EKS-HOS-00060

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00060

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	392.4	5.3E-117	139	420	282

Status

Reviewed

Ensembl Protein

ENSP00000442926

UniProt Accession

Q00537; A8K1U6; B2RCQ2; Q8NEB8;

Protein Name

Cyclin-dependent kinase 17

Protein Synonyms/Alias

Cell division protein kinase 17; PCTAIRE-motif protein kinase 2; Serine/threonine-protein kinase PCTAIRE-2;

Gene Name

CDK17

Gene Synonyms/Alias

CDK17; PCTK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000059758	ENSP00000444459	ENST00000543119
ENSG00000059758	ENSP00000261211	ENST00000261211
ENSG00000059758	ENSP00000450058	ENST00000551816
ENSG00000059758	ENSP00000448132	ENST00000552262
ENSG00000059758	ENSP00000447282	ENST00000552496
ENSG00000059758	ENSP00000447441	ENST00000548734
ENSG00000059758	ENSP00000442926	ENST00000542666

Organism

Homo sapiens

Functional Description

May play a role in terminally differentiated neurons.Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).

Protein Length

470

Protein Sequence
(FASTA)

MHSFLHQYTG SFKKPPLRRP HSVIGGSLGS FMAMPRNGSR LDIVHENLKM GSDGESDQAS 60

GTSSDEVQSP TGVCLRNRIH RRISMEDLNK RLSLPADIRI PDGYLEKLQI NSPPFDQPMS 120

RRSRRASLSE IGFGKMETYI KLEKLGEGTY ATVYKGRSKL TENLVALKEI RLEHEEGAPC 180

TAIREVSLLK DLKHANIVTL HDIVHTDKSL TLVFEYLDKD LKQYMDDCGN IMSMHNVKLF 240

LYQILRGLAY CHRRKVLHRD LKPQNLLINE KGELKLADFG LARAKSVPTK TYSNEVVTLW 300

YRPPDVLLGS SEYSTQIDMW GVGCIFFEMA SGRPLFPGST VEDELHLIFR LLGTPSQETW 360

PGISSNEEFK NYNFPKYKPQ PLINHAPRLD SEGIELITKF LQYESKKRVS AEEAMKHVYF 420

RSLGPRIHAL PESVSIFSLK EIQLQKDPGF RNSSYPETGV FVINHFTCRS 470

Nucleotide Sequence
(FASTA)

ATGCATTCCT TCCTCCACCA GTACACAGGA TCTTTCAAGA AGCCCCCATT GCGGAGACCA 60

CACAGTGTTA TTGGAGGGAG CCTTGGCTCC TTCATGGCAA TGCCCAGAAA TGGAAGCAGA 120

TTAGATATTG TTCATGAAAA TCTAAAAATG GGATCAGATG GTGAGAGTGA CCAAGCTTCT 180

GGGACATCAT CTGATGAAGT CCAGTCACCT ACAGGTGTTT GTCTCAGAAA TCGTATACAT 240

AGACGGATCT CAATGGAGGA TTTAAATAAG CGGTTATCAC TGCCTGCAGA CATCAGAATA 300

CCTGATGGAT ATCTTGAAAA GTTGCAGATA AACAGTCCAC CATTTGACCA ACCAATGAGT 360

CGAAGGTCTC GTAGAGCTTC CTTATCAGAA ATTGGCTTTG GAAAAATGGA AACCTACATC 420

AAATTGGAAA AGCTTGGAGA GGGTACATAT GCAACAGTAT ATAAAGGAAG AAGTAAATTG 480

ACAGAGAATT TGGTGGCATT AAAAGAGATC CGATTGGAAC ATGAAGAAGG TGCACCCTGC 540

ACAGCTATAA GAGAAGTTTC ACTATTAAAG GATTTAAAAC ATGCAAATAT AGTAACCTTA 600

CATGACATTG TTCACACAGA TAAATCCTTG ACTTTGGTGT TTGAGTATCT GGATAAAGAC 660

CTGAAACAGT ACATGGATGA CTGTGGAAAC ATCATGAGTA TGCACAACGT AAAGCTGTTT 720

CTGTACCAAA TTCTACGTGG TTTGGCATAT TGCCATAGAA GAAAGGTATT GCATCGAGAC 780

TTGAAACCAC AGAACCTCCT CATTAATGAG AAAGGAGAAT TAAAGCTAGC AGATTTTGGA 840

CTAGCCCGAG CCAAGTCAGT TCCCACAAAG ACCTACTCAA ATGAAGTTGT CACACTATGG 900

TACCGGCCAC CTGATGTGCT TCTTGGTTCC TCGGAGTACT CAACACAGAT TGACATGTGG 960

GGTGTTGGTT GCATTTTCTT TGAAATGGCT TCTGGAAGAC CTTTATTTCC AGGATCAACC 1020

GTGGAAGATG AACTGCACTT AATTTTCCGA CTGCTAGGAA CTCCATCTCA GGAAACTTGG 1080

CCAGGTATTT CTTCAAATGA GGAGTTCAAG AACTACAACT TTCCAAAATA TAAACCACAG 1140

CCTCTAATTA ACCACGCACC CAGGTTAGAC TCTGAAGGAA TTGAGTTGAT AACAAAATTT 1200

CTTCAGTATG AATCTAAGAA AAGGGTTTCA GCTGAAGAGG CCATGAAACA TGTGTACTTT 1260

CGAAGTCTGG GACCAAGAAT ACATGCTTTA CCAGAAAGTG TATCAATATT CAGTTTGAAA 1320

GAGATTCAGT TGCAAAAGGA CCCGGGTTTT CGAAATTCTT CTTATCCAGA GACAGGTGTG 1380

TTTGTCATAA ACCATTTCAC GTGTCGATCA TGA 1413

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y klek+geGty++vyk+++k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 139   YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANI  197

         7799********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++v+ ++k+l+Lvfe+l++dLk++++++ +  +s+++vk +l+q+l+glay+H++k

Q: 198   VTLHDIVH-TDKSLTLVFEYLDKDLKQYMDDCGN-IMSMHNVKLFLYQILRGLAYCHRRK  255

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLi+++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst

Q: 256   VLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYST  315

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

         ++D+W+vgci+ e+++ +plf+g++  d+l+ if+llgtps+++wp++s+ +e+k ++fp

Q: 316   QIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKnYNFP  375

         *******************************************************99***

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         k+k++ l ++ ++l++++++l++k+l+++ kkR+sa+ea++h yf

Q: 376   KYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYF  420

         ********************************************8

Domain Sequence
(FASTA)

YIKLEKLGEG TYATVYKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKDLKHANIV 60

TLHDIVHTDK SLTLVFEYLD KDLKQYMDDC GNIMSMHNVK LFLYQILRGL AYCHRRKVLH 120

RDLKPQNLLI NEKGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSSEYSTQID 180

MWGVGCIFFE MASGRPLFPG STVEDELHLI FRLLGTPSQE TWPGISSNEE FKNYNFPKYK 240

PQPLINHAPR LDSEGIELIT KFLQYESKKR VSAEEAMKHV YF 282

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0004672	; F:protein kinase activity
GO:0007049	; P:cell cycle

KEGG

hsa:5128

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013