EKS-HOS-00403

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00403

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	548.9	9.5E-165	473	738	266

Status

Reviewed

Ensembl Protein

ENSP00000454050

UniProt Accession

Q06418; O14953; Q86VR3;

Protein Name

Tyrosine-protein kinase receptor TYRO3

Protein Synonyms/Alias

Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase byk;

Gene Name

TYRO3

Gene Synonyms/Alias

TYRO3; BYK, DTK, RSE, SKY;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000092445	ENSP00000454050	ENST00000559066
ENSG00000092445	ENSP00000263798	ENST00000263798
ENSG00000092445	ENSP00000455441	ENST00000568343
ENSG00000092445	ENSP00000452995	ENST00000559851
ENSG00000092445	ENSP00000453835	ENST00000559815

Organism

Homo sapiens

Functional Description

Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to several ligands including TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Protein Length

845

Protein Sequence
(FASTA)

MGAPVKLTVS QGQPVKLNCS VEGMEEPDIQ WVKDGAVVQN LDQLYIPVSE QHWIGFLSLK 60

SVERSDAGRY WCQVEDGGET EISQPVWLTV EGVPFFTVEP KDLAVPPNAP FQLSCEAVGP 120

PEPVTIVWWR GTTKIGGPAP SPSVLNVTGV TQSTMFSCEA HNLKGLASSR TATVHLQALP 180

AAPFNITVTK LSSSNASVAW MPGADGRALL QSCTVQVTQA PGGWEVLAVV VPVPPFTCLL 240

RDLVPATNYS LRVRCANALG PSPYADWVPF QTKGLAPASA PQNLHAIRTD SGLILEWEEV 300

IPEAPLEGPL GPYKLSWVQD NGTQDELTVE GTRANLTGWD PQKDLIVRVC VSNAVGCGPW 360

SQPLVVSSHD RAGQQGPPHS RTSWVPVVLG VLTALVTAAA LALILLRKRR KETRFGQAFD 420

SVMARGEPAV HFRAARSFNR ERPERIEATL DSLGISDELK EKLEDVLIPE QQFTLGRMLG 480

KGEFGSVREA QLKQEDGSFV KVAVKMLKAD IIASSDIEEF LREAACMKEF DHPHVAKLVG 540

VSLRSRAKGR LPIPMVILPF MKHGDLHAFL LASRIGENPF NLPLQTLIRF MVDIACGMEY 600

LSSRNFIHRD LAARNCMLAE DMTVCVADFG LSRKIYSGDY YRQGCASKLP VKWLALESLA 660

DNLYTVQSDV WAFGVTMWEI MTRGQTPYAG IENAEIYNYL IGGNRLKQPP ECMEDVYDLM 720

YQCWSADPKQ RPSFTCLRME LENILGQLSV LSASQDPLYI NIERAEEPTA GGSLELPGRD 780

QPYSGAGDGS GMGAVGGTPS DCRYILTPGG LAEQPGQAEH QPESPLNETQ RLLLLQQGLL 840

PHSSC 845

Nucleotide Sequence
(FASTA)

