EKS-HOS-00065

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00065

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	373.8	2.5E-111	705	997	293

Status

Reviewed

Ensembl Protein

ENSP00000340557

UniProt Accession

Q14004; Q53G78; Q6DKQ9; Q75MH4; Q75MH5; Q96JN4; Q9H4A0; Q9H4A1; Q9UDR4;

Protein Name

Cyclin-dependent kinase 13

Protein Synonyms/Alias

CDC2-related protein kinase 5; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; hCDK13; Cholinesterase-related cell division controller;

Gene Name

CDK13

Gene Synonyms/Alias

CDK13; CDC2L, CDC2L5, CHED, KIAA1791;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000065883	ENSP00000340557	ENST00000340829
ENSG00000065883	ENSP00000181839	ENST00000181839

Organism

Homo sapiens

Functional Description

Cyclin-dependent kinase which displays CTD kinaseactivity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys- 51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.

Protein Length

1452

Protein Sequence
(FASTA)

MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ PPPPPPPLLF 60

LAAPGTAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRAG GRQKRRRGPR AGQEAEKRRV 120

FSLPQPQQDG GGGASSGGGV TPLVEYEDVS SQSEQGLLLG GASAATAATA AGGTGGSGGS 180

PASSSGTQRR GEGSERRPRR DRRSSSGRSK ERHREHRRRD GQRGGSEASK SRSRHSHSGE 240

ERAEVAKSGS SSSSGGRRKS ASATSSSSSS RKDRDSKAHR SRTKSSKEPP SAYKEPPKAY 300

REDKTEPKAY RRRRSLSPLG GRDDSPVSHR ASQSLRSRKS PSPAGGGSSP YSRRLPRSPS 360

PYSRRRSPSY SRHSSYERGG DVSPSPYSSS SWRRSRSPYS PVLRRSGKSR SRSPYSSRHS 420

RSRSRHRLSR SRSRHSSISP STLTLKSSLA AELNKNKKAR AAEAARAAEA AKAAEATKAA 480

EAAAKAAKAS NTSTPTKGNT ETSASASQTN HVKDVKKIKI EHAPSPSSGG TLKNDKAKTK 540

PPLQVTKVEN NLIVDKATKK AVIVGKESKS AATKEESVSL KEKTKPLTPS IGAKEKEQHV 600

ALVTSTLPPL PLPPMLPEDK EADSLRGNIS VKAVKKEVEK KLRCLLADLP LPPELPGGDD 660

LSKSPEEKKT ATQLHSKRRP KICGPRYGET KEKDIDWGKR CVDKFDIIGI IGEGTYGQVY 720

KARDKDTGEM VALKKVRLDN EKEGFPITAI REIKILRQLT HQSIINMKEI VTDKEDALDF 780

KKDKGAFYLV FEYMDHDLMG LLESGLVHFN ENHIKSFMRQ LMEGLDYCHK KNFLHRDIKC 840

SNILLNNRGQ IKLADFGLAR LYSSEESRPY TNKVITLWYR PPELLLGEER YTPAIDVWSC 900

GCILGELFTK KPIFQANQEL AQLELISRIC GSPCPAVWPD VIKLPYFNTM KPKKQYRRKL 960

REEFVFIPAA ALDLFDYMLA LDPSKRCTAE QALQCEFLRD VEPSKMPPPD LPLWQDCHEL 1020

WSKKRRRQKQ MGMTDDVSTI KAPRKDLSLG LDDSRTNTPQ GVLPSSQLKS QGSSNVAPGE 1080

KQTDPSTPQQ ESSKPLGGIQ PSSQTIQPKV ETDAAQAAVQ SAFAVLLTQL IKAQQSKQKD 1140

VLLEERENGS GHEASLQLRP PPEPSTPVSG QDDLIQHQDM RILELTPEPD RPRILPPDQR 1200

PPEPPEPPPV TEEDLDYRTE NQHVPTTSSS LTDPHAGVKA ALLQLLAQHQ PQDDPKREGG 1260

IDYQAGDTYV STSDYKDNFG SSSFSSAPYV SNDGLGSSSA PPLERRSFIG NSDIQSLDNY 1320

STASSHSGGP PQPSAFSESF PSSVAGYGDI YLNAGPMLFS GDKDHRFEYS HGPIAVLANS 1380

SDPSTGPEST HPLPAKMHNY NYGGNLQENP SGPSLMHGQT WTSPAQGPGY SQGYRGHIST 1440

STGRGRGRGL PY 1452

Nucleotide Sequence
(FASTA)

