EKS-HOS-00312

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00312

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/Alpha	267.7	3.9E-79	944	1151	208

Status

Reviewed

Ensembl Protein

ENSP00000426044

UniProt Accession

Q96QP1; B4E3G1; F5H138; Q68CI9; Q6P9F9; Q6ZNK4; Q9P201;

Protein Name

Alpha-protein kinase 1

Protein Synonyms/Alias

Chromosome 4 kinase; Lymphocyte alpha-protein kinase;

Gene Name

ALPK1

Gene Synonyms/Alias

ALPK1; KIAA1527, LAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000073331	ENSP00000424492	ENST00000509722
ENSG00000073331	ENSP00000426044	ENST00000504176
ENSG00000073331	ENSP00000423978	ENST00000515330
ENSG00000073331	ENSP00000425273	ENST00000515106
ENSG00000073331	ENSP00000398048	ENST00000458497
ENSG00000073331	ENSP00000177648	ENST00000177648
ENSG00000073331	ENSP00000425559	ENST00000505127

Organism

Homo sapiens

Functional Description

Kinase that recognizes phosphorylation sites in whichthe surrounding peptides have an alpha-helical conformation.

Protein Length

1166

Protein Sequence
(FASTA)

MCRKRTRART SAAEASLRAS ILARDCAAAA AIVFLVDRFL YGLDVSGKLL QVAKGLHKLQ 60

PATPIAPQVV IRQARISVNS GKLLKAEYIL SSLISNNGAT GTWLYRNESD KVLVQSVCIQ 120

IRGQILQKLG MWYEAAELIW ASIVGYLALP QPDKKGLSTS LGILADIFVS MSKNDYEKFK 180

NNPQINLSLL KEFDHHLLSA AEACKLAAAF SAYTPLFVLT AVNIRGTCLL SYSSSNDCPP 240

ELKNLHLCEA KEAFEIGLLT KRDDEPVTGK QELHSFVKAA FGLTTVHRRL HGETGTVHAA 300

SQLCKEAMGK LYNFSTSSRS QDREALSQEV MSVIAQVKEH LQVQSFSNVD DRSYVPESFE 360

CRLDKLILHG QGDFQKILDT YSQHHTSVCE VFESDCGNNK NEQKDAKTGV CITALKTEIK 420

NIDTVSTTQE KPHCQRDTGI SSSLMGKNVQ RELRRGGRRN WTHSDAFRVS LDQDVETETE 480

PSDYSNGEGA VFNKSLSGSQ TSSAWSNLSG FSSSASWEEV NYHVDDRSAR KEPGKEHLVD 540

TQCSTALSEE LENDREGRAM HSLHSQLHDL SLQEPNNDNL EPSQNQPQQQ MPLTPFSPHN 600

TPGIFLAPGA GLLEGAPEGI QEVRNMGPRN TSAHSRPSYR SASWSSDSGR PKNMGTHPSV 660

QKEEAFEIIV EFPETNCDVK DRQGKEQGEE ISERGAGPTF KASPSWVDPE GETAESTEDA 720

PLDFHRVLHN SLGNISMLPC SSFTPNWPVQ NPDSRKSGGP VAEQGIDPDA STVDEEGQLL 780

DSMDVPCTNG HGSHRLCILR QPPGQRAETP NSSVSGNILF PVLSEDCTTT EEGNQPGNML 840

NCSQNSSSSS VWWLKSPAFS SGSSEGDSPW SYLNSSGSSW VSLPGKMRKE ILEARTLQPD 900

DFEKLLAGVR HDWLFQRLEN TGVFKPSQLH RAHSALLLKY SKKSELWTAQ ETIVYLGDYL 960

TVKKKGRQRN AFWVHHLHQE EILGRYVGKD YKEQKGLWHH FTDVERQMTA QHYVTEFNKR 1020

LYEQNIPTQI FYIPSTILLI LEDKTIKGCI SVEPYILGEF VKLSNNTKVV KTEYKATEYG 1080

LAYGHFSYEF SNHRDVVVDL QGWVTGNGKG LIYLTDPQIH SVDQKVFTTN FGKRGIFYFF 1140

NNQHVECNEI CHRLSLTRPS MEKPCT 1166

Nucleotide Sequence
(FASTA)

