EKS-HOS-00146

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00146

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/CDC7	556.6	7.8E-167	58	569	512

Status

Reviewed

Ensembl Protein

ENSP00000234626

UniProt Accession

O00311; D3DT31; O00558; Q5T5U5;

Protein Name

Cell division cycle 7-related protein kinase

Protein Synonyms/Alias

CDC7-related kinase; HsCdc7; huCdc7;

Gene Name

CDC7

Gene Synonyms/Alias

CDC7; CDC7L1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000097046	ENSP00000393139	ENST00000428239
ENSG00000097046	ENSP00000407477	ENST00000430031
ENSG00000097046	ENSP00000234626	ENST00000234626
ENSG00000097046	ENSP00000398077	ENST00000426137

Organism

Homo sapiens

Functional Description

Seems to phosphorylate critical substrates that regulatethe G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

Protein Length

574

Protein Sequence
(FASTA)

MEASLGIQMD EPMAFSPQRD RFQAEGSLKK NEQNFKLAGV KKDIEKLYEA VPQLSNVFKI 60

EDKIGEGTFS SVYLATAQLQ VGPEEKIALK HLIPTSHPIR IAAELQCLTV AGGQDNVMGV 120

KYCFRKNDHV VIAMPYLEHE SFLDILNSLS FQEVREYMLN LFKALKRIHQ FGIVHRDVKP 180

SNFLYNRRLK KYALVDFGLA QGTHDTKIEL LKFVQSEAQQ ERCSQNKSHI ITGNKIPLSG 240

PVPKELDQQS TTKASVKRPY TNAQIQIKQG KDGKEGSVGL SVQRSVFGER NFNIHSSISH 300

ESPAVKLMKQ SKTVDVLSRK LATKKKAIST KVMNSAVMRK TASSCPASLT CDCYATDKVC 360

SICLSRRQQV APRAGTPGFR APEVLTKCPN QTTAIDMWSA GVIFLSLLSG RYPFYKASDD 420

LTALAQIMTI RGSRETIQAA KTFGKSILCS KEVPAQDLRK LCERLRGMDS STPKLTSDIQ 480

GHASHQPAIS EKTDHKASCL VQTPPGQYSG NSFKKGDSNS CEHCFDEYNT NLEGWNEVPD 540

EAYDLLDKLL DLNPASRITA EEALLHPFFK DMSL 574

Nucleotide Sequence
(FASTA)

