EKS-HOS-00247

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00247

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	388.7	5.3E-116	56	307	252

Status

Reviewed

Ensembl Protein

ENSP00000216288

UniProt Accession

P27448; O60219; Q86TT8; Q8TB41; Q8WX83; Q96RG1; Q9UMY9; Q9UN34;

Protein Name

MAP/microtubule affinity-regulating kinase 3

Protein Synonyms/Alias

C-TAK1; cTAK1; Cdc25C-associated protein kinase 1; ELKL motif kinase 2; EMK-2; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Par-1a; Serine/threonine-protein kinase p78;

Gene Name

MARK3

Gene Synonyms/Alias

MARK3; CTAK1, EMK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000075413	ENSP00000454169	ENST00000560417
ENSG00000075413	ENSP00000216288	ENST00000216288
ENSG00000075413	ENSP00000451623	ENST00000556744
ENSG00000075413	ENSP00000450460	ENST00000554627
ENSG00000075413	ENSP00000411397	ENST00000429436
ENSG00000075413	ENSP00000402104	ENST00000440884
ENSG00000075413	ENSP00000335347	ENST00000335102
ENSG00000075413	ENSP00000450772	ENST00000553942
ENSG00000075413	ENSP00000408092	ENST00000416682
ENSG00000075413	ENSP00000452893	ENST00000561314
ENSG00000075413	ENSP00000452829	ENST00000561225
ENSG00000075413	ENSP00000303698	ENST00000303622

Organism

Homo sapiens

Functional Description

Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.

Protein Length

713

Protein Sequence
(FASTA)

MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ PHIGNYRLLK 60

TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 120

VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARSKFR QIVSAVQYCH QKRIVHRDLK 180

AENLLLDADM NIKIADFGFS NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 240

VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 300

IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT 360

YLLLGRKSSE VRPSSDLNNS TGQSPHHKVQ RSVFSSQKQR RYSDHAGPAI PSVVAYPKRS 420

QTSTADSDLK EDGISSRKSS GSAVGGKGIA PASPMLGNAS NPNKADIPER KKSSTVPSSN 480

TASGGMTRRN TYVCSERTTA DRHSVIQNGK ENSTIPDQRT PVASTHSISS AATPDRIRFP 540

RGTASRSTFH GQPRERRTAT YNGPPASPSL SHEATPLSQT RSRGSTNLFS KLTSKLTRSR 600

NVSAEQKDEN KEAKPRSLRF TWSMKTTSSM DPGDMMREIR KVLDANNCDY EQRERFLLFC 660

VHGDGHAENL VQWEMEVCKL PRLSLNGVRF KRISGTSIAF KNIASKIANE LKL 713

Nucleotide Sequence
(FASTA)

