EKS-HOS-00425
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00425
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/DAPK436.91.1E-13035293259
StatusReviewed
Ensembl ProteinENSP00000263955
UniProt AccessionO94768;
Protein NameSerine/threonine-protein kinase 17B
Protein Synonyms/Alias DAP kinase-related apoptosis-inducing protein kinase 2;
Gene NameSTK17B
Gene Synonyms/Alias STK17B; DRAK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000081320ENSP00000399755ENST00000420683
ENSG00000081320ENSP00000263955ENST00000263955
ENSG00000081320ENSP00000413289ENST00000449152
ENSG00000081320ENSP00000386853ENST00000409228
OrganismHomo sapiens
Functional DescriptionPhosphorylates myosin light chains (By similarity). Actsas a positive regulator of apoptosis.
Protein Length372
Protein Sequence
(FASTA)
MSRRRFDCRS ISGLLTTTPQ IPIKMENFNN FYILTSKELG RGKFAVVRQC ISKSTGQEYA 60
AKFLKKRRRG QDCRAEILHE IAVLELAKSC PRVINLHEVY ENTSEIILIL EYAAGGEIFS 120
LCLPELAEMV SENDVIRLIK QILEGVYYLH QNNIVHLDLK PQNILLSSIY PLGDIKIVDF 180
GMSRKIGHAC ELREIMGTPE YLAPEILNYD PITTATDMWN IGIIAYMLLT HTSPFVGEDN 240
QETYLNISQV NVDYSEETFS SVSQLATDFI QSLLVKNPEK RPTAEICLSH SWLQQWDFEN 300
LFHPEETSSS SQTQDHSVRS SEDKTSKSSC NGTCGDREDK ENIPEDSSMV SKRFRFDDSL 360
PNPHELVSDL LC 372
Nucleotide Sequence
(FASTA)
ATGTCGAGGA GGAGATTTGA TTGCCGAAGT ATTTCAGGCC TACTAACTAC AACTCCTCAA 60
ATTCCAATAA AAATGGAAAA CTTTAATAAT TTCTATATAC TTACATCTAA AGAGCTAGGG 120
AGAGGAAAAT TTGCTGTGGT TAGACAATGT ATATCAAAAT CTACTGGCCA AGAATATGCT 180
GCAAAATTTC TAAAAAAGAG AAGAAGAGGA CAGGATTGTC GAGCAGAAAT TTTACACGAG 240
ATTGCTGTGC TTGAATTGGC AAAGTCTTGT CCCCGTGTTA TTAATCTTCA TGAGGTCTAT 300
GAAAATACAA GTGAAATCAT TTTGATATTG GAATATGCTG CAGGTGGAGA AATTTTCAGC 360
CTGTGTTTAC CTGAGTTGGC TGAAATGGTT TCTGAAAATG ATGTTATCAG ACTCATTAAA 420
CAAATACTTG AAGGAGTTTA TTATCTACAT CAGAATAACA TTGTACACCT TGATTTAAAG 480
CCACAGAATA TATTACTGAG CAGCATATAC CCTCTCGGGG ACATTAAAAT AGTAGATTTT 540
GGAATGTCTC GAAAAATAGG GCATGCGTGT GAACTTCGGG AAATCATGGG AACACCAGAA 600
TATTTAGCTC CAGAAATCCT GAACTATGAT CCCATTACCA CAGCAACAGA TATGTGGAAT 660
ATTGGTATAA TAGCATATAT GTTGTTAACT CACACATCAC CATTTGTGGG AGAAGATAAT 720
CAAGAAACAT ACCTCAATAT TTCTCAAGTT AATGTAGATT ATTCGGAAGA AACTTTTTCA 780
TCAGTTTCAC AGCTGGCCAC AGACTTTATT CAGAGCCTTT TAGTAAAAAA TCCAGAGAAA 840
AGACCAACAG CAGAGATATG CCTTTCTCAT TCTTGGCTAC AGCAGTGGGA CTTTGAAAAC 900
TTGTTTCACC CTGAAGAAAC TTCCAGTTCC TCTCAAACTC AGGATCATTC TGTAAGGTCC 960
TCTGAAGACA AGACTTCTAA ATCCTCCTGT AATGGAACCT GTGGTGATAG AGAAGACAAA 1020
GAGAATATCC CAGAGGATAG CAGCATGGTT TCCAAAAGAT TTCGTTTCGA TGACTCATTA 1080
CCCAATCCCC ATGAACTTGT TTCAGATTTG CTCTGTTAG 1119