ATGCCGAGCA GCTCGGACAC GGCGCTGGGG GGAGGCGGGG GCCTGAGCTG GGCGGAGAAG 60

AAGTTGGAGG AACGCCGCAA GCGGAGGCGA TTCCTGTCCC CTCAGCAGCC GCCGCTGCTG 120

TTGCCGCTCC TGCAGCCGCA GCTCCTGCAA CCGCCGCCGC CCCCGCCGCC TCTGCTCTTC 180

CTGGCTGCTC CCGGCACGGC CGCCGCCGCA GCCGCCGCCG CCGCGGCCTC CTCCTCTTGC 240

TTCAGCCCGG GCCCCCCTCT GGAGGTCAAG CGGCTGGCGA GAGGCAAGAG GCGCGCAGGA 300

GGGCGGCAGA AGCGGCGTCG CGGGCCCCGC GCCGGGCAGG AGGCGGAGAA GCGTCGGGTC 360

TTCTCGCTGC CCCAGCCGCA GCAGGACGGC GGTGGCGGTG CTAGTAGCGG CGGGGGTGTG 420

ACCCCGCTGG TGGAATACGA GGATGTGAGC TCCCAGTCCG AGCAGGGGCT GCTGCTGGGG 480

GGGGCCAGCG CGGCAACGGC GGCGACGGCT GCCGGGGGAA CGGGGGGCAG CGGCGGGAGT 540

CCGGCCTCCT CCTCCGGCAC CCAGCGGCGC GGGGAGGGGT CGGAGCGCAG GCCCCGCCGG 600

GACCGCCGCA GCAGCAGTGG CCGCAGCAAG GAGCGCCACC GCGAGCACCG GCGGCGGGAT 660

GGGCAGCGCG GTGGCAGCGA GGCCTCCAAG TCCCGCAGCC GCCACAGCCA CAGCGGCGAG 720

GAACGGGCCG AGGTCGCCAA GAGCGGCAGC AGCAGCAGCA GCGGCGGCCG CCGGAAAAGC 780

GCTTCGGCCA CATCCAGCAG CAGTAGCAGC CGCAAGGACC GGGACTCGAA GGCCCACCGC 840

AGCCGGACTA AGTCGTCCAA GGAGCCGCCT TCGGCCTACA AGGAACCGCC CAAGGCCTAC 900

CGGGAGGACA AGACCGAGCC TAAGGCCTAC AGGCGGCGGC GGTCCCTCAG CCCACTGGGA 960

GGCCGGGACG ACAGCCCGGT GTCCCACAGG GCCTCTCAGA GCCTGAGGAG CCGCAAGTCC 1020

CCCAGCCCGG CAGGAGGTGG CAGCAGCCCC TATTCTCGGC GGCTGCCGCG CTCCCCGAGC 1080

CCCTACAGTC GCCGCCGCTC CCCCAGCTAC AGCCGCCACA GCTCCTACGA GCGGGGCGGC 1140

GACGTGTCCC CTAGTCCCTA CAGCAGCAGC AGCTGGCGCC GCTCTCGCAG TCCCTACAGC 1200

CCTGTGCTCA GACGGTCTGG AAAATCCCGA AGCAGAAGCC CGTATTCATC TAGGCATTCA 1260

AGATCTCGTA GCAGGCACAG ATTGTCTAGA TCCAGAAGTC GTCATTCTAG TATTTCTCCT 1320

AGCACACTAA CTCTGAAGAG TAGCCTGGCA GCTGAATTGA ACAAGAATAA AAAAGCACGA 1380

GCAGCAGAGG CAGCAAGAGC CGCAGAAGCA GCGAAAGCTG CAGAAGCAAC TAAGGCTGCT 1440

GAGGCTGCTG CCAAGGCTGC AAAAGCTTCA AACACTTCTA CACCTACCAA GGGGAACACG 1500

GAAACTAGTG CCAGTGCATC ACAAACAAAC CATGTGAAGG ATGTGAAGAA AATTAAAATT 1560

GAACATGCAC CTTCTCCCTC AAGTGGTGGA ACTTTAAAAA ATGACAAAGC AAAAACAAAG 1620

CCACCTCTTC AGGTAACGAA GGTGGAAAAT AATTTGATTG TAGATAAAGC CACCAAGAAA 1680

GCAGTCATAG TTGGAAAGGA GAGTAAATCT GCTGCTACAA AGGAGGAATC AGTATCTCTT 1740

AAAGAGAAAA CCAAACCACT TACACCAAGC ATAGGAGCCA AGGAGAAGGA GCAACATGTA 1800

GCTTTAGTCA CCTCTACATT ACCACCGTTA CCTTTGCCTC CCATGCTGCC TGAAGATAAA 1860

GAAGCTGATA GCTTACGAGG AAATATTTCA GTAAAAGCAG TTAAAAAAGA AGTAGAAAAG 1920

AAACTCCGAT GTCTTCTTGC TGATTTACCG CTGCCCCCTG AGCTACCAGG AGGAGATGAT 1980

CTTTCAAAGA GTCCAGAGGA AAAGAAAACA GCAACACAGT TACATAGTAA AAGGAGGCCT 2040

AAAATATGTG GGCCTCGCTA TGGTGAAACC AAAGAAAAAG ATATTGACTG GGGAAAACGC 2100

