EKS-HOS-00154

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00154

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	555.4	8.7E-167	387	663	277

Status

Reviewed

Ensembl Protein

ENSP00000327229

UniProt Accession

P11362; A8K6T9; A8K8V5; C1KBH8; P17049; Q02063; Q02065; Q14306; Q14307; Q53H63; Q59H40; Q5BJG2; Q8N685; Q9UD50; Q9UDF0; Q9UDF1; Q9UDF2;

Protein Name

Fibroblast growth factor receptor 1

Protein Synonyms/Alias

FGFR-1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr;

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1; BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000077782	ENSP00000380302	ENST00000397113
ENSG00000077782	ENSP00000340636	ENST00000341462
ENSG00000077782	ENSP00000434869	ENST00000533668
ENSG00000077782	ENSP00000432972	ENST00000532791
ENSG00000077782	ENSP00000434473	ENST00000530568
ENSG00000077782	ENSP00000392645	ENST00000434187
ENSG00000077782	ENSP00000398318	ENST00000440174
ENSG00000077782	ENSP00000435283	ENST00000529552
ENSG00000077782	ENSP00000327229	ENST00000326324
ENSG00000077782	ENSP00000393312	ENST00000425967
ENSG00000077782	ENSP00000435254	ENST00000487647
ENSG00000077782	ENSP00000434712	ENST00000525001
ENSG00000077782	ENSP00000380297	ENST00000397108
ENSG00000077782	ENSP00000433569	ENST00000526742
ENSG00000077782	ENSP00000348537	ENST00000356207
ENSG00000077782	ENSP00000434800	ENST00000531196
ENSG00000077782	ENSP00000337247	ENST00000335922
ENSG00000077782	ENSP00000380292	ENST00000397103
ENSG00000077782	ENSP00000380280	ENST00000397091
ENSG00000077782	ENSP00000433163	ENST00000484370
ENSG00000077782	ENSP00000400162	ENST00000447712
ENSG00000077782	ENSP00000400708	ENST00000413133

Organism

Homo sapiens

Functional Description

Tyrosine-protein kinase that acts as cell-surfacereceptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

Protein Length

731

Protein Sequence
(FASTA)

MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ DALPSSEDDD DDDDSSSEEK ETDNTKPNPV 60

APYWTSPEKM EKKLHAVPAA KTVKFKCPSS GTPNPTLRWL KNGKEFKPDH RIGGYKVRYA 120

TWSIIMDSVV PSDKGNYTCI VENEYGSINH TYQLDVVERS PHRPILQAGL PANKTVALGS 180

NVEFMCKVYS DPQPHIQWLK HIEVNGSKIG PDNLPYVQIL KTAGVNTTDK EMEVLHLRNV 240

SFEDAGEYTC LAGNSIGLSH HSAWLTVLEA LEERPAVMTS PLYLEIIIYC TGAFLISCMV 300

GSVIVYKMKS GTKKSDFHSQ MAVHKLAKSI PLRRQVTVSA DSSASMNSGV LLVRPSRLSS 360

SGTPMLAGVS EYELPEDPRW ELPRDRLVLG KPLGEGCFGQ VVLAEAIGLD KDKPNRVTKV 420

AVKMLKSDAT EKDLSDLISE MEMMKMIGKH KNIINLLGAC TQDGPLYVIV EYASKGNLRE 480

YLQARRPPGL EYCYNPSHNP EEQLSSKDLV SCAYQVARGM EYLASKKCIH RDLAARNVLV 540

TEDNVMKIAD FGLARDIHHI DYYKKTTNGR LPVKWMAPEA LFDRIYTHQS DVWSFGVLLW 600

EIFTLGGSPY PGVPVEELFK LLKEGHRMDK PSNCTNELYM MMRDCWHAVP SQRPTFKQLV 660

EDLDRIVALT SNQEYLDLSM PLDQYSPSFP DTRSSTCSSG EDSVFSHEPL PEEPCLPRHP 720

AQLANGGLKR R 731

Nucleotide Sequence
(FASTA)

