EKS-HOS-00211

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00211

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/RCK	457.4	8.9E-137	4	285	282

Status

Reviewed

Ensembl Protein

ENSP00000355304

UniProt Accession

Q9UQ07; Q92790; Q93067;

Protein Name

MAPK/MAK/MRK overlapping kinase

Protein Synonyms/Alias

MOK protein kinase; Renal tumor antigen 1; RAGE-1;

Gene Name

MOK

Gene Synonyms/Alias

MOK; RAGE, RAGE1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000080823	ENSP00000429672	ENST00000519058
ENSG00000080823	ENSP00000453762	ENST00000523231
ENSG00000080823	ENSP00000193029	ENST00000193029
ENSG00000080823	ENSP00000355304	ENST00000361847
ENSG00000080823	ENSP00000429348	ENST00000521766
ENSG00000080823	ENSP00000427884	ENST00000524207
ENSG00000080823	ENSP00000429511	ENST00000517537
ENSG00000080823	ENSP00000454098	ENST00000522867
ENSG00000080823	ENSP00000452978	ENST00000524370
ENSG00000080823	ENSP00000430775	ENST00000521388
ENSG00000080823	ENSP00000429469	ENST00000522874
ENSG00000080823	ENSP00000429570	ENST00000518399
ENSG00000080823	ENSP00000454203	ENST00000522534
ENSG00000080823	ENSP00000428942	ENST00000524214
ENSG00000080823	ENSP00000428957	ENST00000520238
ENSG00000080823	ENSP00000453950	ENST00000561150
ENSG00000080823	ENSP00000454829	ENST00000562292
ENSG00000080823	ENSP00000430416	ENST00000521937
ENSG00000080823	ENSP00000428206	ENST00000518482
ENSG00000080823	ENSP00000429428	ENST00000522093
ENSG00000080823	ENSP00000453224	ENST00000517966
ENSG00000080823	ENSP00000453799	ENST00000522537
ENSG00000080823	ENSP00000453449	ENST00000559838
ENSG00000080823	ENSP00000453401	ENST00000559138

Organism

Homo sapiens

Functional Description

Able to phosphorylate several exogenous substrates andto undergo autophosphorylation (By similarity).

Protein Length

419

Protein Sequence
(FASTA)

MKNYKAIGKI GEGTFSEVMK MQSLRDGNYY ACKQMKQRFE SIEQVNNLRE IQALRRLNPH 60

PNILMLHEVV FDRKSGSLAL ICELMDMNIY ELIRGRRYPL SEKKIMHYMY QLCKSLDHIH 120

RNGIFHRDVK PENILIKQDV LKLGDFGSCR SVYSKQPYTE YISTRWYRAP ECLLTDGFYT 180

YKMDLWSAGC VFYEIASLQP LFPGVNELDQ ISKIHDVIGT PAQKILTKFK QSRAMNFDFP 240

FKKGSGIPLL TTNLSPQCLS LLHAMVAYDP DERIAAHQAL QHPYFQEQRK TEKRALGSHR 300

KAGFPEHPVA PEPLSNSCQI SKEGRKQKQS LKQEEDRPKR RGPAYVMELP KLKLSGVVRL 360

SSYSSPTLQS VLGSGTNGRV PVLRPLKCIP ASKKTDPQKD LKPAPQQCRL PTIVRKGGR 419

Nucleotide Sequence
(FASTA)