TGCGTGGATA AATTTGATAT CATCGGAATT ATTGGAGAAG GTACTTACGG ACAAGTTTAC 2160

AAAGCCAGGG ATAAAGACAC TGGAGAAATG GTAGCCTTAA AAAAAGTACG TCTGGATAAT 2220

GAAAAGGAAG GCTTTCCAAT TACAGCAATT CGAGAAATTA AAATTCTCCG GCAGCTTACC 2280

CATCAGAGTA TTATCAATAT GAAGGAAATA GTGACTGATA AAGAAGATGC TTTGGATTTC 2340

AAGAAGGACA AAGGTGCATT TTATCTGGTG TTTGAATATA TGGACCATGA TCTGATGGGA 2400

CTACTGGAAT CAGGCTTGGT TCATTTTAAT GAAAATCACA TAAAGTCATT TATGAGACAG 2460

CTCATGGAGG GTCTGGATTA TTGTCATAAG AAGAACTTTT TGCATAGAGA TATTAAATGT 2520

TCCAATATCC TTCTAAATAA TAGAGGGCAG ATAAAACTTG CAGACTTTGG ACTTGCTCGA 2580

TTGTATAGCT CAGAAGAAAG TCGGCCGTAT ACTAACAAGG TAATTACTTT ATGGTACCGT 2640

CCACCTGAAC TGCTACTGGG AGAAGAACGA TACACACCAG CCATTGATGT ATGGAGCTGT 2700

GGCTGTATCC TTGGCGAACT CTTCACTAAA AAACCTATAT TTCAAGCAAA TCAGGAACTT 2760

GCACAACTAG AATTAATAAG CCGAATATGT GGGAGTCCAT GTCCTGCAGT GTGGCCTGAT 2820

GTAATCAAAC TACCATATTT CAACACCATG AAACCAAAGA AGCAATATCG TCGAAAGTTA 2880

AGAGAAGAAT TTGTTTTTAT TCCTGCAGCT GCGCTAGACT TATTTGATTA CATGCTTGCC 2940

TTGGATCCTA GTAAGCGCTG CACTGCTGAA CAGGCTCTTC AGTGCGAGTT CCTCCGAGAT 3000

GTGGAACCCT CAAAAATGCC TCCACCAGAT CTCCCTTTAT GGCAAGATTG TCATGAGTTA 3060

TGGAGTAAAA AGCGAAGAAG ACAGAAGCAG ATGGGCATGA CTGATGATGT TTCCACAATT 3120

AAAGCCCCCA GGAAGGACTT GTCTCTGGGC TTGGATGACA GCAGAACCAA CACACCCCAG 3180

GGTGTGCTGC CATCTTCACA GCTGAAATCT CAGGGCAGCT CAAATGTGGC ACCTGGTGAA 3240

AAACAGACAG ATCCATCAAC ACCACAACAG GAGTCTTCGA AACCGTTGGG AGGAATTCAG 3300

CCTTCTTCTC AGACCATCCA GCCTAAAGTG GAGACTGATG CTGCCCAGGC GGCTGTGCAG 3360

AGTGCATTTG CAGTTCTGTT GACTCAGTTA ATAAAGGCTC AGCAGTCAAA GCAGAAAGAT 3420

GTGCTACTAG AAGAGAGGGA AAATGGATCG GGACATGAAG CGTCATTACA ACTCAGGCCA 3480

CCTCCAGAAC CTAGCACTCC GGTGTCGGGA CAAGATGACC TCATCCAGCA TCAAGATATG 3540

AGGATCTTGG AGCTAACGCC AGAACCAGAC CGGCCTCGAA TTCTGCCTCC TGACCAACGA 3600

CCTCCCGAGC CTCCTGAACC ACCACCAGTC ACTGAGGAAG ATCTAGATTA TCGGACAGAA 3660

AACCAGCATG TACCCACCAC CAGTTCTTCA TTAACTGACC CTCATGCCGG AGTGAAGGCA 3720

GCCCTGTTAC AGCTGCTTGC TCAGCATCAG CCCCAGGATG ACCCCAAAAG AGAAGGTGGG 3780

ATTGATTATC AAGCAGGAGA CACTTACGTG TCCACTTCAG ACTACAAGGA CAACTTTGGA 3840

TCCTCTTCTT TCTCTTCTGC TCCTTATGTT AGCAATGATG GTCTAGGAAG CAGTTCTGCT 3900

CCACCACTAG AACGACGTAG TTTCATTGGA AATTCAGATA TTCAGTCTTT GGATAACTAC 3960

AGTACTGCTT CATCTCATTC TGGTGGTCCA CCTCAGCCTT CTGCCTTTTC TGAGTCATTT 4020

CCCAGTTCAG TAGCTGGATA TGGAGACATT TACCTCAATG CTGGTCCCAT GTTGTTTAGT 4080

GGAGACAAGG ACCATAGATT TGAATATAGC CATGGTCCTA TTGCAGTCCT GGCAAACAGC 4140