ATGTGGAGCT GGAAGTGCCT CCTCTTCTGG GCTGTGCTGG TCACAGCCAC ACTCTGCACC 60

GCTAGGCCGT CCCCGACCTT GCCTGAACAA GATGCTCTCC CCTCCTCGGA GGATGATGAT 120

GATGATGATG ACTCCTCTTC AGAGGAGAAA GAAACAGATA ACACCAAACC AAACCCCGTA 180

GCTCCATATT GGACATCCCC AGAAAAGATG GAAAAGAAAT TGCATGCAGT GCCGGCTGCC 240

AAGACAGTGA AGTTCAAATG CCCTTCCAGT GGGACCCCAA ACCCCACACT GCGCTGGTTG 300

AAAAATGGCA AAGAATTCAA ACCTGACCAC AGAATTGGAG GCTACAAGGT CCGTTATGCC 360

ACCTGGAGCA TCATAATGGA CTCTGTGGTG CCCTCTGACA AGGGCAACTA CACCTGCATT 420

GTGGAGAATG AGTACGGCAG CATCAACCAC ACATACCAGC TGGATGTCGT GGAGCGGTCC 480

CCTCACCGGC CCATCCTGCA AGCAGGGTTG CCCGCCAACA AAACAGTGGC CCTGGGTAGC 540

AACGTGGAGT TCATGTGTAA GGTGTACAGT GACCCGCAGC CGCACATCCA GTGGCTAAAG 600

CACATCGAGG TGAATGGGAG CAAGATTGGC CCAGACAACC TGCCTTATGT CCAGATCTTG 660

AAGACTGCTG GAGTTAATAC CACCGACAAA GAGATGGAGG TGCTTCACTT AAGAAATGTC 720

TCCTTTGAGG ACGCAGGGGA GTATACGTGC TTGGCGGGTA ACTCTATCGG ACTCTCCCAT 780

CACTCTGCAT GGTTGACCGT TCTGGAAGCC CTGGAAGAGA GGCCGGCAGT GATGACCTCG 840

CCCCTGTACC TGGAGATCAT CATCTATTGC ACAGGGGCCT TCCTCATCTC CTGCATGGTG 900

GGGTCGGTCA TCGTCTACAA GATGAAGAGT GGTACCAAGA AGAGTGACTT CCACAGCCAG 960

ATGGCTGTGC ACAAGCTGGC CAAGAGCATC CCTCTGCGCA GACAGGTAAC AGTGTCTGCT 1020

GACTCCAGTG CATCCATGAA CTCTGGGGTT CTTCTGGTTC GGCCATCACG GCTCTCCTCC 1080

AGTGGGACTC CCATGCTAGC AGGGGTCTCT GAGTATGAGC TTCCCGAAGA CCCTCGCTGG 1140

GAGCTGCCTC GGGACAGACT GGTCTTAGGC AAACCCCTGG GAGAGGGCTG CTTTGGGCAG 1200

GTGGTGTTGG CAGAGGCTAT CGGGCTGGAC AAGGACAAAC CCAACCGTGT GACCAAAGTG 1260

GCTGTGAAGA TGTTGAAGTC GGACGCAACA GAGAAAGACT TGTCAGACCT GATCTCAGAA 1320

ATGGAGATGA TGAAGATGAT CGGGAAGCAT AAGAATATCA TCAACCTGCT GGGGGCCTGC 1380

ACGCAGGATG GTCCCTTGTA TGTCATCGTG GAGTATGCCT CCAAGGGCAA CCTGCGGGAG 1440

TACCTGCAGG CCCGGAGGCC CCCAGGGCTG GAATACTGCT ACAACCCCAG CCACAACCCA 1500

GAGGAGCAGC TCTCCTCCAA GGACCTGGTG TCCTGCGCCT ACCAGGTGGC CCGAGGCATG 1560

GAGTATCTGG CCTCCAAGAA GTGCATACAC CGAGACCTGG CAGCCAGGAA TGTCCTGGTG 1620

ACAGAGGACA ATGTGATGAA GATAGCAGAC TTTGGCCTCG CACGGGACAT TCACCACATC 1680

GACTACTATA AAAAGACAAC CAACGGCCGA CTGCCTGTGA AGTGGATGGC ACCCGAGGCA 1740

TTATTTGACC GGATCTACAC CCACCAGAGT GATGTGTGGT CTTTCGGGGT GCTCCTGTGG 1800

GAGATCTTCA CTCTGGGCGG CTCCCCATAC CCCGGTGTGC CTGTGGAGGA ACTTTTCAAG 1860

CTGCTGAAGG AGGGTCACCG CATGGACAAG CCCAGTAACT GCACCAACGA GCTGTACATG 1920

ATGATGCGGG ACTGCTGGCA TGCAGTGCCC TCACAGAGAC CCACCTTCAA GCAGCTGGTG 1980

GAAGACCTGG ACCGCATCGT GGCCTTGACC TCCAACCAGG AGTACCTGGA CCTGTCCATG 2040

CCCCTGGACC AGTACTCCCC CAGCTTTCCC GACACCCGGA GCTCTACGTG CTCCTCAGGG 2100

GAGGATTCCG TCTTCTCTCA TGAGCCGCTG CCCGAGGAGC CCTGCCTGCC CCGACACCCA 2160

GCCCAGCTTG CCAATGGCGG ACTCAAACGC CGCTGA 2196

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 387   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  446

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++

Q: 447   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  506

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 507   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  566

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 567   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  626

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 627   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  663

