Tag | Content |
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EKPD ID | EKS-HOS-00232 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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STE/STE7 | 392.2 | 6.0E-117 | 102 | 367 | 266 |
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Status | Reviewed |
Ensembl Protein | ENSP00000262445 |
UniProt Accession | P45985; B2R7N7; B3KYB2; D3DTS5; Q5U0B8; Q6FHX4; Q6P9H2; Q6PIE6; |
Protein Name | Dual specificity mitogen-activated protein kinase kinase 4 |
Protein Synonyms/Alias | MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKK; |
Gene Name | MAP2K4 |
Gene Synonyms/Alias | MAP2K4; JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1; |
Ensembl Information | |
Organism | Homo sapiens |
Functional Description | Dual specificity protein kinase which acts as anessential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. |
Protein Length | 399 |
Protein Sequence (FASTA) | MAAPSPSGGG GSGGGSGSGT PGPVGSPAPG HPAVSSMQGK RKALKLNFAN PPFKSTARFT 60 | LNPNPTGVQN PHIERLRTHS IESSGKLKIS PEQHWDFTAE DLKDLGEIGR GAYGSVNKMV 120 | HKPSGQIMAV KRIRSTVDEK EQKQLLMDLD VVMRSSDCPY IVQFYGALFR EGDCWICMEL 180 | MSTSFDKFYK YVYSVLDDVI PEEILGKITL ATVKALNHLK ENLKIIHRDI KPSNILLDRS 240 | GNIKLCDFGI SGQLVDSIAK TRDAGCRPYM APERIDPSAS RQGYDVRSDV WSLGITLYEL 300 | ATGRFPYPKW NSVFDQLTQV VKGDPPQLSN SEEREFSPSF INFVNLCLTK DESKRPKYKE 360 | LLKHPFILMY EERAVEVACY VCKILDQMPA TPSSPMYVD 399 |
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Nucleotide Sequence (FASTA) | ATGGCGGCTC CGAGCCCGAG CGGCGGCGGC GGCTCCGGGG GCGGCAGCGG CAGCGGCACC 60 | CCCGGCCCCG TAGGGTCCCC GGCGCCAGGC CACCCGGCCG TCAGCAGCAT GCAGGGTAAA 120 | CGCAAAGCAC TGAAGTTGAA TTTTGCAAAT CCACCTTTCA AATCTACAGC AAGGTTTACT 180 | CTGAATCCCA ATCCTACAGG AGTTCAAAAC CCACACATAG AGAGACTGAG AACACACAGC 240 | ATTGAGTCAT CAGGAAAACT GAAGATCTCC CCTGAACAAC ACTGGGATTT CACTGCAGAG 300 | GACTTGAAAG ACCTTGGAGA AATTGGACGA GGAGCTTATG GTTCTGTCAA CAAAATGGTC 360 | CACAAACCAA GTGGGCAAAT AATGGCAGTT AAAAGAATTC GGTCAACAGT GGATGAAAAA 420 | GAACAAAAAC AACTTCTTAT GGATTTGGAT GTAGTAATGC GGAGTAGTGA TTGCCCATAC 480 | ATTGTTCAGT TTTATGGTGC ACTCTTCAGA GAGGGTGACT GTTGGATCTG TATGGAACTC 540 | ATGTCTACCT CGTTTGATAA GTTTTACAAA TATGTATATA GTGTATTAGA TGATGTTATT 600 | CCAGAAGAAA TTTTAGGCAA AATCACTTTA GCAACTGTGA AAGCACTAAA CCACTTAAAA 660 | GAAAACTTGA AAATTATTCA CAGAGATATC AAACCTTCCA ATATTCTTCT GGACAGAAGT 720 | GGAAATATTA AGCTCTGTGA CTTCGGCATC AGTGGACAGC TTGTGGACTC TATTGCCAAG 780 | ACAAGAGATG CTGGCTGTAG GCCATACATG GCACCTGAAA GAATAGACCC AAGCGCATCA 840 | CGACAAGGAT ATGATGTCCG CTCTGATGTC TGGAGTTTGG GGATCACATT GTATGAGTTG 900 | GCCACAGGCC GATTTCCTTA TCCAAAGTGG AATAGTGTAT TTGATCAACT AACACAAGTC 960 | GTGAAAGGAG ATCCTCCGCA GCTGAGTAAT TCTGAGGAAA GGGAATTCTC CCCGAGTTTC 1020 | ATCAACTTTG TCAACTTGTG CCTTACGAAG GATGAATCCA AAAGGCCAAA GTATAAAGAG 1080 | CTTCTGAAAC ATCCCTTTAT TTTGATGTAT GAAGAACGTG CCGTTGAGGT CGCATGCTAT 1140 | GTTTGTAAAA TCCTGGATCA AATGCCAGCT ACTCCCAGCT CTCCCATGTA TGTCGATTGA 1200 |
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Domain Profile | S: 1 lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi 60 | l++l+e+G+G++g+V+k++hk+sg+i+avK+ir++++++eqkq+l++l+v+++ss++pyi | Q: 102 LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYI 161 | 68899******************************************************* |
| S: 61 vkfyGafvsegdvsicmelmdgtsldkvlkkvlek.kkripekvlgkiavavvkaleylk 119 | v+fyGa+++egd++icmelm+ ts+dk++k v+++ ++ ipe++lgki++a+vkal++lk | Q: 162 VQFYGALFREGDCWICMELMS-TSFDKFYKYVYSVlDDVIPEEILGKITLATVKALNHLK 220 | *********************.*************9************************ |
| S: 120 eklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg... 175 | e+lkiiHRD+KPsNiL++++G++KlCDFG+sgqlvdsiAk++ +G+++YmaPEri++ | Q: 221 ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRdAGCRPYMAPERIDPsas 280 | *********************************************************999 |
| S: 176 kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee...efseef 232 | ++ Y+v+sdvWslG+tl+elatgr+py+k+++ +++l+++v+++pp+l+++ efs++f | Q: 281 RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSeerEFSPSF 340 | 9***********************************************988788****** |
| S: 233 qefvskClkkdekeRpklkellkhafi 259 | ++fv+ Cl+kde++Rpk+kellkh+fi | Q: 341 INFVNLCLTKDESKRPKYKELLKHPFI 367 | **************************7 |
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Domain Sequence (FASTA) | LKDLGEIGRG AYGSVNKMVH KPSGQIMAVK RIRSTVDEKE QKQLLMDLDV VMRSSDCPYI 60 | VQFYGALFRE GDCWICMELM STSFDKFYKY VYSVLDDVIP EEILGKITLA TVKALNHLKE 120 | NLKIIHRDIK PSNILLDRSG NIKLCDFGIS GQLVDSIAKT RDAGCRPYMA PERIDPSASR 180 | QGYDVRSDVW SLGITLYELA TGRFPYPKWN SVFDQLTQVV KGDPPQLSNS EEREFSPSFI 240 | NFVNLCLTKD ESKRPKYKEL LKHPFI 266 |
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Keyword | 3D-structure; Acetylation; Alternative splicing; Apoptosis; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Stress response; Transferase; Tyrosine-protein kinase. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
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Pfam | |
SMARTs | |
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Prints | |
Created Date | 20-Feb-2013 |