EKS-HOS-00204
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00204
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/MAST529.68.2E-159397670274
StatusReviewed
Ensembl ProteinENSP00000361078
UniProt AccessionQ6P0Q8; O94899; Q5VT07; Q5VT08; Q7LGC4; Q8NDG1; Q96B94; Q9BYE8;
Protein NameMicrotubule-associated serine/threonine-protein kinase 2
Protein Synonyms/Alias
Gene NameMAST2
Gene Synonyms/Alias MAST2; KIAA0807, MAST205;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000086015ENSP00000354671ENST00000361297
ENSG00000086015ENSP00000361079ENST00000372009
ENSG00000086015ENSP00000361078ENST00000372008
OrganismHomo sapiens
Functional DescriptionAppears to link the dystrophin/utrophin network withmicrotubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).
Protein Length792
Protein Sequence
(FASTA)
MFSPTSAPAL FLTKVPFSAD CALATSPLAI FLNPRAHSSP GTPCSSRPLP WSCRTSNRKS 60
LIVTSSTSPT LPRPHSPLHG HTGNSPLDSP RNFSPNAPAH FSFVPARRTD GRRWSLASLP 120
SSGYGTNTPS STVSSSCSSQ EKLHQLPFQP TADELHFLTK HFSTESVPDE EGRQSPAMRP 180
RSRSLSPGRS PVSFDSEIIM MNHVYKERFP KATAQMEERL AEFISSNTPD SVLPLADGAL 240
SFIHHQVIEM ARDCLDKSRS GLITSQYFYE LQDNLEKLLQ DAHERSESSE VAFVMQLVKK 300
LMIIIARPAR LLECLEFDPE EFYHLLEAAE GHAKEGQGIK CDIPRYIVSQ LGLTRDPLEE 360
MAQLSSCDSP DTPETDDSIE GHGASLPSKK TPSEEDFETI KLISNGAYGA VFLVRHKSTR 420
QRFAMKKINK QNLILRNQIQ QAFVERDILT FAENPFVVSM FCSFDTKRHL CMVMEYVEGG 480
DCATLLKNIG ALPVDMVRLY FAETVLALEY LHNYGIVHRD LKPDNLLITS MGHIKLTDFG 540
LSKIGLMSLT TNLYEGHIEK DAREFLDKQV CGTPEYIAPE VILRQGYGKP VDWWAMGIIL 600
YEFLVGCVPF FGDTPEELFG QVISDEIVWP EGDEALPPDA QDLTSKLLHQ NPLERLGTGS 660
AYEVKQHPFF TGLDWTGLLR QKAEFIPQLE SEDDTSYFDT RSERYHHMDS EDEEEVSEDG 720
CLEIRQFSSC SPRFNKVYSS MERLSLLEER RTPPPTKRSL SEEKEDHSDG LAGLKGRDRS 780
WVIGSPEHHP SA 792
Nucleotide Sequence
(FASTA)
ATGTTTTCAC CCACATCTGC TCCAGCCCTC TTCCTCACTA AAGTCCCATT TAGTGCTGAT 60
TGTGCTTTGG CTACTTCTCC TCTTGCCATT TTCCTGAACC CACGAGCCCA CAGCAGTCCT 120
GGCACTCCTT GTTCCAGCCG CCCACTGCCG TGGAGTTGTC GGACAAGTAA CCGCAAGAGC 180
TTGATTGTGA CCTCTAGCAC ATCACCTACA CTACCACGGC CACACTCACC ACTCCATGGC 240
CACACAGGTA ACAGTCCTTT GGACAGCCCC CGGAATTTCT CTCCAAATGC ACCTGCTCAC 300
TTTTCTTTTG TTCCTGCCCG TAGGACTGAT GGGCGGCGCT GGTCTTTGGC CTCTTTGCCC 360
TCTTCAGGAT ATGGAACTAA CACTCCTAGC TCCACTGTCT CATCATCATG CTCCTCACAG 420
GAAAAGCTGC ATCAGTTGCC TTTCCAGCCT ACAGCTGATG AGCTGCACTT TTTGACGAAG 480
CATTTCAGCA CAGAGAGCGT ACCAGATGAG GAAGGACGGC AGTCCCCAGC CATGCGGCCT 540
