| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00344 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| STE/STE20 | 283.3 | 9.4E-84 | 58 | 369 | 312 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000376080 |
| UniProt Accession | Q9C0K7; Q5BKY7; Q9P1L0; |
| Protein Name | STE20-related kinase adapter protein beta |
| Protein Synonyms/Alias | STRAD beta; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; ILP-interacting protein; Pseudokinase ALS2CR2; |
| Gene Name | STRADB |
| Gene Synonyms/Alias | STRADB; ALS2CR2, ILPIP; PRO1038; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Pseudokinase which, in complex with CAB39/MO25(CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). |
| Protein Length | 377 |
Protein Sequence
(FASTA) | | MSLLDCFCTS RTQVESLRPE KQSETSIHQY LVDEPTLSWS RPSTRASEVL CSTNVSHYEL 60 | | QVEIGRGFDN LTSVHLARHT PTGTLVTIKI TNLENCNEER LKALQKAVIL SHFFRHPNIT 120 | | TYWTVFTVGS WLWVISPFMA YGSASQLLRT YFPEGMSETL IRNILFGAVR GLNYLHQNGC 180 | | IHRSIKASHI LISGDGLVTL SGLSHLHSLV KHGQRHRAVY DFPQFSTSVQ PWLSPELLRQ 240 | | DLHGYNVKSD IYSVGITACE LASGQVPFQD MHRTQMLLQK LKGPPYSPLD ISIFPQSESR 300 | | MKNSQSGVDS GIGESVLVSS GTHTVNSDRL HTPSSKTFSP AFFSLVQLCL QQDPEKRPSA 360 | | SSLLSHVFFK QPYFEFL 377 |
|
Nucleotide Sequence
(FASTA) | | ATGTCTCTTT TGGATTGCTT CTGCACTTCA AGAACACAAG TTGAATCACT CAGACCTGAA 60 | | AAACAGTCTG AAACCAGTAT CCATCAATAC TTGGTTGATG AGCCAACCCT TTCCTGGTCA 120 | | CGTCCATCCA CTAGAGCCAG TGAAGTACTA TGTTCCACCA ACGTTTCTCA CTATGAGCTC 180 | | CAAGTAGAAA TAGGAAGAGG ATTTGACAAC TTGACTTCTG TCCATCTTGC ACGGCATACT 240 | | CCCACAGGAA CACTGGTAAC TATAAAAATT ACAAATCTGG AAAACTGCAA TGAAGAACGC 300 | | CTGAAAGCTT TACAGAAAGC CGTGATTCTA TCCCACTTTT TCCGGCATCC CAATATTACA 360 | | ACTTATTGGA CAGTTTTCAC TGTTGGCAGC TGGCTTTGGG TTATTTCTCC ATTTATGGCC 420 | | TATGGTTCAG CAAGTCAACT CTTGAGGACC TATTTTCCTG AAGGAATGAG TGAAACTTTA 480 | | ATAAGAAACA TTCTCTTTGG AGCCGTGAGA GGGTTGAACT ATCTGCACCA AAATGGCTGT 540 | | ATTCACAGGA GTATTAAAGC CAGCCATATC CTCATTTCTG GTGATGGCCT AGTGACCCTC 600 | | TCTGGCCTGT CCCATCTGCA TAGTTTGGTT AAGCATGGAC AGAGGCATAG GGCTGTGTAT 660 | | GATTTCCCAC AGTTCAGCAC ATCAGTGCAG CCGTGGCTGA GTCCAGAACT ACTGAGACAG 720 | | GATTTACATG GGTATAATGT GAAGTCAGAT ATTTACAGTG TTGGGATTAC AGCATGTGAA 780 | | TTAGCCAGTG GGCAGGTGCC TTTCCAGGAC ATGCATAGAA CTCAGATGCT GTTACAGAAA 840 | | CTGAAAGGTC CTCCTTATAG CCCATTGGAT ATCAGTATTT TCCCTCAATC AGAATCCAGA 900 | | ATGAAAAATT CCCAGTCAGG TGTAGACTCT GGGATTGGAG AAAGTGTGCT TGTCTCCAGT 960 | | GGAACTCACA CAGTAAATAG TGACCGATTA CACACACCAT CCTCAAAAAC TTTCTCTCCT 1020 | | GCCTTCTTTA GCTTGGTACA GCTCTGTTTG CAACAAGATC CTGAGAAAAG GCCATCAGCA 1080 | | AGCAGTTTAT TGTCCCATGT TTTCTTCAAA CAGCCTTATT TTGAGTTTCT TTAA 1134 |
|
| Domain Profile | S: 1 yelleeigkG..algkvylarekktgelvaikkinlekq..ekleelqkeisvlkklkhp 56 | yel+ eig+G +l++v+lar+++tg+lv+ik++nle++ e+l++lqk + +++ ++hp | Q: 58 YELQVEIGRGfdNLTSVHLARHTPTGTLVTIKITNLENCneERLKALQKAVILSHFFRHP 117 | 899********99**************************9999***************** |
| S: 57 niveylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHs 116 | ni++y+++f++ ++lw++ ++a+Gs+s+l+++++ ++++E+ i++il +++++L+ylH+ | Q: 118 NITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQ 177 | ************************************************************ |
| S: 117 kkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtp.......ywmAPEv 169 | +++iHr+ika++iL++ +g V+Ls++++ ++l k+++++++v+++p +w++PE+ | Q: 178 NGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPqfstsvqPWLSPEL 237 | **********************************************99999888****** |
| S: 170 iaqeekgYdekaDiwslGItaielaegepPfkdleplkallkilknepp........... 218 | ++q+ +gY+ k+Di+s+GIta+ela+g++Pf+d++++++ll++lk++p | Q: 238 LRQDLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYspldisifpqs 297 | **********************************************94433666666655 |
| S: 219 ..klksk..................................kkfskefkefvekclqknp 242 | + k+fs++f ++v+ clq++p | Q: 298 esR---MknsqsgvdsgigesvlvssgthtvnsdrlhtpssKTFSPAFFSLVQLCLQQDP 354 | 553...0445888888999999999999999999999999899***************** |
| S: 243 ekRpsasellkhkFl 257 | ekRpsas+ll+h F+ | Q: 355 EKRPSASSLLSHVFF 369 | *************97 |
|
Domain Sequence
(FASTA) | | YELQVEIGRG FDNLTSVHLA RHTPTGTLVT IKITNLENCN EERLKALQKA VILSHFFRHP 60 | | NITTYWTVFT VGSWLWVISP FMAYGSASQL LRTYFPEGMS ETLIRNILFG AVRGLNYLHQ 120 | | NGCIHRSIKA SHILISGDGL VTLSGLSHLH SLVKHGQRHR AVYDFPQFST SVQPWLSPEL 180 | | LRQDLHGYNV KSDIYSVGIT ACELASGQVP FQDMHRTQML LQKLKGPPYS PLDISIFPQS 240 | | ESRMKNSQSG VDSGIGESVL VSSGTHTVNS DRLHTPSSKT FSPAFFSLVQ LCLQQDPEKR 300 | | PSASSLLSHV FF 312 |
|
| Keyword | Alternative splicing; ATP-binding; Cell cycle; Complete proteome; Cytoplasm; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | | PS00107 | ; PROTEIN_KINASE_ATP; FALSE_NEG. | | PS50011 | ; PROTEIN_KINASE_DOM; 1. | | PS00108 | ; PROTEIN_KINASE_ST; FALSE_NEG. |
|
| Prints | |
| Created Date | 20-Feb-2013 |