EKS-HOS-00341

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00341

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	312.6	1.1E-92	36	302	267

Status

Reviewed

Ensembl Protein

ENSP00000446237

UniProt Accession

Q8WXR4; B8ZZR2; Q53QE1; Q53T08; Q8IX64; Q8IX65; Q8IX66; Q8IX67; Q8IX68; Q96N94;

Protein Name

Myosin-IIIb

Protein Synonyms/Alias

Gene Name

MYO3B

Gene Synonyms/Alias

MYO3B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000071909	ENSP00000386497	ENST00000409044
ENSG00000071909	ENSP00000314650	ENST00000317935
ENSG00000071909	ENSP00000401160	ENST00000442690
ENSG00000071909	ENSP00000446237	ENST00000484338
ENSG00000071909	ENSP00000335100	ENST00000334231
ENSG00000071909	ENSP00000386213	ENST00000408978

Organism

Homo sapiens

Functional Description

Probable actin-based motor with a protein kinaseactivity.

Protein Length

1105

Protein Sequence
(FASTA)

MLQSALLSTR KHLYGLFHYN PMMLGLESLP DPTDTWEIIE TIGKGTYGKV YKVTNKRDGS 60

LAAVKILDPV SDMDEEIEAE YNILQFLPNH PNVVKFYGMF YKADHCVGGQ LWLVLELCNG 120

GSVTELVKGL LRCGQRLDEA MISYILYGAL LGLQHLHNNR IIHRDVKGNN ILLTTEGGVK 180

LVDFGVSAQL TSTRLRRNTS VGTPFWMAPE VIACEQQYDS SYDARCDVWS LGITAIELGD 240

GDPPLFDMHP VKTLFKIPRN PPPTLLHPEK WCEEFNHFIS QCLIKDFERR PSVTHLLDHP 300

FIKGVHGKVL FLQKQLAKVL QDQKHQNPVA KTRHERMHTR RPYHVEDAEK YCLEDDLVNL 360

EVLDEDTIIH QLQKRYADLL IYTYVGDILI ALNPFQNLSI YSPQFSRLYH GVKRASNPPH 420

IFASADAAYQ CMVTLSKDQC IVISGESGSG KTESAHLIVQ HLTFLGKANN QTLREKILQV 480

NSLVEAFGNS CTAINDNSSR FGKYLEMMFT PTGVVMGARI SEYLLEKSRV IKQAAREKNF 540

HIFYYIYAGL HHQKKLSDFR LPEEKPPRYI ADETGRVMHD ITSKESYRRQ FEAIQHCFRI 600

IGFTDKEVHS VYRILAGILN IGNIEFAAIS SQHQTDKSEV PNAEALQNAA SVLCISPEEL 660

QEALTSHCVV TRGETIIRAN TVDRAADVRD AMSKALYGRL FSWIVNRINT LLQPDENICS 720

AGGGMNVGIL DIFGFENFQR NSFEQLCINI ANEQIQYYFN QHVFALEQME YQNEGIDAVP 780

VEYEDNRPLL DMFLQKPLGL LALLDEESRF PQATDQTLVD KFEDNLRCKY FWRPKGVELC 840

FGIQHYAGKV LYDASGVLEK NRDTLPADVV VVLRTSENKL LQQLFSIPLT KTGNLAQTRA 900

RITVASSSLP PHFSAGKAKV DTLEVIRHPE ETTNMKRQTV ASYFRYSLMD LLSKMVVGQP 960

HFVRCIKPND DREALQFSRE RVLAQLRSTG ILETVSIRRQ GYSHRILFEE FVKRYYYLAF 1020

TAHQTPLASK ESCVAILEKS RLDHWVLGKT KVFLKYYHVE QLNLLLREVI GRVVVLQAYT 1080

KGWLGARRYK RVREKREKGA IAIQS 1105

Nucleotide Sequence
(FASTA)

ATGCTGCAGA GTGCTTTACT TTCAACAAGG AAACATCTGT ATGGATTATT TCACTATAAT 60

CCTATGATGC TTGGACTTGA ATCACTTCCA GATCCCACAG ACACCTGGGA AATTATAGAG 120

ACCATTGGTA AAGGCACCTA TGGCAAAGTC TACAAGGTAA CTAACAAGAG AGATGGGAGC 180

CTGGCTGCAG TGAAAATTCT GGATCCAGTC AGTGATATGG ATGAAGAAAT TGAGGCAGAA 240

TACAACATTT TGCAGTTCCT TCCTAATCAT CCCAATGTTG TAAAGTTTTA TGGGATGTTT 300

TACAAAGCGG ATCACTGTGT AGGGGGACAG CTGTGGCTGG TCCTGGAGCT GTGTAATGGG 360

GGCTCAGTCA CTGAGCTTGT CAAAGGTCTA CTCAGATGTG GCCAGCGGTT GGATGAAGCA 420

ATGATCTCAT ACATCTTGTA CGGGGCCCTC TTGGGCCTTC AGCATTTGCA CAACAACCGA 480

ATCATCCACC GTGATGTGAA GGGGAATAAC ATTCTTCTGA CAACAGAAGG AGGAGTTAAG 540

CTCGTTGACT TTGGTGTTTC AGCTCAACTC ACCAGTACAC GTCTGCGGAG AAACACATCT 600

GTTGGCACCC CGTTCTGGAT GGCCCCTGAG GTCATTGCCT GTGAGCAGCA GTATGACTCT 660

TCCTATGACG CTCGCTGTGA CGTCTGGTCC TTGGGGATCA CAGCTATTGA ACTGGGGGAT 720

GGAGACCCTC CCCTCTTTGA CATGCATCCT GTGAAAACAC TCTTTAAGAT TCCAAGAAAT 780

CCTCCACCTA CTTTACTTCA TCCAGAAAAA TGGTGTGAAG AATTCAACCA CTTTATTTCA 840

CAGTGTCTTA TTAAGGATTT TGAAAGGCGA CCTTCCGTCA CACATCTCCT TGACCACCCA 900

TTTATTAAAG GAGTACATGG AAAAGTTCTG TTTCTGCAAA AACAGCTGGC CAAGGTTCTC 960

CAAGACCAGA AGCATCAAAA TCCTGTTGCT AAAACCAGGC ATGAGAGGAT GCATACCAGA 1020

AGACCTTATC ATGTGGAAGA TGCTGAAAAA TACTGCCTTG AGGATGATTT GGTCAACCTA 1080

GAGGTTCTGG ATGAGGATAC AATTATCCAT CAGTTGCAGA AACGTTATGC AGACTTGCTA 1140

ATTTACACAT ATGTTGGAGA CATCTTAATT GCCTTAAACC CCTTCCAGAA TCTAAGCATA 1200

TACTCTCCAC AGTTTTCCAG ACTTTATCAT GGGGTGAAAC GCGCCTCCAA TCCCCCCCAC 1260

ATATTTGCAT CAGCAGATGC TGCTTACCAG TGCATGGTTA CTCTCAGCAA AGACCAGTGC 1320

ATTGTCATCA GCGGAGAGAG TGGCTCTGGG AAGACAGAAA GCGCCCACCT GATTGTTCAG 1380

CATTTGACTT TCTTGGGAAA GGCCAATAAT CAGACCTTGA GAGAGAAAAT TCTACAAGTC 1440

AACTCCCTGG TGGAAGCCTT TGGGAACTCA TGCACTGCCA TCAATGACAA CTCGAGCCGT 1500

TTTGGAAAAT ATCTGGAAAT GATGTTTACA CCAACTGGAG TTGTGATGGG GGCAAGAATC 1560

TCTGAATATC TCCTGGAAAA ATCCAGAGTT ATAAAACAGG CAGCGAGAGA GAAAAATTTT 1620

CATATATTTT ACTATATTTA TGCTGGTCTT CATCACCAAA AGAAGCTTTC TGATTTCAGA 1680

CTTCCTGAGG AAAAACCTCC TAGGTACATA GCTGATGAAA CTGGAAGGGT GATGCACGAC 1740

ATAACTTCCA AGGAGTCTTA CAGAAGACAA TTCGAAGCAA TTCAGCATTG CTTCAGGATT 1800

ATAGGGTTCA CGGACAAAGA GGTGCACTCA GTGTACAGAA TTTTGGCTGG GATTTTGAAT 1860

ATTGGGAACA TTGAGTTCGC AGCTATTTCC TCTCAACATC AGACTGATAA AAGTGAGGTG 1920

CCCAATGCTG AAGCTTTGCA AAATGCTGCC TCTGTTCTGT GCATTAGCCC TGAAGAGCTC 1980

CAGGAGGCCC TCACCTCCCA CTGTGTGGTC ACCCGGGGCG AGACCATCAT CCGTGCCAAC 2040

ACTGTAGACA GGGCTGCGGA CGTTCGAGAC GCCATGTCCA AAGCCCTGTA TGGGAGGCTC 2100

TTCAGCTGGA TTGTGAATCG CATTAATACA CTCCTGCAGC CAGACGAAAA CATATGTAGT 2160

GCAGGAGGTG GAATGAATGT GGGGATCTTG GATATCTTTG GATTCGAGAA TTTTCAGAGA 2220

AATTCATTTG AGCAGCTCTG CATAAACATC GCCAATGAGC AAATCCAGTA CTATTTCAAT 2280

CAGCATGTTT TTGCTCTTGA GCAGATGGAA TATCAGAATG AAGGCATTGA TGCTGTACCC 2340

GTGGAATATG AGGACAACCG CCCGCTCTTG GACATGTTCC TCCAGAAACC CCTGGGACTG 2400

CTTGCACTTT TGGATGAGGA AAGTCGGTTT CCCCAAGCAA CTGACCAGAC CCTGGTTGAT 2460

AAATTTGAAG ATAATCTACG ATGCAAATAC TTCTGGAGGC CCAAAGGAGT GGAACTGTGC 2520

TTTGGCATTC AGCATTATGC TGGAAAGGTA TTATATGATG CTTCTGGGGT TCTTGAGAAA 2580

AATAGAGACA CTCTCCCTGC CGATGTGGTT GTGGTCCTGA GAACGTCAGA AAACAAGCTT 2640

CTTCAGCAGC TCTTCTCAAT CCCTCTGACC AAAACAGGTA ATTTGGCCCA GACAAGAGCT 2700

AGGATAACAG TGGCCTCAAG TTCTTTGCCT CCACATTTCA GTGCTGGGAA AGCCAAGGTG 2760