CGCTCCCGGA GCCTCAGTCC CGGACGATCC CCAGTATCCT TTGACAGTGA AATAATAATG 600
ATGAATCATG TTTACAAAGA AAGATTCCCA AAGGCCACCG CACAAATGGA AGAGCGACTA 660
GCAGAGTTTA TTTCCTCCAA CACTCCAGAC AGCGTGCTGC CCTTGGCAGA TGGAGCCCTG 720
AGCTTTATTC ATCATCAGGT GATTGAGATG GCCCGAGACT GCCTGGATAA ATCTCGGAGT 780
GGCCTCATTA CATCACAATA CTTCTACGAA CTTCAAGATA ATTTGGAGAA ACTTTTACAA 840
GATGCTCATG AGCGCTCAGA GAGCTCAGAA GTGGCTTTTG TGATGCAGCT GGTGAAAAAG 900
CTGATGATTA TCATTGCCCG CCCAGCACGT CTCCTGGAAT GCCTGGAGTT TGACCCTGAA 960
GAGTTCTACC ACCTTTTAGA AGCAGCTGAG GGCCACGCCA AAGAGGGACA AGGGATTAAA 1020
TGTGACATTC CCCGCTACAT CGTTAGCCAG CTGGGCCTCA CCCGGGATCC CCTAGAAGAA 1080
ATGGCCCAGT TGAGCAGCTG TGACAGTCCT GACACTCCAG AGACAGATGA TTCTATTGAG 1140
GGCCATGGGG CATCTCTGCC ATCTAAAAAG ACACCCTCTG AAGAGGACTT CGAGACCATT 1200
AAGCTCATCA GCAATGGCGC CTATGGGGCT GTATTTCTGG TGCGGCACAA GTCCACCCGG 1260
CAGCGCTTTG CCATGAAGAA GATCAACAAG CAGAACCTGA TCCTACGGAA CCAGATCCAG 1320
CAGGCCTTCG TGGAGCGTGA CATACTGACT TTCGCTGAGA ACCCCTTTGT GGTCAGCATG 1380
TTCTGCTCCT TTGATACCAA GCGCCACTTG TGCATGGTGA TGGAGTACGT TGAAGGGGGA 1440
GACTGTGCCA CTCTGCTGAA GAATATTGGG GCCCTGCCTG TGGACATGGT GCGTCTATAC 1500
TTTGCGGAAA CTGTGCTGGC CCTGGAGTAC TTACACAACT ATGGCATCGT GCACCGTGAC 1560
CTCAAGCCTG ACAACCTCCT AATTACATCC ATGGGGCACA TCAAGCTCAC GGACTTTGGA 1620
CTGTCCAAAA TTGGCCTCAT GAGTCTGACA ACGAACTTGT ATGAGGGTCA TATTGAAAAG 1680
GATGCCCGGG AATTCCTGGA CAAGCAGGTA TGCGGGACCC CAGAATACAT TGCGCCTGAG 1740
GTGATCCTGC GCCAGGGCTA TGGGAAGCCA GTGGACTGGT GGGCCATGGG CATTATCCTG 1800
TATGAGTTCC TGGTGGGCTG CGTCCCTTTT TTTGGAGATA CTCCGGAGGA GCTCTTTGGG 1860
CAGGTGATCA GTGATGAGAT TGTGTGGCCT GAGGGTGATG AGGCACTGCC CCCAGACGCC 1920
CAGGACCTCA CCTCCAAACT GCTCCACCAG AACCCTCTGG AGAGACTTGG CACAGGCAGT 1980
GCCTATGAGG TGAAGCAGCA CCCATTCTTT ACTGGTCTGG ACTGGACAGG ACTTCTCCGC 2040
CAGAAGGCTG AATTTATTCC TCAGTTGGAG TCAGAGGATG ATACTAGCTA TTTTGACACC 2100
CGCTCAGAGC GATACCACCA CATGGACTCG GAGGATGAGG AAGAAGTGAG TGAGGATGGC 2160
TGCCTTGAGA TCCGCCAGTT CTCTTCCTGC TCTCCAAGGT TCAACAAGGT GTACAGCAGC 2220
ATGGAGCGGC TCTCACTGCT CGAGGAGCGC CGGACACCAC CCCCGACCAA GCGCAGCCTG 2280
AGTGAGGAGA AGGAGGACCA TTCAGATGGC CTGGCAGGGC TCAAAGGCCG AGACCGGAGC 2340
TGGGTGATTG GCTCCCCTGA GCATCACCCA AGTGCCTGA 2379
Domain Profile
S: 1     feiiklisrGayGavylvrhketrkrfavkkikkqdlilknqvqqvfaerdilalaenpf  60
         fe+iklis+GayGav+lvrhk+tr+rfa+kki+kq+lil+nq+qq+f+erdil++aenpf
Q: 397   FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF  456
