EKS-HOS-00308
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00308
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Alk522.11.5E-156208477270
StatusReviewed
Ensembl ProteinENSP00000458111
UniProt AccessionP29376; A6NNJ8; B4DL89; E9PFX4;
Protein NameLeukocyte tyrosine kinase receptor
Protein Synonyms/Alias Protein tyrosine kinase 1;
Gene NameLTK
Gene Synonyms/Alias LTK; TYK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000062524ENSP00000392196ENST00000453182
ENSG00000062524ENSP00000458111ENST00000561619
ENSG00000062524ENSP00000263800ENST00000263800
ENSG00000062524ENSP00000347293ENST00000355166
OrganismHomo sapiens
Functional DescriptionOrphan receptor with a tyrosine-protein kinase activity.The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.
Protein Length562
Protein Sequence
(FASTA)
MGCWGQLLVW FGAAGGDASE TDNLWADGED GVSFIHPSSE LFLQPLAVTE NHGEVEIRRH 60
LNCSHCPLRD CQWQAELQLA ECLCPEGMEL AVDNVTCMDL HKPPGPLVLM VAVVATSTLS 120
LLMVCGVLIL GTKRLAGTVD SRLLLSMKQK KWQGLQEMRL PSPELELSKL RTSAIRTAPN 180
PYYCQVGLGP AQSWPLPPGV TEVSPANVTL LRALGHGAFG EVYEGLVIGL PGDSSPLQVA 240
IKTLPELCSP QDELDFLMEA LIISKFRHQN IVRCVGLSLR ATPRLILLEL MSGGDMKSFL 300
RHSRPHLGQP SPLVMRDLLQ LAQDIAQGCH YLEENHFIHR DIAARNCLLS CAGPSRVAKI 360
GDFGMARDIY RASYYRRGDR ALLPVKWMPP EAFLEGIFTS KTDSWSFGVL LWEIFSLGYM 420
PYPGRTNQEV LDFVVGGGRM DPPRGCPGPV YRIMTQCWQH EPELRPSFAS ILERLQYCTQ 480
DPDVLNSLLP MELGPTPEEE GTSGLGNRSL ECLRPPQPQE LSPEKLKSWG GSPLGPWLSS 540
GLKPLKSRGL QPQNLWNPTY RS 562
Nucleotide Sequence
(FASTA)
ATGGGCTGCT GGGGACAGCT GCTGGTGTGG TTCGGAGCCG CGGGGGGCGA CGCTTCAGAG 60
ACTGACAACC TCTGGGCTGA TGGGGAAGAT GGAGTATCCT TCATACACCC CAGCAGCGAG 120
CTCTTCCTGC AGCCTCTGGC AGTCACCGAG AACCACGGAG AGGTAGAGAT CCGAAGGCAC 180
CTCAACTGCA GTCACTGCCC TTTGAGAGAC TGCCAATGGC AGGCAGAGCT CCAGCTGGCT 240
GAATGCCTGT GCCCAGAAGG CATGGAGCTA GCTGTGGATA ACGTCACCTG CATGGACCTG 300
CACAAGCCCC CAGGCCCTCT GGTTCTGATG GTGGCTGTGG TGGCAACCTC AACACTGAGC 360
CTCCTTATGG TGTGTGGGGT CCTGATTCTG GGTACGAAGC GTCTAGCAGG CACAGTTGAT 420
TCAAGGCTGC TCCTCTCCAT GAAGCAGAAG AAGTGGCAGG GCCTGCAGGA GATGAGGCTG 480
CCGAGCCCTG AGCTTGAGCT GAGCAAGCTT CGAACCTCTG CCATCAGGAC AGCCCCCAAT 540
CCCTATTATT GCCAGGTGGG GCTTGGCCCG GCCCAGTCCT GGCCTCTGCC ACCAGGTGTC 600
ACCGAGGTTT CCCCAGCCAA TGTTACTCTG CTCAGAGCCC TGGGCCATGG TGCCTTTGGG 660
GAGGTGTATG AGGGACTGGT AATTGGCCTT CCTGGGGACT CCAGTCCCCT GCAGGTAGCT 720
ATCAAGACCC TGCCAGAACT CTGCTCGCCT CAGGATGAGC TGGATTTCCT CATGGAGGCC 780
CTCATCATCA GCAAGTTTCG CCATCAGAAC ATTGTGCGGT GTGTGGGGCT CAGCCTCAGG 840
GCCACCCCTC GCCTCATTCT GCTGGAACTG ATGTCTGGAG GGGACATGAA GAGTTTCCTG 900
AGGCACAGTC GGCCACACCT GGGCCAGCCA TCACCTCTGG TCATGCGGGA CCTGCTGCAA 960
CTGGCCCAGG ACATAGCCCA GGGCTGCCAC TACCTGGAGG AAAATCACTT CATCCACAGG 1020
GATATTGCCG CCCGGAACTG CCTGCTGAGC TGCGCTGGAC CCAGCCGAGT GGCCAAGATT 1080
GGGGACTTTG GGATGGCACG AGATATCTAC CGGGCCAGTT ATTACCGCAG GGGGGACCGG 1140
GCCTTGCTCC CAGTCAAGTG GATGCCCCCA GAGGCCTTCC TGGAGGGCAT CTTCACATCC 1200
AAGACAGATT CCTGGTCTTT TGGGGTGCTG CTCTGGGAGA TCTTCTCACT GGGCTACATG 1260
CCCTATCCTG GGCGCACCAA CCAGGAGGTG CTGGACTTCG TCGTTGGAGG AGGCCGGATG 1320
GACCCTCCTA GGGGCTGCCC AGGGCCTGTG TACCGCATCA TGACCCAGTG TTGGCAGCAC 1380
GAGCCTGAGC TCCGCCCTAG CTTTGCCAGC ATCTTGGAGC GTCTGCAGTA CTGCACTCAG 1440
GACCCGGATG TGCTGAATTC ACTCCTGCCA ATGGAGCTGG GGCCCACCCC AGAGGAGGAA 1500
GGGACTTCTG GGCTGGGGAA CAGATCTTTG GAGTGCCTAA GACCCCCACA GCCCCAGGAA 1560
CTGAGTCCAG AGAAGTTGAA AAGCTGGGGA GGTAGCCCTC TTGGCCCCTG GCTGTCCTCT 1620
GGCCTCAAGC CCCTCAAATC CAGGGGCCTC CAACCTCAGA ACCTTTGGAA TCCCACTTAT 1680
CGCTCCTGA 1689
Domain Profile
S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60
         ++l+ralG+GafGevyeglv+glpgd+s+l+va+ktlpe +s qdeldfl+ealiiskf+
Q: 208   VTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFR  267
         689*********************************************************
S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120
         h+nivr++G+sl+++prlillel++GGd+ksflr+srp+  q+s+l+m+dll++a+d+a+
Q: 268   HQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQ  327
         ************************************************************
S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180
         Gc+yleen+fihrdiaarn+lls++Gpsrvaki+dfGmardiyra+yyr+g+rallpvkw
Q: 328   GCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKW  387
         ************************************************************
S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240
         mppeafleGiftsktd+wsfGvllwe+fslG++pypg++nqevl++vv Ggr+d+p+++p
Q: 388   MPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCP  447
         ************************************************************
S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270
         g+vyrimt+cw+hepe rp+f+silerlq+
Q: 448   GPVYRIMTQCWQHEPELRPSFASILERLQY  477
         ****************************97
Domain Sequence
(FASTA)
VTLLRALGHG AFGEVYEGLV IGLPGDSSPL QVAIKTLPEL CSPQDELDFL MEALIISKFR 60
HQNIVRCVGL SLRATPRLIL LELMSGGDMK SFLRHSRPHL GQPSPLVMRD LLQLAQDIAQ 120
GCHYLEENHF IHRDIAARNC LLSCAGPSRV AKIGDFGMAR DIYRASYYRR GDRALLPVKW 180
MPPEAFLEGI FTSKTDSWSF GVLLWEIFSL GYMPYPGRTN QEVLDFVVGG GRMDPPRGCP 240
GPVYRIMTQC WQHEPELRPS FASILERLQY 270
KeywordAlternative splicing; ATP-binding; Complete proteome; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal; Systemic lupus erythematosus; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>
EKS-CAJ-00313
EKS-CAP-00342
EKS-EQC-00293
EKS-FEC-00288
EKS-GOG-00303
EKS-ICT-00291
EKS-LOA-00318
EKS-MOD-00296
EKS-MUM-00339
EKS-NOL-00277
EKS-ORC-00283
EKS-OTG-00309
EKS-PAT-00291
EKS-POA-00293
EKS-PTV-00067
EKS-RAN-00318
EKS-SAH-00288
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0008283; P:cell proliferation
GO:0071300; P:cellular response to retinoic acid
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0010976; P:positive regulation of neuron projection development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
hsa:4058;
InterPros
IPR011009; Kinase-like_dom.
IPR026984; LTK.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013