlerifkllgtpsekvwpevsklpeyk.ksf 238 | +D+W+vgci++e+++ + f+g ++ +dqlerif +lgtp+e++wp+v++lp++k ++f | Q: 266 CLDMWGVGCIFVEMIQGVAAFPGMKDiQDQLERIFLVLGTPNEDTWPGVHSLPHFKpERF 325 | ************************99679***************************9999 |
| S: 239 pkkkkkklkekvkklk..ekaldllekllaldpkkRisakealqhkyf 284 | + +++k+l++ ++kl+ ++a dl +kll+++pk+R+sa++al+h+yf | Q: 326 TLYSSKNLRQAWNKLSyvNHAEDLASKLLQCSPKNRLSAQAALSHEYF 373 | 99**********99997678***************************9 |
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Domain Sequence (FASTA) | YEKLEKLGEG SYATVYKGKS KVNGKLVALK VIRLQEEEGT PFTAIREASL LKGLKHANIV 60 | LLHDIIHTKE TLTLVFEYVH TDLCQYMDKH PGGLHPDNVK LFLFQLLRGL SYIHQRYILH 120 | RDLKPQNLLI SDTGELKLAD FGLARAKSVP SHTYSNEVVT LWYRPPDVLL GSTEYSTCLD 180 | MWGVGCIFVE MIQGVAAFPG MKDIQDQLER IFLVLGTPNE DTWPGVHSLP HFKPERFTLY 240 | SSKNLRQAWN KLSYVNHAED LASKLLQCSP KNRLSAQAAL SHEYF 285 |
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Keyword | Alternative splicing; ATP-binding; Cell cycle; Cell division; Cell membrane; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |