EKS-HOS-00206

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00206

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/MAST	526.5	7.4E-158	367	640	274

Status

Reviewed

Ensembl Protein

ENSP00000262811

UniProt Accession

O60307; Q7LDZ8; Q9UPI0;

Protein Name

Microtubule-associated serine/threonine-protein kinase 3

Protein Synonyms/Alias

Gene Name

MAST3

Gene Synonyms/Alias

MAST3; KIAA0561;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000099308	ENSP00000262811	ENST00000262811

Organism

Homo sapiens

Functional Description

Protein Length

1309

Protein Sequence
(FASTA)

MDESSLLRRR GLQKELSLPR RGRGCRSGNR KSLVVGTPSP TLSRPLSPLS VPTAGSSPLD 60

SPRNFSAASA LNFPFARRAD GRRWSLASLP SSGYGTNTPS STLSSSSSSR ERLHQLPFQP 120

TPDELHFLSK HFRSSENVLD EEGGRSPRLR PRSRSLSPGR ATGTFDNEIV MMNHVYRERF 180

PKATAQMEGR LQEFLTAYAP GARLALADGV LGFIHHQIVE LARDCLAKSG ENLVTSRYFL 240

EMQEKLERLL QDAHERSDSE EVSFIVQLVR KLLIIISRPA RLLECLEFDP EEFYHLLEAA 300

EGHAREGQGI KTDLPQYIIG QLGLAKDPLE EMVPLSHLEE EQPPAPESPE SRALVGQSRR 360

KPCESDFETI KLISNGAYGA VYLVRHRDTR QRFAIKKINK QNLILRNQIQ QVFVERDILT 420

FAENPFVVSM FCSFETRRHL CMVMEYVEGG DCATLLKNMG PLPVDMARLY FAETVLALEY 480

LHNYGIVHRD LKPDNLLITS LGHIKLTDFG LSKIGLMSMA TNLYEGHIEK DAREFIDKQV 540

CGTPEYIAPE VIFRQGYGKP VDWWAMGVVL YEFLVGCVPF FGDTPEELFG QVVSDEIMWP 600

EGDEALPADA QDLITRLLRQ SPLDRLGTGG THEVKQHPFF LALDWAGLLR HKAEFVPQLE 660

AEDDTSYFDT RSERYRHLGS EDDETNDEES STEIPQFSSC SHRFSKVYSS SEFLAVQPTP 720

TFAERSFSED REEGWERSEV DYGRRLSADI RLRSWTSSGS SCQSSSSQPE RGPSPSLLNT 780

ISLDTMPKFA FSSEDEGVGP GPAGPKRPVF ILGEPDPPPA ATPVMPKPSS LSADTAALSH 840

ARLRSNSIGA RHSTPRPLDA GRGRRLGGPR DPAPEKSRAS SSGGSGGGSG GRVPKSASVS 900

ALSLIITADD GSGGPLMSPL SPRSLSSNPS SRDSSPSRDP SPVCGSLRPP IVIHSSGKKY 960

GFSLRAIRVY MGDSDVYTVH HVVWSVEDGS PAQEAGLRAG DLITHINGES VLGLVHMDVV 1020

ELLLKSGNKI SLRTTALENT SIKVGPARKN VAKGRMARRS KRSRRRETQD RRKSLFKKIS 1080

KQTSVLHTSR SFSSGLHHSL SSSESLPGSP THSLSPSPTT PCRSPAPDVP ADTTASPPSA 1140

SPSSSSPASP AAAGHTRPSS LHGLAAKLGP PRPKTGRRKS TSSIPPSPLA CPPISAPPPR 1200

SPSPLPGHPP APARSPRLRR GQSADKLGTG ERLDGEAGRR TRGPEAELVV MRRLHLSERR 1260

DSFKKQEAVQ EVSFDEPQEE ATGLPTSVPQ IAVEGEEAVP VALGPTGRD 1309

Nucleotide Sequence
(FASTA)

ATGGACGAGT CGAGCCTCCT GCGGCGCCGC GGGCTCCAGA AGGAGCTGAG CCTGCCACGC 60

CGAGGACGTG GCTGCCGCAG CGGGAACCGC AAGAGCTTGG TGGTAGGAAC GCCCTCCCCG 120

ACCCTCTCCC GGCCCCTGTC GCCATTGTCG GTCCCAACGG CAGGCAGCAG CCCCTTGGAT 180

AGTCCTCGGA ATTTCTCGGC TGCCTCTGCC CTAAATTTCC CCTTTGCCCG GAGGGCAGAC 240

GGCAGAAGAT GGTCCCTCGC GTCTCTCCCA TCTTCCGGCT ATGGAACCAA CACACCCAGC 300

TCCACCCTCT CGTCAAGCTC ATCCTCCCGG GAACGTCTCC ACCAGCTTCC CTTCCAGCCG 360

ACGCCGGACG AGCTGCACTT CCTGTCCAAG CACTTCCGCA GCTCAGAGAA TGTGCTTGAT 420

GAGGAAGGCG GCCGGTCACC CCGCCTCCGA CCCCGCTCTC GCAGTCTCAG CCCGGGCCGT 480

GCAACGGGGA CCTTCGACAA TGAGATTGTC ATGATGAATC ACGTGTACCG GGAGAGGTTC 540

CCCAAGGCCA CAGCACAGAT GGAGGGCCGT CTGCAGGAGT TCCTGACGGC CTACGCGCCC 600

GGCGCCCGGC TGGCGCTGGC TGATGGCGTC TTGGGCTTCA TCCACCACCA GATCGTCGAG 660

CTGGCCCGAG ACTGCTTGGC CAAGTCTGGC GAGAACCTCG TCACCTCCCG CTACTTCCTA 720

GAGATGCAGG AGAAGCTGGA GCGGCTTCTG CAGGATGCCC ATGAGCGTTC GGACAGTGAG 780

GAGGTCAGCT TCATCGTCCA GCTTGTCCGG AAACTGCTGA TCATCATCTC ACGGCCAGCT 840

CGGCTGCTGG AGTGTCTGGA GTTTGACCCT GAGGAATTTT ACCACCTGCT GGAGGCGGCT 900

GAGGGCCATG CGCGGGAGGG CCAAGGCATT AAGACTGACC TTCCACAGTA CATCATTGGG 960

CAGCTGGGCC TGGCCAAGGA CCCCCTGGAG GAGATGGTGC CACTGAGTCA CCTCGAAGAA 1020

GAACAGCCCC CAGCACCTGA GTCCCCAGAG AGCCGCGCCC TGGTCGGCCA GTCACGGAGG 1080

AAGCCATGCG AAAGCGACTT TGAGACCATC AAACTCATTA GCAACGGAGC CTATGGGGCC 1140

GTCTACCTGG TGCGGCACCG TGACACACGG CAGCGCTTTG CCATCAAGAA GATCAACAAA 1200

CAGAACTTGA TCCTGCGTAA CCAGATCCAG CAGGTCTTTG TGGAGCGTGA CATTCTCACC 1260

TTTGCCGAGA ACCCCTTTGT GGTCAGCATG TTCTGCTCCT TTGAGACCCG GCGCCACCTA 1320

TGTATGGTCA TGGAATACGT GGAAGGCGGC GACTGCGCCA CGCTCCTGAA GAACATGGGC 1380

CCGCTGCCCG TGGACATGGC CCGCCTGTAC TTCGCCGAGA CGGTGTTGGC GCTGGAGTAC 1440

CTGCATAACT ATGGCATCGT GCACCGTGAC CTCAAACCAG ACAATCTGCT CATCACCTCG 1500

CTTGGCCACA TCAAGCTCAC GGACTTCGGC CTGTCCAAGA TCGGCCTCAT GAGCATGGCC 1560

ACCAACCTCT ATGAGGGCCA CATCGAGAAG GACGCCCGAG AGTTCATCGA CAAGCAGGTG 1620

TGTGGGACGC CGGAGTACAT AGCCCCCGAG GTGATCTTCC GCCAGGGCTA TGGGAAGCCA 1680

GTGGACTGGT GGGCCATGGG CGTCGTCCTC TATGAGTTTC TGGTGGGCTG CGTGCCTTTC 1740

TTTGGAGATA CCCCCGAGGA ACTCTTCGGT CAGGTGGTCA GCGATGAGAT CATGTGGCCA 1800

GAGGGAGATG AGGCCCTTCC AGCAGACGCC CAGGACCTCA TCACCAGGTT GCTCCGGCAG 1860

AGCCCGCTGG ACCGTCTGGG CACTGGTGGC ACCCACGAAG TGAAGCAGCA CCCCTTTTTC 1920

CTGGCCCTGG ACTGGGCAGG GCTTCTCCGA CACAAAGCCG AGTTCGTGCC CCAGCTCGAA 1980

GCTGAGGATG ATACCAGCTA CTTTGACACA CGTTCGGAAC GTTACCGCCA TCTGGGCTCC 2040

GAGGACGACG AGACCAATGA TGAAGAATCG TCCACAGAGA TCCCCCAGTT CTCCTCCTGC 2100

TCCCACCGGT TCAGCAAGGT CTACAGCAGC TCTGAGTTCC TGGCCGTCCA GCCCACTCCT 2160

ACCTTCGCTG AAAGGAGCTT CAGTGAAGAC CGGGAGGAGG GGTGGGAGCG CAGCGAAGTG 2220

GACTATGGCC GCCGGCTGAG TGCTGACATC CGGCTGAGGT CCTGGACATC CTCTGGATCC 2280

TCCTGTCAGT CATCTTCGTC CCAGCCCGAG CGGGGTCCCA GCCCATCTCT CCTGAATACC 2340

ATCAGCCTGG ACACAATGCC CAAGTTTGCC TTCTCATCAG AGGATGAGGG GGTAGGCCCA 2400

GGCCCTGCAG GCCCCAAGAG GCCCGTCTTC ATTCTAGGGG AGCCTGACCC CCCACCAGCG 2460

GCCACCCCAG TGATGCCCAA GCCCTCGAGC CTTTCTGCCG ACACAGCTGC TCTCAGCCAC 2520

GCCCGCCTAC GGAGCAATAG CATCGGCGCC CGACACTCCA CACCAAGGCC TCTGGATGCC 2580

GGCCGGGGCC GCCGCCTTGG GGGCCCAAGA GACCCAGCCC CTGAGAAGTC CAGAGCCTCC 2640

TCCAGCGGTG GCAGTGGTGG CGGCAGTGGG GGCCGCGTGC CCAAGTCAGC CTCTGTCTCT 2700

GCCCTGTCCC TCATCATCAC GGCAGATGAT GGCAGCGGCG GCCCCCTCAT GAGCCCCCTT 2760

TCCCCGCGCT CTCTGTCCTC GAACCCGTCG TCCCGTGACT CTTCGCCGAG CCGAGACCCG 2820

TCCCCCGTGT GTGGCAGCCT GCGGCCCCCC ATCGTTATCC ACAGCTCTGG CAAGAAGTAC 2880

GGCTTCAGCC TGCGGGCGAT CCGCGTCTAC ATGGGTGATA GCGACGTCTA CACTGTGCAC 2940

CACGTCGTCT GGAGTGTGGA GGACGGAAGC CCCGCCCAGG AGGCGGGCCT GCGGGCTGGG 3000

GACCTCATCA CCCACATCAA CGGGGAGTCA GTGCTGGGGC TGGTGCACAT GGACGTCGTG 3060

GAGCTGCTGC TGAAGAGCGG CAACAAGATA TCCCTGCGGA CCACAGCCCT GGAGAACACC 3120

TCCATCAAGG TGGGCCCCGC CCGGAAGAAT GTGGCCAAGG GCCGCATGGC ACGCAGGAGC 3180

AAGAGGAGCC GTCGGCGGGA GACCCAGGAT CGGCGGAAGT CACTTTTCAA GAAGATCTCC 3240

AAGCAGACCT CCGTGCTGCA CACCAGCCGC AGCTTCTCCT CCGGACTCCA CCACTCACTG 3300

TCATCCAGTG AGAGCCTCCC CGGCTCGCCC ACCCACAGCC TCTCCCCCAG CCCCACCACT 3360

CCCTGCCGAA GCCCAGCCCC TGATGTCCCA GCAGATACCA CTGCATCCCC ACCCAGCGCA 3420

TCCCCGAGCT CCAGCAGCCC CGCCTCCCCA GCTGCTGCTG GCCACACCCG CCCCAGCTCC 3480

CTGCACGGCC TGGCTGCCAA GCTTGGGCCA CCCCGCCCCA AGACTGGCCG CCGCAAGTCC 3540

ACCAGCAGCA TCCCGCCCTC CCCGCTGGCC TGCCCGCCCA TCTCCGCGCC CCCACCCCGC 3600

TCGCCCTCGC CCCTGCCCGG GCACCCGCCC GCACCTGCCC GATCCCCGCG GCTGCGCCGG 3660

GGCCAGTCAG CTGACAAGCT GGGCACAGGG GAGCGGCTGG ATGGGGAGGC GGGGCGGCGC 3720

ACTCGTGGGC CAGAGGCCGA GCTCGTGGTC ATGCGGCGGC TGCACCTGTC CGAGCGCCGA 3780

GACTCCTTCA AGAAGCAGGA GGCCGTGCAG GAGGTTAGCT TCGATGAGCC GCAGGAGGAG 3840