ATGTGTCGGA AGAGGACAAG AGCGAGGACC AGCGCTGCAG AGGCGTCCCT GAGGGCCTCC 60

ATCCTCGCTC GGGACTGTGC GGCTGCGGCG GCTATTGTGT TCTTGGTGGA CCGGTTCCTG 120

TATGGGCTCG ACGTCTCTGG AAAACTTCTG CAGGTCGCCA AAGGTCTCCA CAAGTTGCAG 180

CCAGCCACGC CAATTGCCCC GCAGGTGGTT ATTCGCCAAG CCCGAATCTC CGTGAACTCA 240

GGAAAACTTT TAAAAGCAGA GTATATTCTG AGCAGTCTAA TAAGCAACAA TGGAGCAACG 300

GGTACCTGGC TGTACAGAAA TGAAAGTGAC AAGGTCCTGG TGCAGTCGGT CTGTATACAG 360

ATCAGAGGGC AGATTCTGCA AAAGCTGGGG ATGTGGTACG AAGCAGCAGA GTTAATATGG 420

GCCTCCATTG TAGGATATTT GGCACTTCCT CAGCCGGATA AAAAGGGCCT CTCCACGTCG 480

CTAGGTATAC TGGCAGACAT CTTTGTTTCC ATGAGCAAGA ACGATTATGA AAAGTTTAAA 540

AACAATCCAC AAATTAATTT GAGCCTGCTG AAGGAGTTTG ACCACCATTT GCTGTCCGCT 600

GCAGAAGCCT GCAAGCTGGC AGCTGCCTTC AGTGCCTATA CGCCGCTCTT CGTGCTCACA 660

GCTGTGAATA TCCGTGGCAC GTGTTTATTG TCCTACAGTA GTTCAAATGA CTGTCCTCCA 720

GAATTGAAAA ACTTACATCT GTGTGAAGCC AAAGAGGCCT TTGAGATTGG CCTCCTCACC 780

AAGAGAGATG ATGAGCCTGT TACTGGAAAA CAGGAGCTTC ACAGCTTTGT CAAAGCTGCT 840

TTCGGTCTCA CCACAGTGCA CAGAAGGCTC CATGGGGAGA CAGGGACGGT CCATGCAGCA 900

AGTCAGCTCT GTAAGGAAGC AATGGGGAAG CTGTACAATT TCAGCACTTC CTCCAGAAGT 960

CAGGACAGAG AAGCTCTGTC TCAAGAAGTT ATGTCTGTGA TTGCCCAGGT GAAGGAACAT 1020

TTACAAGTTC AAAGCTTCTC AAATGTAGAT GACAGATCTT ATGTTCCCGA GAGTTTCGAG 1080

TGCAGGTTGG ATAAACTTAT CTTGCATGGG CAAGGGGATT TCCAAAAAAT CCTTGACACC 1140

TATTCACAGC ACCATACTTC GGTGTGTGAA GTATTTGAAA GTGATTGTGG AAACAACAAA 1200

AATGAACAGA AAGATGCAAA AACAGGAGTC TGCATCACTG CTCTAAAAAC AGAAATAAAA 1260

AACATAGATA CTGTGAGTAC TACTCAAGAA AAGCCACATT GTCAAAGAGA CACAGGAATA 1320

TCTTCCTCCC TAATGGGTAA GAATGTTCAG AGGGAACTCA GAAGGGGAGG AAGGAGAAAC 1380

TGGACCCATT CTGATGCATT TCGAGTCTCC TTGGATCAAG ATGTGGAGAC TGAGACTGAG 1440

CCATCGGACT ACAGCAATGG TGAGGGAGCT GTTTTCAACA AGTCTCTGAG TGGCAGCCAG 1500

ACTTCCAGTG CTTGGAGCAA CTTATCAGGG TTTAGTTCCT CTGCAAGCTG GGAGGAAGTG 1560

AATTATCACG TTGACGACAG GTCAGCCAGA AAAGAGCCTG GCAAAGAACA TCTGGTGGAC 1620

ACTCAGTGTT CCACTGCCTT GTCTGAGGAG CTAGAGAATG ACAGGGAAGG CAGAGCTATG 1680

CATTCATTGC ATTCACAGCT TCATGATCTC TCTCTTCAGG AACCCAACAA TGACAATTTG 1740

GAGCCTTCTC AAAATCAGCC ACAGCAACAG ATGCCCTTGA CACCCTTCTC GCCTCATAAT 1800

ACCCCAGGCA TTTTCTTGGC CCCTGGTGCA GGGCTTCTAG AAGGAGCTCC AGAAGGTATC 1860

CAGGAAGTCA GAAATATGGG ACCCAGAAAT ACTTCTGCTC ACTCCAGACC CTCATATCGT 1920

TCTGCTTCTT GGTCTTCTGA TTCTGGTAGG CCCAAGAATA TGGGCACACA TCCTTCAGTC 1980

CAAAAAGAAG AAGCCTTTGA AATAATTGTT GAGTTTCCAG AAACCAACTG CGATGTCAAA 2040

GACAGGCAGG GGAAAGAGCA GGGAGAAGAA ATTAGTGAAA GAGGCGCAGG CCCTACATTT 2100

AAAGCTAGTC CCTCCTGGGT TGACCCAGAA GGAGAAACAG CAGAAAGCAC TGAAGATGCA 2160

CCCTTAGACT TTCACAGGGT CCTGCACAAT TCTCTGGGAA ACATTTCCAT GCTGCCATGT 2220

AGCTCCTTCA CCCCTAATTG GCCTGTTCAA AATCCTGACT CCAGAAAAAG TGGTGGCCCA 2280

GTCGCAGAGC AGGGCATCGA CCCTGATGCC TCCACAGTGG ATGAGGAGGG GCAACTGCTC 2340

GACAGCATGG ATGTTCCCTG CACAAATGGG CACGGCTCTC ATAGACTGTG CATTCTGAGA 2400

