EKS-HOS-00152

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00152

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	559.2	6.2E-168	390	666	277

Status

Reviewed

Ensembl Protein

ENSP00000337665

UniProt Accession

P21802; B4DFC2; E7EVR6; E9PCR0; P18443; Q01742; Q12922; Q14300; Q14301; Q14302; Q14303; Q14304; Q14305; Q14672; Q14718; Q14719; Q1KHY5; Q86YI4; Q8IXC7; Q96KL9; Q96KM0; Q96KM1; Q96KM2; Q9NZU2; Q9NZU3; Q9UD01; Q9UD02; Q9UIH3; Q9UIH4; Q9UIH5; Q9UIH6; Q9UIH7; Q9UIH8; Q9UM87; Q9UMC6; Q9UNS7; Q9UQH7; Q9UQH8; Q9UQH9; Q9UQI0;

Protein Name

Fibroblast growth factor receptor 2

Protein Synonyms/Alias

FGFR-2; K-sam; KGFR; Keratinocyte growth factor receptor;

Gene Name

FGFR2

Gene Synonyms/Alias

FGFR2; BEK, KGFR, KSAM;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000066468	ENSP00000350166	ENST00000357555
ENSG00000066468	ENSP00000353262	ENST00000360144
ENSG00000066468	ENSP00000358056	ENST00000369060
ENSG00000066468	ENSP00000358055	ENST00000369059
ENSG00000066468	ENSP00000358057	ENST00000369061
ENSG00000066468	ENSP00000358052	ENST00000369056
ENSG00000066468	ENSP00000309878	ENST00000351936
ENSG00000066468	ENSP00000352309	ENST00000359354
ENSG00000066468	ENSP00000358054	ENST00000369058
ENSG00000066468	ENSP00000337665	ENST00000336553
ENSG00000066468	ENSP00000351276	ENST00000358487
ENSG00000066468	ENSP00000404219	ENST00000429361
ENSG00000066468	ENSP00000263451	ENST00000346997
ENSG00000066468	ENSP00000410294	ENST00000457416
ENSG00000066468	ENSP00000348559	ENST00000356226

Organism

Homo sapiens

Functional Description

Tyrosine-protein kinase that acts as cell-surfacereceptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

Protein Length

669

Protein Sequence
(FASTA)

MVSWGRFICL VVVTMATLSL ARPSFSLVED TTLEPEDAIS SGDDEDDTDG AEDFVSENSN 60

NKRAPYWTNT EKMEKRLHAV PAANTVKFRC PAGGNPMPTM RWLKNGKEFK QEHRIGGYKV 120

RNQHWSLIME SVVPSDKGNY TCVVENEYGS INHTYHLDVV ERSPHRPILQ AGLPANASTV 180

VGGDVEFVCK VYSDAQPHIQ WIKHVEKNGS KYGPDGLPYL KVLKAAGVNT TDKEIEVLYI 240

RNVTFEDAGE YTCLAGNSIG ISFHSAWLTV LPAPGREKEI TASPDYLEIA IYCIGVFLIA 300

CMVVTVILCR MKNTTKKPDF SSQPAVHKLT KRIPLRRQVS AESSSSMNSN TPLVRITTRL 360

SSTADTPMLA GVSEYELPED PKWEFPRDKL TLGKPLGEGC FGQVVMAEAV GIDKDKPKEA 420

VTVAVKMLKD DATEKDLSDL VSEMEMMKMI GKHKNIINLL GACTQDGPLY VIVEYASKGN 480

LREYLRARRP PGMEYSYDIN RVPEEQMTFK DLVSCTYQLA RGMEYLASQK CIHRDLAARN 540

VLVTENNVMK IADFGLARDI NNIDYYKKTT NGRLPVKWMA PEALFDRVYT HQSDVWSFGV 600

LMWEIFTLGG SPYPGIPVEE LFKLLKEGHR MDKPANCTNE LYMMMRDCWH AVPSQRPTFK 660

QLVEDLDRI 669

Nucleotide Sequence
(FASTA)