ATGGAGGCGT CTTTGGGGAT TCAGATGGAT GAGCCAATGG CTTTTTCTCC CCAGCGTGAC 60

CGGTTTCAGG CTGAAGGCTC TTTAAAAAAA AACGAGCAGA ATTTTAAACT TGCAGGTGTT 120

AAAAAAGATA TTGAGAAGCT TTATGAAGCT GTACCACAGC TTAGTAATGT GTTTAAGATT 180

GAGGACAAAA TTGGAGAAGG CACTTTCAGC TCTGTTTATT TGGCCACAGC ACAGTTACAA 240

GTAGGACCTG AAGAGAAAAT TGCTCTAAAA CACTTGATTC CAACAAGTCA TCCTATAAGA 300

ATTGCAGCTG AACTTCAGTG CCTAACAGTG GCTGGGGGGC AAGATAATGT CATGGGAGTT 360

AAATACTGCT TTAGGAAGAA TGATCATGTA GTTATTGCTA TGCCATATCT GGAGCATGAG 420

TCGTTTTTGG ACATTCTGAA TTCTCTTTCC TTTCAAGAAG TACGGGAATA TATGCTTAAT 480

CTGTTCAAAG CTTTGAAACG CATTCATCAG TTTGGTATTG TTCACCGTGA TGTTAAGCCC 540

AGCAATTTTT TATATAATAG GCGCCTGAAA AAGTATGCCT TGGTAGACTT TGGTTTGGCC 600

CAAGGAACCC ATGATACGAA AATAGAGCTT CTTAAATTTG TCCAGTCTGA AGCTCAGCAG 660

GAAAGGTGTT CACAAAACAA ATCCCACATA ATCACAGGAA ACAAGATTCC ACTGAGTGGC 720

CCAGTACCTA AGGAGCTGGA TCAGCAGTCC ACCACAAAAG CTTCTGTTAA AAGACCCTAC 780

ACAAATGCAC AAATTCAGAT TAAACAAGGA AAAGACGGAA AGGAGGGATC TGTAGGCCTT 840

TCTGTCCAGC GCTCTGTTTT TGGAGAAAGA AATTTCAATA TACACAGCTC CATTTCACAT 900

GAGAGCCCTG CAGTGAAACT CATGAAGCAG TCAAAGACTG TGGATGTACT GTCTAGAAAG 960

TTAGCAACAA AAAAGAAGGC TATTTCTACA AAAGTTATGA ATAGTGCTGT GATGAGGAAA 1020

ACTGCCAGTT CTTGCCCAGC TAGCCTGACC TGTGACTGCT ATGCAACAGA TAAAGTTTGT 1080

AGTATTTGCC TTTCAAGGCG TCAGCAGGTT GCCCCTAGGG CAGGTACACC AGGATTCAGA 1140

GCACCAGAGG TCTTGACAAA GTGCCCCAAT CAAACTACAG CAATTGACAT GTGGTCTGCA 1200

GGTGTCATAT TTCTTTCTTT GCTTAGTGGA CGATATCCAT TTTATAAAGC AAGTGATGAT 1260

TTAACTGCTT TGGCCCAAAT TATGACAATT AGGGGATCCA GAGAAACTAT CCAAGCTGCT 1320

AAAACTTTTG GGAAATCAAT ATTATGTAGC AAAGAAGTTC CAGCACAAGA CTTGAGAAAA 1380

CTCTGTGAGA GACTCAGGGG TATGGATTCT AGCACTCCCA AGTTAACAAG TGATATACAA 1440

GGGCATGCTT CTCATCAACC AGCTATTTCA GAGAAGACTG ACCATAAAGC TTCTTGCCTC 1500

GTTCAAACAC CTCCAGGACA ATACTCAGGG AATTCATTTA AAAAGGGGGA TAGTAATAGC 1560

TGTGAGCATT GTTTTGATGA GTATAATACC AATTTAGAAG GCTGGAATGA GGTACCTGAT 1620

GAAGCTTATG ACCTGCTTGA TAAACTTCTA GATCTAAATC CAGCTTCAAG AATAACAGCA 1680

GAAGAAGCTT TGTTGCATCC ATTTTTTAAA GATATGAGCT TGTGA 1725

Domain Profile

S: 1     fkikdkiGeGtfssvylataqleegleekialkhliptshPeriaaeLelltvlgGqenv  60

         fki+dkiGeGtfssvylataql++g+eekialkhliptshP+riaaeL++ltv+gGq+nv

Q: 58    FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV  117

         9***********************************************************

S: 61    vglkecfrkndsvvivlpylehesfldllrslsfqevreYlrnLlvalkrvhkfgivhrD  120

         +g+k+cfrknd+vvi++pylehesfld+l+slsfqevreY++nL++alkr+h+fgivhrD

Q: 118   MGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRD  177

         ************************************************************

S: 121   vkpsnfLynrrlkkfaLvDfGLaq..............seaqkeecsrn..........l  156

         vkpsnfLynrrlkk+aLvDfGLaq              seaq+e+cs+n          +

Q: 178   VKPSNFLYNRRLKKYALVDFGLAQgthdtkiellkfvqSEAQQERCSQNkshiitgnkiP  237

         ***********************************************************9

S: 157   lsaavekevd..................................................  166

         ls++v+ke+d

Q: 238   LSGPVPKELDqqsttkasvkrpytnaqiqikqgkdgkegsvglsvqrsvfgernfnihss  297

         ************************************************************

S: 167   ....................................................tcdcygtd  174

                                                             tcdcy+td

Q: 298   ishespavklmkqsktvdvlsrklatkkkaistkvmnsavmrktasscpaslTCDCYATD  357

         ************************************************************

S: 175   kvcsvclsrrqqvanraGtpGfraPevLlkipdqttaiDiwsaGvilLsllsgryPffka  234

         kvcs+clsrrqqva+raGtpGfraPevL+k+p+qttaiD+wsaGvi+LsllsgryPf+ka

Q: 358   KVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKA  417

         ************************************************************

S: 235   sddlealaeivtilGsreiikaakafgksvllskevp.......................  271

         sddl+ala+i+ti+Gsre+i+aak+fgks+l+skevp

Q: 418   SDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPaqdlrklcerlrgmdsstpklts  477

         ************************************************************

S: 272   .......................................dsdsye...............  277

                                                ds+s+e

Q: 478   diqghashqpaisektdhkasclvqtppgqysgnsfkkgDSNSCEhcfdeyntnlegwne  537

         **************************************9888887888999999999999

S: 278   .PdeaydlldkllelnPakritaeealkhpff  308

          Pdeaydlldkll+lnPa+ritaeeal+hpff

Q: 538   vPDEAYDLLDKLLDLNPASRITAEEALLHPFF  569

         *******************************8

Domain Sequence
(FASTA)

FKIEDKIGEG TFSSVYLATA QLQVGPEEKI ALKHLIPTSH PIRIAAELQC LTVAGGQDNV 60

MGVKYCFRKN DHVVIAMPYL EHESFLDILN SLSFQEVREY MLNLFKALKR IHQFGIVHRD 120

VKPSNFLYNR RLKKYALVDF GLAQGTHDTK IELLKFVQSE AQQERCSQNK SHIITGNKIP 180

LSGPVPKELD QQSTTKASVK RPYTNAQIQI KQGKDGKEGS VGLSVQRSVF GERNFNIHSS 240

ISHESPAVKL MKQSKTVDVL SRKLATKKKA ISTKVMNSAV MRKTASSCPA SLTCDCYATD 300

KVCSICLSRR QQVAPRAGTP GFRAPEVLTK CPNQTTAIDM WSAGVIFLSL LSGRYPFYKA 360

SDDLTALAQI MTIRGSRETI QAAKTFGKSI LCSKEVPAQD LRKLCERLRG MDSSTPKLTS 420

DIQGHASHQP AISEKTDHKA SCLVQTPPGQ YSGNSFKKGD SNSCEHCFDE YNTNLEGWNE 480

VPDEAYDLLD KLLDLNPASR ITAEEALLHP FF 512

Keyword

3D-structure; Alternative splicing; ATP-binding; Cell cycle; Cell division; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005654	; C:nucleoplasm
GO:0005524	; F:ATP binding
GO:0016301	; F:kinase activity
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000075	; P:cell cycle checkpoint
GO:0051301	; P:cell division
GO:0006260	; P:DNA replication
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0000216	; P:M/G1 transition of mitotic cell cycle
GO:0008284	; P:positive regulation of cell proliferation
GO:0033261	; P:regulation of S phase

KEGG

hsa:8317

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013