CAGCCGCCTG GTCAGAGGGC GGAGACCCCC AATTCCTCTG TAAGCGGTAA CATCCTCTTC 2460

CCTGTCCTCA GCGAGGACTG CACTACCACA GAGGAAGGAA ATCAGCCTGG AAACATGCTA 2520

AACTGCAGCC AGAACTCCAG CTCATCCTCA GTGTGGTGGC TGAAATCACC TGCATTTTCC 2580

AGTGGTTCTT CTGAGGGGGA CAGCCCTTGG TCCTATCTGA ATTCCAGTGG GAGTTCTTGG 2640

GTTTCATTGC CGGGAAAGAT GAGGAAAGAG ATCCTTGAGG CTCGCACCTT GCAACCTGAT 2700

GACTTTGAAA AGCTGTTGGC AGGAGTGAGG CATGATTGGC TGTTTCAGAG ACTAGAGAAT 2760

ACGGGGGTTT TTAAGCCCAG TCAACTCCAC CGAGCACATA GTGCTCTTTT GTTAAAATAT 2820

TCAAAAAAAT CTGAACTGTG GACGGCCCAG GAAACTATTG TCTATTTGGG GGACTACTTG 2880

ACTGTGAAGA AAAAAGGCAG ACAAAGAAAT GCTTTTTGGG TTCATCATCT TCATCAAGAA 2940

GAAATTCTGG GGAGGTATGT TGGGAAAGAC TATAAGGAGC AGAAGGGGCT CTGGCACCAC 3000

TTCACTGATG TGGAGCGACA GATGACCGCA CAGCACTATG TGACAGAATT TAACAAGAGA 3060

CTCTATGAAC AAAACATTCC CACCCAGATA TTCTACATCC CATCCACAAT ACTACTGATT 3120

TTAGAGGACA AGACAATAAA GGGATGTATC AGTGTGGAGC CTTACATACT GGGAGAATTT 3180

GTAAAATTGT CAAATAACAC GAAAGTGGTG AAAACAGAAT ACAAAGCCAC AGAATATGGC 3240

TTGGCCTATG GCCATTTTTC TTATGAGTTT TCTAATCATA GAGATGTTGT GGTCGATTTA 3300

CAAGGTTGGG TAACCGGTAA TGGAAAAGGA CTCATCTACC TCACAGATCC CCAGATTCAC 3360

TCCGTTGATC AGAAAGTTTT CACTACCAAT TTTGGAAAGA GAGGAATTTT TTACTTCTTT 3420

AATAACCAGC ATGTGGAATG TAATGAAATC TGCCATCGTC TTTCTTTGAC TAGACCTTCA 3480

ATGGAGAAAC CATGCACATA G 3501

Domain Profile

S: 2     sesWsqqetivlikvlskeekkGalRkalrvkkgslflvkeelkevvryvakiykeqkvl  61

         se+W++qetiv+++++++++kkG++R+a++v    ++l++ee+++  ryv+k+ykeqk+l

Q: 944   SELWTAQETIVYLGDYLTVKKKGRQRNAFWV----HHLHQEEILG--RYVGKDYKEQKGL  997

         799****************************....**********..*************

S: 62    hlylrdverqraaqklvtefn.....qvkPkkivyiprlievfLkdrtsknqlltvEeyl  116

         +++++dverq++aq++vtefn     q++P++i+yip++i+++L+d+t+k ++++vE+y+

Q: 998   WHHFTDVERQMTAQHYVTEFNkrlyeQNIPTQIFYIPSTILLILEDKTIK-GCISVEPYI  1056

         **************************************************.*********

S: 117   lGefvKynnnngdeikrenkleelmlafsHftyeytngellVvDlqG..vgek.....lT  169

         lGefvK++nn++ ++k+e+k++e++la++Hf+ye++n++++VvDlqG  +g++     lT

Q: 1057  LGEFVKLSNNTK-VVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGwvTGNGkgliyLT  1115

         ************.**********************************97777799*****

S: 170   DpqiatksrgtkfgkanlgeraiknFfakhh..CNeiC  205

         Dpqi++  +++k++++n+g+r+i++Ff+++h  CNeiC

Q: 1116  DPQIHS--VDQKVFTTNFGKRGIFYFFNNQHveCNEIC  1151

         ******..******************************

Domain Sequence
(FASTA)

SELWTAQETI VYLGDYLTVK KKGRQRNAFW VHHLHQEEIL GRYVGKDYKE QKGLWHHFTD 60

VERQMTAQHY VTEFNKRLYE QNIPTQIFYI PSTILLILED KTIKGCISVE PYILGEFVKL 120

SNNTKVVKTE YKATEYGLAY GHFSYEFSNH RDVVVDLQGW VTGNGKGLIY LTDPQIHSVD 180

QKVFTTNFGK RGIFYFFNNQ HVECNEIC 208

Keyword

Alternative splicing; Complete proteome; Kinase; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>