AGTGACCCTT CCACGGGGCC AGAGAGTACT CATCCTTTGC CAGCAAAGAT GCACAACTAT 4200

AACTATGGTG GTAACTTACA GGAAAATCCG AGTGGCCCCA GCCTCATGCA TGGACAGACC 4260

TGGACTTCTC CTGCCCAAGG ACCTGGATAT TCACAAGGAT ACAGGGGACA TATTAGCACA 4320

TCAACTGGCA GAGGCAGAGG CAGAGGGTTA CCATACTGA 4359

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vyka+dk+tge+vAlKk+rl++ekeg+pita+rEi++l++l+h+ i

Q: 705   FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSI  764

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         ++++e+v+         kdk  +yLvfe++++dL+ ll++    +++++++ks+++ql+e

Q: 765   INMKEIVTdkedaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFNENHIKSFMRQLME  823

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar +ss+++  yt++v+TlwYr+Pe

Q: 824   GLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESrPYTNKVITLWYRPPE  883

         ***************************************7665527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq+++e  qle i++++g+p  +vwp+v k

Q: 884   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIK  943

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhky  283

         lp +++  pkk+++ kl+e++  +  +aldl++ +laldp+kR++a++alq ++

Q: 944   LPYFNTMKPKKQYRrKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEF  997

         *****7777777777******999999************************988

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKARD KDTGEMVALK KVRLDNEKEG FPITAIREIK ILRQLTHQSI 60

INMKEIVTDK EDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFNENHI KSFMRQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNRGQIKLA DFGLARLYSS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANQELAQLE LISRICGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRKLREEF VFIPAAALDL FDYMLALDPS KRCTAEQALQ CEF 293

Keyword

Acetylation; Alternative splicing; ATP-binding; Complete proteome; Host-virus interaction; Kinase; mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA editing; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0019908	; C:nuclear cyclin-dependent protein kinase holoenzyme complex
GO:0016607	; C:nuclear speck
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0000380	; P:alternative mRNA splicing, via spliceosome
GO:0007049	; P:cell cycle
GO:0030097	; P:hemopoiesis
GO:0070816	; P:phosphorylation of RNA polymerase II C-terminal domain
GO:0008284	; P:positive regulation of cell proliferation
GO:0007088	; P:regulation of mitosis
GO:0019048	; P:virus-host interaction

KEGG

hsa:8621

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013