EKS-HOS-00335

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00335

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	324.3	3.0E-96	453	700	248

Status

Reviewed

Ensembl Protein

ENSP00000322957

UniProt Accession

Q9P286; A8K5T6; D3DW14; Q5W115; Q9BX09; Q9ULF6;

Protein Name

Serine/threonine-protein kinase PAK 7

Protein Synonyms/Alias

p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7;

Gene Name

PAK7

Gene Synonyms/Alias

PAK7; KIAA1264, PAK5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000101349	ENSP00000367686	ENST00000378429
ENSG00000101349	ENSP00000367679	ENST00000378423
ENSG00000101349	ENSP00000322957	ENST00000353224

Organism

Homo sapiens

Functional Description

Serine/threonine protein kinase that plays a role in avariety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.

Protein Length

719

Protein Sequence
(FASTA)

MFGKKKKKIE ISGPSNFEHR VHTGFDPQEQ KFTGLPQQWH SLLADTANRP KPMVDPSCIT 60

PIQLAPMKTI VRGNKPCKET SINGLLEDFD NISVTRSNSL RKESPPTPDQ GASSHGPGHA 120

EENGFITFSQ YSSESDTTAD YTTEKYREKS LYGDDLDPYY RGSHAAKQNG HVMKMKHGEA 180

YYSEVKPLKS DFARFSADYH SHLDSLSKPS EYSDLKWEYQ RASSSSPLDY SFQFTPSRTA 240

GTSGCSKESL AYSESEWGPS LDDYDRRPKS SYLNQTSPQP TMRQRSRSGS GLQEPMMPFG 300

ASAFKTHPQG HSYNSYTYPR LSEPTMCIPK VDYDRAQMVL SPPLSGSDTY PRGPAKLPQS 360

QSKSGYSSSS HQYPSGYHKA TLYHHPSLQS SSQYISTASY LSSLSLSSST YPPPSWGSSS 420

DQQPSRVSHE QFRAALQLVV SPGDPREYLA NFIKIGEGST GIVCIATEKH TGKQVAVKKM 480

DLRKQQRREL LFNEVVIMRD YHHDNVVDMY SSYLVGDELW VVMEFLEGGA LTDIVTHTRM 540

NEEQIATVCL SVLRALSYLH NQGVIHRDIK SDSILLTSDG RIKLSDFGFC AQVSKEVPKR 600

KSLVGTPYWM APEVISRLPY GTEVDIWSLG IMVIEMIDGE PPYFNEPPLQ AMRRIRDSLP 660

PRVKDLHKVS SVLRGFLDLM LVREPSQRAT AQELLGHPFL KLAGPPSCIV PLMRQYRHH 719

Nucleotide Sequence
(FASTA)