         99**********************************************************
S: 61    vvslyysletrrnlylvmeyveGGdvksllkniGaldvemarlyiaevvlaleylhryGi  120
         vvs+++s++t+r+l++vmeyveGGd+++llkniGal+v+m+rly+ae+vlaleylh+yGi
Q: 457   VVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGI  516
         ************************************************************
S: 121   vhrdlkPdnllitseGhikltdfGlskvglmslttnlyegyidkdarefldkqvcgtPey  180
         vhrdlkPdnllits+GhikltdfGlsk+glmslttnlyeg+i+kdarefldkqvcgtPey
Q: 517   VHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEY  576
         ************************************************************
S: 181   iaPevilrqgygkpvdwwalgiilyeflvgivpffgdtpeelfaqvlsdeivwPekdeal  240
         iaPevilrqgygkpvdwwa+giilyeflvg+vpffgdtpeelf+qv+sdeivwPe+deal
Q: 577   IAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEAL  636
         ************************************************************
S: 241   ssealelisellesnPrerlgtgsaaevkqhefl  274
         +++a++l+s+ll++nP erlgtgsa+evkqh+f+
Q: 637   PPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFF  670
         ********************************97
Domain Sequence
(FASTA)
FETIKLISNG AYGAVFLVRH KSTRQRFAMK KINKQNLILR NQIQQAFVER DILTFAENPF 60
VVSMFCSFDT KRHLCMVMEY VEGGDCATLL KNIGALPVDM VRLYFAETVL ALEYLHNYGI 120
VHRDLKPDNL LITSMGHIKL TDFGLSKIGL MSLTTNLYEG HIEKDAREFL DKQVCGTPEY 180
IAPEVILRQG YGKPVDWWAM GIILYEFLVG CVPFFGDTPE ELFGQVISDE IVWPEGDEAL 240
PPDAQDLTSK LLHQNPLERL GTGSAYEVKQ HPFF 274
Keyword3D-structure; Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation.
Sequence SourceEnsembl
Orthology
Ortholog group
Ictidomys tridecemlineatus"; ?>Ornithorhynchus anatinus"; ?>Pan troglodytes"; ?>Xiphophorus maculatus"; ?>
EKS-ICT-00191
EKS-ORA-00178
EKS-PAT-00192
EKS-XIM-00252
Gene Ontology
GO:0005737; C:cytoplasm
GO:0015630; C:microtubule cytoskeleton
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006468; P:protein phosphorylation
GO:0045075; P:regulation of interleukin-12 biosynthetic process
GO:0048515; P:spermatid differentiation
KEGG
hsa:23139;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR015022; MA_Ser/Thr_Kinase_dom.
IPR023142; MAST_pre-PK_dom.
IPR001478; PDZ.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF08926; DUF1908; 1.
PF00595; PDZ; 1.
PF00069; Pkinase; 1.
SMARTs
SM00228; PDZ; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50106; PDZ; 1.
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013