ATGAAGAACT ATAAAGCAAT TGGCAAAATA GGAGAGGGAA CGTTTTCTGA AGTTATGAAG 60

ATGCAAAGCC TGAGAGATGG AAACTACTAT GCATGTAAAC AAATGAAGCA GCGCTTTGAA 120

AGTATTGAGC AAGTCAACAA CCTACGAGAG ATCCAAGCAC TGAGGCGCCT GAATCCGCAC 180

CCAAACATTC TTATGTTGCA TGAAGTGGTT TTTGACAGAA AATCTGGTTC TCTTGCACTA 240

ATATGTGAAC TTATGGACAT GAATATTTAT GAGCTAATAC GAGGGAGAAG ATACCCATTA 300

TCAGAAAAAA AAATTATGCA CTATATGTAC CAGTTATGTA AGTCCCTGGA TCATATTCAC 360

AGAAATGGAA TATTTCACAG AGATGTAAAA CCAGAAAATA TACTAATAAA GCAGGATGTC 420

CTGAAATTAG GGGACTTTGG CTCCTGCCGG AGTGTCTATT CCAAGCAGCC GTACACGGAA 480

TACATCTCCA CCCGCTGGTA CCGGGCCCCG GAGTGTCTCC TCACTGATGG GTTCTACACG 540

TACAAGATGG ACCTGTGGAG CGCCGGCTGT GTGTTCTACG AGATCGCCAG TCTGCAGCCC 600

CTCTTTCCTG GAGTAAATGA ACTGGACCAA ATCTCAAAAA TCCACGATGT CATCGGCACA 660

CCCGCTCAGA AGATCCTCAC CAAGTTCAAA CAGTCGAGAG CTATGAATTT TGATTTTCCT 720

TTTAAAAAGG GATCAGGAAT ACCTCTACTA ACAACCAATT TGTCCCCACA ATGCCTCTCC 780

CTCCTGCACG CAATGGTGGC CTATGATCCC GATGAGAGAA TCGCCGCCCA CCAGGCCCTG 840

CAGCACCCCT ACTTCCAAGA ACAGAGGAAA ACAGAGAAGC GGGCTCTGGG CAGCCACAGA 900

AAAGCTGGCT TTCCGGAGCA CCCTGTGGCA CCGGAACCAC TCAGTAACAG CTGCCAGATT 960

TCCAAGGAGG GCAGAAAGCA GAAACAGTCC CTAAAGCAAG AGGAGGACCG TCCCAAGAGA 1020

CGAGGACCGG CCTATGTCAT GGAACTGCCC AAACTAAAGC TTTCGGGAGT GGTCAGACTG 1080

TCGTCTTACT CCAGCCCCAC GCTGCAGTCC GTGCTTGGAT CTGGAACAAA TGGAAGAGTG 1140

CCGGTGCTGA GACCCTTGAA GTGCATCCCT GCGAGCAAGA AGACAGATCC GCAGAAGGAC 1200

CTTAAGCCTG CCCCGCAGCA GTGTCGCCTG CCCACCATAG TGCGGAAAGG CGGAAGATAA 1260

Domain Profile

S: 1     yklikklGdGtfgevllakslktgelvaikkmkrkfesleevtnlrevkslkklnahdni  60

         yk+i k+G+Gtf+ev++++sl++g+++a+k+mk++fes+e+v+nlre+++l++ln+h+ni

Q: 4     YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQVNNLREIQALRRLNPHPNI  63

         99**********************************************************

S: 61    iklkeviidrendslylvlelmeenlyqlikdrrkllsesklksilyqilkglafihkhg  120

         ++l+ev++dr+++sl+l++elm++n+y+li++rr+ lse+k+++++yq++k+l++ih++g

Q: 64    LMLHEVVFDRKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIHRNG  123

         ************************************************************

S: 121   ffhrdlkPenilikgselvkladfGlarevrsknPytdyvstrwyraPevllrsgvyssp  180

         +fhrd+kPenilik ++++kl+dfG++r+v+sk+Pyt+y+strwyraPe+ll++g+y+++

Q: 124   IFHRDVKPENILIK-QDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYK  182

         **************.*********************************************

S: 181   ldlwavGcvlaevavlrplfPGaseidqifkilevlGtPkkkewdeayklasalnlkfpq  240

         +dlw++Gcv++e+a+l+plfPG++e+dqi+ki++v+GtP++k +++ +k+++a+n++fp+

Q: 183   MDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPAQKILTK-FKQSRAMNFDFPF  241

         *********************************************9.*************

S: 241   vegsslktlvsnaskealellkdllaydPderataqqalkypyf  284

         ++gs+++ l++n+s ++l+ll++++aydPder++a+qal++pyf

Q: 242   KKGSGIPLLTTNLSPQCLSLLHAMVAYDPDERIAAHQALQHPYF  285

         *******************************************9

Domain Sequence
(FASTA)

YKAIGKIGEG TFSEVMKMQS LRDGNYYACK QMKQRFESIE QVNNLREIQA LRRLNPHPNI 60

LMLHEVVFDR KSGSLALICE LMDMNIYELI RGRRYPLSEK KIMHYMYQLC KSLDHIHRNG 120

IFHRDVKPEN ILIKQDVLKL GDFGSCRSVY SKQPYTEYIS TRWYRAPECL LTDGFYTYKM 180

DLWSAGCVFY EIASLQPLFP GVNELDQISK IHDVIGTPAQ KILTKFKQSR AMNFDFPFKK 240

GSGIPLLTTN LSPQCLSLLH AMVAYDPDER IAAHQALQHP YF 282

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007049	; P:cell cycle
GO:0007165	; P:signal transduction

KEGG

hsa:5891

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013