GCCACTGGGC TGCCCACCTC AGTGCCACAG ATCGCCGTGG AGGGCGAGGA AGCCGTGCCA 3900

GTAGCTCTCG GGCCCACCGG AAGAGACTGA 3930

Domain Profile

S: 1     feiiklisrGayGavylvrhketrkrfavkkikkqdlilknqvqqvfaerdilalaenpf  60

         fe+iklis+GayGavylvrh++tr+rfa+kki+kq+lil+nq+qqvf+erdil++aenpf

Q: 367   FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPF  426

         99**********************************************************

S: 61    vvslyysletrrnlylvmeyveGGdvksllkniGaldvemarlyiaevvlaleylhryGi  120

         vvs+++s+etrr+l++vmeyveGGd+++llkn+G+l+v+marly+ae+vlaleylh+yGi

Q: 427   VVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGI  486

         ************************************************************

S: 121   vhrdlkPdnllitseGhikltdfGlskvglmslttnlyegyidkdarefldkqvcgtPey  180

         vhrdlkPdnllits GhikltdfGlsk+glms++tnlyeg+i+kdaref+dkqvcgtPey

Q: 487   VHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEY  546

         ************************************************************

S: 181   iaPevilrqgygkpvdwwalgiilyeflvgivpffgdtpeelfaqvlsdeivwPekdeal  240

         iaPevi+rqgygkpvdwwa+g++lyeflvg+vpffgdtpeelf+qv+sdei+wPe+deal

Q: 547   IAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEAL  606

         ************************************************************

S: 241   ssealelisellesnPrerlgtgsaaevkqhefl  274

         +++a++li++ll+++P +rlgtg+++evkqh+f+

Q: 607   PADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFF  640

         ********************************97

Domain Sequence
(FASTA)

FETIKLISNG AYGAVYLVRH RDTRQRFAIK KINKQNLILR NQIQQVFVER DILTFAENPF 60

VVSMFCSFET RRHLCMVMEY VEGGDCATLL KNMGPLPVDM ARLYFAETVL ALEYLHNYGI 120

VHRDLKPDNL LITSLGHIKL TDFGLSKIGL MSMATNLYEG HIEKDAREFI DKQVCGTPEY 180

IAPEVIFRQG YGKPVDWWAM GVVLYEFLVG CVPFFGDTPE ELFGQVVSDE IMWPEGDEAL 240

PADAQDLITR LLRQSPLDRL GTGGTHEVKQ HPFF 274

Keyword

3D-structure; Acetylation; ATP-binding; Complete proteome; Kinase; Magnesium; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

hsa:23031

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR015022	; MA_Ser/Thr_Kinase_dom.
IPR023142	; MAST_pre-PK_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08926	; DUF1908; 1.
PF00595	; PDZ; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00228	; PDZ; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013