| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00243 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/MAPKAPK | 402.9 | 2.9E-120 | 85 | 368 | 284 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000309485 |
| UniProt Accession | Q9HBH9; Q6GPI3; Q9HBH8; Q9UHR0; Q9Y2N6; |
| Protein Name | MAP kinase-interacting serine/threonine-protein kinase 2 |
| Protein Synonyms/Alias | MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2; |
| Gene Name | MKNK2 |
| Gene Synonyms/Alias | MKNK2; GPRK7, MNK2; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Serine/threonine-protein kinase that phosphorylatesSFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. |
| Protein Length | 414 |
Protein Sequence
(FASTA) | | MVQKKPAELQ GFHRSFKGQN PFELAFSLDQ PDHGDSDFGL QCSARPDMPA SQPIDIPDAK 60 | | KRGKKKKRGR ATDSFSGRFE DVYQLQEDVL GEGAHARVQT CINLITSQEY AVKIIEKQPG 120 | | HIRSRVFREV EMLYQCQGHR NVLELIEFFE EEDRFYLVFE KMRGGSILSH IHKRRHFNEL 180 | | EASVVVQDVA SALDFLHNKG IAHRDLKPEN ILCEHPNQVS PVKICDFDLG SGIKLNGDCS 240 | | PISTPELLTP CGSAEYMAPE VVEAFSEEAS IYDKRCDLWS LGVILYILLS GYPPFVGRCG 300 | | SDCGWDRGEA CPACQNMLFE SIQEGKYEFP DKDWAHISCA AKDLISKLLV RDAKQRLSAA 360 | | QVLQHPWVQG CAPENTLPTP MVLQRWDSHF LLPPHPCRIH VRPGGLVRTV TVNE 414 |
|
Nucleotide Sequence
(FASTA) | | ATGGTGCAGA AGAAACCAGC CGAACTTCAG GGTTTCCACC GTTCGTTCAA GGGGCAGAAC 60 | | CCCTTCGAGC TGGCCTTCTC CCTAGACCAG CCCGACCACG GAGACTCTGA CTTTGGCCTG 120 | | CAGTGCTCAG CCCGCCCTGA CATGCCCGCC AGCCAGCCCA TTGACATCCC GGACGCCAAG 180 | | AAGAGGGGCA AGAAGAAGAA GCGCGGCCGG GCCACCGACA GCTTCTCGGG CAGGTTTGAA 240 | | GACGTCTACC AGCTGCAGGA AGATGTGCTG GGGGAGGGCG CTCATGCCCG AGTGCAGACC 300 | | TGCATCAACC TGATCACCAG CCAGGAGTAC GCCGTCAAGA TCATTGAGAA GCAGCCAGGC 360 | | CACATTCGGA GCAGGGTTTT CAGGGAGGTG GAGATGCTGT ACCAGTGCCA GGGACACAGG 420 | | AACGTCCTAG AGCTGATTGA GTTCTTCGAG GAGGAGGACC GCTTCTACCT GGTGTTTGAG 480 | | AAGATGCGGG GAGGCTCCAT CCTGAGCCAC ATCCACAAGC GCCGGCACTT CAACGAGCTG 540 | | GAGGCCAGCG TGGTGGTGCA GGACGTGGCC AGCGCCTTGG ACTTTCTGCA TAACAAAGGC 600 | | ATCGCCCACA GGGACCTAAA GCCGGAAAAC ATCCTCTGTG AGCACCCCAA CCAGGTCTCC 660 | | CCCGTGAAGA TCTGTGACTT CGACCTGGGC AGCGGCATCA AACTCAACGG GGACTGCTCC 720 | | CCTATCTCCA CCCCGGAGCT GCTCACTCCG TGCGGCTCGG CGGAGTACAT GGCCCCGGAG 780 | | GTAGTGGAGG CCTTCAGCGA GGAGGCTAGC ATCTACGACA AGCGCTGCGA CCTGTGGAGC 840 | | CTGGGCGTCA TCTTGTATAT CCTACTCAGC GGCTACCCGC CCTTCGTGGG CCGCTGTGGC 900 | | AGCGACTGCG GCTGGGACCG CGGCGAGGCC TGCCCTGCCT GCCAGAACAT GCTGTTTGAG 960 | | AGCATCCAGG AGGGCAAGTA CGAGTTCCCC GACAAGGACT GGGCCCACAT CTCCTGCGCT 1020 | | GCCAAAGACC TCATCTCCAA GCTGCTGGTC CGTGACGCCA AGCAGAGGCT GAGTGCCGCC 1080 | | CAAGTCCTGC AGCACCCCTG GGTTCAGGGG TGCGCCCCGG AGAACACCTT GCCCACTCCC 1140 | | ATGGTCCTGC AGAGGTGGGA CAGTCACTTC CTCCTCCCTC CCCACCCCTG TCGCATCCAC 1200 | | GTGCGACCTG GAGGACTGGT CAGAACCGTT ACTGTGAATG AGTGA 1245 |
|
| Domain Profile | S: 2 lteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghknive 56 | l+e+vlGeG++++v++c++ t+++ya+ki+ + r++v+reve+++q++gh+n++e | Q: 85 LQEDVLGEGAHARVQTCINLITSQEYAVKIIekqpgHIRSRVFREVEMLYQCQGHRNVLE 144 | 789********************************************************* |
| S: 57 lidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhskn 116 | li++fe +e+r++lv+ek++GG++ls+i++r++f+e eas vv+d+asal+flh+k+ | Q: 145 LIEFFE----EEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKG 200 | ******....9************************************************* |
| S: 117 iahrDlkpenlLyeskeknapvklcDfglaketeee........eelktpcltaeyvaPe 168 | iahrDlkpen+L+e++++++pvk+cDf+l+++++ + +el tpc++aey+aPe | Q: 201 IAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNgdcspistPELLTPCGSAEYMAPE 260 | ********************************955556899999**************** |
| S: 169 vleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskklke 217 | v+ea++eea++ydk+CDlWslGvilyill+GypPf++++g a++++l+e | Q: 261 VVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGsdcgwdrgeacPACQNMLFE 320 | ***************************************99*********99******** |
| S: 218 riqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv 265 | +iqegkyefP+++W+++s +akdli+klL+rd+k+rl++++vl+hpwv | Q: 321 SIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 368 | ***********************************************8 |
|
Domain Sequence
(FASTA) | | LQEDVLGEGA HARVQTCINL ITSQEYAVKI IEKQPGHIRS RVFREVEMLY QCQGHRNVLE 60 | | LIEFFEEEDR FYLVFEKMRG GSILSHIHKR RHFNELEASV VVQDVASALD FLHNKGIAHR 120 | | DLKPENILCE HPNQVSPVKI CDFDLGSGIK LNGDCSPIST PELLTPCGSA EYMAPEVVEA 180 | | FSEEASIYDK RCDLWSLGVI LYILLSGYPP FVGRCGSDCG WDRGEACPAC QNMLFESIQE 240 | | GKYEFPDKDW AHISCAAKDL ISKLLVRDAK QRLSAAQVLQ HPWV 284 |
|
| Keyword | 3D-structure; Alternative splicing; Apoptosis; ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Translation regulation; Zinc. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |