EKS-HOS-00167

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00167

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	494.1	4.1E-148	326	583	258

Status

Reviewed

Ensembl Protein

ENSP00000386050

UniProt Accession

Q15349; B3KTK9; Q15419; Q59GJ3; Q5TI68; Q96J38; Q9UJN5;

Protein Name

Ribosomal protein S6 kinase alpha-2

Protein Synonyms/Alias

S6K-alpha-2; 90 kDa ribosomal protein S6 kinase 2; p90-RSK 2; p90RSK2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; Ribosomal S6 kinase 3; RSK-3; pp90RSK3;

Gene Name

RPS6KA2

Gene Synonyms/Alias

RPS6KA2; MAPKAPK1C, RSK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000071242	ENSP00000265678	ENST00000265678
ENSG00000071242	ENSP00000427015	ENST00000503859
ENSG00000071242	ENSP00000355828	ENST00000366863
ENSG00000071242	ENSP00000427605	ENST00000512860
ENSG00000071242	ENSP00000422484	ENST00000481261
ENSG00000071242	ENSP00000422435	ENST00000510118
ENSG00000071242	ENSP00000425148	ENST00000506565
ENSG00000071242	ENSP00000422197	ENST00000507350
ENSG00000071242	ENSP00000386050	ENST00000405189
ENSG00000071242	ENSP00000425458	ENST00000511034
ENSG00000071242	ENSP00000423114	ENST00000507371

Organism

Homo sapiens

Functional Description

Serine/threonine-protein kinase that acts downstream ofERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.

Protein Length

644

Protein Sequence
(FASTA)

MKVLKKATLK VRDRVRSKME RDILAEVNHP FIVKLHYAFQ TEGKLYLILD FLRGGDLFTR 60

LSKEVMFTEE DVKFYLAELA LALDHLHSLG IIYRDLKPEN ILLDEEGHIK ITDFGLSKEA 120

IDHDKRAYSF CGTIEYMAPE VVNRRGHTQS ADWWSFGVLM FEMLTGSLPF QGKDRKETMA 180

LILKAKLGMP QFLSGEAQSL LRALFKRNPC NRLGAGIDGV EEIKRHPFFV TIDWNTLYRK 240

EIKPPFKPAV GRPEDTFHFD PEFTARTPTD SPGVPPSANA HHLFRGFSFV ASSLIQEPSQ 300

QDLHKVPVHP IVQQLHGNNI HFTDGYEIKE DIGVGSYSVC KRCVHKATDT EYAVKIIDKS 360

KRDPSEEIEI LLRYGQHPNI ITLKDVYDDG KFVYLVMELM RGGELLDRIL RQRYFSEREA 420

SDVLCTITKT MDYLHSQGVV HRDLKPSNIL YRDESGSPES IRVCDFGFAK QLRAGNGLLM 480

TPCYTANFVA PEVLKRQGYD AACDIWSLGI LLYTMLAGFT PFANGPDDTP EEILARIGSG 540

KYALSGGNWD SISDAAKDVV SKMLHVDPHQ RLTAMQVLKH PWVVNREYLS PNQLSRQDVH 600

LVKGAMAATY FALNRTPQAP RLEPVLSSNL AQRRGMKRLT STRL 644

Nucleotide Sequence
(FASTA)

ATGAAGGTCC TTAAGAAAGC CACCCTAAAA GTTCGGGACC GAGTGAGATC GAAGATGGAG 60

AGAGACATCT TGGCAGAAGT GAATCACCCC TTCATTGTGA AGCTTCATTA TGCCTTTCAG 120

ACGGAAGGAA AGCTCTACCT GATCCTGGAC TTCCTGCGGG GAGGGGACCT CTTCACCCGG 180

CTCTCCAAAG AGGTCATGTT CACGGAGGAG GATGTCAAGT TCTACCTGGC TGAGCTGGCC 240

TTGGCTTTAG ACCATCTCCA CAGCCTGGGG ATCATCTACA GAGATCTGAA GCCTGAGAAC 300

ATCCTCCTGG ATGAAGAGGG GCACATTAAG ATCACAGATT TCGGCCTGAG TAAGGAGGCC 360

ATTGACCACG ACAAGAGAGC GTACTCCTTC TGCGGGACGA TCGAGTACAT GGCGCCCGAG 420

GTGGTGAACC GGCGAGGACA CACGCAGAGT GCCGACTGGT GGTCCTTCGG CGTGCTCATG 480

TTTGAGATGC TCACGGGGTC CCTGCCGTTC CAGGGGAAGG ACAGGAAGGA GACCATGGCT 540

CTCATCCTCA AAGCCAAGCT GGGGATGCCG CAGTTCCTCA GTGGGGAGGC ACAGAGTTTG 600

CTGCGAGCTC TCTTCAAACG GAACCCCTGC AACCGGCTGG GTGCTGGCAT TGACGGAGTG 660

GAGGAAATTA AGCGCCATCC CTTCTTTGTG ACCATAGACT GGAACACGCT GTACCGGAAG 720

GAGATCAAGC CACCGTTCAA ACCAGCAGTG GGCAGGCCTG AGGACACCTT CCACTTTGAC 780

CCCGAGTTCA CAGCGCGGAC GCCCACAGAC TCTCCTGGCG TCCCCCCGAG TGCAAACGCT 840

CATCACCTGT TTAGAGGATT CAGCTTTGTG GCCTCAAGCC TGATCCAGGA GCCCTCACAG 900

CAAGATCTGC ACAAAGTCCC AGTTCACCCA ATCGTGCAGC AGTTACACGG GAACAACATC 960

CACTTCACCG ATGGCTACGA GATCAAGGAG GACATCGGGG TGGGCTCCTA CTCAGTGTGC 1020

AAGCGATGTG TGCATAAAGC CACAGACACC GAGTATGCCG TGAAGATCAT TGATAAGAGC 1080

AAGAGAGACC CCTCGGAAGA GATTGAGATC CTCCTGCGGT ACGGCCAGCA CCCGAACATC 1140

ATCACCCTCA AGGATGTCTA TGATGATGGC AAGTTTGTGT ACCTGGTAAT GGAGCTGATG 1200

CGTGGTGGGG AGCTCCTGGA CCGCATCCTC CGGCAGAGAT ACTTCTCGGA GCGCGAAGCC 1260

AGTGACGTCC TGTGCACCAT CACCAAGACC ATGGACTACC TCCATTCCCA GGGGGTTGTT 1320

CATCGAGACC TGAAGCCGAG TAACATCCTG TACAGGGATG AGTCGGGGAG CCCAGAATCC 1380

ATCCGAGTCT GCGACTTCGG CTTTGCCAAG CAGCTGCGCG CGGGGAACGG GCTGCTCATG 1440

ACACCCTGCT ACACGGCCAA TTTCGTGGCC CCGGAGGTCC TGAAGCGTCA AGGCTATGAT 1500

GCGGCGTGTG ACATCTGGAG TTTGGGGATC CTGTTGTACA CCATGCTGGC AGGATTTACC 1560

CCTTTTGCAA ATGGGCCAGA CGATACCCCT GAGGAGATTC TGGCGCGGAT CGGCAGTGGG 1620

AAGTATGCCC TTTCTGGGGG AAACTGGGAC TCGATATCTG ACGCAGCTAA AGACGTCGTG 1680

TCCAAGATGC TCCACGTGGA CCCTCATCAG CGCCTGACGG CGATGCAAGT GCTCAAACAC 1740

CCGTGGGTGG TCAACAGAGA GTACCTGTCC CCAAACCAGC TCAGCCGACA GGACGTGCAC 1800

CTGGTGAAGG GCGCGATGGC CGCCACCTAC TTTGCTCTAA ACAGAACACC TCAGGCCCCG 1860

CGGCTGGAGC CCGTGCTGTC ATCCAACCTG GCTCAGCGCA GAGGCATGAA GAGACTCACG 1920

TCCACGCGGC TGTAG 1935

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         ye+ked+GvGsysvckrcvhkat++e+avkiidkskrd+seeieillry+qhpni+tlkd

Q: 326   YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKD  385

         789*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgk+vylv+el++GGelldri+++++fsereas++l+t++k+++ylh+qGvvhrdlk

Q: 386   VYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLK  445

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nily+des+++esi+++dfGfak++ra ngll+tpcyt+nfvapevlkrqGyd+acd+

Q: 446   PSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDI  505

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslG+llytmlaG++pfangp+dt+eeila+i++Gk++lsG++wds+s++akd+vsk+l+

Q: 506   WSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLH  565

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++q+lkh+w+

Q: 566   VDPHQRLTAMQVLKHPWV  583

         *****************7

Domain Sequence
(FASTA)

YEIKEDIGVG SYSVCKRCVH KATDTEYAVK IIDKSKRDPS EEIEILLRYG QHPNIITLKD 60

VYDDGKFVYL VMELMRGGEL LDRILRQRYF SEREASDVLC TITKTMDYLH SQGVVHRDLK 120

PSNILYRDES GSPESIRVCD FGFAKQLRAG NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180

WSLGILLYTM LAGFTPFANG PDDTPEEILA RIGSGKYALS GGNWDSISDA AKDVVSKMLH 240

VDPHQRLTAM QVLKHPWV 258

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Isopeptide bond; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Tumor suppressor; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005654	; C:nucleoplasm
GO:0005819	; C:spindle
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004711	; F:ribosomal protein S6 kinase activity
GO:0007411	; P:axon guidance
GO:0002035	; P:brain renin-angiotensin system
GO:0010659	; P:cardiac muscle cell apoptotic process
GO:0071322	; P:cellular response to carbohydrate stimulus
GO:0060047	; P:heart contraction
GO:0007507	; P:heart development
GO:0045087	; P:innate immune response
GO:0000089	; P:mitotic metaphase
GO:0002755	; P:MyD88-dependent toll-like receptor signaling pathway
GO:0045786	; P:negative regulation of cell cycle
GO:0008285	; P:negative regulation of cell proliferation
GO:0048011	; P:nerve growth factor receptor signaling pathway
GO:0001556	; P:oocyte maturation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043065	; P:positive regulation of apoptotic process
GO:0010628	; P:positive regulation of gene expression
GO:0070613	; P:regulation of protein processing
GO:0051403	; P:stress-activated MAPK cascade
GO:0007268	; P:synaptic transmission
GO:0008063	; P:Toll signaling pathway
GO:0034130	; P:toll-like receptor 1 signaling pathway
GO:0034134	; P:toll-like receptor 2 signaling pathway
GO:0034138	; P:toll-like receptor 3 signaling pathway
GO:0034142	; P:toll-like receptor 4 signaling pathway
GO:0035666	; P:TRIF-dependent toll-like receptor signaling pathway

KEGG

hsa:6196

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013