EKS-HOS-00455
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00455
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/PDHK216.94.2E-64236361126
StatusReviewed
Ensembl ProteinENSP00000368460
UniProt AccessionQ15120; B4DXG6;
Protein Name[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial
Protein Synonyms/Alias Pyruvate dehydrogenase kinase isoform 3;
Gene NamePDK3
Gene Synonyms/Alias PDK3; PDHK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000067992ENSP00000368460ENST00000379162
ENSG00000067992ENSP00000387536ENST00000441463
OrganismHomo sapiens
Functional DescriptionInhibits the mitochondrial pyruvate dehydrogenasecomplex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
Protein Length406
Protein Sequence
(FASTA)
MRLFRWLLKQ PVPKQIERYS RFSPSPLSIK QFLDFGRDNA CEKTSYMFLR KELPVRLANT 60
MREVNLLPDN LLNRPSVGLV QSWYMQSFLE LLEYENKSPE DPQVLDNFLQ VLIKVRNRHN 120
DVVPTMAQGV IEYKEKFGFD PFISTNIQYF LDRFYTNRIS FRMLINQHTL LFGGDTNPVH 180
PKHIGSIDPT CNVADVVKDA YETAKMLCEQ YYLVAPELEV EEFNAKAPDK PIQVVYVPSH 240
LFHMLFELFK NSMRATVELY EDRKEGYPAV KTLVTLGKED LSIKISDLGG GVPLRKIDRL 300
FNYMYSTAPR PSLEPTRAAP LAGFGYGLPI SRLYARYFQG DLKLYSMEGV GTDAVIYLKA 360
LSSESFERLP VFNKSAWRHY KTTPEADDWS NPSSEPRDAS KYKAKQ 406
Nucleotide Sequence
(FASTA)
ATGCGGCTGT TCCGGTGGCT GCTGAAGCAG CCGGTGCCCA AGCAGATCGA GCGCTACTCG 60
CGCTTTTCGC CGTCGCCGCT CTCCATCAAA CAATTCCTGG ACTTCGGGAG AGATAATGCA 120
TGTGAGAAAA CTTCATATAT GTTTCTACGA AAGGAACTTC CTGTGCGGCT GGCTAACACA 180
ATGAGAGAAG TTAATCTTCT GCCGGATAAT TTACTTAACC GCCCTTCAGT GGGATTGGTT 240
CAGAGTTGGT ATATGCAGAG TTTTCTTGAA CTTTTAGAAT ATGAAAATAA GAGCCCTGAG 300
GATCCACAGG TCTTGGATAA CTTTCTACAA GTTCTGATTA AAGTCAGAAA TAGACACAAT 360
GATGTGGTTC CTACAATGGC ACAAGGAGTG ATTGAATACA AGGAGAAGTT TGGGTTTGAT 420
CCTTTCATTA GCACTAACAT CCAATATTTT CTGGATCGGT TTTATACCAA CCGCATCTCT 480
TTCCGCATGC TTATTAATCA GCACACACTT CTGTTTGGGG GTGACACTAA TCCTGTTCAT 540
CCTAAACACA TAGGAAGTAT CGATCCCACC TGTAACGTGG CGGATGTGGT GAAAGATGCA 600
TATGAAACAG CCAAGATGCT GTGTGAACAG TATTACCTGG TAGCTCCAGA GCTGGAAGTT 660
GAAGAATTCA ATGCCAAAGC GCCAGACAAA CCTATTCAGG TGGTTTATGT GCCCTCACAT 720
CTGTTTCATA TGCTATTTGA GTTGTTCAAG AACTCAATGA GAGCGACAGT TGAACTCTAT 780
GAAGACAGAA AAGAGGGCTA CCCTGCTGTT AAAACCCTCG TTACTTTGGG TAAAGAAGAC 840
TTATCCATTA AGATCAGTGA CCTAGGTGGT GGTGTCCCAC TTCGAAAAAT AGATCGTCTT 900
TTTAACTACA TGTATTCTAC TGCTCCTAGA CCCAGCCTGG AGCCTACCAG AGCTGCCCCT 960
TTGGCTGGAT TTGGTTATGG TTTGCCAATT TCCCGTCTGT ATGCTAGATA TTTTCAAGGA 1020
