EKS-HOS-00375
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00375
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src442.42.3E-132241490250
StatusReviewed
Ensembl ProteinENSP00000429848
UniProt AccessionP08631; A8K1I1; B4DQB6; E1P5M2; Q29RX1; Q2VPE2; Q504R5; Q5T7K1; Q5T7K2; Q96CC0; Q9H5Y5; Q9NUA4; Q9UMJ5;
Protein NameTyrosine-protein kinase HCK
Protein Synonyms/Alias Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck;
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000101336ENSP00000365012ENST00000375852
ENSG00000101336ENSP00000262651ENST00000262651
ENSG00000101336ENSP00000429848ENST00000520553
ENSG00000101336ENSP00000365022ENST00000375862
ENSG00000101336ENSP00000427757ENST00000518730
ENSG00000101336ENSP00000444986ENST00000534862
ENSG00000101336ENSP00000420457ENST00000486475
ENSG00000101336ENSP00000441169ENST00000538448
OrganismHomo sapiens
Functional DescriptionNon-receptor tyrosine-protein kinase found inhematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
Protein Length505
Protein Sequence
(FASTA)
MGCMKSKFLQ VGGNTFSKTE TSASPHCPVY VPDPTSTIKP GPNSHNSNTP GIREAGSEDI 60
IVVALYDYEA IHHEDLSFQK GDQMVVLEES GEWWKARSLA TRKEGYIPSN YVARVDSLET 120
EEWFFKGISR KDAERQLLAP GNMLGSFMIR DSETTKGSYS LSVRDYDPRQ GDTVKHYKIR 180
TLDNGGFYIS PRSTFSTLQE LVDHYKKGND GLCQKLSVPC MSSKPQKPWE KDAWEIPRES 240
LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANVMKT LQHDKLVKLH 300
AVVTKEPIYI ITEFMAKGSL LDFLKSDEGS KQPLPKLIDF SAQIAEGMAF IEQRNYIHRD 360
LRAANILVSA SLVCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 420
SFGILLMEIV TYGRIPYPGM SNPEVIRALE RGYRMPRPEN CPEELYNIMM RCWKNRPEER 480
PTFEYIQSVL DDFYTATESQ YQQQP 505
Nucleotide Sequence
(FASTA)
ATGGGGTGCA TGAAGTCCAA GTTCCTCCAG GTCGGAGGCA ATACATTCTC AAAAACTGAA 60
ACCAGCGCCA GCCCACACTG TCCTGTGTAC GTGCCGGATC CCACATCCAC CATCAAGCCG 120
GGGCCTAATA GCCACAACAG CAACACACCA GGAATCAGGG AGGCAGGCTC TGAGGACATC 180
ATCGTGGTTG CCCTGTATGA TTACGAGGCC ATTCACCACG AAGACCTCAG CTTCCAGAAG 240
GGGGACCAGA TGGTGGTCCT AGAGGAATCC GGGGAGTGGT GGAAGGCTCG ATCCCTGGCC 300
ACCCGGAAGG AGGGCTACAT CCCAAGCAAC TATGTCGCCC GCGTTGACTC TCTGGAGACA 360
GAGGAGTGGT TTTTCAAGGG CATCAGCCGG AAGGACGCAG AGCGCCAACT GCTGGCTCCC 420
GGCAACATGC TGGGCTCCTT CATGATCCGG GATAGCGAGA CCACTAAAGG AAGCTACTCT 480
TTGTCCGTGC GAGACTACGA CCCTCGGCAG GGAGATACCG TGAAACATTA CAAGATCCGG 540
ACCCTGGACA ACGGGGGCTT CTACATATCC CCCCGAAGCA CCTTCAGCAC TCTGCAGGAG 600
CTGGTGGACC ACTACAAGAA GGGGAACGAC GGGCTCTGCC AGAAACTGTC GGTGCCCTGC 660
ATGTCTTCCA AGCCCCAGAA GCCTTGGGAG AAAGATGCCT GGGAGATCCC TCGGGAATCC 720
CTCAAGCTGG AGAAGAAACT TGGAGCTGGG CAGTTTGGGG AAGTCTGGAT GGCCACCTAC 780
AACAAGCACA CCAAGGTGGC AGTGAAGACG ATGAAGCCAG GGAGCATGTC GGTGGAGGCC 840
TTCCTGGCAG AGGCCAACGT GATGAAAACT CTGCAGCATG ACAAGCTGGT CAAACTTCAT 900
GCGGTGGTCA CCAAGGAGCC CATCTACATC ATCACGGAGT TCATGGCCAA AGGAAGCTTG 960
CTGGACTTTC TGAAAAGTGA TGAGGGCAGC AAGCAGCCAT TGCCAAAACT CATTGACTTC 1020
TCAGCCCAGA TTGCAGAAGG CATGGCCTTC ATCGAGCAGA GGAACTACAT CCACCGAGAC 1080
CTCCGAGCTG CCAACATCTT GGTCTCTGCA TCCCTGGTGT GTAAGATTGC TGACTTTGGC 1140
CTGGCCCGGG TCATTGAGGA CAACGAGTAC ACGGCTCGGG AAGGGGCCAA GTTCCCCATC 1200
AAGTGGACAG CTCCTGAAGC CATCAACTTT GGCTCCTTCA CCATCAAGTC AGACGTCTGG 1260
TCCTTTGGTA TCCTGCTGAT GGAGATCGTC ACCTACGGCC GGATCCCTTA CCCAGGGATG 1320
TCAAACCCTG AAGTGATCCG AGCTCTGGAG CGTGGATACC GGATGCCTCG CCCAGAGAAC 1380
TGCCCAGAGG AGCTCTACAA CATCATGATG CGCTGCTGGA AAAACCGTCC GGAGGAGCGG 1440
CCGACCTTCG AATACATCCA GAGTGTGCTG GATGACTTCT ACACGGCCAC AGAGAGCCAG 1500
TACCAACAGC AGCCATGA 1518
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lkl+kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+
Q: 241   LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLH  300
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyi+te+makGslldflk++eg+k++lpkl+d++aq+aeGma++e++n+ihr
Q: 301   AVVTK-EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR  359
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+ slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 360   DLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  419
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+G++PypGm+n ev++++ergyr+prpe+cpeely+++++cwk++pee
Q: 420   WSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEE  479
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q+vl
Q: 480   RPTFEYIQSVL  490
         *******9976
Domain Sequence
(FASTA)
LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANVMKT LQHDKLVKLH 60
AVVTKEPIYI ITEFMAKGSL LDFLKSDEGS KQPLPKLIDF SAQIAEGMAF IEQRNYIHRD 120
LRAANILVSA SLVCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180
SFGILLMEIV TYGRIPYPGM SNPEVIRALE RGYRMPRPEN CPEELYNIMM RCWKNRPEER 240
PTFEYIQSVL 250
Keyword3D-structure; Alternative initiation; Alternative splicing; ATP-binding; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Exocytosis; Golgi apparatus; Host-virus interaction; Immunity; Inflammatory response; Innate immunity; Kinase; Lipoprotein; Lysosome; Membrane; Myristate; Nucleotide-binding; Nucleus; Palmitate; Phagocytosis; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase; Ubl conjugation.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-POA-00365
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-XIM-00467
Gene Ontology
GO:0005901; C:caveola
GO:0042995; C:cell projection
GO:0005856; C:cytoskeleton
GO:0005829; C:cytosol
GO:0031234; C:extrinsic to internal side of plasma membrane
GO:0005925; C:focal adhesion
GO:0005794; C:Golgi apparatus
GO:0005764; C:lysosome
GO:0005634; C:nucleus
GO:0030133; C:transport vesicle
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0007155; P:cell adhesion
GO:0050830; P:defense response to Gram-positive bacterium
GO:0006954; P:inflammatory response
GO:0002758; P:innate immune response-activating signal transduction
GO:0007229; P:integrin-mediated signaling pathway
GO:0060333; P:interferon-gamma-mediated signaling pathway
GO:0043299; P:leukocyte degranulation
GO:0002522; P:leukocyte migration involved in immune response
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0007498; P:mesoderm development
GO:0043066; P:negative regulation of apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0006909; P:phagocytosis
GO:2000251; P:positive regulation of actin cytoskeleton reorganization
GO:0030838; P:positive regulation of actin filament polymerization
GO:0008284; P:positive regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0050690; P:regulation of defense response to virus by virus
GO:0050727; P:regulation of inflammatory response
GO:0050764; P:regulation of phagocytosis
GO:0071801; P:regulation of podosome assembly
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
GO:0045728; P:respiratory burst after phagocytosis
GO:0016032; P:viral reproduction
GO:0019048; P:virus-host interaction
KEGG
hsa:3055;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013