EKS-HOS-00413

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00413

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	409.7	3.2E-122	104	382	279

Status

Reviewed

Ensembl Protein

ENSP00000409852

UniProt Accession

Q9Y616; B4DQ57;

Protein Name

Interleukin-1 receptor-associated kinase 3

Protein Synonyms/Alias

IRAK-3; IL-1 receptor-associated kinase M; IRAK-M;

Gene Name

IRAK3

Gene Synonyms/Alias

IRAK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000090376	ENSP00000261233	ENST00000261233
ENSG00000090376	ENSP00000409852	ENST00000457197
ENSG00000090376	ENSP00000441321	ENST00000545837

Organism

Homo sapiens

Functional Description

Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity).

Protein Length

535

Protein Sequence
(FASTA)

MAGNCGARGA LSAHTLLFDL PPALLGELCA VLDSCDGALG WRGLGAVLSP SEKSYQEGGF 60

PNILFKETAN VTVDNVLIPE HNEKGILLKS SISFQNIIEG TRNFHKDFLI GEGEIFEVYR 120

VEIQNLTYAV KLFKQEKKMQ CKKHWKRFLS ELEVLLLFHH PNILELAAYF TETEKFCLIY 180

PYMRNGTLFD RLQCVGDTAP LPWHIRIGIL IGISKAIHYL HNVQPCSVIC GSISSANILL 240

DDQFQPKLTD FAMAHFRSHL EHQSCTINMT SSSSKHLWYM PEEYIRQGKL SIKTDVYSFG 300

IVIMEVLTGC RVVLDDPKHI QLRDLLRELM EKRGLDSCLS FLDKKVPPCP RNFSAKLFCL 360

AGRCAATRAK LRPSMDEVLN TLESTQASLY FAEDPPTSLK SFRCPSPLFL ENVPSIPVED 420

DESQNNNLLP SDEGLRIDRM TQKTPFECSQ SEVMFLSLDK KPESKRNEEA CNMPSSSCEE 480

SWFPKYIVPS QDLRPYKVNI DPSSEAPGHS CRSRPVESSC SSKFSWDEYE QYKKE 535

Nucleotide Sequence
(FASTA)