ATGTTTGGGA AGAAAAAGAA AAAGATTGAA ATATCTGGCC CGTCCAACTT TGAACACAGG 60

GTTCATACTG GGTTTGATCC ACAAGAGCAG AAGTTTACCG GCCTTCCCCA GCAGTGGCAC 120

AGCCTGTTAG CAGATACGGC CAACAGGCCA AAGCCTATGG TGGACCCTTC ATGCATCACA 180

CCCATCCAGC TGGCTCCTAT GAAGACAATC GTTAGAGGAA ACAAACCCTG CAAGGAAACC 240

TCCATCAACG GCCTGCTAGA GGATTTTGAC AACATCTCGG TGACTCGCTC CAACTCCCTA 300

AGGAAAGAAA GCCCACCCAC CCCAGATCAG GGAGCCTCCA GCCACGGTCC AGGCCACGCG 360

GAAGAAAATG GCTTCATCAC CTTCTCCCAG TATTCCAGCG AATCCGATAC TACTGCTGAC 420

TACACGACCG AAAAGTACAG GGAGAAGAGT CTCTATGGAG ATGATCTGGA TCCGTATTAT 480

AGAGGCAGCC ACGCAGCCAA GCAAAATGGG CACGTAATGA AAATGAAGCA CGGGGAGGCC 540

TACTATTCTG AGGTGAAGCC TTTGAAATCC GATTTTGCCA GATTTTCTGC CGATTATCAC 600

TCACATTTGG ACTCACTGAG CAAACCAAGT GAATACAGTG ACCTCAAGTG GGAGTATCAG 660

AGAGCCTCGA GTAGCTCCCC TCTGGATTAT TCATTCCAAT TCACACCTTC TAGAACTGCA 720

GGGACCAGCG GGTGCTCCAA GGAGAGCCTG GCGTACAGTG AAAGTGAATG GGGACCCAGC 780

CTGGATGACT ATGACAGGAG GCCAAAGTCT TCGTACCTGA ATCAGACAAG CCCTCAGCCC 840

ACCATGCGGC AGAGGTCCAG GTCAGGCTCG GGACTCCAGG AACCGATGAT GCCATTTGGA 900

GCAAGTGCAT TTAAAACCCA TCCCCAAGGA CACTCCTACA ACTCCTACAC CTACCCTCGC 960

TTGTCCGAGC CCACAATGTG CATTCCAAAG GTGGATTACG ATCGAGCACA GATGGTCCTC 1020

AGCCCTCCAC TGTCAGGGTC TGACACCTAC CCCAGGGGCC CTGCCAAACT ACCTCAAAGT 1080

CAAAGCAAAT CGGGCTATTC CTCAAGCAGT CACCAGTACC CGTCTGGGTA CCACAAAGCC 1140

ACCTTGTACC ATCACCCCTC CCTGCAGAGC AGTTCGCAGT ACATCTCCAC GGCTTCCTAC 1200

CTGAGCTCCC TCAGCCTCTC ATCCAGCACC TACCCGCCGC CCAGCTGGGG CTCCTCCTCC 1260

GACCAGCAGC CCTCCAGGGT GTCCCATGAA CAGTTTCGGG CGGCCCTGCA GCTGGTGGTC 1320

AGCCCAGGAG ACCCCAGGGA ATACTTGGCC AACTTTATCA AAATCGGGGA AGGCTCAACC 1380

GGCATCGTAT GCATCGCCAC CGAGAAACAC ACAGGGAAAC AAGTTGCAGT GAAGAAAATG 1440

GACCTCCGGA AGCAACAGAG ACGAGAACTG CTTTTCAATG AGGTCGTGAT CATGCGGGAT 1500

TACCACCATG ACAATGTGGT TGACATGTAC AGCAGCTACC TTGTCGGCGA TGAGCTCTGG 1560

GTGGTCATGG AGTTTCTAGA AGGTGGTGCC TTGACAGACA TTGTGACTCA CACCAGAATG 1620

AATGAAGAAC AGATAGCTAC TGTCTGCCTG TCAGTTCTGA GAGCTCTCTC CTACCTTCAT 1680

AACCAAGGAG TGATTCACAG GGACATAAAA AGTGACTCCA TCCTCCTGAC AAGCGATGGC 1740

CGGATAAAGT TGTCTGATTT TGGTTTCTGT GCTCAAGTTT CCAAAGAGGT GCCGAAGAGG 1800

AAATCATTGG TTGGCACTCC CTACTGGATG GCCCCTGAGG TGATTTCTAG GCTACCTTAT 1860

GGGACAGAGG TGGACATCTG GTCCCTCGGG ATCATGGTGA TAGAAATGAT TGATGGCGAG 1920

CCCCCCTACT TCAATGAGCC TCCCCTCCAG GCGATGCGGA GGATCCGGGA CAGTTTACCT 1980

CCAAGAGTGA AGGACCTACA CAAGGTTTCT TCAGTGCTCC GGGGATTCCT AGACTTGATG 2040

TTGGTGAGGG AGCCCTCTCA GAGAGCAACA GCCCAGGAAC TCCTCGGACA TCCATTCTTA 2100

AAACTAGCAG GTCCACCGTC TTGCATCGTC CCCCTCATGA GACAATACAG GCATCACTGA 2160

Domain Profile

S: 5     eeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyles  64

          +ig+G++g v++a+ek+tg++va+kk++l+kq++ e+l++e+ ++++++h n+v++++s

Q: 453   IKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSS  512

         58**********************************************************

S: 65    flkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdi  124

         +l+ +elw+vme+l+gG+l+d+v+   +++++Eeqia+++ +vl+aL+ylH+++viHrdi

Q: 513   YLVGDELWVVMEFLEGGALTDIVT---HTRMNEEQIATVCLSVLRALSYLHNQGVIHRDI  569

         ************************...9********************************

S: 125   kakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiw  184

         k+++iLlt++g++kLsdfg++aq++k++ krk++vgtpywmAPEvi+  +  Y +++Diw

Q: 570   KSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS--RLPYGTEVDIW  627

         ***********************************************..9**********

S: 185   slGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpek  244

         slGI++ie+++gepP+++++pl+a+ +i ++ pp++k+ +k+s+ ++ f++ +l ++p++

Q: 628   SLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQ  687

         ************************************************************

S: 245   RpsasellkhkFl  257

         R++a+ell h+Fl

Q: 688   RATAQELLGHPFL  700

         ************7

Domain Sequence
(FASTA)

IKIGEGSTGI VCIATEKHTG KQVAVKKMDL RKQQRRELLF NEVVIMRDYH HDNVVDMYSS 60

YLVGDELWVV MEFLEGGALT DIVTHTRMNE EQIATVCLSV LRALSYLHNQ GVIHRDIKSD 120

SILLTSDGRI KLSDFGFCAQ VSKEVPKRKS LVGTPYWMAP EVISRLPYGT EVDIWSLGIM 180

VIEMIDGEPP YFNEPPLQAM RRIRDSLPPR VKDLHKVSSV LRGFLDLMLV REPSQRATAQ 240

ELLGHPFL 248

Keyword

3D-structure; Apoptosis; ATP-binding; Complete proteome; Cytoplasm; Kinase; Mitochondrion; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0016049	; P:cell growth
GO:0016477	; P:cell migration
GO:0008283	; P:cell proliferation
GO:0007010	; P:cytoskeleton organization
GO:0007165	; P:signal transduction

KEGG

hsa:57144

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

Created Date

20-Feb-2013