ATGTCCACTA GGACCCCATT GCCAACGGTG AATGAACGAG ACACTGAAAA CCACACGTCA 60

CATGGAGATG GGCGTCAAGA AGTTACCTCT CGTACCAGCC GCTCAGGAGC TCGGTGTAGA 120

AACTCTATAG CCTCCTGTGC AGATGAACAA CCTCACATCG GAAACTACAG ACTGTTGAAA 180

ACAATCGGCA AGGGGAATTT TGCAAAAGTA AAATTGGCAA GACATATCCT TACAGGCAGA 240

GAGGTTGCAA TAAAAATAAT TGACAAAACT CAGTTGAATC CAACAAGTCT ACAAAAGCTC 300

TTCAGAGAAG TAAGAATAAT GAAGATTTTA AATCATCCCA ATATAGTGAA GTTATTCGAA 360

GTCATTGAAA CTGAAAAAAC ACTCTACCTA ATCATGGAAT ATGCAAGTGG AGGTGAAGTA 420

TTTGACTATT TGGTTGCACA TGGCAGGATG AAGGAAAAAG AAGCAAGATC TAAATTTAGA 480

CAGATTGTGT CTGCAGTTCA ATACTGCCAT CAGAAACGGA TCGTACATCG AGACCTCAAG 540

GCTGAAAATC TATTGTTAGA TGCCGATATG AACATTAAAA TAGCAGATTT CGGTTTTAGC 600

AATGAATTTA CTGTTGGCGG TAAACTCGAC ACGTTTTGTG GCAGTCCTCC ATACGCAGCA 660

CCTGAGCTCT TCCAGGGCAA GAAATATGAC GGGCCAGAAG TGGATGTGTG GAGTCTGGGG 720

GTCATTTTAT ACACACTAGT CAGTGGCTCA CTTCCCTTTG ATGGGCAAAA CCTAAAGGAA 780

CTGAGAGAGA GAGTATTAAG AGGGAAATAC AGAATTCCCT TCTACATGTC TACAGACTGT 840

GAAAACCTTC TCAAACGTTT CCTGGTGCTA AATCCAATTA AACGCGGCAC TCTAGAGCAA 900

ATCATGAAGG ACAGGTGGAT CAATGCAGGG CATGAAGAAG ATGAACTCAA ACCATTTGTT 960

GAACCAGAGC TAGACATCTC AGACCAAAAA AGAATAGATA TTATGGTGGG AATGGGATAT 1020

TCACAAGAAG AAATTCAAGA ATCTCTTAGT AAGATGAAAT ACGATGAAAT CACAGCTACA 1080

TATTTGTTAT TGGGGAGAAA ATCTTCAGAG GTTAGGCCGA GCAGTGATCT CAACAACAGT 1140

ACTGGCCAGT CTCCTCACCA CAAAGTGCAG AGAAGTGTTT TTTCAAGCCA AAAGCAAAGA 1200

CGCTACAGTG ACCATGCTGG ACCAGCTATT CCTTCTGTTG TGGCGTATCC GAAAAGGAGT 1260

CAGACCAGCA CTGCAGATAG TGACCTCAAA GAAGATGGAA TTTCCTCCCG GAAATCAAGT 1320

GGCAGTGCTG TTGGAGGAAA GGGAATTGCT CCAGCCAGTC CCATGCTTGG GAATGCAAGT 1380

AATCCTAATA AGGCGGATAT TCCTGAACGC AAGAAAAGCT CCACTGTCCC TAGTAGTAAC 1440

ACAGCATCTG GTGGAATGAC ACGACGAAAT ACTTATGTTT GCAGTGAGAG AACTACAGCT 1500

GATAGACACT CAGTGATTCA GAATGGCAAA GAAAACAGCA CTATTCCTGA TCAGAGAACT 1560

CCAGTTGCTT CAACACACAG TATCAGTAGT GCAGCCACCC CAGATCGAAT CCGCTTCCCA 1620

AGAGGCACTG CCAGTCGTAG CACTTTCCAC GGCCAGCCCC GGGAACGGCG AACCGCAACA 1680

TATAATGGCC CTCCTGCCTC TCCCAGCCTG TCCCATGAAG CCACACCATT GTCCCAGACT 1740

CGAAGCCGAG GCTCCACTAA TCTCTTTAGT AAATTAACTT CAAAACTCAC AAGGAGTCGC 1800

AATGTATCTG CTGAGCAAAA AGATGAAAAC AAAGAAGCAA AGCCTCGATC CCTACGCTTC 1860

ACCTGGAGCA TGAAAACCAC TAGTTCAATG GATCCCGGGG ACATGATGCG GGAAATCCGC 1920

AAAGTGTTGG ACGCCAATAA CTGCGACTAT GAGCAGAGGG AGCGCTTCTT GCTCTTCTGC 1980

GTCCACGGAG ATGGGCACGC GGAGAACCTC GTGCAGTGGG AAATGGAAGT GTGCAAGCTG 2040

CCAAGACTGT CTCTGAACGG GGTCCGGTTT AAGCGGATAT CGGGGACATC CATAGCCTTC 2100

AAAAATATTG CTTCCAAAAT TGCCAATGAG CTAAAGCTGT AA 2142

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++va+Kii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 56    YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  115

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lyl++eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k+iv

Q: 116   VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV  175

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g +l+tfcGsppYaaPel++gkkY+gp+vD

Q: 176   HRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVD  235

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+++Lv +p kR

Q: 236   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR  295

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 296   GTLEQIMKDRWI  307

         ***********7

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGREVAIK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLIMEYA SGGEVFDYLV AHGRMKEKEA RSKFRQIVSA VQYCHQKRIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GGKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK RFLVLNPIKR 240

GTLEQIMKDR WI 252

Keyword

3D-structure; Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

hsa:4140

;

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013