| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00435 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| AGC/SGK | 530.8 | 3.3E-159 | 35 | 292 | 258 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000362184 |
| UniProt Accession | Q9HBY8; Q52PK5; Q5H8Y6; Q5H8Z1; Q5TZR3; Q9UKG6; |
| Protein Name | Serine/threonine-protein kinase Sgk2 |
| Protein Synonyms/Alias | Serum/glucocorticoid-regulated kinase 2; |
| Gene Name | SGK2 |
| Gene Synonyms/Alias | SGK2; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Serine/threonine-protein kinase which is involved in theregulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. |
| Protein Length | 367 |
Protein Sequence
(FASTA) | | MNSSPAGTPS PQPSRANGNI NLGPSANPNA QPTDFDFLKV IGKGNYGKVL LAKRKSDGAF 60 | | YAVKVLQKKS ILKKKEQSHI MAERSVLLKN VRHPFLVGLR YSFQTPEKLY FVLDYVNGGE 120 | | LFFHLQRERR FLEPRARFYA AEVASAIGYL HSLNIIYRDL KPENILLDCQ GHVVLTDFGL 180 | | CKEGVEPEDT TSTFCGTPEY LAPEVLRKEP YDRAVDWWCL GAVLYEMLHG LPPFYSQDVS 240 | | QMYENILHQP LQIPGGRTVA ACDLLQSLLH KDQRQRLGSK ADFLEIKNHV FFSPINWDDL 300 | | YHKRLTPPFN PNVTGPADLK HFDPEFTQEA VSKSIGCTPD TVASSSGASS AFLGFSYAPE 360 | | DDDILDC 367 |
|
Nucleotide Sequence
(FASTA) | | ATGAACTCTA GCCCAGCTGG GACCCCAAGT CCACAGCCCT CCAGGGCCAA TGGGAACATC 60 | | AACCTGGGGC CTTCAGCCAA CCCAAATGCC CAGCCCACGG ACTTCGACTT CCTCAAAGTC 120 | | ATCGGCAAAG GGAACTACGG GAAGGTCCTA CTGGCCAAGC GCAAGTCTGA TGGGGCGTTC 180 | | TATGCAGTGA AGGTACTACA GAAAAAGTCC ATCTTAAAGA AGAAAGAGCA GAGCCACATC 240 | | ATGGCAGAGC GCAGTGTGCT TCTGAAGAAC GTGCGGCACC CCTTCCTCGT GGGCCTGCGC 300 | | TACTCCTTCC AGACACCTGA GAAGCTCTAC TTCGTGCTCG ACTATGTCAA CGGGGGAGAG 360 | | CTCTTCTTCC ACCTGCAGCG GGAGCGCCGG TTCCTGGAGC CCCGGGCCAG GTTCTACGCT 420 | | GCTGAGGTGG CCAGCGCCAT TGGCTACCTG CACTCCCTCA ACATCATTTA CAGGGATCTG 480 | | AAACCAGAGA ACATTCTCTT GGACTGCCAG GGACACGTGG TGCTGACGGA TTTTGGCCTC 540 | | TGCAAGGAAG GTGTAGAGCC TGAAGACACC ACATCCACAT TCTGTGGTAC CCCTGAGTAC 600 | | TTGGCACCTG AAGTGCTTCG GAAAGAGCCT TATGATCGAG CAGTGGACTG GTGGTGCTTG 660 | | GGGGCAGTCC TCTACGAGAT GCTCCATGGC CTGCCGCCCT TCTACAGCCA AGATGTATCC 720 | | CAGATGTATG AGAACATTCT GCACCAGCCG CTACAGATCC CCGGAGGCCG GACAGTGGCC 780 | | GCCTGTGACC TCCTGCAAAG CCTTCTCCAC AAGGACCAGA GGCAGCGGCT GGGCTCCAAA 840 | | GCAGACTTTC TTGAGATTAA GAACCATGTA TTCTTCAGCC CCATAAACTG GGATGACCTG 900 | | TACCACAAGA GGCTAACTCC ACCCTTCAAC CCAAATGTGA CAGGACCTGC TGACTTGAAG 960 | | CATTTTGACC CAGAGTTCAC CCAGGAAGCT GTGTCCAAGT CCATTGGCTG TACCCCTGAC 1020 | | ACTGTGGCCA GCAGCTCTGG GGCCTCAAGT GCATTCCTGG GATTTTCTTA TGCGCCAGAG 1080 | | GATGATGACA TCTTGGATTG CTAG 1104 |
|
| Domain Profile | S: 1 fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp 60 | fdflkvigkg++gkvllakrk+d++fyavkvlqkk+ilkkke++himaer+vllknv+hp | Q: 35 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 94 | 9*********************************************************** |
| S: 61 flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln 120 | flvgl+ysfqt+eklyfvldyvnggelffhlqrer+fleprarfyaae+asa+gylhsln | Q: 95 FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN 154 | ************************************************************ |
| S: 121 ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt 180 | i+yrdlkpenilld++ghvvltdfglcke++e edttstfcgtpeylapevlrk+pydr+ | Q: 155 IIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRA 214 | ************************************************************ |
| S: 181 vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk 240 | vdwwclgavlyeml+glppfys+dv++my+nil++plq+++g++vaa++ll++ll+kd++ | Q: 215 VDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQR 274 | ************************************************************ |
| S: 241 krlgakedfleiknhvff 258 | +rlg+k+dfleiknhvff | Q: 275 QRLGSKADFLEIKNHVFF 292 | *****************9 |
|
Domain Sequence
(FASTA) | | FDFLKVIGKG NYGKVLLAKR KSDGAFYAVK VLQKKSILKK KEQSHIMAER SVLLKNVRHP 60 | | FLVGLRYSFQ TPEKLYFVLD YVNGGELFFH LQRERRFLEP RARFYAAEVA SAIGYLHSLN 120 | | IIYRDLKPEN ILLDCQGHVV LTDFGLCKEG VEPEDTTSTF CGTPEYLAPE VLRKEPYDRA 180 | | VDWWCLGAVL YEMLHGLPPF YSQDVSQMYE NILHQPLQIP GGRTVAACDL LQSLLHKDQR 240 | | QRLGSKADFL EIKNHVFF 258 |
|
| Keyword | Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |