EKS-HOS-00149

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00149

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/RIO	286.9	5.4E-85	96	318	223

Status

Reviewed

Ensembl Protein

ENSP00000420932

UniProt Accession

Q9BVS4; Q9NUT0;

Protein Name

Serine/threonine-protein kinase RIO2

Protein Synonyms/Alias

RIO kinase 2;

Gene Name

RIOK2

Gene Synonyms/Alias

RIOK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000058729	ENSP00000420932	ENST00000508447
ENSG00000058729	ENSP00000283109	ENST00000283109
ENSG00000058729	ENSP00000421830	ENST00000511293
ENSG00000058729	ENSP00000422772	ENST00000511012
ENSG00000058729	ENSP00000424325	ENST00000510384

Organism

Homo sapiens

Functional Description

Protein Length

474

Protein Sequence
(FASTA)

MGKVNVAKLR YMSRDDFRVL TAVEMGMKNH EIVPGSLIAS IASLKHGGCN KVLRELVKHK 60

LIAWERTKTV QGYRLTNAGY DYLALKTLSS RQVVESVGNQ MGVGKESDIY IVANEEGQQF 120

ALKLHRLGRT SFRNLKNKRD YHKHRHNVSW LYLSRLSAMK EFAYMKALYE RKFPVPKPID 180

YNRHAVVMEL INGYPLCQIH HVEDPASVYD EAMELIVKLA NHGLIHGDFN EFNLILDESD 240

HITMIDFPQM VSTSHPNAEW YFDRDVKCIK DFFMKRFSYE SELFPTFKDI RREDTLDVEV 300

SASGYTKEMQ ADDELLHPLG PDDKNIETKE GSEFSFSDGE VAEKAEVYGS ENESERNCLE 360

ESEGCYCRSS GDPEQIKEDS LSEESADARS FEMTEFNQAL EEIKGQVVEN NSVTEFSEEK 420

NRTENYNRQD GQRVQGGVPA GSDEYEDECP HLIALSSLNR EFRPFRYRLL SIAF 474

Nucleotide Sequence
(FASTA)

