Tag | Content |
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EKPD ID | EPS-HOS-00026 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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PPM/PP2C | 201.6 | 9.6E-59 | 53 | 307 | 255 |
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Status | Reviewed |
Ensembl Protein | ENSP00000439915 |
UniProt Accession | P49593; A8K6G3; Q96PM2; |
Protein Name | Protein phosphatase 1F |
Protein Synonyms/Alias | Ca(2+)/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; CaMKPase; Partner of PIX 2; Protein fem-2 homolog; hFem-2; |
Gene Name | PPM1F |
Gene Synonyms/Alias | PPM1F; KIAA0015, POPX2; |
Ensembl Information | |
Organism | Homo sapiens |
Functional Description | Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis. |
Protein Length | 350 |
Protein Sequence (FASTA) | MGLCPSTRET APPAVLDAQS LAQSFFNRLW EVAGQWQKQV PLAARASQRQ WLVSIHAIRN 60 | TRRKMEDRHV SLPSFNQLFG LSDPVNRAYF AVFDGHGGVD AARYAAVHVH TNAARQPELP 120 | TDPEGALREA FRRTDQMFLR KAKRERLQSG TTGVCALIAG ATLHVAWLGD SQVILVQQGQ 180 | VVKLMEPHRP ERQDEKARIE ALGGFVSHMD CWRVNGTLAV SRAIGDVFQK PYVSGEADAA 240 | SRALTGSEDY LLLACDGFFD VVPHQEVVGL VQSHLTRQQG SGLRVAEELV AAARERGSHD 300 | NITVMVVFLR DPQELLEGGN QGEGDPQAEG RRQDLPSSLP EPETQAPPRS 350 |
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Nucleotide Sequence (FASTA) | ATGGGTCTCT GTCCGTCCAC GCGGGAGACA GCGCCACCTG CCGTGCTGGA TGCCCAAAGC 60 | CTGGCACAGA GTTTCTTTAA CCGCCTTTGG GAAGTCGCCG GCCAGTGGCA GAAGCAGGTG 120 | CCATTGGCTG CCCGGGCCTC ACAGCGGCAG TGGCTGGTCT CCATCCACGC CATCCGGAAC 180 | ACTCGCCGCA AGATGGAGGA CCGGCACGTG TCCCTCCCTT CCTTCAACCA GCTCTTCGGC 240 | TTGTCTGACC CTGTGAACCG CGCCTACTTT GCTGTGTTTG ATGGTCACGG AGGCGTGGAT 300 | GCTGCGAGGT ACGCCGCTGT CCACGTGCAC ACCAACGCTG CCCGCCAGCC AGAGCTGCCC 360 | ACAGACCCTG AGGGAGCCCT CAGAGAAGCC TTCCGGCGCA CCGACCAGAT GTTTCTCAGG 420 | AAAGCCAAGC GAGAGCGGCT GCAGAGCGGC ACCACAGGTG TGTGTGCGCT CATTGCAGGA 480 | GCGACCCTGC ACGTCGCCTG GCTCGGGGAT TCCCAGGTCA TTTTGGTACA GCAGGGACAG 540 | GTGGTGAAGC TGATGGAGCC ACACAGACCA GAACGGCAGG ATGAGAAGGC GCGCATTGAA 600 | GCATTGGGTG GCTTTGTGTC TCACATGGAC TGCTGGAGAG TCAACGGGAC CCTGGCCGTC 660 | TCCAGAGCCA TCGGGGATGT CTTCCAGAAG CCCTACGTGT CTGGGGAGGC CGATGCAGCT 720 | TCCCGGGCGC TGACGGGCTC CGAGGACTAC CTGCTGCTTG CCTGTGATGG CTTCTTTGAC 780 | GTCGTACCCC ACCAGGAAGT TGTTGGCCTG GTCCAGAGCC ACCTGACCAG GCAGCAGGGC 840 | AGCGGGCTCC GTGTCGCCGA GGAGCTGGTG GCTGCGGCCC GGGAGCGGGG CTCCCACGAC 900 | AACATCACGG TCATGGTGGT CTTCCTCAGG GACCCCCAAG AGCTGCTGGA GGGCGGGAAC 960 | CAGGGAGAAG GGGACCCCCA GGCAGAAGGG AGGAGGCAGG ACTTGCCCTC CAGCCTTCCA 1020 | GAACCTGAGA CCCAGGCTCC ACCAAGAAGC TAG 1053 |
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Domain Profile | S: 3 vgvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklhei 60 | v++ ++ + r++med++ s p+f + + +d a+f+v+DGhgg ++a++++ ++h+ | Q: 53 VSIHAIRNTRRKMEDRHVSLPSFNQLFGLSDPvnRAYFAVFDGHGGVDAARYAAVHVHTN 112 | 6678999******************99888887789************************ |