ATGGCGGGGA ACTGTGGGGC CCGCGGCGCG CTGTCGGCGC ACACGCTGCT GTTCGACCTG 60

CCGCCCGCGC TGCTCGGAGA GCTCTGCGCT GTTCTGGACA GCTGCGACGG CGCGCTGGGC 120

TGGCGCGGCC TGGGAGCAGT GTTGAGTCCT TCAGAGAAGA GTTATCAGGA AGGTGGATTT 180

CCAAATATAT TATTCAAGGA AACAGCCAAT GTCACCGTGG ATAATGTTCT TATTCCTGAA 240

CATAATGAAA AAGGAATACT GCTTAAATCT TCCATCAGCT TTCAAAATAT CATAGAAGGA 300

ACTAGAAATT TCCACAAAGA CTTCCTAATT GGAGAAGGAG AGATTTTTGA GGTATACAGA 360

GTGGAGATTC AAAACCTAAC ATATGCTGTC AAATTATTTA AACAGGAGAA AAAAATGCAG 420

TGTAAGAAGC ATTGGAAGAG GTTTTTATCT GAGCTTGAAG TTTTACTACT GTTTCATCAC 480

CCAAACATAC TAGAGTTGGC TGCATATTTT ACAGAGACTG AGAAGTTCTG TCTGATTTAT 540

CCATACATGA GAAATGGAAC ACTTTTTGAC AGATTGCAGT GTGTAGGTGA CACGGCCCCA 600

CTCCCTTGGC ACATTCGAAT CGGTATATTA ATAGGAATAT CCAAAGCCAT TCACTACCTG 660

CACAACGTTC AACCATGCTC GGTCATCTGT GGCAGTATAT CAAGTGCAAA CATCCTTTTG 720

GATGATCAGT TTCAACCCAA ACTAACTGAT TTTGCCATGG CACACTTCCG GTCCCACCTA 780

GAACATCAGA GTTGTACCAT AAATATGACC AGCAGCAGCA GTAAACATCT GTGGTACATG 840

CCAGAAGAGT ACATCAGACA GGGGAAACTT TCCATTAAAA CAGATGTCTA CAGCTTTGGA 900

ATTGTAATAA TGGAAGTTCT AACAGGATGT AGAGTAGTGT TAGATGATCC AAAACATATC 960

CAGCTGCGGG ATCTCCTTAG AGAATTGATG GAGAAGAGAG GCCTGGATTC ATGTCTCTCA 1020

TTTCTAGATA AGAAAGTGCC TCCCTGCCCT CGGAATTTCT CTGCCAAGCT CTTCTGTTTG 1080

GCAGGCCGGT GTGCTGCAAC GCGGGCAAAG TTAAGACCAT CAATGGATGA AGTTTTAAAT 1140

ACTCTTGAAA GTACTCAAGC CAGCTTGTAT TTTGCTGAAG ATCCTCCCAC ATCACTAAAG 1200

TCCTTCAGGT GTCCTTCTCC TCTATTCCTG GAGAATGTAC CAAGTATTCC AGTGGAAGAT 1260

GATGAAAGCC AGAATAACAA TTTACTACCT TCTGATGAAG GCCTGAGGAT AGACAGAATG 1320

ACTCAGAAAA CTCCTTTTGA ATGCAGCCAG TCTGAGGTTA TGTTTCTGAG CTTGGACAAA 1380

AAGCCAGAGA GCAAGAGAAA TGAGGAAGCT TGCAACATGC CCAGTTCTTC TTGTGAAGAA 1440

AGTTGGTTCC CAAAGTATAT AGTTCCATCC CAGGACTTAA GGCCCTATAA GGTAAATATA 1500

GATCCTTCTT CAGAAGCTCC AGGGCATTCT TGCAGGAGCA GGCCAGTGGA GAGCAGCTGT 1560

TCCTCCAAAT TTTCCTGGGA TGAATATGAA CAGTACAAAA AAGAATAA 1608

Domain Profile

S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60

         f++d+ igeG+++evyr+e++n+++avk +k+e+++++k+++++fl+El+vl+ f+H+ni

Q: 104   FHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNI  163

         89**********************************************************

S: 61    lellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHea  120

         lel++y++e+ek+cL+Y+ym+nG+L+drLqc ++++pL+W++R+ il+G+++ai++LH++

Q: 164   LELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNV  223

         ************************************************************

S: 121   sp.slihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpee  179

         +p s+i+g+i+saNiLLD++++pKl+Df++a+f+++ e+qs+t+++ts+ +++l+Y+pee

Q: 224   QPcSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEE  283

         ************************************************************

S: 180   firvgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfld  239

         +ir+g+l++k+DvySfGiV++EvltG+r+v +d+k+ +L+dll+e +e+++++++ +fld

Q: 284   YIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLD  343

         ************************************************************

S: 240   kkagkleeellealielalaclaekakkrPtmsqvlell  278

         kk+++++++++++l++la++c+a++ak rP+m++vl++l

Q: 344   KKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTL  382

         ***********************************9987

Domain Sequence
(FASTA)

FHKDFLIGEG EIFEVYRVEI QNLTYAVKLF KQEKKMQCKK HWKRFLSELE VLLLFHHPNI 60

LELAAYFTET EKFCLIYPYM RNGTLFDRLQ CVGDTAPLPW HIRIGILIGI SKAIHYLHNV 120

QPCSVICGSI SSANILLDDQ FQPKLTDFAM AHFRSHLEHQ SCTINMTSSS SKHLWYMPEE 180

YIRQGKLSIK TDVYSFGIVI MEVLTGCRVV LDDPKHIQLR DLLRELMEKR GLDSCLSFLD 240

KKVPPCPRNF SAKLFCLAGR CAATRAKLRP SMDEVLNTL 279

Keyword

Alternative splicing; Asthma; ATP-binding; Complete proteome; Kinase; Magnesium; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0070498	; P:interleukin-1-mediated signaling pathway
GO:0002755	; P:MyD88-dependent toll-like receptor signaling pathway
GO:0001960	; P:negative regulation of cytokine-mediated signaling pathway
GO:0045824	; P:negative regulation of innate immune response
GO:0032695	; P:negative regulation of interleukin-12 production
GO:0032715	; P:negative regulation of interleukin-6 production
GO:0010936	; P:negative regulation of macrophage cytokine production
GO:0043407	; P:negative regulation of MAP kinase activity
GO:0032088	; P:negative regulation of NF-kappaB transcription factor activity
GO:0042177	; P:negative regulation of protein catabolic process
GO:0043242	; P:negative regulation of protein complex disassembly
GO:0034122	; P:negative regulation of toll-like receptor signaling pathway
GO:0032720	; P:negative regulation of tumor necrosis factor production
GO:0010933	; P:positive regulation of macrophage tolerance induction
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777	; P:protein autophosphorylation
GO:0043330	; P:response to exogenous dsRNA
GO:0032496	; P:response to lipopolysaccharide
GO:0032494	; P:response to peptidoglycan
GO:0009615	; P:response to virus

KEGG

hsa:11213

;

InterPros

IPR000488	; Death.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00005

; DEATH; 1.

Prosites

PS50017	; DEATH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

Created Date

20-Feb-2013