ATGGGGAAAG TGAATGTGGC CAAGTTGCGT TACATGAGCC GAGATGACTT CAGGGTCTTG 60

ACCGCGGTTG AAATGGGCAT GAAGAACCAT GAAATTGTTC CCGGCAGTTT GATTGCTTCT 120

ATAGCCAGCC TTAAACATGG TGGCTGTAAT AAAGTTTTAA GAGAATTAGT GAAACATAAA 180

CTCATAGCTT GGGAGCGTAC CAAAACTGTC CAGGGCTATC GGTTGACAAA TGCAGGATAT 240

GATTACCTAG CTTTGAAAAC ACTTTCTTCT AGGCAAGTAG TTGAGTCTGT TGGAAACCAG 300

ATGGGTGTTG GCAAAGAATC AGATATTTAC ATTGTTGCAA ATGAAGAAGG ACAACAATTT 360

GCATTAAAGC TTCACAGACT AGGAAGAACC TCGTTTCGAA ATTTGAAAAA CAAACGCGAT 420

TATCATAAAC ATAGGCACAA TGTGTCATGG CTATATTTAT CTCGTCTCTC TGCCATGAAG 480

GAATTTGCCT ATATGAAGGC ATTGTATGAG AGGAAATTTC CAGTTCCAAA GCCAATTGAT 540

TACAATCGTC ATGCAGTGGT CATGGAACTC ATAAATGGTT ATCCACTATG TCAGATACAC 600

CATGTTGAAG ATCCTGCATC AGTATATGAT GAAGCTATGG AACTAATTGT CAAACTTGCA 660

AATCATGGGC TGATTCATGG AGATTTTAAT GAATTTAATC TCATTTTGGA TGAAAGTGAC 720

CATATCACCA TGATTGATTT TCCACAGATG GTTTCAACTT CTCATCCCAA TGCTGAGTGG 780

TATTTTGACA GAGATGTTAA ATGCATTAAA GATTTCTTTA TGAAACGTTT CAGCTACGAA 840

AGTGAGCTTT TTCCAACTTT TAAGGATATC AGGAGAGAAG ACACTCTTGA TGTGGAGGTT 900

TCTGCCAGTG GCTACACAAA GGAAATGCAG GCAGATGATG AACTGCTTCA TCCATTAGGT 960

CCAGATGATA AAAATATTGA AACAAAAGAG GGATCTGAAT TCTCATTTTC AGATGGAGAA 1020

GTGGCAGAAA AAGCAGAGGT TTACGGGTCA GAAAATGAAA GTGAACGGAA CTGTCTAGAA 1080

GAATCAGAGG GCTGCTATTG CAGATCATCT GGAGACCCTG AACAAATAAA GGAAGACAGT 1140

TTATCAGAAG AGAGTGCTGA TGCACGGAGT TTTGAAATGA CTGAATTCAA TCAAGCTTTA 1200

GAAGAAATAA AAGGGCAGGT TGTTGAAAAC AACTCTGTAA CTGAATTTTC TGAGGAGAAA 1260

AACAGAACTG AAAATTACAA CAGGCAAGAT GGTCAGAGAG TTCAAGGAGG AGTCCCTGCT 1320

GGCTCTGACG AGTATGAAGA TGAATGCCCT CATCTAATTG CCTTGTCGTC ATTAAATAGA 1380

GAATTCAGGC CTTTCAGGTA TAGACTTCTG TCGATTGCTT TTTAA 1425

Domain Profile

S: 2     svgntigvgkesdvykvsekngeeraiKiy...ktsllvlknrdkYvdgefrfkksrska  58

         svgn++gvgkesd+y v++++g+++a+K++   +ts+++lkn+++Y       +k+r+++

Q: 96    SVGNQMGVGKESDIYIVANEEGQQFALKLHrlgRTSFRNLKNKRDY-------HKHRHNV  148

         79********************************************.......9******

S: 59    nprklsrlwAeKEfrnlkrlyekgvpvPepidlkrhvlvmeligrdgypapklkdvklke  118

         ++++lsrl+A+KEf+++k+lye+++pvP+pid++rh++vmeli  +gyp+++++    +

Q: 149   SWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELI--NGYPLCQIH----HV  202

         *******************************************..*********....9*

S: 119   eeikelYsdllalivklynegrLvHaDlsEfnill.eddklvliDvsqsveieHpdalef  177

         e+ +++Y+++++livkl+n+g L+H+D++Efn++l e+d++++iD++q+v+++Hp+a+++

Q: 203   EDPASVYDEAMELIVKLANHG-LIHGDFNEFNLILdESDHITMIDFPQMVSTSHPNAEWY  261

         *********************.*************899**********************

S: 178   lrrDvknvkefFkkklvy.........dvlrerelfelvsasgltkekeaddeilea  225

         ++rDvk++k+fF+k+++y         d++re++l+ +vsasg+tke++adde+l++

Q: 262   FDRDVKCIKDFFMKRFSYeselfptfkDIRREDTLDVEVSASGYTKEMQADDELLHP  318

         *****************************************************9987

Domain Sequence
(FASTA)

SVGNQMGVGK ESDIYIVANE EGQQFALKLH RLGRTSFRNL KNKRDYHKHR HNVSWLYLSR 60

LSAMKEFAYM KALYERKFPV PKPIDYNRHA VVMELINGYP LCQIHHVEDP ASVYDEAMEL 120

IVKLANHGLI HGDFNEFNLI LDESDHITMI DFPQMVSTSH PNAEWYFDRD VKCIKDFFMK 180

RFSYESELFP TFKDIRREDT LDVEVSASGY TKEMQADDEL LHP 223

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

hsa:55781

;

InterPros

IPR011009	; Kinase-like_dom.
IPR018934	; RIO-like_kinase.
IPR015285	; RIO2_kinase_winged_hlx_N.
IPR018935	; RIO_kinase_CS.
IPR011991	; WHTH_trsnscrt_rep_DNA-bd.

Pfam

PF01163	; RIO1; 1.
PF09202	; Rio2_N; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; FALSE_NEG.
PS01245	; RIO1; 1.

Prints

Created Date

20-Feb-2013