GATCTGAAAC TGTATTCCAT GGAAGGAGTG GGTACTGATG CTGTCATTTA TTTGAAGGCT 1080
CTTTCAAGTG AGTCATTTGA GAGACTTCCA GTTTTTAATA AGTCCGCATG GCGCCATTAC 1140
AAGACCACGC CTGAAGCCGA TGATTGGAGC AATCCCAGCA GTGAACCCAG GGATGCTTCA 1200
AAATACAAAG CAAAACAGTA A 1221
Domain Profile
S: 1     yvpshlyyllfellknamratveshedkkv.lpdvkvlvalgkedliikisdrGGGvplr  59
         yvpshl+++lfel+kn+mratve +ed+k+ +p+vk+lv+lgkedl+ikisd GGGvplr
Q: 236   YVPSHLFHMLFELFKNSMRATVELYEDRKEgYPAVKTLVTLGKEDLSIKISDLGGGVPLR  295
         9***************************999*****************************
S: 60    kidrlldymystapapskddaraaplaGfGyGlpisrlyakylqGdlkllsleGiGtdav  119
         kidrl++ymystap+ps +++raaplaGfGyGlpisrlya+y+qGdlkl+s+eG+Gtdav
Q: 296   KIDRLFNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAV  355
         ************************************************************
S: 120   iylkal  125
         iylkal
Q: 356   IYLKAL  361
         ****85
Domain Sequence
(FASTA)
YVPSHLFHML FELFKNSMRA TVELYEDRKE GYPAVKTLVT LGKEDLSIKI SDLGGGVPLR 60
KIDRLFNYMY STAPRPSLEP TRAAPLAGFG YGLPISRLYA RYFQGDLKLY SMEGVGTDAV 120
IYLKAL 126
Keyword3D-structure; Alternative splicing; ATP-binding; Carbohydrate metabolism; Complete proteome; Glucose metabolism; Kinase; Mitochondrion; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>
EKS-AIM-00418
EKS-ANC-00434
EKS-BOT-00448
EKS-CAE-00378
EKS-CAJ-00453
EKS-CAF-00447
EKS-CAP-00482
EKS-CII-00254
EKS-DAR-00852
EKS-DRM-00211
EKS-EQC-00438
EKS-ERE-00045
EKS-FEC-00427
EKS-GAM-00260
EKS-GAG-00377
EKS-GAA-00542
EKS-GOG-00440
EKS-ICT-00427
EKS-LAC-00462
EKS-LOA-00455
EKS-MAM-00446
EKS-MOD-00437
EKS-MUM-00479
EKS-MUP-00441
EKS-MYL-00439
EKS-NOL-00407
EKS-OCP-00110
EKS-ORN-00565
EKS-ORC-00419
EKS-ORL-00517
EKS-OTG-00451
EKS-PAT-00423
EKS-PES-00394
EKS-PEM-00246
EKS-POA-00437
EKS-PTV-00156
EKS-RAN-00460
EKS-SAH-00414
EKS-SOA-00041
EKS-SUS-00395
EKS-TAG-00513
EKS-TAR-00559
EKS-TAS-00061
EKS-TEN-00562
EKS-TUB-00041
EKS-TUT-00159
EKS-VIP-00082
EKS-XET-00600
EKS-XIM-00559
EKS-SAC-00132
Gene Ontology
GO:0005759; C:mitochondrial matrix
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0006006; P:glucose metabolic process
GO:0006090; P:pyruvate metabolic process
GO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate
KEGG
hsa:5165;
InterPros
IPR003594; ATPase-like_ATP-bd.
IPR018955; BCDHK/PDK_N.
IPR005467; Sig_transdc_His_kinase_core.
Pfam
PF10436; BCDHK_Adom3; 1.
PF02518; HATPase_c; 1.
SMARTs
SM00387; HATPase_c; 1.
Prosites
PS50109; HIS_KIN; 1.
Prints
Created Date20-Feb-2013