| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00311 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Atypical/Alpha | 287.7 | 2.9E-85 | 121 | 318 | 198 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000456243 |
| UniProt Accession | O00418; Q8N588; |
| Protein Name | Eukaryotic elongation factor 2 kinase |
| Protein Synonyms/Alias | eEF-2 kinase; eEF-2K; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; |
| Gene Name | EEF2K |
| Gene Synonyms/Alias | EEF2K; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Threonine kinase that regulates protein synthesis bycontrolling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. |
| Protein Length | 412 |
Protein Sequence
(FASTA) | | MADEDLIFRL EGVDGGQSPR AGHDGDSDGD SDDEEGYFIC PITDDPSSNQ NVNSKVNKYY 60 | | SNLTKSERYS SSGSPANSFH FKEAWKHAIQ KAKHMPDPWA EFHLEDIATE RATRHRYNAV 120 | | TGEWLDDEVL IKMASQPFGR GAMRECFRTK KLSNFLHAQQ WKGASNYVAK RYIEPVDRDV 180 | | YFEDVRLQME AKLWGEEYNR HKPPKQVDIM QMCIIELKDR PGKPLFHLEH YIEGKYIKYN 240 | | SNSGFVRDDN IRLTPQAFSH FTFERSGHQL IVVDIQGVGD LYTDPQIHTE TGTDFGDGNL 300 | | GVRGMALFFY SHACNRICES MGLAPFDLSP RERDAVNQNT KLLQSAKTIL RGTEEKCGSP 360 | | QVRTLSGSRP PLLRPLSENS GDENMSDVTF DSLPSSPSSA TPHSQKLDHL RE 412 |
|
Nucleotide Sequence
(FASTA) | | ATGGCAGACG AAGATCTCAT CTTCCGCCTG GAAGGCGTTG ATGGCGGCCA GTCCCCCCGA 60 | | GCTGGCCATG ATGGTGATTC TGATGGGGAC AGCGACGATG AGGAAGGTTA CTTCATCTGC 120 | | CCCATCACGG ATGACCCAAG CTCGAACCAG AATGTCAATT CCAAGGTTAA TAAGTACTAC 180 | | AGCAACCTAA CAAAAAGTGA GCGGTATAGC TCCAGCGGGT CCCCGGCAAA CTCCTTCCAC 240 | | TTCAAGGAAG CCTGGAAGCA CGCAATCCAG AAGGCCAAGC ACATGCCCGA CCCCTGGGCT 300 | | GAGTTCCACC TGGAAGATAT TGCCACCGAA CGTGCTACTC GACACAGGTA CAACGCCGTC 360 | | ACCGGGGAAT GGCTGGATGA TGAAGTTCTG ATCAAGATGG CATCTCAGCC CTTCGGCCGA 420 | | GGAGCAATGA GGGAGTGCTT CCGGACGAAG AAGCTCTCCA ACTTCTTGCA TGCCCAGCAG 480 | | TGGAAGGGCG CCTCCAACTA CGTGGCGAAG CGCTACATCG AGCCCGTAGA CCGGGATGTG 540 | | TACTTTGAGG ACGTGCGTCT ACAGATGGAG GCCAAGCTCT GGGGGGAGGA GTATAATCGG 600 | | CACAAGCCCC CCAAGCAGGT GGACATCATG CAGATGTGCA TCATCGAGCT GAAGGACAGA 660 | | CCGGGCAAGC CCCTCTTCCA CCTGGAGCAC TACATCGAGG GCAAGTACAT CAAGTACAAC 720 | | TCCAACTCTG GCTTTGTCCG CGATGACAAC ATCCGCCTGA CGCCGCAGGC CTTCAGCCAC 780 | | TTCACTTTTG AGCGTTCCGG CCATCAGCTG ATAGTGGTGG ACATCCAGGG AGTTGGGGAT 840 | | CTCTACACTG ACCCACAGAT CCACACGGAG ACGGGCACTG ACTTTGGAGA CGGCAACCTA 900 | | GGTGTCCGCG GGATGGCGCT CTTCTTCTAC TCTCATGCCT GCAACCGGAT TTGCGAGAGC 960 | | ATGGGCCTTG CTCCCTTTGA CCTCTCGCCC CGGGAGAGGG ATGCAGTGAA TCAGAACACC 1020 | | AAGCTGCTGC AATCAGCCAA GACCATCTTG AGAGGAACAG AGGAAAAATG TGGGAGCCCC 1080 | | CAAGTAAGGA CCCTCTCTGG GAGCCGGCCA CCCCTGCTCC GTCCCCTTTC AGAGAACTCT 1140 | | GGAGACGAGA ACATGAGCGA CGTGACCTTC GACTCTCTCC CTTCTTCCCC ATCTTCGGCC 1200 | | ACACCACACA GCCAGAAGCT AGACCACCTC CGTGAGTGA 1239 |
|
| Domain Profile | S: 2 sesWsqqetivlikvlskeekkGalRkalrvkkgslflvkeelkevvryvakiykeqkvl 61 | +++W+++e vlik++s+++++Ga+R+++r+kk+s+fl+++++k++++yvak+y+e++++ | Q: 121 TGEWLDDE--VLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDR 178 | 789*****..************************************************** |
| S: 62 hlylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknqlltvEeyllGefv 121 | ++y++dv+ q++a+ +++e+n++kP+k+v+i+++++++Lkdr++k +l+++E+y++G+++ | Q: 179 DVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGK-PLFHLEHYIEGKYI 237 | *********************************************.************** |
| S: 122 KynnnngdeikrenkleelmlafsHftyeytngellVvDlqGvgeklTDpqiatksrgtk 181 | Kyn+n+g ++r+++++ +++afsHft+e+++++l+VvD+qGvg+ +TDpqi+t ++gt+ | Q: 238 KYNSNSG--FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHT-ETGTD 294 | *******..*********************************************.***** |
| S: 182 fgkanlgeraiknFfakhhCNeiC 205 | fg++nlg+r+++ Ff++h+CN+iC | Q: 295 FGDGNLGVRGMALFFYSHACNRIC 318 | ************************ |
|
Domain Sequence
(FASTA) | | TGEWLDDEVL IKMASQPFGR GAMRECFRTK KLSNFLHAQQ WKGASNYVAK RYIEPVDRDV 60 | | YFEDVRLQME AKLWGEEYNR HKPPKQVDIM QMCIIELKDR PGKPLFHLEH YIEGKYIKYN 120 | | SNSGFVRDDN IRLTPQAFSH FTFERSGHQL IVVDIQGVGD LYTDPQIHTE TGTDFGDGNL 180 | | GVRGMALFFY SHACNRIC 198 |
|
| Keyword | ATP-binding; Calcium; Calmodulin-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |