EKS-HOS-00212

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00212

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	531.0	2.7E-159	5	288	284

Status

Reviewed

Ensembl Protein

ENSP00000379176

UniProt Accession

Q00532; Q2M3A4; Q6QUA0; Q8WXQ5;

Protein Name

Cyclin-dependent kinase-like 1

Protein Synonyms/Alias

Protein kinase p42 KKIALRE; Serine/threonine-protein kinase KKIALRE;

Gene Name

CDKL1

Gene Synonyms/Alias

CDKL1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000100490	ENSP00000379176	ENST00000395834
ENSG00000100490	ENSP00000216378	ENST00000216378
ENSG00000100490	ENSP00000435044	ENST00000534267
ENSG00000100490	ENSP00000431449	ENST00000525911

Organism

Homo sapiens

Functional Description

Protein Length

358

Protein Sequence
(FASTA)

MMEKYEKIGK IGEGSYGVVF KCRNRDTGQI VAIKKFLESE DDPVIKKIAL REIRMLKQLK 60

HPNLVNLLEV FRRKRRLHLV FEYCDHTVLH ELDRYQRGVP EHLVKSITWQ TLQAVNFCHK 120

HNCIHRDVKP ENILITKHSV IKLCDFGFAR LLTGPSDYYT DYVATRWYRS PELLVGDTQY 180

GPPVDVWAIG CVFAELLSGV PLWPGKSDVD QLYLIRKTLG DLIPRHQQVF STNQYFSGVK 240

IPDPEDMEPL ELKFPNISYP ALGLLKGCLH MDPTQRLTCE QLLHHPYFEN IREIEDLAKE 300

HNKPTRKTLR KSRKHHCFTE TSKLQYLPQL TGSSILPALD NKKYYCDTKK LNYRFPNI 358

Nucleotide Sequence
(FASTA)

ATGATGGAGA AGTATGAAAA AATTGGGAAA ATTGGAGAAG GATCCTATGG AGTTGTTTTC 60

AAATGTAGAA ACAGGGACAC GGGTCAGATT GTGGCCATCA AGAAGTTTCT GGAATCAGAA 120

GATGACCCTG TCATAAAGAA AATTGCCCTT CGGGAAATCC GAATGCTCAA GCAACTCAAG 180

CATCCCAACC TTGTTAACCT CCTGGAAGTC TTCAGGAGGA AACGGAGGCT TCACCTGGTG 240

TTTGAATATT GTGACCACAC AGTTCTCCAT GAGTTGGACA GATACCAAAG AGGGGTACCA 300

GAACATCTCG TGAAGAGCAT AACTTGGCAG ACACTGCAAG CTGTAAATTT TTGCCATAAA 360

CACAATTGCA TACATAGAGA CGTGAAGCCA GAAAATATCC TCATCACGAA ACATTCCGTG 420

ATTAAGCTTT GTGACTTTGG ATTTGCTCGG CTTTTGACTG GACCGAGTGA CTACTATACA 480

GACTACGTGG CTACCAGGTG GTACCGCTCC CCTGAGCTGC TGGTGGGGGA CACGCAGTAC 540

GGCCCCCCGG TGGATGTTTG GGCAATTGGC TGTGTCTTTG CTGAGCTGCT GTCAGGAGTG 600

CCTCTGTGGC CAGGAAAATC GGATGTGGAT CAGCTGTATC TGATTAGGAA GACCTTGGGG 660

GATCTCATTC CTAGGCACCA GCAAGTGTTT AGCACGAATC AGTACTTCAG TGGAGTGAAA 720

ATTCCAGACC CTGAAGATAT GGAACCACTT GAATTAAAAT TCCCAAACAT CTCTTATCCT 780

GCCCTGGGGC TCCTAAAGGG CTGTCTCCAC ATGGACCCTA CTCAAAGGCT GACATGTGAA 840

CAGCTGTTGC ATCACCCATA TTTTGAAAAC ATCAGAGAAA TAGAGGATTT GGCAAAAGAA 900

CACAACAAAC CAACAAGGAA GACCCTAAGA AAGAGCCGAA AGCACCACTG CTTTACAGAA 960

ACATCCAAGT TGCAGTACCT ACCCCAGCTA ACTGGCAGCA GCATCCTTCC AGCTTTGGAT 1020

AATAAGAAGT ACTACTGTGA TACCAAGAAA CTTAACTACC GTTTTCCAAA CATTTAA 1077

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         yek+gk+GeGsyGvv+kcrn+dtgqivaikkflesedd+++kkialrei++lkqlkh+nl

Q: 5     YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNL  64

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnllevfrrk++l+lvfey+d+tvl+el+ry++Gv+e+lvk+i++q+l+a++fchk+n+i

Q: 65    VNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCI  124

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrd+kpenili+k++v+klcdfGfarll++p+d+ytdyvatrwyr+pellvgdt+yG++v

Q: 125   HRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPV  184

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwaiGc++aell+G pl+pgksdvdqly+irktlG+liprhq++fs+n++f+Gvk+p++

Q: 185   DVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDP  244

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         ed+e+le k+p++++ +l llk+cl++dp++rl+ce+ll+h+yf

Q: 245   EDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYF  288

         *******************************************9

Domain Sequence
(FASTA)

YEKIGKIGEG SYGVVFKCRN RDTGQIVAIK KFLESEDDPV IKKIALREIR MLKQLKHPNL 60

VNLLEVFRRK RRLHLVFEYC DHTVLHELDR YQRGVPEHLV KSITWQTLQA VNFCHKHNCI 120

HRDVKPENIL ITKHSVIKLC DFGFARLLTG PSDYYTDYVA TRWYRSPELL VGDTQYGPPV 180

DVWAIGCVFA ELLSGVPLWP GKSDVDQLYL IRKTLGDLIP RHQQVFSTNQ YFSGVKIPDP 240

EDMEPLELKF PNISYPALGL LKGCLHMDPT QRLTCEQLLH HPYF 284

Keyword

3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0007507	; P:heart development

KEGG

hsa:8814

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013