Tag | Content |
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EKPD ID | EKS-HOS-00375 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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TK/Src | 442.4 | 2.3E-132 | 241 | 490 | 250 |
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Status | Reviewed |
Ensembl Protein | ENSP00000429848 |
UniProt Accession | P08631; A8K1I1; B4DQB6; E1P5M2; Q29RX1; Q2VPE2; Q504R5; Q5T7K1; Q5T7K2; Q96CC0; Q9H5Y5; Q9NUA4; Q9UMJ5; |
Protein Name | Tyrosine-protein kinase HCK |
Protein Synonyms/Alias | Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck; |
Gene Name | HCK |
Gene Synonyms/Alias | HCK; |
Ensembl Information | |
Organism | Homo sapiens |
Functional Description | Non-receptor tyrosine-protein kinase found inhematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. |
Protein Length | 505 |
Protein Sequence (FASTA) | MGCMKSKFLQ VGGNTFSKTE TSASPHCPVY VPDPTSTIKP GPNSHNSNTP GIREAGSEDI 60 | IVVALYDYEA IHHEDLSFQK GDQMVVLEES GEWWKARSLA TRKEGYIPSN YVARVDSLET 120 | EEWFFKGISR KDAERQLLAP GNMLGSFMIR DSETTKGSYS LSVRDYDPRQ GDTVKHYKIR 180 | TLDNGGFYIS PRSTFSTLQE LVDHYKKGND GLCQKLSVPC MSSKPQKPWE KDAWEIPRES 240 | LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANVMKT LQHDKLVKLH 300 | AVVTKEPIYI ITEFMAKGSL LDFLKSDEGS KQPLPKLIDF SAQIAEGMAF IEQRNYIHRD 360 | LRAANILVSA SLVCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 420 | SFGILLMEIV TYGRIPYPGM SNPEVIRALE RGYRMPRPEN CPEELYNIMM RCWKNRPEER 480 | PTFEYIQSVL DDFYTATESQ YQQQP 505 |
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Nucleotide Sequence (FASTA) | ATGGGGTGCA TGAAGTCCAA GTTCCTCCAG GTCGGAGGCA ATACATTCTC AAAAACTGAA 60 | ACCAGCGCCA GCCCACACTG TCCTGTGTAC GTGCCGGATC CCACATCCAC CATCAAGCCG 120 | GGGCCTAATA GCCACAACAG CAACACACCA GGAATCAGGG AGGCAGGCTC TGAGGACATC 180 | ATCGTGGTTG CCCTGTATGA TTACGAGGCC ATTCACCACG AAGACCTCAG CTTCCAGAAG 240 | GGGGACCAGA TGGTGGTCCT AGAGGAATCC GGGGAGTGGT GGAAGGCTCG ATCCCTGGCC 300 | ACCCGGAAGG AGGGCTACAT CCCAAGCAAC TATGTCGCCC GCGTTGACTC TCTGGAGACA 360 | GAGGAGTGGT TTTTCAAGGG CATCAGCCGG AAGGACGCAG AGCGCCAACT GCTGGCTCCC 420 | GGCAACATGC TGGGCTCCTT CATGATCCGG GATAGCGAGA CCACTAAAGG AAGCTACTCT 480 | TTGTCCGTGC GAGACTACGA CCCTCGGCAG GGAGATACCG TGAAACATTA CAAGATCCGG 540 | ACCCTGGACA ACGGGGGCTT CTACATATCC CCCCGAAGCA CCTTCAGCAC TCTGCAGGAG 600 | CTGGTGGACC ACTACAAGAA GGGGAACGAC GGGCTCTGCC AGAAACTGTC GGTGCCCTGC 660 | ATGTCTTCCA AGCCCCAGAA GCCTTGGGAG AAAGATGCCT GGGAGATCCC TCGGGAATCC 720 | CTCAAGCTGG AGAAGAAACT TGGAGCTGGG CAGTTTGGGG AAGTCTGGAT GGCCACCTAC 780 | AACAAGCACA CCAAGGTGGC AGTGAAGACG ATGAAGCCAG GGAGCATGTC GGTGGAGGCC 840 | TTCCTGGCAG AGGCCAACGT GATGAAAACT CTGCAGCATG ACAAGCTGGT CAAACTTCAT 900 | GCGGTGGTCA CCAAGGAGCC CATCTACATC ATCACGGAGT TCATGGCCAA AGGAAGCTTG 960 | CTGGACTTTC TGAAAAGTGA TGAGGGCAGC AAGCAGCCAT TGCCAAAACT CATTGACTTC 1020 | TCAGCCCAGA TTGCAGAAGG CATGGCCTTC ATCGAGCAGA GGAACTACAT CCACCGAGAC 1080 | CTCCGAGCTG CCAACATCTT GGTCTCTGCA TCCCTGGTGT GTAAGATTGC TGACTTTGGC 1140 | CTGGCCCGGG TCATTGAGGA CAACGAGTAC ACGGCTCGGG AAGGGGCCAA GTTCCCCATC 1200 | AAGTGGACAG CTCCTGAAGC CATCAACTTT GGCTCCTTCA CCATCAAGTC AGACGTCTGG 1260 | TCCTTTGGTA TCCTGCTGAT GGAGATCGTC ACCTACGGCC GGATCCCTTA CCCAGGGATG 1320 | TCAAACCCTG AAGTGATCCG AGCTCTGGAG CGTGGATACC GGATGCCTCG CCCAGAGAAC 1380 | TGCCCAGAGG AGCTCTACAA CATCATGATG CGCTGCTGGA AAAACCGTCC GGAGGAGCGG 1440 | CCGACCTTCG AATACATCCA GAGTGTGCTG GATGACTTCT ACACGGCCAC AGAGAGCCAG 1500 | TACCAACAGC AGCCATGA 1518 |
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Domain Profile | S: 1 lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly 60 | lkl+kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+ | Q: 241 LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLH 300 | 689********************************************************* |
| S: 61 avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr 120 | avv++ ePiyi+te+makGslldflk++eg+k++lpkl+d++aq+aeGma++e++n+ihr | Q: 301 AVVTK-EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR 359 | ****9.****************************************************** |
| S: 121 dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv 180 | dl+a+n+lv+ slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv | Q: 360 DLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV 419 | ************************************************************ |
| S: 181 WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee 240 | WsfGill+eivt+G++PypGm+n ev++++ergyr+prpe+cpeely+++++cwk++pee | Q: 420 WSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEE 479 | ************************************************************ |
| S: 241 rPtfetlqevl 251 | rPtfe++q+vl | Q: 480 RPTFEYIQSVL 490 | *******9976 |
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Domain Sequence (FASTA) | LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANVMKT LQHDKLVKLH 60 | AVVTKEPIYI ITEFMAKGSL LDFLKSDEGS KQPLPKLIDF SAQIAEGMAF IEQRNYIHRD 120 | LRAANILVSA SLVCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180 | SFGILLMEIV TYGRIPYPGM SNPEVIRALE RGYRMPRPEN CPEELYNIMM RCWKNRPEER 240 | PTFEYIQSVL 250 |
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Keyword | 3D-structure; Alternative initiation; Alternative splicing; ATP-binding; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Exocytosis; Golgi apparatus; Host-virus interaction; Immunity; Inflammatory response; Innate immunity; Kinase; Lipoprotein; Lysosome; Membrane; Myristate; Nucleotide-binding; Nucleus; Palmitate; Phagocytosis; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase; Ubl conjugation. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
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Created Date | 20-Feb-2013 |