| S: 61 laeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyva 120 | a++ e ++ + al++aF +td+ + l +++ + +sG+t v+ali + +l+va | Q: 113 AARQPE----LPTDPEGALREAFRRTDQMF--LRKAKRERLQSGTTGVCALIAGATLHVA 166 | ****77....7889999*************..8888889999****************** |
| S: 121 nvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalGd 180 | +GdS+++L ++g++v+l + H+p+r+dE++Rie+ gg v d+ Rv+G LavsRa+Gd | Q: 167 WLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGD 226 | ********************************************99************** |
| S: 181 lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa 239 | ++ kpyv+ e + s lt ++++l La+DG +dvv+ +e+v lv+++l+ ++ + +a | Q: 227 VFQKPYVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTrQQGSGLRVA 286 | ************************************************996777899*** |
| S: 240 kkLvklalargskdnvsaivv 260 | ++Lv+ a++rgs+dn++++vv | Q: 287 EELVAAARERGSHDNITVMVV 307 | *****************9997 |
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Domain Sequence (FASTA) | VSIHAIRNTR RKMEDRHVSL PSFNQLFGLS DPVNRAYFAV FDGHGGVDAA RYAAVHVHTN 60 | AARQPELPTD PEGALREAFR RTDQMFLRKA KRERLQSGTT GVCALIAGAT LHVAWLGDSQ 120 | VILVQQGQVV KLMEPHRPER QDEKARIEAL GGFVSHMDCW RVNGTLAVSR AIGDVFQKPY 180 | VSGEADAASR ALTGSEDYLL LACDGFFDVV PHQEVVGLVQ SHLTRQQGSG LRVAEELVAA 240 | ARERGSHDNI TVMVV 255 |
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Keyword | Apoptosis; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Polymorphism; Protein phosphatase; Reference proteome. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | GO:0005829 | ; C:cytosol | GO:0043234 | ; C:protein complex | GO:0033192 | ; F:calmodulin-dependent protein phosphatase activity | GO:0046872 | ; F:metal ion binding | GO:0035690 | ; P:cellular response to drug | GO:0097193 | ; P:intrinsic apoptotic signaling pathway | GO:0033137 | ; P:negative regulation of peptidyl-serine phosphorylation | GO:0044387 | ; P:negative regulation of protein kinase activity by regulation of protein phosphorylation | GO:0045892 | ; P:negative regulation of transcription, DNA-dependent | GO:0035970 | ; P:peptidyl-threonine dephosphorylation | GO:0050921 | ; P:positive regulation of chemotaxis | GO:0043280 | ; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | GO:0010634 | ; P:positive regulation of epithelial cell migration | GO:0051894 | ; P:positive regulation of focal adhesion assembly | GO:0010628 | ; P:positive regulation of gene expression | GO:0045927 | ; P:positive regulation of growth | GO:0051496 | ; P:positive regulation of stress fiber assembly |
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KEGG | |
InterPros | |
Pfam | |
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Prosites | |
Prints | |
Created Date | 20-Feb-2013 |