EPS-HOS-00031

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00031

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	90.0	1.0E-24	57	334	278

Status

Reviewed

Ensembl Protein

ENSP00000333049

UniProt Accession

Q15750; Q2PP09; Q8IZW2;

Protein Name

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1;

Gene Name

TAB1

Gene Synonyms/Alias

TAB1; MAP3K7IP1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000100324	ENSP00000216160	ENST00000216160
ENSG00000100324	ENSP00000333049	ENST00000331454

Organism

Homo sapiens

Functional Description

May be an important signaling intermediate between TGFBreceptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Protein Length

462

Protein Sequence
(FASTA)

MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE DSWLKFRSEN 60

NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA DVRRVLLQAF DVVERSFLES 120

IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKTLER EISGGAMAVV AVLLNNKLYV 180

ANVGTNRALL CKSTVDGLQV TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST 240

RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 300

GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR FCPRHEDMTL 360

LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST SKTSVTLSLV MPSQGQMVNG 420

AHSASTLDEA TPTLTKDPSR PASDLTAIPQ CQLNLLGSLT PG 462

Nucleotide Sequence
(FASTA)

ATGGCGGCGC AGAGGAGGAG CTTGCTGCAG AGTGAGCAGC AGCCAAGCTG GACAGATGAC 60

CTGCCTCTCT GCCACCTCTC TGGGGTTGGC TCAGCCTCCA ACCGCAGCTA CTCTGCTGAT 120

GGCAAGGGCA CTGAGAGCCA CCCGCCAGAG GACAGCTGGC TCAAGTTCAG GAGTGAGAAC 180

AACTGCTTCC TGTATGGGGT CTTCAACGGC TATGATGGCA ACCGAGTGAC CAACTTCGTG 240

GCCCAGCGGC TGTCCGCAGA GCTCCTGCTG GGCCAGCTGA ATGCCGAGCA CGCCGAGGCC 300

GATGTGCGGC GTGTGCTGCT GCAGGCCTTC GATGTGGTGG AGAGGAGCTT CCTGGAGTCC 360

ATTGACGACG CCTTGGCTGA GAAGGCAAGC CTCCAGTCGC AATTGCCAGA GGGAGTCCCT 420

CAGCACCAGC TGCCTCCTCA GTATCAGAAG ATCCTTGAGA GACTCAAGAC GTTAGAGAGG 480

GAAATTTCGG GAGGGGCCAT GGCCGTTGTG GCGGTCCTTC TCAACAACAA GCTCTACGTC 540

GCCAATGTCG GTACAAACCG TGCACTTTTA TGCAAATCGA CAGTGGATGG GTTGCAGGTG 600

ACACAGCTGA ACGTGGACCA CACCACAGAG AACGAGGATG AGCTCTTCCG TCTTTCGCAG 660

CTGGGCTTGG ATGCTGGAAA GATCAAGCAG GTGGGGATCA TCTGTGGGCA GGAGAGCACC 720

CGGCGGATCG GGGATTACAA GGTTAAATAT GGCTACACGG ACATTGACCT TCTCAGCGCT 780

GCCAAGTCCA AACCAATCAT CGCAGAGCCA GAAATCCATG GGGCACAGCC GCTGGATGGG 840

GTGACGGGCT TCTTGGTGCT GATGTCGGAG GGGTTGTACA AGGCCCTAGA GGCAGCCCAT 900

GGGCCTGGGC AGGCCAACCA GGAGATTGCT GCGATGATTG ACACTGAGTT TGCCAAGCAG 960

ACCTCCCTGG ACGCAGTGGC CCAGGCCGTC GTGGACCGGG TGAAGCGCAT CCACAGCGAC 1020

ACCTTCGCCA GTGGTGGGGA GCGTGCCAGG TTCTGCCCCC GGCACGAGGA CATGACCCTG 1080

CTAGTGAGGA ACTTTGGCTA CCCGCTGGGC GAAATGAGCC AGCCCACACC GAGCCCAGCC 1140

CCAGCTGCAG GAGGACGAGT GTACCCTGTG TCTGTGCCAT ACTCCAGCGC CCAGAGCACC 1200

AGCAAGACCA GCGTGACCCT CTCCCTTGTC ATGCCCTCCC AGGGCCAGAT GGTCAACGGG 1260

GCTCACAGTG CTTCCACCCT GGACGAAGCC ACCCCCACCC TCACCAAAGA CCCTTCCAGG 1320

CCTGCAAGCG ATTTGACAGC CATCCCTCAG TGCCAACTAA ACCTCCTGGG CAGCCTGACC 1380

CCAGGGTAG 1389

Domain Profile

