EKS-HOS-00306
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00306
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR457.27.3E-13766322257
StatusReviewed
Ensembl ProteinENSP00000399178
UniProt AccessionP21860; A8K6L6; B4DIK7; B4DV32; E9PDT8; Q9BUD7;
Protein NameReceptor tyrosine-protein kinase erbB-3
Protein Synonyms/Alias Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3;
Gene NameERBB3
Gene Synonyms/Alias ERBB3; HER3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000065361ENSP00000448636ENST00000549282
ENSG00000065361ENSP00000448671ENST00000550869
ENSG00000065361ENSP00000449138ENST00000549061
ENSG00000065361ENSP00000449713ENST00000549672
ENSG00000065361ENSP00000448729ENST00000549832
ENSG00000065361ENSP00000415753ENST00000411731
ENSG00000065361ENSP00000448483ENST00000551085
ENSG00000065361ENSP00000399178ENST00000450146
ENSG00000065361ENSP00000267101ENST00000267101
ENSG00000065361ENSP00000449129ENST00000553131
ENSG00000065361ENSP00000447510ENST00000551242
ENSG00000065361ENSP00000448946ENST00000550070
ENSG00000065361ENSP00000446909ENST00000552833
ENSG00000065361ENSP00000408340ENST00000415288
OrganismHomo sapiens
Functional DescriptionBinds and is activated by neuregulins and NTAK.
Protein Length699
Protein Sequence
(FASTA)
MALTVIAGLV VIFMMLGGTF LYWRGRRIQN KRAMRRYLER GESIEPLDPS EKANKVLARI 60
FKETELRKLK VLGSGVFGTV HKGVWIPEGE SIKIPVCIKV IEDKSGRQSF QAVTDHMLAI 120
GSLDHAHIVR LLGLCPGSSL QLVTQYLPLG SLLDHVRQHR GALGPQLLLN WGVQIAKGMY 180
YLEEHGMVHR NLAARNVLLK SPSQVQVADF GVADLLPPDD KQLLYSEAKT PIKWMALESI 240
HFGKYTHQSD VWSYGVTVWE LMTFGAEPYA GLRLAEVPDL LEKGERLAQP QICTIDVYMV 300
MVKCWMIDEN IRPTFKELAN EFTRMARDPP RYLVIKRESG PGIAPGPEPH GLTNKKLEEV 360
ELEPELDLDL DLEAEEDNLA TTTLGSALSL PVGTLNRPRG SQSLLSPSSG YMPMNQGNLG 420
ESCQESAVSG SSERCPRPVS LHPMPRGCLA SESSEGHVTG SEAELQEKVS MCRSRSRSRS 480
PRPRGDSAYH SQRHSLLTPV TPLSPPGLEE EDVNGYVMPD THLKGTPSSR EGTLSSVGLS 540
SVLGTEEEDE DEEYEYMNRR RRHSPPHPPR PSSLEELGYE YMDVGSDLSA SLGSTQSCPL 600
HPVPIMPTAG TTPDEDYEYM NRQRDGGGPG GDYAAMGACP ASEQGYEEMR AFQGPGHQAP 660
HVHYARLKTL RSLEATDSAF DNPDYWHSRL FPKANAQRT 699
Nucleotide Sequence
(FASTA)
ATGGCTTTGA CAGTGATAGC AGGATTGGTA GTGATTTTCA TGATGCTGGG CGGCACTTTT 60
CTCTACTGGC GTGGGCGCCG GATTCAGAAT AAAAGGGCTA TGAGGCGATA CTTGGAACGG 120
GGTGAGAGCA TAGAGCCTCT GGACCCCAGT GAGAAGGCTA ACAAAGTCTT GGCCAGAATC 180
TTCAAAGAGA CAGAGCTAAG GAAGCTTAAA GTGCTTGGCT CGGGTGTCTT TGGAACTGTG 240
CACAAAGGAG TGTGGATCCC TGAGGGTGAA TCAATCAAGA TTCCAGTCTG CATTAAAGTC 300
ATTGAGGACA AGAGTGGACG GCAGAGTTTT CAAGCTGTGA CAGATCATAT GCTGGCCATT 360
GGCAGCCTGG ACCATGCCCA CATTGTAAGG CTGCTGGGAC TATGCCCAGG GTCATCTCTG 420
CAGCTTGTCA CTCAATATTT GCCTCTGGGT TCTCTGCTGG ATCATGTGAG ACAACACCGG 480
GGGGCACTGG GGCCACAGCT GCTGCTCAAC TGGGGAGTAC AAATTGCCAA GGGAATGTAC 540
TACCTTGAGG AACATGGTAT GGTGCATAGA AACCTGGCTG CCCGAAACGT GCTACTCAAG 600
TCACCCAGTC AGGTTCAGGT GGCAGATTTT GGTGTGGCTG ACCTGCTGCC TCCTGATGAT 660
AAGCAGCTGC TATACAGTGA GGCCAAGACT CCAATTAAGT GGATGGCCCT TGAGAGTATC 720
CACTTTGGGA AATACACACA CCAGAGTGAT GTCTGGAGCT ATGGTGTGAC AGTTTGGGAG 780
TTGATGACCT TCGGGGCAGA GCCCTATGCA GGGCTACGAT TGGCTGAAGT ACCAGACCTG 840
CTAGAGAAGG GGGAGCGGTT GGCACAGCCC CAGATCTGCA CAATTGATGT CTACATGGTG 900
ATGGTCAAGT GTTGGATGAT TGATGAGAAC ATTCGCCCAA CCTTTAAAGA ACTAGCCAAT 960
GAGTTCACCA GGATGGCCCG AGACCCACCA CGGTATCTGG TCATAAAGAG AGAGAGTGGG 1020
CCTGGAATAG CCCCTGGGCC AGAGCCCCAT GGTCTGACAA ACAAGAAGCT AGAGGAAGTA 1080
GAGCTGGAGC CAGAACTAGA CCTAGACCTA GACTTGGAAG CAGAGGAGGA CAACCTGGCA 1140
ACCACCACAC TGGGCTCCGC CCTCAGCCTA CCAGTTGGAA CACTTAATCG GCCACGTGGG 1200
AGCCAGAGCC TTTTAAGTCC ATCATCTGGA TACATGCCCA TGAACCAGGG TAATCTTGGG 1260
GAGTCTTGCC AGGAGTCTGC AGTTTCTGGG AGCAGTGAAC GGTGCCCCCG TCCAGTCTCT 1320
CTACACCCAA TGCCACGGGG ATGCCTGGCA TCAGAGTCAT CAGAGGGGCA TGTAACAGGC 1380
TCTGAGGCTG AGCTCCAGGA GAAAGTGTCA ATGTGTAGGA GCCGGAGCAG GAGCCGGAGC 1440
CCACGGCCAC GCGGAGATAG CGCCTACCAT TCCCAGCGCC ACAGTCTGCT GACTCCTGTT 1500