GACACTCTGG AGGTGATACG GCATCCGGAA GAAACCACCA ACATGAAGAG GCAAACTGTG 2820

GCTTCTTACT TCCGGTATTC TCTGATGGAC CTGCTCTCCA AAATGGTGGT TGGACAGCCC 2880

CACTTTGTGC GCTGCATTAA ACCCAATGAT GACCGAGAGG CCCTGCAGTT CTCTCGAGAG 2940

AGGGTGCTGG CCCAGCTCCG CTCCACAGGG ATTCTGGAGA CAGTCAGCAT CCGCCGCCAG 3000

GGCTATTCCC ACCGCATCCT TTTTGAAGAA TTTGTGAAAA GGTATTATTA CTTGGCATTC 3060

ACAGCACATC AAACACCTCT TGCTAGCAAA GAGAGCTGTG TGGCTATCTT GGAAAAGTCC 3120

AGATTAGATC ACTGGGTACT GGGAAAAACA AAGGTTTTTC TCAAATATTA CCATGTTGAG 3180

CAATTAAATT TGCTGCTTCG AGAAGTCATA GGCAGAGTGG TTGTGCTGCA GGCATATACC 3240

AAGGGGTGGC TTGGAGCCAG GAGATACAAA AGGGTCAGAG AGAAGAGAGA GAAGGGAGCC 3300

ATTGCCATCC AGTCAG 3316

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkkl.khpniv  59

         +e++e+igkG++gkvy+ ++k+ g+l+a+k+++  + ++ ee++ e+++l+ l +hpn+v

Q: 36    WEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVS-DMDEEIEAEYNILQFLpNHPNVV  94

         799******************************998.9*************98356****

S: 60    eylesflk.....eeelwlvmeylagGslsdlvk..eelkselkEeqiayilrevlkaLe  112

         +++++f+k       +lwlv+e+++gGs+++lvk    + ++l+E  i+yil ++l +L+

Q: 95    KFYGMFYKadhcvGGQLWLVLELCNGGSVTELVKglLRCGQRLDEAMISYILYGALLGLQ  154

         *******99888889*******************777899********************

S: 113   ylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaq  172

         +lH++++iHrd+k++niLlt+eg VkL+dfgv+aql++tr +r+t vgtp+wmAPEvia+

Q: 155   HLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIAC  214

         ************************************************************

S: 173   e...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfske  229

         e   +++Yd+++D+wslGItaiel +g+pP++d++p+k l+ki++n+pp+l +++k+++e

Q: 215   EqqyDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKWCEE  274

         9888899*****************************************************

S: 230   fkefvekclqknpekRpsasellkhkFl  257

         f++f+++cl k++e+Rps+++ll+h+F+

Q: 275   FNHFISQCLIKDFERRPSVTHLLDHPFI  302

         ***************************7

Domain Sequence
(FASTA)

WEIIETIGKG TYGKVYKVTN KRDGSLAAVK ILDPVSDMDE EIEAEYNILQ FLPNHPNVVK 60

FYGMFYKADH CVGGQLWLVL ELCNGGSVTE LVKGLLRCGQ RLDEAMISYI LYGALLGLQH 120

LHNNRIIHRD VKGNNILLTT EGGVKLVDFG VSAQLTSTRL RRNTSVGTPF WMAPEVIACE 180

QQYDSSYDAR CDVWSLGITA IELGDGDPPL FDMHPVKTLF KIPRNPPPTL LHPEKWCEEF 240

NHFISQCLIK DFERRPSVTH LLDHPFI 267

Keyword

Actin-binding; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Motor protein; Myosin; Nucleotide-binding; Polymorphism; Reference proteome; Repeat; Sensory transduction; Serine/threonine-protein kinase; Transferase; Vision.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016459	; C:myosin complex
GO:0005524	; F:ATP binding
GO:0003774	; F:motor activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0050896	; P:response to stimulus
GO:0007601	; P:visual perception

KEGG

hsa:140469

;

InterPros

IPR000048	; IQ_motif_EF-hand-BS.
IPR011009	; Kinase-like_dom.
IPR001609	; Myosin_head_motor_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00612	; IQ; 1.
PF00063	; Myosin_head; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00015	; IQ; 2.
SM00242	; MYSc; 1.
SM00220	; S_TKc; 1.

Prosites

PS50096	; IQ; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00193

; MYOSINHEAVY.

Created Date

20-Feb-2013