ATGGGAGCCC CGGTGAAGCT GACAGTGTCT CAGGGGCAGC CGGTGAAGCT CAACTGCAGT 60

GTGGAGGGGA TGGAGGAGCC TGACATCCAG TGGGTGAAGG ATGGGGCTGT GGTCCAGAAC 120

TTGGACCAGT TGTACATCCC AGTCAGCGAG CAGCACTGGA TCGGCTTCCT CAGCCTGAAG 180

TCAGTGGAGC GCTCTGACGC CGGCCGGTAC TGGTGCCAGG TGGAGGATGG GGGTGAAACC 240

GAGATCTCCC AGCCAGTGTG GCTCACGGTA GAAGGTGTGC CATTTTTCAC AGTGGAGCCA 300

AAAGATCTGG CAGTGCCACC CAATGCCCCT TTCCAACTGT CTTGTGAGGC TGTGGGTCCC 360

CCTGAACCTG TTACCATTGT CTGGTGGAGA GGAACTACGA AGATCGGGGG ACCCGCTCCC 420

TCTCCATCTG TTTTAAATGT AACAGGGGTG ACCCAGAGCA CCATGTTTTC CTGTGAAGCT 480

CACAACCTAA AAGGCCTGGC CTCTTCTCGC ACAGCCACTG TTCACCTTCA AGCACTGCCT 540

GCAGCCCCCT TCAACATCAC CGTGACAAAG CTTTCCAGCA GCAACGCTAG TGTGGCCTGG 600

ATGCCAGGTG CTGATGGCCG AGCTCTGCTA CAGTCCTGTA CAGTTCAGGT GACACAGGCC 660

CCAGGAGGCT GGGAAGTCCT GGCTGTTGTG GTCCCTGTGC CCCCCTTTAC CTGCCTGCTC 720

CGGGACCTGG TGCCTGCCAC CAACTACAGC CTCAGGGTGC GCTGTGCCAA TGCCTTGGGG 780

CCCTCTCCCT ATGCTGACTG GGTGCCCTTT CAGACCAAGG GTCTAGCCCC AGCCAGCGCT 840

CCCCAAAACC TCCATGCCAT CCGCACAGAT TCAGGCCTCA TCTTGGAGTG GGAAGAAGTG 900

ATCCCCGAGG CCCCTTTGGA AGGCCCCCTG GGACCCTACA AACTGTCCTG GGTTCAAGAC 960

AATGGAACCC AGGATGAGCT GACAGTGGAG GGGACCAGGG CCAATTTGAC AGGCTGGGAT 1020

CCCCAAAAGG ACCTGATCGT ACGTGTGTGC GTCTCCAATG CAGTTGGCTG TGGACCCTGG 1080

AGTCAGCCAC TGGTGGTCTC TTCTCATGAC CGTGCAGGCC AGCAGGGCCC TCCTCACAGC 1140

CGCACATCCT GGGTACCTGT GGTCCTTGGT GTGCTAACGG CCCTGGTGAC GGCTGCTGCC 1200

CTGGCCCTCA TCCTGCTTCG AAAGAGACGG AAAGAGACGC GGTTTGGGCA AGCCTTTGAC 1260

AGTGTCATGG CCCGGGGAGA GCCAGCCGTT CACTTCCGGG CAGCCCGGTC CTTCAATCGA 1320

GAAAGGCCCG AGCGCATCGA GGCCACATTG GACAGCTTGG GCATCAGCGA TGAACTAAAG 1380

GAAAAACTGG AGGATGTGCT CATCCCAGAG CAGCAGTTCA CCCTGGGCCG GATGTTGGGC 1440

AAAGGAGAGT TTGGTTCAGT GCGGGAGGCC CAGCTGAAGC AAGAGGATGG CTCCTTTGTG 1500

AAAGTGGCTG TGAAGATGCT GAAAGCTGAC ATCATTGCCT CAAGCGACAT TGAAGAGTTC 1560

CTCAGGGAAG CAGCTTGCAT GAAGGAGTTT GACCATCCAC ACGTGGCCAA ACTTGTTGGG 1620

GTAAGCCTCC GGAGCAGGGC TAAAGGCCGT CTCCCCATCC CCATGGTCAT CTTGCCCTTC 1680

ATGAAGCATG GGGACCTGCA TGCCTTCCTG CTCGCCTCCC GGATTGGGGA GAACCCCTTT 1740

AACCTACCCC TCCAGACCCT GATCCGGTTC ATGGTGGACA TTGCCTGCGG CATGGAGTAC 1800

CTGAGCTCTC GGAACTTCAT CCACCGAGAC CTGGCTGCTC GGAATTGCAT GCTGGCAGAG 1860

GACATGACAG TGTGTGTGGC TGACTTCGGA CTCTCCCGGA AGATCTACAG TGGGGACTAC 1920

TATCGTCAAG GCTGTGCCTC CAAACTGCCT GTCAAGTGGC TGGCCCTGGA GAGCCTGGCC 1980

GACAACCTGT ATACTGTGCA GAGTGACGTG TGGGCGTTCG GGGTGACCAT GTGGGAGATC 2040

ATGACACGTG GGCAGACGCC ATATGCTGGC ATCGAAAACG CTGAGATTTA CAACTACCTC 2100

ATTGGCGGGA ACCGCCTGAA ACAGCCTCCG GAGTGTATGG AGGACGTGTA TGATCTCATG 2160

TACCAGTGCT GGAGTGCTGA CCCCAAGCAG CGCCCGAGCT TTACTTGTCT GCGAATGGAA 2220

CTGGAGAACA TCTTGGGCCA GCTGTCTGTG CTATCTGCCA GCCAGGACCC CTTATACATC 2280

AACATCGAGA GAGCTGAGGA GCCCACTGCG GGAGGCAGCC TGGAGCTACC TGGCAGGGAT 2340