ACCCCACTCT CCCCACCCGG GTTAGAGGAA GAGGATGTCA ACGGTTATGT CATGCCAGAT 1560
ACACACCTCA AAGGTACTCC CTCCTCCCGG GAAGGCACCC TTTCTTCAGT GGGTCTCAGT 1620
TCTGTCCTGG GTACTGAAGA AGAAGATGAA GATGAGGAGT ATGAATACAT GAACCGGAGG 1680
AGAAGGCACA GTCCACCTCA TCCCCCTAGG CCAAGTTCCC TTGAGGAGCT GGGTTATGAG 1740
TACATGGATG TGGGGTCAGA CCTCAGTGCC TCTCTGGGCA GCACACAGAG TTGCCCACTC 1800
CACCCTGTAC CCATCATGCC CACTGCAGGC ACAACTCCAG ATGAAGACTA TGAATATATG 1860
AATCGGCAAC GAGATGGAGG TGGTCCTGGG GGTGATTATG CAGCCATGGG GGCCTGCCCA 1920
GCATCTGAGC AAGGGTATGA AGAGATGAGA GCTTTTCAGG GGCCTGGACA TCAGGCCCCC 1980
CATGTCCATT ATGCCCGCCT AAAAACTCTA CGTAGCTTAG AGGCTACAGA CTCTGCCTTT 2040
GATAACCCTG ATTACTGGCA TAGCAGGCTT TTCCCCAAGG CTAATGCCCA GAGAACGTAA 2100
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+klkvlGsG+fGtv+kG+wipege++kipv+ikv+e+k+g++++++++d++l+++sldh
Q: 66    LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDH  125
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         a++vrllglc  s+lqlvtq+lplG+lld+vr+h+++lG+q llnw+vqiakGm+ylee+
Q: 126   AHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEH  185
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
          +vhr+laarnvl+ksp++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky
Q: 186   GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKY  245
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGa+py+g++++e+pdllekGerlaqp+ictidvymv+vkcw
Q: 246   THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCW  305
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+++rp+fkela+ef
Q: 306   MIDENIRPTFKELANEF  322
         ****************9
Domain Sequence
(FASTA)
LRKLKVLGSG VFGTVHKGVW IPEGESIKIP VCIKVIEDKS GRQSFQAVTD HMLAIGSLDH 60
AHIVRLLGLC PGSSLQLVTQ YLPLGSLLDH VRQHRGALGP QLLLNWGVQI AKGMYYLEEH 120
GMVHRNLAAR NVLLKSPSQV QVADFGVADL LPPDDKQLLY SEAKTPIKWM ALESIHFGKY 180
THQSDVWSYG VTVWELMTFG AEPYAGLRLA EVPDLLEKGE RLAQPQICTI DVYMVMVKCW 240
MIDENIRPTF KELANEF 257
Keyword3D-structure; Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Secreted; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Canis familiaris"; ?>Macaca mulatta"; ?>Nomascus leucogenys"; ?>Sus scrofa"; ?>
EKS-CAF-00306
EKS-MAM-00303
EKS-NOL-00276
EKS-SUS-00263
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0005615; C:extracellular space
GO:0005887; C:integral to plasma membrane
GO:0016328; C:lateral plasma membrane
GO:0005634; C:nucleus
GO:0045211; C:postsynaptic membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0019838; F:growth factor binding
GO:0046982; F:protein heterodimerization activity
GO:0042803; F:protein homodimerization activity
GO:0030296; F:protein tyrosine kinase activator activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0004888; F:transmembrane signaling receptor activity
GO:0007409; P:axonogenesis
GO:0032869; P:cellular response to insulin stimulus
GO:0007623; P:circadian rhythm
GO:0021545; P:cranial nerve development
GO:0003197; P:endocardial cushion development
GO:0007507; P:heart development
GO:0060056; P:mammary gland involution
GO:0007162; P:negative regulation of cell adhesion
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0051048; P:negative regulation of secretion
GO:0009968; P:negative regulation of signal transduction
GO:0051402; P:neuron apoptotic process
GO:0042476; P:odontogenesis
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0046326; P:positive regulation of glucose import
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0042127; P:regulation of cell proliferation
GO:0042493; P:response to drug
GO:0014037; P:Schwann cell differentiation
GO:0007519; P:skeletal muscle tissue development
GO:0043586; P:tongue development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060; P:wound healing
KEGG
hsa:2065;
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; FALSE_NEG.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013