Domain Profile
S: 3     tgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirse  62
         t+kelg+Gkfavvr+c++kstG+eyaakflkkrr    r++++r+ei +e+avl++++s+
Q: 35    TSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRR----RGQDCRAEILHEIAVLELAKSC  90
         789*******************************....**********************
S: 63    pnvinlhevyenksdvililelvaGGelfd..llaekeslseeeatellkqilegvkylh  120
         p+vinlhevyen+s++ilile++aGGe+f+  l + +e++se+++++l+kqilegv+ylh
Q: 91    PRVINLHEVYENTSEIILILEYAAGGEIFSlcLPELAEMVSENDVIRLIKQILEGVYYLH  150
         ******************************777899************************
S: 121   skkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivny  180
         +++ivhldlkP+nill++ + p gdik++dfG+srki +++el+ei+GtPe++aPei+ny
Q: 151   QNNIVHLDLKPQNILLSSIY-PLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNY  209
         ********************.***************************************
S: 181   eplsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdf  240
         +p++++tdmw+iG+i+y+ll+++sPf+G+++qet+lnis+vn+d+see+fssvs+la+df
Q: 210   DPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDF  269
         ************************************************************
S: 241   irrllvkdpekrltieeclehswl  264
         i++llvk+pekr t+e cl+hswl
Q: 270   IQSLLVKNPEKRPTAEICLSHSWL  293
         ***********************7
Domain Sequence
(FASTA)
TSKELGRGKF AVVRQCISKS TGQEYAAKFL KKRRRGQDCR AEILHEIAVL ELAKSCPRVI 60
NLHEVYENTS EIILILEYAA GGEIFSLCLP ELAEMVSEND VIRLIKQILE GVYYLHQNNI 120
VHLDLKPQNI LLSSIYPLGD IKIVDFGMSR KIGHACELRE IMGTPEYLAP EILNYDPITT 180
ATDMWNIGII AYMLLTHTSP FVGEDNQETY LNISQVNVDY SEETFSSVSQ LATDFIQSLL 240
VKNPEKRPTA EICLSHSWL 259
Keyword3D-structure; Apoptosis; ATP-binding; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00389
EKS-ANC-00403
EKS-BOT-00415
EKS-CAJ-00419
EKS-CAF-00418
EKS-CAP-00443
EKS-CHH-00012
EKS-DAR-00807
EKS-DIO-00070
EKS-EQC-00407
EKS-ERE-00012
EKS-FEC-00400
EKS-GAG-00352
EKS-GAA-00510
EKS-GOG-00409
EKS-ICT-00398
EKS-LOA-00428
EKS-MAM-00415
EKS-MOD-00404
EKS-MUM-00451
EKS-MUP-00412
EKS-MYL-00410
EKS-NOL-00378
EKS-ORN-00532
EKS-ORC-00389
EKS-ORL-00483
EKS-OTG-00422
EKS-PAT-00393
EKS-PES-00372
EKS-POA-00407
EKS-PTV-00119
EKS-RAN-00432
EKS-SAH-00386
EKS-SOA-00015
EKS-SUS-00365
EKS-TAG-00486
EKS-TUT-00129
EKS-VIP-00065
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006915; P:apoptotic process
GO:0006917; P:induction of apoptosis
GO:0007243; P:intracellular protein kinase cascade
GO:0046777; P:protein autophosphorylation
KEGG
hsa:9262;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013