CAGCCCTACA GTGGGGCTGG GGATGGCAGT GGCATGGGGG CAGTGGGTGG CACTCCCAGT 2400

GACTGTCGGT ACATACTCAC CCCCGGAGGG CTGGCTGAGC AGCCAGGGCA GGCAGAGCAC 2460

CAGCCAGAGA GTCCCCTCAA TGAGACACAG AGGCTTTTGC TGCTGCAGCA AGGGCTACTG 2520

CCACACAGTA GCTGTTAG 2538

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         ++lg++lg+gefgsv+e+qlkqedgs++kvavk+lk+diia+s+ieefl+eaacmkefdh

Q: 473   FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDH  532

         68**********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         p+v++lvgvsl+s++kgrlp+p+vilpfmk+gdlhafll+sr+genp++lplqtl++fmv

Q: 533   PHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMV  592

         ************************************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         dia+gmeylssrnfihrdlaarncmlaedmtvcvadfgls+kiysgdyyrqg+++klpvk

Q: 593   DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK  652

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl++gnrlkqp++c

Q: 653   WLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPEC  712

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvlr  266

         ++++ydlmy+cw+adpk+rpsf+ lr

Q: 713   MEDVYDLMYQCWSADPKQRPSFTCLR  738

         ***********************998

Domain Sequence
(FASTA)

FTLGRMLGKG EFGSVREAQL KQEDGSFVKV AVKMLKADII ASSDIEEFLR EAACMKEFDH 60

PHVAKLVGVS LRSRAKGRLP IPMVILPFMK HGDLHAFLLA SRIGENPFNL PLQTLIRFMV 120

DIACGMEYLS SRNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 180

WLALESLADN LYTVQSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIG GNRLKQPPEC 240

MEDVYDLMYQ CWSADPKQRP SFTCLR 266

Keyword

3D-structure; ATP-binding; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005789	; C:endoplasmic reticulum membrane
GO:0005887	; C:integral to plasma membrane
GO:0005635	; C:nuclear envelope
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0043277	; P:apoptotic cell clearance
GO:0021885	; P:forebrain cell migration
GO:0001779	; P:natural killer cell differentiation
GO:0050728	; P:negative regulation of inflammatory response
GO:0045824	; P:negative regulation of innate immune response
GO:0051250	; P:negative regulation of lymphocyte activation
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:0034122	; P:negative regulation of toll-like receptor signaling pathway
GO:0070050	; P:neuron homeostasis
GO:0042698	; P:ovulation cycle
GO:0014065	; P:phosphatidylinositol 3-kinase cascade
GO:0070527	; P:platelet aggregation
GO:0046777	; P:protein autophosphorylation
GO:0043491	; P:protein kinase B signaling cascade
GO:0032940	; P:secretion by cell
GO:0007283	; P:spermatogenesis
GO:0034446	; P:substrate adhesion-dependent cell spreading
GO:0060068	; P:vagina development

KEGG

hsa:7301

;

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 1.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013