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

3D-structure; Alternative splicing; ATP-binding; Cell membrane; Chromosomal rearrangement; Complete proteome; Craniosynostosis; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; Disease mutation; Disulfide bond; Dwarfism; Glycoprotein; Heparin-binding; Hypogonadotropic hypogonadism; Immunoglobulin domain; Kallmann syndrome; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transcription; Transcription regulation; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016023	; C:cytoplasmic membrane-bounded vesicle
GO:0005829	; C:cytosol
GO:0005576	; C:extracellular region
GO:0005887	; C:integral to plasma membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0017134	; F:fibroblast growth factor binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008201	; F:heparin binding
GO:0001525	; P:angiogenesis
GO:0060117	; P:auditory receptor cell development
GO:0007411	; P:axon guidance
GO:0060445	; P:branching involved in salivary gland morphogenesis
GO:0048469	; P:cell maturation
GO:0021954	; P:central nervous system neuron development
GO:0002062	; P:chondrocyte differentiation
GO:0043009	; P:chordate embryonic development
GO:0030326	; P:embryonic limb morphogenesis
GO:0035607	; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0001701	; P:in utero embryonic development
GO:0042472	; P:inner ear morphogenesis
GO:0008286	; P:insulin receptor signaling pathway
GO:0060484	; P:lung-associated mesenchyme development
GO:0000165	; P:MAPK cascade
GO:0048762	; P:mesenchymal cell differentiation
GO:0030901	; P:midbrain development
GO:0042474	; P:middle ear morphogenesis
GO:0021837	; P:motogenic signaling involved in postnatal olfactory bulb interneuron migration
GO:0043066	; P:negative regulation of apoptotic process
GO:0045668	; P:negative regulation of osteoblast differentiation
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0001764	; P:neuron migration
GO:0001759	; P:organ induction
GO:0042473	; P:outer ear morphogenesis
GO:0048339	; P:paraxial mesoderm development
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0048015	; P:phosphatidylinositol-mediated signaling
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0045787	; P:positive regulation of cell cycle
GO:0008284	; P:positive regulation of cell proliferation
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0043410	; P:positive regulation of MAPK cascade
GO:0090080	; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045666	; P:positive regulation of neuron differentiation
GO:0010976	; P:positive regulation of neuron projection development
GO:0014068	; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0051930	; P:regulation of sensory perception of pain
GO:0072091	; P:regulation of stem cell proliferation
GO:0007605	; P:sensory perception of sound
GO:0048705	; P:skeletal system morphogenesis
GO:0019827	; P:stem cell maintenance
GO:0006351	; P:transcription, DNA-dependent
GO:0001657	; P:ureteric bud development
GO:0021847	; P:ventricular zone neuroblast division

KEGG

hsa:2260

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013