S: 29    pekkdrlaffgvyDGhggsevakfcseklheilaeelesseseerkvkkalakaFlstde  88

         +++++   ++gv++G  g++v++f++++l+  l     + e  e++v+++l +aF  +++

Q: 57    RSENN-CFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVER  115

         44444.589********************976665555599*******************

S: 89    el................................kvleeksldidk..sGstavvalikd  114

          +                                k+le+ ++ +++   G+ avva++ +

Q: 116   SFlesiddalaekaslqsqlpegvpqhqlppqyqKILERLKTLEREisGGAMAVVAVLLN  175

         *******************************99966666666666676999*********

S: 115   sklyvanvGdSravLcrng.k...avelssdHkpsredEleRieeag...gsvilkdgaR  167

         +klyvanvG  ra+Lc++  +   + +l +dH++++edEl R+++ g   g++ +

Q: 176   NKLYVANVGTNRALLCKSTvDglqVTQLNVDHTTENEDELFRLSQLGldaGKIKQVG--I  233

         ****************9663366699*********************9777777665..6

S: 168   vlGvLavsRalGdlylk..............pyvtpePevtshrl.tsedefliLasDGl  212

         ++G  + +R +Gd+++k              + +++ePe++  +  +  + fl+L s Gl

Q: 234   ICG-QESTRRIGDYKVKygytdidllsaaksKPIIAEPEIHGAQPlDGVTGFLVLMSEGL  292

         677.69************************999*******98765155555*********

S: 213   wdvvs........neeavslvrdvlekkeaeqeaakkLvkla  246

         ++ ++        n+e+ +++     k+++++++a+ +v++

Q: 293   YKALEaahgpgqaNQEIAAMIDTEFAKQTSLDAVAQAVVDRV  334

         **9863333333366666666666667888888888877765

Domain Sequence
(FASTA)

RSENNCFLYG VFNGYDGNRV TNFVAQRLSA ELLLGQLNAE HAEADVRRVL LQAFDVVERS 60

FLESIDDALA EKASLQSQLP EGVPQHQLPP QYQKILERLK TLEREISGGA MAVVAVLLNN 120

KLYVANVGTN RALLCKSTVD GLQVTQLNVD HTTENEDELF RLSQLGLDAG KIKQVGIICG 180

QESTRRIGDY KVKYGYTDID LLSAAKSKPI IAEPEIHGAQ PLDGVTGFLV LMSEGLYKAL 240

EAAHGPGQAN QEIAAMIDTE FAKQTSLDAV AQAVVDRV 278

Keyword

3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0010008	; C:endosome membrane
GO:0043234	; C:protein complex
GO:0003824	; F:catalytic activity
GO:0008047	; F:enzyme activator activity
GO:0019209	; F:kinase activator activity
GO:0000187	; P:activation of MAPK activity
GO:0000185	; P:activation of MAPKKK activity
GO:0003007	; P:heart morphogenesis
GO:0007249	; P:I-kappaB kinase/NF-kappaB cascade
GO:0001701	; P:in utero embryonic development
GO:0045087	; P:innate immune response
GO:0007254	; P:JNK cascade
GO:0030324	; P:lung development
GO:0002755	; P:MyD88-dependent toll-like receptor signaling pathway
GO:0070423	; P:nucleotide-binding oligomerization domain containing signaling pathway
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0008063	; P:Toll signaling pathway
GO:0034130	; P:toll-like receptor 1 signaling pathway
GO:0034134	; P:toll-like receptor 2 signaling pathway
GO:0034138	; P:toll-like receptor 3 signaling pathway
GO:0034142	; P:toll-like receptor 4 signaling pathway
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0035666	; P:TRIF-dependent toll-like receptor signaling pathway

KEGG

hsa:10454

;

InterPros

IPR001932	; PP2C-like.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

Prints

Created Date

20-Feb-2013