EKS-HOS-00242

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00242

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	403.8	1.5E-120	49	333	285

Status

Reviewed

Ensembl Protein

ENSP00000339573

UniProt Accession

Q9BUB5; D3DQ20; D3DQ21; O00312; Q5TC06; Q5TC07; Q6V0N6;

Protein Name

MAP kinase-interacting serine/threonine-protein kinase 1

Protein Synonyms/Alias

MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1;

Gene Name

MKNK1

Gene Synonyms/Alias

MKNK1; MNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000079277	ENSP00000339573	ENST00000341183
ENSG00000079277	ENSP00000432369	ENST00000474868
ENSG00000079277	ENSP00000431837	ENST00000532783
ENSG00000079277	ENSP00000435163	ENST00000529170
ENSG00000079277	ENSP00000433038	ENST00000528077
ENSG00000079277	ENSP00000434493	ENST00000531355
ENSG00000079277	ENSP00000432665	ENST00000528237
ENSG00000079277	ENSP00000436709	ENST00000496619
ENSG00000079277	ENSP00000361017	ENST00000371949
ENSG00000079277	ENSP00000339197	ENST00000342571
ENSG00000079277	ENSP00000434021	ENST00000531769
ENSG00000079277	ENSP00000361013	ENST00000371945
ENSG00000079277	ENSP00000361014	ENST00000371946
ENSG00000079277	ENSP00000361012	ENST00000371944
ENSG00000079277	ENSP00000411135	ENST00000428112
ENSG00000079277	ENSP00000434834	ENST00000465783
ENSG00000079277	ENSP00000431985	ENST00000532110
ENSG00000079277	ENSP00000434051	ENST00000526513
ENSG00000079277	ENSP00000435069	ENST00000524749
ENSG00000079277	ENSP00000440974	ENST00000545730

Organism

Homo sapiens

Functional Description

May play a role in the response to environmental stressand cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7- methylguanosine-containing mRNA cap.

Protein Length

347

Protein Sequence
(FASTA)

MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL TSELLGEGAY 60

AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ CQGNKNILEL IEFFEDDTRF 120

YLVFEKLQGG SILAHIQKQK HFNEREASRV VRDVAAALDF LHTKGIAHRD LKPENILCES 180

PEKVSPVKIC DFDLGSGMKL NNSCTPITTP ELTTPCGSAE YMAPEVVEVF TDQATFYDKR 240

CDLWSLGVVL YIMLSGYPPF VGHCGADCGW DRGEVCRVCQ NKLFESIQEG KYEFPDKDWA 300

HISSEAKDLI SKLLVRDAKQ RLSAAQVLQH PWVQGEQQHN GPDALRS 347

Nucleotide Sequence
(FASTA)

ATGGTATCTT CTCAAAAGTT GGAAAAACCT ATAGAGATGG GCAGTAGCGA ACCCCTTCCC 60

ATCGCAGATG GTGACAGGAG GAGGAAGAAG AAGCGGAGGG GCCGGGCCAC TGACTCCTTG 120

CCAGGAAAGT TTGAAGATAT GTACAAGCTG ACCTCTGAAT TGCTTGGAGA GGGAGCCTAT 180

GCCAAAGTTC AAGGTGCCGT GAGCCTACAG AATGGCAAAG AGTATGCCGT CAAAATCATC 240

GAGAAACAAG CAGGGCACAG TCGGAGTAGG GTGTTTCGAG AGGTGGAGAC GCTGTATCAG 300

TGTCAGGGAA ACAAGAACAT TTTGGAGCTG ATTGAGTTCT TTGAAGATGA CACAAGGTTT 360

TACTTGGTCT TTGAGAAATT GCAAGGAGGT TCCATCTTAG CCCACATCCA GAAGCAAAAG 420

CACTTCAATG AGCGAGAAGC CAGCCGAGTG GTGCGGGACG TTGCTGCTGC CCTTGACTTC 480

CTGCATACCA AAGGCATTGC TCATCGTGAT CTGAAACCAG AAAATATATT GTGTGAATCT 540

CCAGAAAAGG TGTCTCCAGT GAAAATCTGT GACTTTGACT TGGGCAGTGG GATGAAACTG 600

AACAACTCCT GTACCCCCAT AACCACACCA GAGCTGACCA CCCCATGTGG CTCTGCAGAA 660

TACATGGCCC CTGAGGTAGT GGAGGTCTTC ACGGACCAGG CCACATTCTA CGACAAGCGC 720

TGTGACCTGT GGAGCCTGGG CGTGGTCCTC TACATCATGC TGAGTGGCTA CCCACCCTTC 780

GTGGGTCACT GCGGGGCCGA CTGTGGCTGG GACCGGGGCG AGGTCTGCAG GGTGTGCCAG 840

AACAAGCTGT TTGAAAGCAT CCAGGAAGGC AAGTATGAGT TTCCTGACAA GGACTGGGCA 900

CACATCTCCA GTGAAGCCAA AGACCTCATC TCCAAGCTCC TGGTGCGAGA TGCAAAGCAG 960

AGACTTAGCG CCGCCCAAGT TCTGCAGCAC CCATGGGTGC AGGGGGAACA GCAGCACAAT 1020

GGACCTGACG CTCTTCGCAG CTGA 1044

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghkniv  55

         klt+e+lGeG+++kv+ +v+ ++g++ya+ki+     ++r++v+reve+++q++g+kni+

Q: 49    KLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIekqagHSRSRVFREVETLYQCQGNKNIL  108

         5799********************************************************

S: 56    elidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhsk  115

         eli++fe    d++r++lv+ekl+GG++l++iq++k+f+e+eas+vv+d+a+al+flh+k

Q: 109   ELIEFFE----DDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK  164

         *******....*************************************************

S: 116   niahrDlkpenlLyeskeknapvklcDfglaketeee........eelktpcltaeyvaP  167

         +iahrDlkpen+L+es+ek++pvk+cDf+l+++++ +        +el+tpc++aey+aP

Q: 165   GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNnsctpittPELTTPCGSAEYMAP  224

         *********************************943346899999***************

S: 168   evleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskklk  216

         ev+e+++++a++ydk+CDlWslGv+lyi+l+GypPf++++g           r +++kl+

Q: 225   EVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGadcgwdrgevcRVCQNKLF  284

         ****************************************99******************

S: 217   eriqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         e+iqegkyefP+++W+++s+eakdli+klL+rd+k+rl++++vl+hpwv

Q: 285   ESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV  333

         ************************************************8

Domain Sequence
(FASTA)

KLTSELLGEG AYAKVQGAVS LQNGKEYAVK IIEKQAGHSR SRVFREVETL YQCQGNKNIL 60

ELIEFFEDDT RFYLVFEKLQ GGSILAHIQK QKHFNEREAS RVVRDVAAAL DFLHTKGIAH 120

RDLKPENILC ESPEKVSPVK ICDFDLGSGM KLNNSCTPIT TPELTTPCGS AEYMAPEVVE 180

VFTDQATFYD KRCDLWSLGV VLYIMLSGYP PFVGHCGADC GWDRGEVCRV CQNKLFESIQ 240

EGKYEFPDKD WAHISSEAKD LISKLLVRDA KQRLSAAQVL QHPWV 285

Keyword

3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Translation regulation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008543	; P:fibroblast growth factor receptor signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0006417	; P:regulation of translation

KEGG

hsa:8569

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013