ATGGTCAGCT GGGGTCGTTT CATCTGCCTG GTCGTGGTCA CCATGGCAAC CTTGTCCCTG 60

GCCCGGCCCT CCTTCAGTTT AGTTGAGGAT ACCACATTAG AGCCAGAAGA TGCCATCTCA 120

TCCGGAGATG ATGAGGATGA CACCGATGGT GCGGAAGATT TTGTCAGTGA GAACAGTAAC 180

AACAAGAGAG CACCATACTG GACCAACACA GAAAAGATGG AAAAGCGGCT CCATGCTGTG 240

CCTGCGGCCA ACACTGTCAA GTTTCGCTGC CCAGCCGGGG GGAACCCAAT GCCAACCATG 300

CGGTGGCTGA AAAACGGGAA GGAGTTTAAG CAGGAGCATC GCATTGGAGG CTACAAGGTA 360

CGAAACCAGC ACTGGAGCCT CATTATGGAA AGTGTGGTCC CATCTGACAA GGGAAATTAT 420

ACCTGTGTAG TGGAGAATGA ATACGGGTCC ATCAATCACA CGTACCACCT GGATGTTGTG 480

GAGCGATCGC CTCACCGGCC CATCCTCCAA GCCGGACTGC CGGCAAATGC CTCCACAGTG 540

GTCGGAGGAG ACGTAGAGTT TGTCTGCAAG GTTTACAGTG ATGCCCAGCC CCACATCCAG 600

TGGATCAAGC ACGTGGAAAA GAACGGCAGT AAATACGGGC CCGACGGGCT GCCCTACCTC 660

AAGGTTCTCA AGGCCGCCGG TGTTAACACC ACGGACAAAG AGATTGAGGT TCTCTATATT 720

CGGAATGTAA CTTTTGAGGA CGCTGGGGAA TATACGTGCT TGGCGGGTAA TTCTATTGGG 780

ATATCCTTTC ACTCTGCATG GTTGACAGTT CTGCCAGCGC CTGGAAGAGA AAAGGAGATT 840

ACAGCTTCCC CAGACTACCT GGAGATAGCC ATTTACTGCA TAGGGGTCTT CTTAATCGCC 900

TGTATGGTGG TAACAGTCAT CCTGTGCCGA ATGAAGAACA CGACCAAGAA GCCAGACTTC 960

AGCAGCCAGC CGGCTGTGCA CAAGCTGACC AAACGTATCC CCCTGCGGAG ACAGGTTTCG 1020

GCTGAGTCCA GCTCCTCCAT GAACTCCAAC ACCCCGCTGG TGAGGATAAC AACACGCCTC 1080

TCTTCAACGG CAGACACCCC CATGCTGGCA GGGGTCTCCG AGTATGAACT TCCAGAGGAC 1140

CCAAAATGGG AGTTTCCAAG AGATAAGCTG ACACTGGGCA AGCCCCTGGG AGAAGGTTGC 1200

TTTGGGCAAG TGGTCATGGC GGAAGCAGTG GGAATTGACA AAGACAAGCC CAAGGAGGCG 1260

GTCACCGTGG CCGTGAAGAT GTTGAAAGAT GATGCCACAG AGAAAGACCT TTCTGATCTG 1320

GTGTCAGAGA TGGAGATGAT GAAGATGATT GGGAAACACA AGAATATCAT AAATCTTCTT 1380

GGAGCCTGCA CACAGGATGG GCCTCTCTAT GTCATAGTTG AGTATGCCTC TAAAGGCAAC 1440

CTCCGAGAAT ACCTCCGAGC CCGGAGGCCA CCCGGGATGG AGTACTCCTA TGACATTAAC 1500

CGTGTTCCTG AGGAGCAGAT GACCTTCAAG GACTTGGTGT CATGCACCTA CCAGCTGGCC 1560

AGAGGCATGG AGTACTTGGC TTCCCAAAAA TGTATTCATC GAGATTTAGC AGCCAGAAAT 1620

GTTTTGGTAA CAGAAAACAA TGTGATGAAA ATAGCAGACT TTGGACTCGC CAGAGATATC 1680

AACAATATAG ACTATTACAA AAAGACCACC AATGGGCGGC TTCCAGTCAA GTGGATGGCT 1740

CCAGAAGCCC TGTTTGATAG AGTATACACT CATCAGAGTG ATGTCTGGTC CTTCGGGGTG 1800

TTAATGTGGG AGATCTTCAC TTTAGGGGGC TCGCCCTACC CAGGGATTCC CGTGGAGGAA 1860

CTTTTTAAGC TGCTGAAGGA AGGACACAGA ATGGATAAGC CAGCCAACTG CACCAACGAA 1920

CTGTACATGA TGATGAGGGA CTGTTGGCAT GCAGTGCCCT CCCAGAGACC AACGTTCAAG 1980

CAGTTGGTAG AAGACTTGGA TCGAATTC 2008

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+

Q: 390   LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  449

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d ++++eeq+t+

Q: 450   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF  509

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt

Q: 510   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  569

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 570   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  629

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl

Q: 630   RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  666

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 120

KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

3D-structure; Alternative splicing; Apoptosis; ATP-binding; Cell membrane; Complete proteome; Craniosynostosis; Cytoplasmic vesicle; Disease mutation; Disulfide bond; Ectodermal dysplasia; Glycoprotein; Golgi apparatus; Heparin-binding; Immunoglobulin domain; Kinase; Lacrimo-auriculo-dento-digital syndrome; Membrane; Mental retardation; Nucleotide-binding; Phosphoprotein; Polymorphism; Proto-oncogene; Receptor; Reference proteome; Repeat; Secreted; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005938	; C:cell cortex
GO:0009986	; C:cell surface
GO:0016023	; C:cytoplasmic membrane-bounded vesicle
GO:0060076	; C:excitatory synapse
GO:0005576	; C:extracellular region
GO:0005794	; C:Golgi apparatus
GO:0005887	; C:integral to plasma membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0017134	; F:fibroblast growth factor binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008201	; F:heparin binding
GO:0001525	; P:angiogenesis
GO:0006915	; P:apoptotic process
GO:0007409	; P:axonogenesis
GO:0030282	; P:bone mineralization
GO:0060349	; P:bone morphogenesis
GO:0060667	; P:branch elongation involved in salivary gland morphogenesis
GO:0060670	; P:branching involved in labyrinthine layer morphogenesis
GO:0048755	; P:branching morphogenesis of a nerve
GO:0060449	; P:bud elongation involved in lung branching
GO:0045165	; P:cell fate commitment
GO:0007267	; P:cell-cell signaling
GO:0048557	; P:embryonic digestive tract morphogenesis
GO:0009880	; P:embryonic pattern specification
GO:0061031	; P:endodermal digestive tract morphogenesis
GO:0060664	; P:epithelial cell proliferation involved in salivary gland morphogenesis
GO:0035603	; P:fibroblast growth factor receptor signaling pathway involved in hemopoiesis
GO:0060595	; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0035602	; P:fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow
GO:0035607	; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0035604	; P:fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
GO:0031069	; P:hair follicle morphogenesis
GO:0008286	; P:insulin receptor signaling pathway
GO:0032808	; P:lacrimal gland development
GO:0060601	; P:lateral sprouting from an epithelium
GO:0070307	; P:lens fiber cell development
GO:0060174	; P:limb bud formation
GO:0048286	; P:lung alveolus development
GO:0060463	; P:lung lobe morphogenesis
GO:0060484	; P:lung-associated mesenchyme development
GO:0060615	; P:mammary gland bud formation
GO:0003149	; P:membranous septum morphogenesis
GO:0060915	; P:mesenchymal cell differentiation involved in lung development
GO:0060916	; P:mesenchymal cell proliferation involved in lung development
GO:0030901	; P:midbrain development
GO:0035264	; P:multicellular organism growth
GO:0008285	; P:negative regulation of cell proliferation
GO:0045839	; P:negative regulation of mitosis
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0007528	; P:neuromuscular junction development
GO:0042476	; P:odontogenesis
GO:0035265	; P:organ growth
GO:0030916	; P:otic vesicle formation
GO:0003148	; P:outflow tract septum morphogenesis
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0045787	; P:positive regulation of cell cycle
GO:0051781	; P:positive regulation of cell division
GO:0060501	; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374	; P:positive regulation of ERK1 and ERK2 cascade
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0010518	; P:positive regulation of phospholipase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009791	; P:post-embryonic development
GO:0060527	; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523	; P:prostate epithelial cord elongation
GO:0046777	; P:protein autophosphorylation
GO:0021860	; P:pyramidal neuron development
GO:0060687	; P:regulation of branching involved in prostate gland morphogenesis
GO:0010453	; P:regulation of cell fate commitment
GO:0040036	; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0040014	; P:regulation of multicellular organism growth
GO:0045667	; P:regulation of osteoblast differentiation
GO:0033688	; P:regulation of osteoblast proliferation
GO:0051150	; P:regulation of smooth muscle cell differentiation
GO:0008589	; P:regulation of smoothened signaling pathway
GO:0060529	; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0048489	; P:synaptic vesicle transport
GO:0001657	; P:ureteric bud development
GO:0055010	; P:ventricular cardiac muscle tissue morphogenesis
GO:0021847	; P:ventricular zone neuroblast division

KEGG

hsa:2263

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013